Selection of markers

ABSTRACT

Methods of selecting a portfolio of markers for use in a diagnostic applications include defining diagnostic parameters, establishing a relationship among the parameters so that they are optimized, and selecting an optimal group of markers for the diagnostic application. The diagnostic parameters can include a measure of the relative degree of expression of a gene, a measure of the variation in the measurement of the degree of expression of the gene, and the relationship between the diagnostic and discriminating parameters can be a mean variance relationship.  
     Machines programmed to conduct the method and articles that comprise instructions for their operation are further aspects of the invention.

BACKGROUND

[0001] This application claims the benefit of U.S. ProvisionalApplication No.60/368,790 filed on March 29, 2002.

[0002] The invention relates to the selection of portfolios ofdiagnostic markers.

[0003] A few single gene diagnostic markers such as her-2-neu arecurrently in use. Usually, however, diseases are not easily diagnosedwith molecular diagnostics for one particular gene. Multiple markers areoften required and the number of such markers that may be included in aassay based on differential gene modulation can be large, even in thehundreds of genes. It is desirable to group markers into portfolios sothat the most reliable results are obtained using the smallest number ofmarkers necessary to obtain such a result. This is particularly true inassays that contain multiple steps such as nucleic acid amplificationsteps.

SUMMARY OF THE INVENTION

[0004] The invention is a method of selecting a portfolio of markers foruse in a diagnostic application in which diagnostic parameters aredefined, a relationship among the parameters is established so that theyare optimized, and the relationship is used to select an optimal groupof markers for the diagnostic application.

[0005] In another aspect of the invention, the diagnostic parametersinclude a measure of the relative degree of expression of a gene, ameasure of the variation in the measurement of the degree of expressionof the gene, and the relationship between the diagnostic anddiscriminating parameters is a mean variance relationship.

[0006] Machines programmed to conduct the inventive method and articlesthat comprise instructions for their operation are further aspects ofthe invention.

DETAILED DESCRIPTION

[0007] The methods of this invention can be used in conjunction with anymethod for determining the gene expression patterns of relevant cells aswell as protein based methods of determining gene expression. Preferredmethods for establishing gene expression profiles include determiningthe amount of RNA that is produced by a gene that can code for a proteinor peptide. This is accomplished by reverse transcriptase PCR (RT-PCR),competitive RT-PCR, real time RT-PCR, differential display RT-PCR,Northern Blot analysis and other related tests. While it is possible toconduct these techniques using individual PCR reactions, it is best toamplify copy DNA (cDNA) or copy RNA (cRNA) produced from mRNA andanalyze it via microarray. A number of different array configurationsand methods for their production are known to those of skill in the artand are described in U.S. patents such as: U.S. Pat. Nos. 5,445,934;5,532,128; 5,556,752; 5,242,974; 5,384,261; 5,405,783; 5,412,087;5,424,186; 5,429,807; 5,436,327; 5,472,672; 5,527,681; 5,529,756;5,545,531; 5,554,501; 5,561,071; 5,571,639; 5,593,839; 5,599,695;5,624,711; 5,658,734; and 5,700,637; the disclosures of which areincorporated herein by reference.

[0008] Microarray technology allows for the measurement of thesteady-state mRNA level of thousands of genes simultaneously therebypresenting a powerful tool for identifying effects such as the onset,arrest, or modulation of uncontrolled cell proliferation. Two microarraytechnologies are currently in wide use. The first are cDNA arrays andthe second are oligonucleotide arrays. Although differences exist in theconstruction of these chips, essentially all downstream data analysisand output are the same. The product of these analyses are typicallymeasurements of the intensity of the signal received from a labeledprobe used to detect a cDNA sequence from the sample that hybridizes toa nucleic acid sequence at a known location on the microarray.Typically, the intensity of the signal is proportional to the quantityof cDNA, and thus mRNA, expressed in the sample cells. A large number ofsuch techniques are available and useful. Preferred methods fordetermining gene expression can be found in U.S. Pat. Nos. 6,271,002 toLinsley, et al.; 6,218,122 to Friend, et al.; 6,218,114 to Peck, et al.;and 6,004,755 to Wang, et al., the disclosure of each of which isincorporated herein by reference.

[0009] Analysis of the expression levels is conducted by comparing suchintensities. This is best done by generating a ratio matrix of theexpression intensities of genes in a test sample versus those in acontrol sample. For instance, the gene expression intensities from adiseased tissue can be compared with the expression intensitiesgenerated from normal tissue of the same type (e.g., diseased colontissue sample vs. normal colon tissue sample). A ratio of theseexpression intensities indicates the fold-change in gene expressionbetween the test and control samples.

[0010] Modulated genes are those that are differentially expressed as upregulated or down regulated in non-normal cells. Up regulation and downregulation are relative terms meaning that a detectable difference(beyond the contribution of noise in the system used to measure it) isfound in the amount of expression of the genes relative to somebaseline. In this case, the baseline is the measured gene expression ofa normal cell. The genes of interest in the non-normal cells are theneither up regulated or down regulated relative to the baseline levelusing the same measurement method.

[0011] Preferably, levels of up and down regulation are distinguishedbased on fold changes of the intensity measurements of hybridizedmicroarray probes. For example, in the case in which a 1.5 fold or moredifference is used to make such distinctions, the diseased cell is foundto yield at least 1.5 times more, or 1.5 times less intensity than thenormal cells.

[0012] Other methods of making distinctions are available. For example,statistical tests can be used to find the genes most significantlydifferent between diverse groups of samples. The Student's t-test is anexample of a robust statistical test that can be used to findsignificant differences between two groups. The lower the p-value, themore compelling the evidence that the gene is showing a differencebetween the different groups. Nevertheless, since microarrays measuremore than one gene at a time, tens of thousands of statistical tests maybe asked at one time. Because of this, there is likelihood to see smallp-values just by chance and adjustments for this using a Sidakcorrection as well as a randomization/permutation experiment can bemade.

[0013] A p-value less than 0.05 by the t-test is evidence that the geneis significantly different. More compelling evidence is a p-value lessthen 0.05 after the Sidak correct is factored in. For a large number ofsamples in each group, a p-value less than 0.05 after therandomization/permutation test is the most compelling evidence of asignificant difference.

[0014] Genes can be grouped so that information obtained about the setof genes in the group provides a sound basis for making clinicallyrelevant judgments such as a diagnosis, prognosis, or treatment choice.These sets of genes make up the portfolios of the invention. As withmost diagnostic markers, it is often desirable to use the fewest numberof markers sufficient to make a correct medical judgment. This preventsa delay in treatment pending further analysis as well as inappropriateuse of time and resources. Preferred optimal portfolio is one thatemploys the fewest number of markers for making such judgments whilemeeting conditions that maximize the probability that such judgments areindeed correct. These conditions will generally include sensitivity andspecificity requirements. In the context of microarray based detectionmethods, the sensitivity of the portfolio can be reflected in the folddifferences exhibited by a gene's expression in the diseased or aberrantstate relative to the normal state. The detection of the differentialexpression of a gene is sensitive if it exhibits a large fold changerelative to the expression of the gene in another state. Another aspectof sensitivity is the ability to distinguish signal from noise. Forexample, while the expression of a set of genes may show adequatesensitivity for defining a given disease state, if the signal that isgenerated by one (e.g., intensity measurements in microarrays) is belowa level that easily distinguished from noise in a given setting (e.g., aclinical laboratory) then that gene should be excluded from the optimalportfolio. A procedure for setting conditions such as these that definethe optimal portfolio can be incorporated into the inventive methods.

[0015] Specificity can be reflected in statistical measurements of thecorrelation of the signaling of gene expression with the condition ofinterest. If the differential expression of a set of genes is observedto produce a large fold change but they do so for a number of conditionsother than the condition of interest (e.g. multiple disease states) thenthe gene expression profile for that set of genes is non-specific.Statistical measurements of correlation of data or the degree ofconsistency of data such as standard deviation, correlationcoefficients, and the like can be a used as such measurements. Inconsidering a group of genes for inclusion in a portfolio, a smallstandard deviation in expression measurements correlates with greaterspecificity. Genes that display similar expression patterns may beco-regulated by an identical factor that pushes the genes in the samedirection. If this factor is sufficient but not necessary forclassifying a sample, then these genes will fail to correctly identify asample if the markers are all related to this single factor.Diversification then results in selecting as few markers as possible,yet covers as many different optimal expression patterns that arecontained in the data set.

[0016] In the method of the invention, a group of genetic markers isselected for use in diagnostic applications. These groups of markers are“portfolios”. Diagnostic applications include the detection oridentification of a disease state or condition of a subject, determiningthe likelihood that a subject will contract a given disease orcondition, determining the likelihood that a subject with a disease orcondition will respond to therapy, determining the prognosis of asubject with a disease or condition (or its likely progression orregression), and determining the effect of a treatment on a subject witha disease or condition. For example, the method can be used to establishportfolios for detecting the presence or likelihood of a subjectcontracting colon cancer or the likelihood that such a subject willrespond favorably to cytotoxic drugs.

[0017] The portfolios selected by the method of the invention contain anumber and type of markers that assure accurate and precise results andare economized in terms of the number of genes that comprise theportfolio. The method of the invention can be used to establish optimalgene expression portfolios for any disease, condition, or state that isconcomitant with the expression of multiple genes. An optimal portfolioin the context of the instant invention refers to a gene expressionprofile that provides an assessment of the condition of a subject (basedupon the condition for which the analysis was undertaken) according topredetermined standards of at least two of the following parameters:accuracy, precision, and number of genes comprising the portfolio.

[0018] Most preferably, the markers employed in the portfolio arenucleic acid sequences that express mRNA (“genes”). Expression of themarkers may occur ordinarily in a healthy subject and be more highlyexpressed or less highly expressed when an event that is the object ofthe diagnostic application occurs. Alternatively, expression may notoccur except when the event that is the object of the diagnosticapplication occurs.

[0019] Marker attributes, features, indicia, or measurements that can becompared to make diagnostic judgments are diagnostic parameters used inthe method. Indicators of gene expression levels are the most preferreddiagnostic parameters. Such indicators include intensity measurementsread from microarrays, as described above. Other diagnostic parametersare also possible such as indicators of the relative degree ofmethylation of the markers.

[0020] Distinctions are made among the diagnostic parameters through theuse of mathematical/statistical values that are related to each other.The preferred distinctions are mean signal readings indicative of geneexpression and measurements of the variance of such readings. The mostpreferred distinctions are made by use of the mean of signal ratiosbetween different group readings (e.g., microarray intensitymeasurements) and the standard deviations of the signal ratiomeasurements. A great number of such mathematical/statistical values canbe used in their place such as return at a given percentile.

[0021] A relationship among diagnostic parameter distinctions is used tooptimize the selection of markers useful for the diagnostic application.Typically, this is done through the use of linear or quadraticprogramming algorithms. However, heuristic approaches can also beapplied or can be used to supplement input data selection or dataoutput. The most preferred relationship is a mean-variance relationshipsuch as that described in Mean-Variance Analysis in Portfolio Choice andCapital Markets by Harry M. Markowitz (Frank J. Fabozzi Associates, NewHope, Pa.: 2000, ISBN: 1-883249-75-9) which is incorporated herein byreference. The relationship is best understood in the context of theselection of stocks for a financial investment portfolio. This is thecontext for which the relationship was developed and elucidated.

[0022] The investor looking to optimize a portfolio of stocks can selectfrom a large number of possible stocks, each having a historical rate ofreturn and a risk factor. The mean variance method uses a critical linealgorithm of linear programming or quadratic programming to identify allfeasible portfolios that minimize risk (as measured by variance orstandard deviation) for a given level of expected return and maximizeexpected return for a given level of risk. When standard deviation isplotted against expected return an efficient frontier is generated.Selection of stocks along the efficient frontier results in adiversified stock portfolio optimized in terms of return and risk.

[0023] When the mean variance relationship is used in the method of theinstant invention, diagnostic parameters such as microarray signalintensity and standard deviation replace the return and risk factorvalues used in the selection of financial portfolios. Most preferably,when the mean variance relationship is applied, a commercial computersoftware application such as the “Wagner Associates Mean-VarianceOptimization Application”, referred to as “Wagner Software” throughoutthis specification. This software uses functions from the “WagnerAssociates Mean-Variance Optimization Library” to determine an efficientfrontier and optimal portfolios in the Markowitz sense. Since suchapplications are made for financial applications, it may be necessary topreprocess input data so that it can conform to conventions required bythe software. For example, when Wagner Software is employed inconjunction with microarray intensity measurements the following datatransformation method is employed.

[0024] A relationship between each genes baseline and experimental valuemust first be established. The preferred process is conducted asfollows. A baseline class is selected. Typically, this will comprisegenes from a population that does not have the condition of interest.For example, if one were interested in selecting a portfolio of genesthat are diagnostic for breast cancer, samples from patients withoutbreast cancer can be used to make the baseline class. Once the baselineclass is selected, the arithmetic mean and standard deviation iscalculated for the indicator of gene expression of each gene forbaseline class samples. This indicator is typically the fluorescentintensity of a microarray reading. The statistical data computed is thenused to calculate a baseline value of (X*Standard Deviation+Mean) foreach gene. This is the baseline reading for the gene from which allother samples will be compared. X is a stringency variable selected bythe person formulating the portfolio. Higher values of X are morestringent than lower. Preferably, X is in the range of 0.5 to 3 with 2to 3 being more preferred and 3 being most preferred.

[0025] Ratios between each experimental sample (those displaying thecondition of interest) versus baseline readings are then calculated. Theratios are then transformed to base 10 logarithmic values for ease ofdata handling by the software. This enables down regulated genes todisplay negative values necessary for optimization according to theMarkman mean-variance algorithm using the Wagner Software.

[0026] The preprocessed data comprising these transformed ratios areused as inputs in place of the asset return values that are normallyused in the Wagner Software when it is used for financial analysispurposes.

[0027] Once an efficient frontier is formulated, an optimized portfoliois selected for a given input level (return) or variance thatcorresponds to a point on the frontier. These inputs or variances arethe predetermined standards set by the person formulating the portfolio.Stated differently, one seeking the optimum portfolio determines anacceptable input level (indicative of sensitivity) or a given level ofvariance (indicative of specificity) and selects the genes that liealong the efficient frontier that correspond to that input level orvariance. The Wagner Software can select such genes when an input levelor variance is selected. It can also assign a weight to each gene in theportfolio as it would for a stock in a stock portfolio.

[0028] Determining whether a sample has the condition for which theportfolio is diagnostic can be conducted by comparing the expression ofthe genes in the portfolio for the patient sample with calculated valuesof differentially expressed genes used to establish the portfolio.Preferably, a portfolio value is first generated by summing themultiples of the intensity value of each gene in the portfolio by theweight assigned to that gene in the portfolio selection process. Aboundary value is then calculated by (Y*standard deviation+mean of theportfolio value for baseline groups) where Y is a stringency valuehaving the same meaning as X described above. A sample having aportfolio value greater than the boundary value of the baseline class isthen classified as having the condition. If desired, this process can beconducted iteratively in accordance with well known statistical methodsfor improving confidence levels.

[0029] Optionally one can reiterate this process until best predictionaccuracy is obtained. The process of portfolio selection andcharacterization of an unknown is summarized as follows:

[0030] 1. Choose baseline class

[0031] 2. Calculate mean, and standard deviation of each gene forbaseline class samples

[0032] 3. Calculate (X*Standard Deviation+Mean) for each gene. This isthe baseline reading from which all other samples will be compared. X isa stringency variable with higher values of X being more stringent thanlower.

[0033] 4. Calculate ratio between each Experimental sample versusbaseline reading calculated in step 3.

[0034] 5. Transform ratios such that ratios less than 1 are negative(eg. using Log base 10). (Down regulated genes now correctly havenegative values necessary for MV optimization).

[0035] 6. These transformed ratios are used as inputs in place of theasset returns that are normally used in the software application.

[0036] 7. The software will plot the efficient frontier and return anoptimized portfolio at any point along the efficient frontier.

[0037] 8. Choose a desired return or variance on the efficient frontier.

[0038] 9. Calculate the Portfolio's Value for each sample by summing themultiples of each gene's intensity value by the weight generated by theportfolio selection algorithm.

[0039] 10. Calculate a boundary value by adding the mean Portfolio Valuefor Baseline groups to the multiple of Y and the Standard Deviation ofthe Baseline's Portfolio Values. Values greater than this boundary valueshall be classified as the Experimental Class.

[0040] 11. Optionally one can reiterate this process until bestprediction accuracy is obtained.

[0041] A second portfolio can optionally be created by reversing thebaseline and experimental calculation. This creates a new portfolio ofgenes which are up-regulated in the original baseline class. This secondportfolio's value can be subtracted from the first to create a newclassification value based on multiple portfolios.

[0042] Another useful method of pre-selecting genes from gene expressiondata so that it can be used as input for a process for selecting aportfolio is based on a threshold given by${1 \leq {\frac{\left( {\mu_{t} - \mu_{n}} \right)}{\left( {\sigma_{t} + \sigma_{n}} \right)}}},$

[0043] where μ_(t) is the mean of the subset known to possess thedisease or condition, μ_(n) is the mean of the subset of normal samples,and σ_(t)+σ_(n) represent the combined standard deviations. A signal tonoise cutoff can also be used by pre-selecting the data according to arelationship such as$0.5 \leq {{\frac{\left( {\mu_{t} - {MAX}_{n}} \right)}{\left( {\sigma_{t} + \sigma_{n}} \right)}}.}$

[0044] This ensures that genes that are pre-selected based on theirdifferential modulation are differentiated in a clinically significantway. That is, above the noise level of instrumentation appropriate tothe task of measuring the diagnostic parameters. For each markerpre-selected according to these criteria, a matrix is established inwhich columns represents samples, rows represent markers and eachelement is a normalized intensity measurement for the expression of thatmarker according to the relationship:$\frac{\left( {\mu_{t} - I} \right)}{\mu_{t}}$

[0045] where I is the intensity measurement.

[0046] Using this process of creating input for financial portfoliosoftware make also allows one to set additional boundary conditions todefine the optimal portfolios. For example, portfolio size can belimited to a fixed range or number of markers. This can be done eitherby making data pre-selection criteria more stringent (e.g.,${.8} \leq {\frac{\left( {\mu_{t} - {MAX}_{n}} \right)}{\left( {\sigma_{t} + \sigma_{n}} \right)}}$

[0047] instead of$0.5 \leq {\frac{\left( {\mu_{t} - {MAX}_{n}} \right)}{\left( {\sigma_{t} + \sigma_{n}} \right)}}$

[0048] ) or by using programming features such as restricting portfoliosize. One could, for example, set the boundary condition that theefficient frontier is to be selected from among only the optimal 10genes. One could also use all of the genes pre-selected for determiningthe efficient frontier and then limit the number of genes selected(e.g., no more than 10).

[0049] The process of selecting a portfolio can also include theapplication of heuristic rules. Preferably, such rules are formulatedbased on biology and an understanding of the technology used to produceclinical results. More preferably, they are applied to output from theoptimization method. For example, the mean variance method of portfolioselection can be applied to microarray data for a number of genesdifferentially expressed in subjects with breast cancer. Output from themethod would be an optimized set of genes that could include some genesthat are expressed in peripheral blood as well as in diseased breasttissue. If sample used in the testing method are obtained fromperipheral blood and certain genes differentially expressed in instancesof breast cancer could also be differentially expressed in peripheralblood, then a heuristic rule can be applied in which a portfolio isselected from the efficient frontier excluding those that aredifferentially expressed in peripheral blood. Of course, the rule can beapplied prior to the formation of the efficient frontier by, forexample, applying the rule during data pre-selection.

[0050] Other heuristic rules can be applied that are not necessarilyrelated to the biology in question. For example, one can apply the rulethat only a given percentage of the portfolio can be represented by aparticular gene or genes. Commercially available software such as theWagner Software readily accommodates these types of heuristics. This canbe useful, for example, when factors other than accuracy and precision(e.g., anticipated licensing fees) have an impact on the desirability ofincluding one or more genes.

[0051] Other relationships aside from the mean-variance relationship canbe used in the method of the invention provided that they optimize theportfolio according to predetermined attributes such as assay accuracyand precision. Two examples are the Martin simultaneous equationapproach (Elton, Edwin J. and Martin J. Gruber (1987), Modern PortfolioTheory Investment Analysis, Third Edition, John Wiley, New York, 1987)and Genetic Algorithms (Davis, L., (1989), Adapting OperatorProbabilities in Genetic Algorithms, in Proceedings of the ThirdInternational Conference on Genetic Algorithms, Morgan Kaufmann: SanMateo, pp. 61-69). There are also many ways to adapt the mean-variancerelationship to handle skewed data such as where a marker detectiontechnology exhibits a known bias. These include, for example, theSemi-Deviation method in which the square root of the average squared(negative) deviation from a reference signal and includes only thosesignal values that fall below the reference signal.

[0052] Articles of this invention include representations of the geneexpression profiles that make up the portfolios useful for treating,diagnosing, prognosticating, and otherwise assessing diseases. Theserepresentations are reduced to a medium that can be automatically readby a machine such as computer readable media (magnetic, optical, and thelike). The articles can also include instructions for assessing the geneexpression profiles in such media. For example, the articles maycomprise a CD ROM having computer instructions for comparing geneexpression profiles of the portfolios of genes described above. Thearticles may also have gene expression profiles digitally recordedtherein so that they may be compared with gene expression data frompatient samples. Alternatively, the profiles can be recorded indifferent representational format. A graphical recordation is one suchformat.

[0053] Different types of articles of manufacture according to theinvention are media or formatted assays used to reveal gene expressionprofiles. These can comprise, for example, microarrays in which sequencecomplements or probes are affixed to a matrix to which the sequencesindicative of the genes of interest combine creating a readabledeterminant of their presence. When such a microarray contains anoptimized portfolio great savings in time, process steps, and resourcesare attained by minimizing the number of cDNA or oligonucleotides thatmust be applied to the substrate, reacted with the sample, read by ananalyzer, processed for results, and (sometimes) verified.

[0054] Other articles according to the invention can be fashioned intoreagent kits for conducting hybridization, amplification, and signalgeneration indicative of the level of expression of the genes in theportfolios established through the method of the invention. Kits madeaccording to the invention include formatted assays for determining thegene expression profiles. These can include all or some of the materialsneeded to conduct the assays such as reagents and instructions.

EXAMPLES Example 1

[0055] Producing an Optimized Portfolio

[0056] Gene expression data was recently produced from tissue samplesrepresentative of eleven different types of cancers. The data waspublished in Cancer Research 61: 7388-7393, 2001 andhttp://carrier.gnf.org/welsh/epican/. See, Andrew I. Su et al.,“Molecular Classification of Human Carcinomas by Use of Gene ExpressionSignatures.” The data included intensity measurements obtained with theuse of an “U95” a oligonucleotide microarray (commercially availablefrom Affymetrix, Inc.).

[0057] Measurements of the expression of genes from the published data(fluorescent intensity measurements) was used to select optimum geneexpression portfolios for a panel of markers to determine whether acirculating cell is indicative of the presence of breast cancer,prostate cancer, ovarian cancer, colorectal cancer, or lung cancer. Suchcirculating cells would preferably be epithelial cells.

[0058] The data in the study was collected from the following samples:24 adenocarcinomas, 12 infilitrating ductal breast adenocarcenomas, 21colorectal adenocarcinomas, 23 ovarian adenocarcinomas, 25 lungcarcinomas, and data from the following additional samples: 19 prostateadenocarcinomas, 12 breast carinomas, 13 colon carcinomas, 13 ovariancarcinomas, 13 ovarian carcinomas, and 89 lung carcenomas.

[0059] Using intensity readings from a collection of normal samples asthe baseline class, the arithmetic mean, and standard deviation of eachgene were calculated followed by a calculation of the value (X*StandardDeviation+Mean) for each gene. The stringency variable, X, was assigneda value of 3 in this case. Ratios were then calculated between eachExperimental sample described in the study versus the baseline valuecalculations. The ratios were transformed into common logarithms. Thesevalues were then used as the input values for the Wagner Software.

[0060] This procedure selected an efficient frontier along which aminimum set of markers for each tumor type that have the lowest amountof variation for a selected level of differential (chosen at the bestsignal to noise ratio point). Optimization by the software resulted inthe selection of a portfolio of 24 genes including 2 for prostatecancer, 5 for breast cancer, 6 for colon cancer, 2 for ovarian cancer,and 9 for lung cancer markers (Table 1). TABLE 1 Cancer Type AccessionName Description Seq, ID No. PR NM_001648 KLK3 kallikrein 3, (prostatespecific antigen) Seq. ID No. 1 PR NM_005551 KLK2 kallikrein 2,prostatic Seq. ID No. 2 BR NM_004064 CDKN1B cyclin-dependent kinaseinhibitor 1B (p27, Kip1) Seq. ID No. 34 BR NM_002411 MGB1 mammaglobin 1Seq. ID No. 3 BR NM_005264 GFRA1 GDNF family receptor alpha 1 Seq. IDNo. 4 BR None C180R chromosome 18 open reading frame 1 Seq. ID No. 98 F1BR NM_000095 COMP cartilage oligomeric matrix protein Seq. ID No. 67 CONM_001804 CDX1 caudal type homeo box transcription factor 1 Seq. ID No.8 CO NM_001046 SLC12 solute carrier family 12 (sodium/potassium/chlorideSeq. ID No. 9 A2 transporters), member 2 CO NM_001285 CLCA1 chloridechannel, calcium activated, family member 1 Seq. ID No. 11 CO NM_007052NOX1 NADPH oxidase 1 Seq. ID No. 13 CO NM_002457 MUC2 mucin 2,intestinal/tracheal Seq. ID No. 14 CO NM_004063 CDH17 cadherin 17, LIcadherin Seq. ID No. 15 LU_A NM_021950 M54A2 membrane-spanning4-domains, Seq. ID No. 17 subfamily A, member 2 LU_A NM_000964 ASAHLN-acylsphingosine amidohydrolase (acid ceramidase)- Seq. ID No. 18 likeLU_A NM_006495 EVI2B ecotropic viral integration site 2B Seq. ID No. 20LU_A NM_006864 LILRB3 leukocyte immunoglobulin-like receptor, subfamilyB Seq. ID No. 21 LU_A X67301 none H. sapiens mRNA for IgM heavy chainSeq. ID No. 22 constant region (Ab63) LU_A NM_002123 HLA- majorhistocompatibility complex, class II, DQ beta 1 Seq. ID No. 23 DQB1 LU_SNM_000673 ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma Seq. IDNo. 24 polypeptide LU_S NM_003722 TP63 tumor protein 63 kDa with stronghomology to p53 Seq. ID No. 26 LU_S None SOX2 SRY (sex determiningregion Y)-box 2 Seq. ID No. 32 OV NM_000906 NPR1 natriuretic peptidereceptor A/guanylate cyclase A Seq. ID No. 28 OV NM_000378 WT1 Wilmstumor 1 Seq. ID No. 30

Example 2

[0061] Heuristic Step

[0062] A heuristic rule was further applied to the portfolio obtained inExample 1. That is, the rule stated that if the gene/marker identifiedwould likely be expressed in peripheral blood or were well-characterizedtissue markers (e.g. PSA, mammaglobin, etc.), then such genes/markerwould be removed from the portfolio. Application of the rule enabled theestablishment of a portfolio of genes/markers that are optimized for usein a screening application in which the patient sample is obtained byassaying components found in the peripheral blood such as epithelialcells. The result of the selected portfolio contains 31 genes as shownin Table 2. TABLE 2 Cancer Type Accession Name Description Seq. ID No.PR Hs.12784 KIAA0293 KIAA0293 protein Seq. ID No. 67 PR NM_006562 LBX1transcription factor similar to D. melanogaster Seq. ID No. 33homeodomain protein lady bird late PR NM_016026 LOC51109 CGI-82 proteinSeq. ID No. 34 PR HG2261- none Antigen Seq. ID No. 99 HT2352 PRNM_012449 STEAP six transmembrane epithelial antigen of the prostateSeq. ID No. 35 PR NM_001634 AMD1 5-adenosylmethionine decarboxylase 1Seq. ID No. 36 PR HG2261- none Antigen | Seq. ID No. 100 HT2351 PRNM_006457 LIM LIM protein (similar to rat protein kinase C-binding Seq.ID No. 37 enigma) BR NM_005853 IRX5 iroquois homeobox protein 5 Seq. IDNo. 38 BR NM_005264 GFRA1 GDNF family receptor alpha 1 Seq. ID No. 39 BRnone C18ORF1 chromosome 18 open reading frame 1 Seq. ID No. 98 BRNM_000095 COMP cartilage oligomeric matrix protein Seq. ID No. 41(pseudoachondroplasia, epiphyseal dysplasia 1, multiple) CO NM_001265CDX2 caudal type homeo box transcription factor 2 Seq. ID No. 43 CONM_001046 SLC12A2 solute carrier family 12 (sodium/potassium/chlorideSeq. ID No. 44 transporters), member 2 CO NM_001285 CLOA1 chloridechannel, calcium activated, family member-1 Seq. ID No. 46 CO NM_004063CDH17 cadherin 17, LI cadherin (liver-intestine) Seq. ID No. 48 OVNM_000906 NPR1 natriuretic peptide receptor A/guanylate cyclase A Seq.ID No. 50 (atrionatriuretic peptide receptor A) OV NM_005504 BCAT1branched chain aminotransferase 1, cytosolic Seq. ID No. 52 OV NM_002398MEIS1 Meis1 (mouse) homolog Seq. ID No. 53 OV none SPON1 spondin 1,(f-spondin) extracellular matrix protein Seq. ID No. 69 OV NM_001692none M25809:Human endomembrane proton pump Seq. ID No. 54 subunit mRNA|GenBank==M25809 OV NM_002774 KLK6 kallikrein 6 (neurosin, zyme) Seq. IDNo. 55 LU_A NM_000964 ASAHL N-acylsphingosine amidohydrolase (acid Seq.ID No. 56 ceramidase)-like LU_A NM_002838 PTPRC protein tyrosinephosphatase, receptor type, C Seq. ID No. 58 LU_A NM_015364 MD-2 MD-2protein Seq. ID No. 59 LU_A NM_006875 PIM2 pim-2 oncogene Seq. ID No. 60LU_S NM_005554 KRT6A keratin 6A Seq. ID No. 61 LU_S NM_000673 ADH7alcohol dehydrogenase 7 (class IV), mu or sigma Seq. ID No. 62polypeptide LU_S NM_003722 TP63 tumor protein 63 kDa with stronghomology to p53 Seq. ID No. 64 LU_S none SOX2 SRY (sex determiningregion Y)-box 2 Seq. ID No. 32 LU_S NM_005688 ABCC5 ATP-bindingcassette, sub-family C (CFTR/MRP), Seq. ID No. 66 member 5

Example 3

[0063] Prognostic Portfolios

[0064] A patient sample set with known clinical outcomes was used totest the portfolio selection method of the invention. The sample set isdescribed in van't Veer, L. J et al. Gene Expression Profiling PredictsClinical Outcome of Breast Cancer, Nature, 415, 530-536, (2002),incorporated herein by reference. In that study, breast tissue sampleswere obtained from 78 patients exhibiting sporadic breast tumors. Thepatients were all less than 55 years of age and presented with a tumorless than 5 cm. All were lymph node negative. Thirty four of thepatients presented with distant metastases in less than 5 years while 44showed no distant metastases in the same period.

[0065] The data from the study were then processed according to themethod of the invention. Sample number 54 was removed from furtheranalysis due to a high percentage of missing values. The mean andstandard deviation of the intensity measurements for each gene werecalculated using the non-metastatic samples as the baseline. Adiscriminating value of X*(Standard Deviation+Mean) was then calculatedfor each baseline gene (X was assigned a value of 3). This value wasused to ensure the resulting portfolio would be stringent. A ratio ofthe discriminating value to the baseline value was then calculated foreach metastatic sample. This ratio was then converted to a commonlogarithm. This data was then imported into Wagner Software whichproduced an efficient frontier from which a portfolio of 16 genes wasselected. The baseline and experimental values were then reversed and asecond portfolio of 12 markers representing genes up-regulated in thenon-metastatic cases was produced. The second portfolio's value issubtracted from the first portfolios value to create a combinedportfolio value from all 28 genes. This final portfolio is comprised ofgenes from Seq. ID No. 70 -97. 17 of the genes of this portfolio werealso present in the 70 gene portfolio described in the reference. Thegenes of the portfolio are identified below. (Seq. ID No. 70, Seq. IDNo. 72, Seq. ID No. 73-77, Seq. ID No. 79, Seq. ID No. 80, Seq. ID No.85, Seq. ID No. 87, Seq. ID No. 91-93, Seq. ID No. 95 and Seq. ID. No.97.)

[0066] 28 Gene List (2 Portfolios) Up in Metastatic Patients(Portfolio 1) Contig53226_RC Seq. ID No. 89 NM_012214 Seq. ID No. 82NM_020386 Seq. ID No. 86 NM_004504 Seq. ID No. 81 AA555029_RC Seq. IDNo. 70 AL080059 Seq. ID No. 74 AF055033 Seq. ID No. 73 NM_016448 Seq. IDNo. 85 Contig40831_RC Seq. ID No. 95 Contig63649_RC Seq. ID No. 91Contig24252_RC Seq. ID No. 93 NM_000436 Seq. ID No. 75 Contig55313_RCSeq. ID No. 90 Contig25991 Seq. ID No. 97 NM_000788 Seq. ID No. 76 Up inNon-Metastatic Patients (Portfolio 2) Seq. ID No. 71 AB033007Contig42421_RC Seq. ID No. 96 NM_003748 Seq. ID No. 78 NM_013262 Seq. IDNo. 83 NM_003862 Seq. ID No. 79 NM_003882 Seq. ID No. 80 Contig48328_RCSeq. ID No. 87 NM_015416 Seq. ID No. 84 AB037863 Seq. ID No. 72Contig27312_RC Seq. ID No. 88 Contig32125_RC Seq. ID No. 92Contig49670_RC Seq. ID No. 94 17 Overlap Systematic name NM_003862 Seq.ID No. 79 NM_003882 Seq. ID No. 80 Contig48328_RC Seq. ID No. 87AA555029_RC Seq. ID No. 70 AL080059 Seq. ID No. 74 AF055033 Seq. ID No.73 AF055033 Seq. ID No. 73 NM_016448 Seq. ID No. 85 AB037863 Seq. ID No.72 Contig40831_RC Seq. ID No. 95 Contig63649_RC Seq. ID No. 91Contig24252_RC Seq. ID No. 93 NM_000436 Seq. ID No. 75 NM_002019 Seq. IDNo. 77 Contig32125_RC Seq. ID No. 92 Contig25991 Seq. ID No. 97NM_000788 Seq. ID No. 76

[0067] The two portfolios were then used to determine the prognosis ofthe 78 original samples by comparing gene expression signatures from themicroarray data according to the method for testing the classificationaccuracy described in the reference. In the case of the 70 geneportfolio, 81% of the samples were properly characterized according toan optimized threshold biased to include ambiguous signatures asindicative of poor prognosis (85% for an absolute threshold). Thisportfolio misclassified 3 patients with a poor prognosis as having agood prognosis using the optimized threshold (5 for the absolutethreshold). Twelve patients with a good prognosis were misclassified ashaving a good prognosis when they had a bad prognosis using theoptimized threshold (8 for absolute).

[0068] In the case of the 28 gene portfolio, 94% of the samples wereproperly characterized according to an optimized threshold biased toinclude ambiguous signatures as indicative of poor prognosis (93% for anabsolute threshold). This portfolio misclassified 3 patients with a poorprognosis as having a good prognosis using the optimized threshold (5for the absolute threshold). Three patients with a good prognosis weremisclassified as having a good prognosis when they had a bad prognosisusing the optimized threshold (2 for absolute).

[0069] Comparing the two profiles, it is apparent that the profilesselected according to the method of the invention are much moreeconomical and produce results that are more accurate and reliable thanthose of the comparative portfolio.

0 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 100 <210> SEQ ID NO 1<211> LENGTH: 1466 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE:1 agccccaagc ttaccacctg cacccggaga gctgtgtgtc accatgtggg tcccggttgt 60cttcctcacc ctgtccgtga cgtggattgg tgctgcaccc ctcatcctgt ctcggattgt 120gggaggctgg gagtgcgaga agcattccca accctggcag gtgcttgtgg cctctcgtgg 180cagggcagtc tgcggcggtg ttctggtgca cccccagtgg gtcctcacag ctgcccactg 240catcaggaac aaaagcgtga tcttgctggg tcggcacagc ctgtttcatc ctgaagacac 300aggccaggta tttcaggtca gccacagctt cccacacccg ctctacgata tgagcctcct 360gaagaatcga ttcctcaggc caggtgatga ctccagccac gacctcatgc tgctccgcct 420gtcagagcct gccgagctca cggatgctgt gaaggtcatg gacctgccca cccaggagcc 480agcactgggg accacctgct acgcctcagg ctggggcagc attgaaccag aggagttctt 540gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg tgtgtgcgca 600agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga cagggggcaa 660aagcacctgc tcgggtgatt ctgggggccc acttgtctgt aatggtgtgc ttcaaggtat 720cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg ccttccctgt acaccaaggt 780ggtgcattac cggaagtgga tcaaggacac catcgtggcc aacccctgag cacccctatc 840aaccccctat tgtagtaaac ttggaacctt ggaaatgacc aggccaagac tcaagcctcc 900ccagttctac tgacctttgt ccttaggtgt gaggtccagg gttgctagga aaagaaatca 960gcagacacag gtgtagacca gagtgtttct taaatggtgt aattttgtcc tctctgtgtc 1020ctggggaata ctggccatgc ctggagacat atcactcaat ttctctgagg acacagatag 1080gatggggtgt ctgtgttatt tgtggggtac agagatgaaa gaggggtggg atccacactg 1140agagagtgga gagtgacatg tgctggacac tgtccatgaa gcactgagca gaagctggag 1200gcacaacgca ccagacactc acagcaagga tggagctgaa aacataaccc actctgtcct 1260ggaggcactg ggaagcctag agaaggctgt gagccaagga gggagggtct tcctttggca 1320tgggatgggg atgaagtaag gagagggact ggaccccctg gaagctgatt cactatgggg 1380ggaggtgtat tgaagtcctc cagacaaccc tcagatttga tgatttccta gtagaactca 1440cagaaataaa gagctgttat actgtg 1466 <210> SEQ ID NO 2 <211> LENGTH: 785<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 2 atgtgggacctggttctctc catcgccttg tctgtggggt gcactggtgc cgtgcccctc 60 atccagtctcggattgtggg aggctgggag tgtgagaagc attcccaacc ctggcaggtg 120 gctgtgtacagtcatggatg ggcacactgt gggggtgtcc tggtgcaccc ccagtgggtg 180 ctcacagctgcccattgcct aaagaagaat agccaggtct ggctgggtcg gcacaacctg 240 tttgagcctgaagacacagg ccagagggtc cctgtcagcc acagcttccc acacccgctc 300 tacaatatgagccttctgaa gcatcaaagc cttagaccag atgaagactc cagccatgac 360 ctcatgctgctccgcctgtc agagcctgcc aagatcacag tgttgtgaag gtcctgggcc 420 tgcccacccaggagccagca ctggggacca cctgctacgc ctcaggctgg ggcagcatcg 480 aaccagaggagttcttgcgc cccaggagtc ttcagtgtgt gagcctccat ctcctgtcca 540 atgacatgtgtgctagagct tactctgaga aggtgacaga gttcatgttg tgtgctgggc 600 tctggacaggtggtaaagac acttgtgggg gtgattctgg gggtccactt gtctgtaatg 660 gggtgcttcaaggtatcaca tcatggggcc ctgagccatg tgccctgcct gaaaagcctg 720 ctgtgtacaccaaggtggtg cattaccgga agtggatcaa ggacaccatc gcagccaacc 780 cctga 785<210> SEQ ID NO 3 <211> LENGTH: 503 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 3 gacagcggct tccttgatcc ttgccacccg cgactgaacaccgacagcag cagcctcacc 60 atgaagttgc tgatggtcct catgctggcg gccctctcccagcactgcta cgcaggctct 120 ggctgcccct tattggagaa tgtgatttcc aagacaatcaatccacaagt gtctaagact 180 gaatacaaag aacttcttca agagttcata gacgacaatgccactacaaa tgccatagat 240 gaattgaagg aatgttttct taaccaaacg gatgaaactctgagcaatgt tgaggtgttt 300 atgcaattaa tatatgacag cagtctttgt gatttattttaactttctgc aagacctttg 360 gctcacagaa ctgcagggta tggtgagaaa ccaactacggattgctgcaa accacacctt 420 ctctttctta tgtcttttta ctacaaacta caagacaattgttgaaacct gctatacatg 480 tttattttaa taaattgatg gca 503 <210> SEQ ID NO4 <211> LENGTH: 2560 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 4 gaattccggc cagaagaaat ctggcctcgg aacacgccat tctccgcgccgcttccaata 60 accactaaca tccctaacga gcatccgagc cgagggctct gctcggaaatcgtcctggcc 120 caactcggcc cttcgagctc tcgaagatta ccgcatctat tttttttttcttttttttct 180 tttcctagcg cagataaagt gagcccggaa agggaaggag ggggcggggacaccattgcc 240 ctgaaagaat aaataagtaa ataaacaaac tggctcctcg ccgcagctggacgcggtcgg 300 ttgagtccag gttgggtcgg acctgaaccc ctaaaagcgg aaccgcctcccgccctcgcc 360 atcccggagc tgagtcgccg gcggcggtgg ctgctgccag acccggagtttcctctttca 420 ctggatggag ctgaactttg ggcggccaga gcagcacagc tgtccggggatcgctgcacg 480 ctgagctccc tcggcaagac ccagcggcgg ctcgggattt ttttgggggggcggggacca 540 gccccgcgcc ggcaccatgt tcctggcgac cctgtacttc gcgctgccgctcttggactt 600 gctcctgtcg gccgaagtga gcggcggaga ccgcctggat tgcgtgaaagccagtgatca 660 gtgcctgaag gagcagagct gcagcaccaa gtaccgcacg ctaaggcagtgcgtggcggg 720 caaggagacc aacttcagcc tggcatccgg cctggaggcc aaggatgagtgccgcagcgc 780 catggaggcc ctgaagcaga agtcgctcta caactgccgc tgcaagcggggtatgaagaa 840 ggagaagaac tgcctgcgca tttactggag catgtaccag agcctgcagggaaatgatct 900 gctggaggat tccccatatg aaccagttaa cagcagattg tcagatatattccgggtggt 960 cccattcata tcagatgttt ttcagcaagt ggagcacatt cccaaagggaacaactgcct 1020 ggatgcagcg aaggcctgca acctcgacga catttgcaag aagtacaggtcggcgtacat 1080 caccccgtgc accaccagcg tgtccaacga tgtctgcaac cgccgcaagtgccacaaggc 1140 cctccggcag ttctttgaca aggtcccggc caagcacagc tacggaatgctcttctgctc 1200 ctgccgggac atcgcctgca cagagcggag gcgacagacc atcgtgcctgtgtgctccta 1260 tgaagagagg gagaagccca actgtttgaa tttgcaggac tcctgcaagacgaattacat 1320 ctgcagatct cgccttgcgg atttttttac caactgccag ccagagtcaaggtctgtcag 1380 cagctgtcta aaggaaaact acgctgactg cctcctcgcc tactcggggcttattggcac 1440 agtcatgacc cccaactaca tagactccag tagcctcagt gtggccccatggtgtgactg 1500 cagcaacagt gggaacgacc tagaagagtg cttgaaattt ttgaatttcttcaaggacaa 1560 tacatgtctt aaaaatgcaa ttcaagcctt tggcaatggc tccgatgtgaccgtgtggca 1620 gccagccttc ccagtacaga ccaccactgc cactaccacc actgccctccgggttaagaa 1680 caagcccctg gggccagcag ggtctgagaa tgaaattccc actcatgttttgccaccgtg 1740 tgcaaattta caggcacaga agctgaaatc caatgtgtcg ggcaatacacacctctgtat 1800 ttccaatggt aattatgaaa aagaaggtct cggtgcttcc agccacataaccacaaaatc 1860 aatggctgct cctccaagct gtggtctgag cccactgctg gtcctggtggtaaccgctct 1920 gtccacccta ttatctttaa cagaaacatc atagctgcat taaaaaaatacaatatggac 1980 atgtaaaaag acaaaaacca agttatctgt ttcctgttct cttgtatagctgaaattcca 2040 gtttaggagc tcagttgaga aacagttcca ttcaactgga acatttttttttttcctttt 2100 aagaaagctt cttgtgatcc ttcggggctt ctgtgaaaaa cctgatgcagtgctccatcc 2160 aaactcagaa ggctttggga tatgctgtat tttaaaggga cagtttgtaacttgggctgt 2220 aaagcaaact ggggctgtgt tttcgatgat gatgatcatc atgatcatgatgattttaac 2280 agttttactt ctggcctttc ctagctagag aaggagttaa tatttctaaggtaactccca 2340 tatctccttt aatgacattg atttctaatg atataaattt cagcctacattgatgccaag 2400 cttttttgcc acaaagaaga ttcttaccaa gagtgggctt tgtggaaacagctggtactg 2460 atgttcacct ttatatatgt actagcattt tccacgctga tgtttatgtactgtaaacag 2520 ttctgcactc ttgtacaaaa gaaaaaacca cccggaattc 2560 <210>SEQ ID NO 5 <211> LENGTH: 2560 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 5 gaattccggc cagaagaaat ctggcctcgg aacacgccat tctccgcgccgcttccaata 60 accactaaca tccctaacga gcatccgagc cgagggctct gctcggaaatcgtcctggcc 120 caactcggcc cttcgagctc tcgaagatta ccgcatctat tttttttttcttttttttct 180 tttcctagcg cagataaagt gagcccggaa agggaaggag ggggcggggacaccattgcc 240 ctgaaagaat aaataagtaa ataaacaaac tggctcctcg ccgcagctggacgcggtcgg 300 ttgagtccag gttgggtcgg acctgaaccc ctaaaagcgg aaccgcctcccgccctcgcc 360 atcccggagc tgagtcgccg gcggcggtgg ctgctgccag acccggagtttcctctttca 420 ctggatggag ctgaactttg ggcggccaga gcagcacagc tgtccggggatcgctgcacg 480 ctgagctccc tcggcaagac ccagcggcgg ctcgggattt ttttgggggggcggggacca 540 gccccgcgcc ggcaccatgt tcctggcgac cctgtacttc gcgctgccgctcttggactt 600 gctcctgtcg gccgaagtga gcggcggaga ccgcctggat tgcgtgaaagccagtgatca 660 gtgcctgaag gagcagagct gcagcaccaa gtaccgcacg ctaaggcagtgcgtggcggg 720 caaggagacc aacttcagcc tggcatccgg cctggaggcc aaggatgagtgccgcagcgc 780 catggaggcc ctgaagcaga agtcgctcta caactgccgc tgcaagcggggtatgaagaa 840 ggagaagaac tgcctgcgca tttactggag catgtaccag agcctgcagggaaatgatct 900 gctggaggat tccccatatg aaccagttaa cagcagattg tcagatatattccgggtggt 960 cccattcata tcagatgttt ttcagcaagt ggagcacatt cccaaagggaacaactgcct 1020 ggatgcagcg aaggcctgca acctcgacga catttgcaag aagtacaggtcggcgtacat 1080 caccccgtgc accaccagcg tgtccaacga tgtctgcaac cgccgcaagtgccacaaggc 1140 cctccggcag ttctttgaca aggtcccggc caagcacagc tacggaatgctcttctgctc 1200 ctgccgggac atcgcctgca cagagcggag gcgacagacc atcgtgcctgtgtgctccta 1260 tgaagagagg gagaagccca actgtttgaa tttgcaggac tcctgcaagacgaattacat 1320 ctgcagatct cgccttgcgg atttttttac caactgccag ccagagtcaaggtctgtcag 1380 cagctgtcta aaggaaaact acgctgactg cctcctcgcc tactcggggcttattggcac 1440 agtcatgacc cccaactaca tagactccag tagcctcagt gtggccccatggtgtgactg 1500 cagcaacagt gggaacgacc tagaagagtg cttgaaattt ttgaatttcttcaaggacaa 1560 tacatgtctt aaaaatgcaa ttcaagcctt tggcaatggc tccgatgtgaccgtgtggca 1620 gccagccttc ccagtacaga ccaccactgc cactaccacc actgccctccgggttaagaa 1680 caagcccctg gggccagcag ggtctgagaa tgaaattccc actcatgttttgccaccgtg 1740 tgcaaattta caggcacaga agctgaaatc caatgtgtcg ggcaatacacacctctgtat 1800 ttccaatggt aattatgaaa aagaaggtct cggtgcttcc agccacataaccacaaaatc 1860 aatggctgct cctccaagct gtggtctgag cccactgctg gtcctggtggtaaccgctct 1920 gtccacccta ttatctttaa cagaaacatc atagctgcat taaaaaaatacaatatggac 1980 atgtaaaaag acaaaaacca agttatctgt ttcctgttct cttgtatagctgaaattcca 2040 gtttaggagc tcagttgaga aacagttcca ttcaactgga acatttttttttttcctttt 2100 aagaaagctt cttgtgatcc ttcggggctt ctgtgaaaaa cctgatgcagtgctccatcc 2160 aaactcagaa ggctttggga tatgctgtat tttaaaggga cagtttgtaacttgggctgt 2220 aaagcaaact ggggctgtgt tttcgatgat gatgatcatc atgatcatgatgattttaac 2280 agttttactt ctggcctttc ctagctagag aaggagttaa tatttctaaggtaactccca 2340 tatctccttt aatgacattg atttctaatg atataaattt cagcctacattgatgccaag 2400 cttttttgcc acaaagaaga ttcttaccaa gagtgggctt tgtggaaacagctggtactg 2460 atgttcacct ttatatatgt actagcattt tccacgctga tgtttatgtactgtaaacag 2520 ttctgcactc ttgtacaaaa gaaaaaacca cccggaattc 2560 <210>SEQ ID NO 6 <211> LENGTH: 2439 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 6 cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttcttctgctcac 60 cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcagacctgggccc 120 gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgcgggactggct 180 gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagtgtgacgcgtg 240 cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgctccactgcgc 300 gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcggccgctgcgg 360 cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtcaacgagtgcaa 420 cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggttccgctgcga 480 ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctggctttcgccaa 540 ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaacataactgcgt 600 ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgtgccagcccgg 660 cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttctgccccgacgg 720 ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatggctcgcggtc 780 gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcgacactgacct 840 agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgtaaggacaactg 900 cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcggagacgcctg 960 cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcccgctggtgcg 1020 gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcgacaactgccg 1080 gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcgatgcgtgcga 1140 cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgccctagggtacccaa 1200 ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgacaactgtcccca 1260 gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatgcttgtgacag 1320 cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtcccacggtgcc 1380 taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcgacgacgacga 1440 cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgcctaaccccggcca 1500 ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttgatgcagacaa 1560 ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctcaccgacttcag 1620 ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgaccccaactgggt 1680 ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccaggcctggctgt 1740 gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtgaacacggtcac 1800 ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagcttctacgtggt 1860 catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtgctgtggccga 1920 gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaacagctgcggaa 1980 cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtggaaggacccgcg 2040 aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcaccggccccaagt 2100 gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgacagcaacgtggt 2160 cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctcccaggagaacat 2220 catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggactatgagaccca 2280 tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagccaccctcacc 2340 gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagggggaagtgag 2400 aagggctcag agaggacaaa ataaagtgtg tgtgcaggg 2439 <210>SEQ ID NO 7 <211> LENGTH: 2439 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 7 cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttcttctgctcac 60 cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcagacctgggccc 120 gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgcgggactggct 180 gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagtgtgacgcgtg 240 cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgctccactgcgc 300 gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcggccgctgcgg 360 cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtcaacgagtgcaa 420 cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggttccgctgcga 480 ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctggctttcgccaa 540 ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaacataactgcgt 600 ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgtgccagcccgg 660 cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttctgccccgacgg 720 ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatggctcgcggtc 780 gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcgacactgacct 840 agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgtaaggacaactg 900 cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcggagacgcctg 960 cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcccgctggtgcg 1020 gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcgacaactgccg 1080 gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcgatgcgtgcga 1140 cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgccctagggtacccaa 1200 ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgacaactgtcccca 1260 gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatgcttgtgacag 1320 cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtcccacggtgcc 1380 taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcgacgacgacga 1440 cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgcctaaccccggcca 1500 ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttgatgcagacaa 1560 ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctcaccgacttcag 1620 ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgaccccaactgggt 1680 ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccaggcctggctgt 1740 gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtgaacacggtcac 1800 ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagcttctacgtggt 1860 catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtgctgtggccga 1920 gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaacagctgcggaa 1980 cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtggaaggacccgcg 2040 aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcaccggccccaagt 2100 gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgacagcaacgtggt 2160 cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctcccaggagaacat 2220 catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggactatgagaccca 2280 tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagccaccctcacc 2340 gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagggggaagtgag 2400 aagggctcag agaggacaaa ataaagtgtg tgtgcaggg 2439 <210>SEQ ID NO 8 <211> LENGTH: 1699 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 8 aggtgagcgg ttgctcgtcg tcggggcggc cggcagcggc ggctccagggcccagcatgc 60 gcgggggacc ccgcggccac catgtatgtg ggctatgtgc tggacaaggattcgcccgtg 120 taccccggcc cagccaggcc agccagcctc ggcctgggcc cggcaaactacggccccccg 180 gccccgcccc cggcgccccc gcagtacccc gacttctcca gctactctcacgtggagccg 240 gcccccgcgc ccccgacggc ctggggggcg cccttccctg cgcccaaggacgactgggcc 300 gccgcctacg gcccgggccc cgcggcccct gccgccagcc cagcttcgctggcattcggg 360 ccccctccag actttagccc ggtgccggcg ccccctgggc ccggcccgggcctcctggcg 420 cagcccctcg ggggcccggg cacaccgtcc tcgcccggag cgcagaggccgacgccctac 480 gagtggatgc ggcgcagcgt ggcggccgga ggcggcggtg gcagcggtaagactcggacc 540 aaggacaagt accgcgtggt ctacaccgac caccaacgcc tggagctggagaaggagttt 600 cattacagcc gttacatcac aatccggcgg aaatcagagc tggctgccaatctggggctc 660 actgaacggc aggtgaagat ctggttccaa aaccggcggg caaaggagcgcaaagtgaac 720 aagaagaaac agcagcagca acagccccca cagccgccga tggcccacgacatcacggcc 780 accccagccg ggccatccct ggggggcctg tgtcccagca acaccagcctcctggccacc 840 tcctctccaa tgcctgtgaa agaggagttt ctgccatagc cccatgcccagcctgtgcgc 900 cgggggacct ggggactcgg gtgctgggag tgtggctcct gtgggcccaggaggtctggt 960 ccgagtctca gccctgacct tctgggacat ggtggacagt cacctatccaccctctgcat 1020 ccccttggcc cattgtgtgc agtaagcctg ttggataaag accttccagctcctgtgttc 1080 tagacctctg ggggataagg gagtccaggg tggatgatct caatctcccgtgggcatctc 1140 aagccccaaa tggttggggg aggggcctag acaaggctcc aggccccacctcctcctcca 1200 tacgttcaga ggtgcagctg gaggcctgtg tggggaccac actgatcctggagaaaaggg 1260 atggagctga aaaagatgga atgcttgcag agcatgacct gaggagggaggaacgtggtc 1320 aactcacacc tgcctcttct gcagcctcac ctctacctgc ccccatcataagggcactga 1380 gcccttccca ggctggatac taagcacaaa gcccatagca ctgggctctgatggctgctc 1440 cactgggtta cagaatcaca gccctcatga tcattctcag tgagggctctggattgagag 1500 ggaggccctg ggaggagaga agggggcaga gtcttcccta ccaggtttctacacccccgc 1560 caggctgccc atcagggccc agggagcccc cagaggactt tattcggaccaagcagagct 1620 cacagctgga caggtgttgt atatagagtg gaatctcttg gatgcagcttcaagaataaa 1680 tttttcttct cttttcaaa 1699 <210> SEQ ID NO 9 <211>LENGTH: 4098 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 9ggtggcctct gtggccgtcc aggctagcgg cggcccgcag gcggcgggga gaaagactct 60ctcacctggt cttgcggctg tggccaccgc cggccagggg tgtggagggc gtgctgccgg 120agacgtccgc cgggctctgc agttccgccg ggggtcgggc agctatggag ccgcggccca 180cggcgccctc ctccggcgcc ccgggactgg ccggggtcgg ggagacgccg tcagccgctg 240cgctggccgc agccagggtg gaactgcccg gcacggctgt gccctcggtg ccggaggatg 300ctgcgcccgc gagccgggac ggcggcgggg tccgcgatga gggccccgcg gcggccgggg 360acgggctggg cagacccttg gggcccaccc cgagccagag ccgtttccag gtggacctgg 420tttccgagaa cgccgggcgg gccgctgctg cggcggcggc ggcggcggcg gcagcggcgg 480cggctggtgc tggggcgggg gccaagcaga cccccgcgga cggggaagcc agcggcgaga 540gcgagccagc taaaggcagc gaggaagcca agggccgctt ccgcgtgaac ttcgtggacc 600cagctgcctc ctcgtcggct gaagacagcc tgtcagatgc tgccggggtc ggagtcgacg 660ggcccaacgt gagcttccag aacggcgggg acacggtgct gagcgagggc agcagcctgc 720actccggcgg cggcggcggc agtgggcacc accagcacta ctattatgat acccacacca 780acacctacta cctgcgcacc ttcggccaca acaccatgga cgctgtgccc aggatcgatc 840actaccggca cacagccgcg cagctgggcg agaagctgct ccggcctagc ctggcggagc 900tccacgacga gctggaaaag gaaccttttg aggatggctt tgcaaatggg gaagaaagta 960ctccaaccag agatgctgtg gtcacgtata ctgcagaaag taaaggagtc gtgaagtttg 1020gctggatcaa gggtgtatta gtacgttgta tgttaaacat ttggggtgtg atgcttttca 1080ttagattgtc atggattgtg ggtcaagctg gaataggtct atcagtcctt gtaataatga 1140tggccactgt tgtgacaact atcacaggat tgtctacttc agcaatagca actaatggat 1200ttgtaagagg aggaggagca tattatttaa tatctagaag tctagggcca gaatttggtg 1260gtgcaattgg tctaatcttc gcctttgcca acgctgttgc agttgctatg tatgtggttg 1320gatttgcaga aaccgtggtg gagttgctta aggaacattc catacttatg atagatgaaa 1380tcaatgatat ccgaattatt ggagccatta cagtcgtgat tcttttaggt atctcagtag 1440ctggaatgga gtgggaagca aaagctcaga ttgttctttt ggtgatccta cttcttgcta 1500ttggtgattt cgtcatagga acatttatcc cactggagag caagaagcca aaagggtttt 1560ttggttataa atctgaaata tttaatgaga actttgggcc cgattttcga gaggaagaga 1620ctttcttttc tgtatttgcc atcttttttc ctgctgcaac tggtattctg gctggagcaa 1680atatctcagg tgatcttgca gatcctcagt cagccatacc caaaggaaca ctcctagcca 1740ttttaattac tacattggtt tacgtaggaa ttgcagtatc tgtaggttct tgtgttgttc 1800gagatgccac tggaaacgtt aatgacacta tcgtaacaga gctaacaaac tgtacttctg 1860cagcctgcaa attaaacttt gatttttcat cttgtgaaag cagtccttgt tcctatggcc 1920taatgaacaa cttccaggta atgagtatgg tgtcaggatt tacaccacta atttctgcag 1980gtatattttc agccactctt tcttcagcat tagcatccct agtgagtgct cccaaaatat 2040ttcaggctct atgtaaggac aacatctacc cagctttcca gatgtttgct aaaggttatg 2100ggaaaaataa tgaacctctt cgtggctaca tcttaacatt cttaattgca cttggattca 2160tcttaattgc tgaactgaat gttattgcac caattatctc aaacttcttc cttgcatcat 2220atgcattgat caatttttca gtattccatg catcacttgc aaaatctcca ggatggcgtc 2280ctgcattcaa atactacaac atgtggatat cacttcttgg agcaattctt tgttgcatag 2340taatgttcgt cattaactgg tgggctgcat tgctaacata tgtgatagtc cttgggctgt 2400atatttatgt tacctacaaa aaaccagatg tgaattgggg atcctctaca caagccctga 2460cttacctgaa tgcactgcag cattcaattc gtctttctgg agtggaagac cacgtgaaaa 2520actttaggcc acagtgtctt gttatgacag gtgctccaaa ctcacgtcca gctttacttc 2580atcttgttca tgatttcaca aaaaatgttg gtttgatgat ctgtggccat gtacatatgg 2640gtcctcgaag acaagccatg aaagagatgt ccatcgatca agccaaatat cagcgatggc 2700ttattaagaa caaaatgaag gcattttatg ctccagtaca tgcagatgac ttgagagaag 2760gtgcacagta tttgatgcag gctgctggtc ttggtcgtat gaagccaaac acacttgtcc 2820ttggatttaa gaaagattgg ttgcaagcag atatgaggga tgtggatatg tatataaact 2880tatttcatga tgcttttgac atacaatatg gagtagtggt tattcgccta aaagaaggtc 2940tggatatatc tcatcttcaa ggacaagaag aattattgtc atcacaagag aaatctcctg 3000gcaccaagga tgtggtagta agtgtggaat atagtaaaaa gtccgattta gatacttcca 3060aaccactcag tgaaaaacca attacacaca aagttgagga agaggatggc aagactgcaa 3120ctcaaccact gttgaaaaaa gaatccaaag gccctattgt gcctttaaat gtagctgacc 3180aaaagcttct tgaagctagt acacagtttc agaaaaaaca aggaaagaat actattgatg 3240tctggtggct ttttgatgat ggaggtttga ccttattgat accttacctt ctgacgacca 3300agaaaaaatg gaaagactgt aagatcagag tattcattgg tggaaagata aacagaatag 3360accatgaccg gagagcgatg gctactttgc ttagcaagtt ccggatagac ttttctgata 3420tcatggttct aggagatatc aataccaaac caaagaaaga aaatattata gcttttgagg 3480aaatcattga gccatacaga cttcatgaag atgataaaga gcaagatatt gcagataaaa 3540tgaaagaaga tgaaccatgg cgaataacag ataatgagct tgaactttat aagaccaaga 3600cataccggca gatcaggtta aatgagttat taaaggaaca ttcaagcaca gctaatatta 3660ttgtcatgag tctcccagtt gcacgaaaag gtgctgtgtc tagtgctctc tacatggcat 3720ggttagaagc tctatctaag gacctaccac caatcctcct agttcgtggg aatcatcaga 3780gtgtccttac cttctattca taaatgttct atacagtgga cagccctcca gaatggtact 3840tcagtgccta gtgtagtaac ctgaaatctt caatgacaca ttaacatcac aatggcgaat 3900ggtgactttt ctttcacgat ttcattaatt tgaaagcaca caggaaagct tgctccattg 3960ataacgtgta tggagacttc ggttttagtc aattccatat ctcaatctta atggtgattc 4020ttctctgttg aactgaagtt tgtgagagta gttttccttt gctacttgaa tagcaataaa 4080agcgtgttaa ctttttgg 4098 <210> SEQ ID NO 10 <211> LENGTH: 4098 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 10 ggtggcctct gtggccgtccaggctagcgg cggcccgcag gcggcgggga gaaagactct 60 ctcacctggt cttgcggctgtggccaccgc cggccagggg tgtggagggc gtgctgccgg 120 agacgtccgc cgggctctgcagttccgccg ggggtcgggc agctatggag ccgcggccca 180 cggcgccctc ctccggcgccccgggactgg ccggggtcgg ggagacgccg tcagccgctg 240 cgctggccgc agccagggtggaactgcccg gcacggctgt gccctcggtg ccggaggatg 300 ctgcgcccgc gagccgggacggcggcgggg tccgcgatga gggccccgcg gcggccgggg 360 acgggctggg cagacccttggggcccaccc cgagccagag ccgtttccag gtggacctgg 420 tttccgagaa cgccgggcgggccgctgctg cggcggcggc ggcggcggcg gcagcggcgg 480 cggctggtgc tggggcgggggccaagcaga cccccgcgga cggggaagcc agcggcgaga 540 gcgagccagc taaaggcagcgaggaagcca agggccgctt ccgcgtgaac ttcgtggacc 600 cagctgcctc ctcgtcggctgaagacagcc tgtcagatgc tgccggggtc ggagtcgacg 660 ggcccaacgt gagcttccagaacggcgggg acacggtgct gagcgagggc agcagcctgc 720 actccggcgg cggcggcggcagtgggcacc accagcacta ctattatgat acccacacca 780 acacctacta cctgcgcaccttcggccaca acaccatgga cgctgtgccc aggatcgatc 840 actaccggca cacagccgcgcagctgggcg agaagctgct ccggcctagc ctggcggagc 900 tccacgacga gctggaaaaggaaccttttg aggatggctt tgcaaatggg gaagaaagta 960 ctccaaccag agatgctgtggtcacgtata ctgcagaaag taaaggagtc gtgaagtttg 1020 gctggatcaa gggtgtattagtacgttgta tgttaaacat ttggggtgtg atgcttttca 1080 ttagattgtc atggattgtgggtcaagctg gaataggtct atcagtcctt gtaataatga 1140 tggccactgt tgtgacaactatcacaggat tgtctacttc agcaatagca actaatggat 1200 ttgtaagagg aggaggagcatattatttaa tatctagaag tctagggcca gaatttggtg 1260 gtgcaattgg tctaatcttcgcctttgcca acgctgttgc agttgctatg tatgtggttg 1320 gatttgcaga aaccgtggtggagttgctta aggaacattc catacttatg atagatgaaa 1380 tcaatgatat ccgaattattggagccatta cagtcgtgat tcttttaggt atctcagtag 1440 ctggaatgga gtgggaagcaaaagctcaga ttgttctttt ggtgatccta cttcttgcta 1500 ttggtgattt cgtcataggaacatttatcc cactggagag caagaagcca aaagggtttt 1560 ttggttataa atctgaaatatttaatgaga actttgggcc cgattttcga gaggaagaga 1620 ctttcttttc tgtatttgccatcttttttc ctgctgcaac tggtattctg gctggagcaa 1680 atatctcagg tgatcttgcagatcctcagt cagccatacc caaaggaaca ctcctagcca 1740 ttttaattac tacattggtttacgtaggaa ttgcagtatc tgtaggttct tgtgttgttc 1800 gagatgccac tggaaacgttaatgacacta tcgtaacaga gctaacaaac tgtacttctg 1860 cagcctgcaa attaaactttgatttttcat cttgtgaaag cagtccttgt tcctatggcc 1920 taatgaacaa cttccaggtaatgagtatgg tgtcaggatt tacaccacta atttctgcag 1980 gtatattttc agccactctttcttcagcat tagcatccct agtgagtgct cccaaaatat 2040 ttcaggctct atgtaaggacaacatctacc cagctttcca gatgtttgct aaaggttatg 2100 ggaaaaataa tgaacctcttcgtggctaca tcttaacatt cttaattgca cttggattca 2160 tcttaattgc tgaactgaatgttattgcac caattatctc aaacttcttc cttgcatcat 2220 atgcattgat caatttttcagtattccatg catcacttgc aaaatctcca ggatggcgtc 2280 ctgcattcaa atactacaacatgtggatat cacttcttgg agcaattctt tgttgcatag 2340 taatgttcgt cattaactggtgggctgcat tgctaacata tgtgatagtc cttgggctgt 2400 atatttatgt tacctacaaaaaaccagatg tgaattgggg atcctctaca caagccctga 2460 cttacctgaa tgcactgcagcattcaattc gtctttctgg agtggaagac cacgtgaaaa 2520 actttaggcc acagtgtcttgttatgacag gtgctccaaa ctcacgtcca gctttacttc 2580 atcttgttca tgatttcacaaaaaatgttg gtttgatgat ctgtggccat gtacatatgg 2640 gtcctcgaag acaagccatgaaagagatgt ccatcgatca agccaaatat cagcgatggc 2700 ttattaagaa caaaatgaaggcattttatg ctccagtaca tgcagatgac ttgagagaag 2760 gtgcacagta tttgatgcaggctgctggtc ttggtcgtat gaagccaaac acacttgtcc 2820 ttggatttaa gaaagattggttgcaagcag atatgaggga tgtggatatg tatataaact 2880 tatttcatga tgcttttgacatacaatatg gagtagtggt tattcgccta aaagaaggtc 2940 tggatatatc tcatcttcaaggacaagaag aattattgtc atcacaagag aaatctcctg 3000 gcaccaagga tgtggtagtaagtgtggaat atagtaaaaa gtccgattta gatacttcca 3060 aaccactcag tgaaaaaccaattacacaca aagttgagga agaggatggc aagactgcaa 3120 ctcaaccact gttgaaaaaagaatccaaag gccctattgt gcctttaaat gtagctgacc 3180 aaaagcttct tgaagctagtacacagtttc agaaaaaaca aggaaagaat actattgatg 3240 tctggtggct ttttgatgatggaggtttga ccttattgat accttacctt ctgacgacca 3300 agaaaaaatg gaaagactgtaagatcagag tattcattgg tggaaagata aacagaatag 3360 accatgaccg gagagcgatggctactttgc ttagcaagtt ccggatagac ttttctgata 3420 tcatggttct aggagatatcaataccaaac caaagaaaga aaatattata gcttttgagg 3480 aaatcattga gccatacagacttcatgaag atgataaaga gcaagatatt gcagataaaa 3540 tgaaagaaga tgaaccatggcgaataacag ataatgagct tgaactttat aagaccaaga 3600 cataccggca gatcaggttaaatgagttat taaaggaaca ttcaagcaca gctaatatta 3660 ttgtcatgag tctcccagttgcacgaaaag gtgctgtgtc tagtgctctc tacatggcat 3720 ggttagaagc tctatctaaggacctaccac caatcctcct agttcgtggg aatcatcaga 3780 gtgtccttac cttctattcataaatgttct atacagtgga cagccctcca gaatggtact 3840 tcagtgccta gtgtagtaacctgaaatctt caatgacaca ttaacatcac aatggcgaat 3900 ggtgactttt ctttcacgatttcattaatt tgaaagcaca caggaaagct tgctccattg 3960 ataacgtgta tggagacttcggttttagtc aattccatat ctcaatctta atggtgattc 4020 ttctctgttg aactgaagtttgtgagagta gttttccttt gctacttgaa tagcaataaa 4080 agcgtgttaa ctttttgg4098 <210> SEQ ID NO 11 <211> LENGTH: 3311 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 11 tgctaatgct tttggtacaa atggatgtggaatataattg aatattttct tgtttaaggg 60 gagcatgaag aggtgttgag gttatgtcaagcatctggca cagctgaagg cagatggaaa 120 tatttacaag tacgcaattt gagactaagatattgttatc attctcctat tgaagacaag 180 agcaatagta aaacacatca ggtcagggggttaaagacct gtgataaacc acttccgata 240 agttggaaac gtgtgtctat attttcatatctgtatatat ataatggtaa agaaagacac 300 cttcgtaacc cgcattttcc aaagagaggaatcacaggga gatgtacagc aatggggcca 360 tttaagagtt ctgtgttcat cttgattcttcaccttctag aaggggccct gagtaattca 420 ctcattcagc tgaacaacaa tggctatgaaggcattgtcg ttgcaatcga ccccaatgtg 480 ccagaagatg aaacactcat tcaacaaataaaggacatgg tgacccaggc atctctgtat 540 ctgtttgaag ctacaggaaa gcgattttatttcaaaaatg ttgccatttt gattcctgaa 600 acatggaaga caaaggctga ctatgtgagaccaaaacttg agacctacaa aaatgctgat 660 gttctggttg ctgagtctac tcctccaggtaatgatgaac cctacactga gcagatgggc 720 aactgtggag agaagggtga aaggatccacctcactcctg atttcattgc aggaaaaaag 780 ttagctgaat atggaccaca aggtaaggcatttgtccatg agtgggctca tctacgatgg 840 ggagtatttg acgagtacaa taatgatgagaaattctact tatccaatgg aagaatacaa 900 gcagtaagat gttcagcagg tattactggtacaaatgtag taaagaagtg tcagggaggc 960 agctgttaca ccaaaagatg cacattcaataaagttacag gactctatga aaaaggatgt 1020 gagtttgttc tccaatcccg ccagacggagaaggcttcta taatgtttgc acaacatgtt 1080 gattctatag ttgaattctg tacagaacaaaaccacaaca aagaagctcc aaacaagcaa 1140 aatcaaaaat gcaatctccg aagcacatgggaagtgatcc gtgattctga ggactttaag 1200 aaaaccactc ctatgacaac acagccaccaaatcccacct tctcattgct gcagattgga 1260 caaagaattg tgtgtttagt ccttgacaaatctggaagca tggcgactgg taaccgcctc 1320 aatcgactga atcaagcagg ccagcttttcctgctgcaga cagttgagct ggggtcctgg 1380 gttgggatgg tgacatttga cagtgctgcccatgtacaaa gtgaactcat acagataaac 1440 agtggcagtg acagggacac actcgccaaaagattacctg cagcagcttc aggagggacg 1500 tccatctgca gcgggcttcg atcggcatttactgtgatta ggaagaaata tccaactgat 1560 ggatctgaaa ttgtgctgct gacggatggggaagacaaca ctataagtgg gtgctttaac 1620 gaggtcaaac aaagtggtgc catcatccacacagtcgctt tggggccctc tgcagctcaa 1680 gaactagagg agctgtccaa aatgacaggaggtttacaga catatgcttc agatcaagtt 1740 cagaacaatg gcctcattga tgcttttggggccctttcat caggaaatgg agctgtctct 1800 cagcgctcca tccagcttga gagtaagggattaaccctcc agaacagcca gtggatgaat 1860 ggcacagtga tcgtggacag caccgtgggaaaggacactt tgtttcttat cacctggaca 1920 acgcagcctc cccaaatcct tctctgggatcccagtggac agaagcaagg tggctttgta 1980 gtggacaaaa acaccaaaat ggcctacctccaaatcccag gcattgctaa ggttggcact 2040 tggaaataca gtctgcaagc aagctcacaaaccttgaccc tgactgtcac gtcccgtgcg 2100 tccaatgcta ccctgcctcc aattacagtgacttccaaaa cgaacaagga caccagcaaa 2160 ttccccagcc ctctggtagt ttatgcaaatattcgccaag gagcctcccc aattctcagg 2220 gccagtgtca cagccctgat tgaatcagtgaatggaaaaa cagttacctt ggaactactg 2280 gataatggag caggtgctga tgctactaaggatgacggtg tctactcaag gtatttcaca 2340 acttatgaca cgaatggtag atacagtgtaaaagtgcggg ctctgggagg agttaacgca 2400 gccagacgga gagtgatacc ccagcagagtggagcactgt acatacctgg ctggattgag 2460 aatgatgaaa tacaatggaa tccaccaagacctgaaatta ataaggatga tgttcaacac 2520 aagcaagtgt gtttcagcag aacatcctcgggaggctcat ttgtggcttc tgatgtccca 2580 aatgctccca tacctgatct cttcccacctggccaaatca ccgacctgaa ggcggaaatt 2640 cacgggggca gtctcattaa tctgacttggacagctcctg gggatgatta tgaccatgga 2700 acagctcaca agtatatcat tcgaataagtacaagtattc ttgatctcag agacaagttc 2760 aatgaatctc ttcaagtgaa tactactgctctcatcccaa aggaagccaa ctctgaggaa 2820 gtctttttgt ttaaaccaga aaacattacttttgaaaatg gcacagatct tttcattgct 2880 attcaggctg ttgataaggt cgatctgaaatcagaaatat ccaacattgc acgagtatct 2940 ttgtttattc ctccacagac tccgccagagacacctagtc ctgatgaaac gtctgctcct 3000 tgtcctaata ttcatatcaa cagcaccattcctggcattc acattttaaa aattatgtgg 3060 aagtggatag gagaactgca gctgtcaatagcctagggct gaatttttgt cagataaata 3120 aaataaatca ttcatccttt ttttgattataaaattttct aaaatgtatt ttagacttcc 3180 tgtagggggc gatatactaa atgtatatagtacatttata ctaaatgtat tcctgtaggg 3240 ggcgatatac taaatgtatt ttagacttcctgtagggggc gataaaataa aatgctaaac 3300 aactgggtaa a 3311 <210> SEQ ID NO12 <211> LENGTH: 3311 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 12 tgctaatgct tttggtacaa atggatgtgg aatataattg aatattttcttgtttaaggg 60 gagcatgaag aggtgttgag gttatgtcaa gcatctggca cagctgaaggcagatggaaa 120 tatttacaag tacgcaattt gagactaaga tattgttatc attctcctattgaagacaag 180 agcaatagta aaacacatca ggtcaggggg ttaaagacct gtgataaaccacttccgata 240 agttggaaac gtgtgtctat attttcatat ctgtatatat ataatggtaaagaaagacac 300 cttcgtaacc cgcattttcc aaagagagga atcacaggga gatgtacagcaatggggcca 360 tttaagagtt ctgtgttcat cttgattctt caccttctag aaggggccctgagtaattca 420 ctcattcagc tgaacaacaa tggctatgaa ggcattgtcg ttgcaatcgaccccaatgtg 480 ccagaagatg aaacactcat tcaacaaata aaggacatgg tgacccaggcatctctgtat 540 ctgtttgaag ctacaggaaa gcgattttat ttcaaaaatg ttgccattttgattcctgaa 600 acatggaaga caaaggctga ctatgtgaga ccaaaacttg agacctacaaaaatgctgat 660 gttctggttg ctgagtctac tcctccaggt aatgatgaac cctacactgagcagatgggc 720 aactgtggag agaagggtga aaggatccac ctcactcctg atttcattgcaggaaaaaag 780 ttagctgaat atggaccaca aggtaaggca tttgtccatg agtgggctcatctacgatgg 840 ggagtatttg acgagtacaa taatgatgag aaattctact tatccaatggaagaatacaa 900 gcagtaagat gttcagcagg tattactggt acaaatgtag taaagaagtgtcagggaggc 960 agctgttaca ccaaaagatg cacattcaat aaagttacag gactctatgaaaaaggatgt 1020 gagtttgttc tccaatcccg ccagacggag aaggcttcta taatgtttgcacaacatgtt 1080 gattctatag ttgaattctg tacagaacaa aaccacaaca aagaagctccaaacaagcaa 1140 aatcaaaaat gcaatctccg aagcacatgg gaagtgatcc gtgattctgaggactttaag 1200 aaaaccactc ctatgacaac acagccacca aatcccacct tctcattgctgcagattgga 1260 caaagaattg tgtgtttagt ccttgacaaa tctggaagca tggcgactggtaaccgcctc 1320 aatcgactga atcaagcagg ccagcttttc ctgctgcaga cagttgagctggggtcctgg 1380 gttgggatgg tgacatttga cagtgctgcc catgtacaaa gtgaactcatacagataaac 1440 agtggcagtg acagggacac actcgccaaa agattacctg cagcagcttcaggagggacg 1500 tccatctgca gcgggcttcg atcggcattt actgtgatta ggaagaaatatccaactgat 1560 ggatctgaaa ttgtgctgct gacggatggg gaagacaaca ctataagtgggtgctttaac 1620 gaggtcaaac aaagtggtgc catcatccac acagtcgctt tggggccctctgcagctcaa 1680 gaactagagg agctgtccaa aatgacagga ggtttacaga catatgcttcagatcaagtt 1740 cagaacaatg gcctcattga tgcttttggg gccctttcat caggaaatggagctgtctct 1800 cagcgctcca tccagcttga gagtaaggga ttaaccctcc agaacagccagtggatgaat 1860 ggcacagtga tcgtggacag caccgtggga aaggacactt tgtttcttatcacctggaca 1920 acgcagcctc cccaaatcct tctctgggat cccagtggac agaagcaaggtggctttgta 1980 gtggacaaaa acaccaaaat ggcctacctc caaatcccag gcattgctaaggttggcact 2040 tggaaataca gtctgcaagc aagctcacaa accttgaccc tgactgtcacgtcccgtgcg 2100 tccaatgcta ccctgcctcc aattacagtg acttccaaaa cgaacaaggacaccagcaaa 2160 ttccccagcc ctctggtagt ttatgcaaat attcgccaag gagcctccccaattctcagg 2220 gccagtgtca cagccctgat tgaatcagtg aatggaaaaa cagttaccttggaactactg 2280 gataatggag caggtgctga tgctactaag gatgacggtg tctactcaaggtatttcaca 2340 acttatgaca cgaatggtag atacagtgta aaagtgcggg ctctgggaggagttaacgca 2400 gccagacgga gagtgatacc ccagcagagt ggagcactgt acatacctggctggattgag 2460 aatgatgaaa tacaatggaa tccaccaaga cctgaaatta ataaggatgatgttcaacac 2520 aagcaagtgt gtttcagcag aacatcctcg ggaggctcat ttgtggcttctgatgtccca 2580 aatgctccca tacctgatct cttcccacct ggccaaatca ccgacctgaaggcggaaatt 2640 cacgggggca gtctcattaa tctgacttgg acagctcctg gggatgattatgaccatgga 2700 acagctcaca agtatatcat tcgaataagt acaagtattc ttgatctcagagacaagttc 2760 aatgaatctc ttcaagtgaa tactactgct ctcatcccaa aggaagccaactctgaggaa 2820 gtctttttgt ttaaaccaga aaacattact tttgaaaatg gcacagatcttttcattgct 2880 attcaggctg ttgataaggt cgatctgaaa tcagaaatat ccaacattgcacgagtatct 2940 ttgtttattc ctccacagac tccgccagag acacctagtc ctgatgaaacgtctgctcct 3000 tgtcctaata ttcatatcaa cagcaccatt cctggcattc acattttaaaaattatgtgg 3060 aagtggatag gagaactgca gctgtcaata gcctagggct gaatttttgtcagataaata 3120 aaataaatca ttcatccttt ttttgattat aaaattttct aaaatgtattttagacttcc 3180 tgtagggggc gatatactaa atgtatatag tacatttata ctaaatgtattcctgtaggg 3240 ggcgatatac taaatgtatt ttagacttcc tgtagggggc gataaaataaaatgctaaac 3300 aactgggtaa a 3311 <210> SEQ ID NO 13 <211> LENGTH: 15720<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 13 caacccacaccgcccctgcc agccaccatg gggctgccac tagcccgcct ggcggctgtg 60 tgcctggccctgtctttggc agggggctcg gagctccaga cagagggcag aacccgatac 120 cacggccgcaacgtctgcag cacctggggc aacttccact acaagacctt cgacggggac 180 gtcttccgcttccccggcct ctgcgactac aacttcgcct ccgactgccg aggctcctac 240 aaggaatttgctgtgcacct gaagcggggt ccgggccagg ctgaggcccc cgccggggtg 300 gagtccatcctgctgaccat caaggatgac accatctacc tcacccgcca cctggctgtg 360 cttaacggggccgtggtcag caccccgcac tacagccccg ggctgctcat tgagaagagc 420 gatgcctacaccaaagtcta ctcccgcgcc ggcctcaccc tcatgtggaa ccgggaggat 480 gcactcatgctggagctgga cactaagttc cggaaccaca cctgtggcct ctgcggggac 540 tacaacggcctgcagagcta ttcagaattc ctctctgacg gcgtgctctt cagtcccctg 600 gagtttgggaacatgcagaa gatcaaccag cccgatgtgg tgtgtgagga tcccgaggag 660 gaggtggcccccgcatcctg ctccgagcac cgcgccgagt gtgagaggct gctgaccgcc 720 gaggccttcgcggactgtca ggacctggtg ccgctggagc cgtatctgcg cgcctgccag 780 caggaccgctgccggtgccc gggcggtgac acctgcgtct gcagcaccgt ggccgagttc 840 tcccgccagtgctcccacgc cggcggccgg cccgggaact ggaggaccgc cacgctctgc 900 cccaagacctgccccgggaa cctggtgtac ctggagagcg gctcgccctg catggacacc 960 tgctcacacctggaggtgag cagcctgtgc gaggagcacc gcatggacgg ctgtttctgc 1020 ccagaaggcaccgtatatga cgacatcggg gacagtggct gcgttcctgt gagccagtgc 1080 cactgcaggctgcacggaca cctgtacaca ccgggccagg agatcaccaa tgactgcgag 1140 cagtgtgtctgtaacgctgg ccgctgggtg tgcaaagacc tgccctgccc cggcacctgt 1200 gccctggaaggcggctccca catcaccacc ttcgatggga agacgtacac cttccacggg 1260 gactgctactatgtcctggc caagggtgac cacaacgatt cctacgctct cctgggcgag 1320 ctggccccctgtggctccac agacaagcag acctgcctga agacggtggt gctgctggct 1380 gacaagaagaagaatgcggt ggtcttcaag tccgatggca gtgtactgct caaccagctg 1440 caggtgaacctgccccacgt gaccgcgagc ttctctgtct tccgcccgtc ttcctaccac 1500 atcatggtgagcatggccat tggcgtccgg ctgcaggtgc agctggcccc agtcatgcaa 1560 ctctttgtgacactggacca ggcctcccag gggcaggtgc agggcctctg cgggaacttc 1620 aacggcctggaaggtgacga cttcaagacg gccagcgggc tggtggaggc cacgggggcc 1680 ggctttgccaacacctggaa ggcacagtca acctgccatg acaagctgga ctggttggac 1740 gatccctgctccctgaacat cgagagcgcc aactacgccg agcactggtg ctccctcctg 1800 aagaagacagagaccccctt tggcaggtgc cactcggctg tggaccctgc tgagtattac 1860 aagaggtgcaaatatgacac gtgtaactgt cagaacaatg aggactgcct gtgcgccgcc 1920 ctgtcctcctacgcgcgcgc ctgcaccgcc aagggcgtca tgctgtgggg ctggcgggag 1980 catgtctgcaacaaggatgt gggctcctgc cccaactcgc aggtcttcct gtacaacctg 2040 accacctgccagcagacctg ccgctccctc tccgaggccg acagccactg tctcgagggc 2100 tttgcgcctgtggacggctg cggctgccct gaccacacct tcctggacga gaagggccgc 2160 tgcgtacccctggccaagtg ctcctgttac caccgcggtc tctacctgga ggcgggggat 2220 gtggtcgtcaggcaggaaga acgatgtgtg tgccgggatg ggcggctgca ctgtaggcag 2280 atccggctgatcggccagag ctgcacggcc ccaaagatcc acatggactg cagcaacctg 2340 actgcactggccacctcgaa gccccgagcc ctcagctgcc agacgctggc cgccggctat 2400 taccacacagagtgtgtcag tggctgtgtg tgccccgacg ggctgatgga tgacggccgg 2460 ggtggctgcgtggtggagaa ggaatgccct tgcgtccata acaacgacct gtattcttcc 2520 ggcgccaagatcaaggtgga ctgcaatacc tgcacctgca agagaggacg ctgggtgtgc 2580 acccaggctgtgtgccatgg cacctgctcc atttacggga gtggccacta catcaccttt 2640 gatgggaagtactacgactt tgacggacac tgctcctacg tggctgttca ggactactgc 2700 ggccagaactcctcactggg ctcattcagc atcatcaccg agaacgtccc ctgtggcact 2760 acgggcgtcacctgctccaa ggccatcaag atcttcatgg ggaggacgga gctgaagttg 2820 gaagacaagcaccgtgtggt gatccagcgt gatgagggtc accacgtggc ctacaccacg 2880 cgggaggtgggccagtacct ggtggtggag tccagcacgg gcatcatcgt catctgggac 2940 aagaggaccaccgtgttcat caagctggct ccctcctaca agggcaccgt gtgtggcctg 3000 tgtgggaactttgaccaccg ctccaacaac gacttcacca cgcgggacca catggtggtg 3060 agcagcgagctggacttcgg gaacagctgg aaggaggccc ccacctgccc agatgtgagc 3120 accaaccccgagccctgcag cctgaacccg caccgccgct cctgggccga gaagcagtgc 3180 agcatcctcaaaagcagcgt gttcagcatc tgccacagca aggtggaccc caagcccttc 3240 tacgaggcctgtgtgcacga ctcgtgctcc tgtgacacgg gtggggactg tgagtgcttc 3300 tgctctgccgtggcctccta cgcccaggag tgtaccaaag agggggcctg cgtgttctgg 3360 aggacgccggacctgtgccc catattctgc gactactaca accctccgca tgagtgtgag 3420 tggcactatgagccatgtgg gaaccggagc ttcgagacct gcaggaccat caacggcatc 3480 cactccaacatctccgtgtc ctacctggag ggctgctacc cccggtgccc caaggacagg 3540 cccatctatgaggaggatct gaagaagtgt gtcactgcag acaagtgtgg ctgctatgtc 3600 gaggacacccactacccacc tggagcatcg gttcccaccg aggagacctg caagtcctgc 3660 gtgtgtaccaactcctccca agtcgtctgc aggccggagg aaggaaagat tcttaaccag 3720 acccaggatggcgccttctg ctactgggag atctgtggcc ccaacgggac ggtggagaag 3780 cacttcaacatctgttccat tacgacacgc ccgtccaccc tgaccacctt caccaccatc 3840 accctccccaccacccccac ctccttcacc actaccacca ccaccaccac cccgacctcc 3900 agcacagttttatcaacaac tccgaagctg tgctgcctct ggtctgactg gatcaatgag 3960 gaccaccccagcagtggcag cgacgacggt gaccgagaac catttgatgg ggtctgcggg 4020 gcccctgaggacatcgagtg caggtcggtc aaggatcccc acctcagctt ggagcagcat 4080 ggccagaaggtgcagtgtga tgtctctgtt gggttcattt gcaagaatga agaccagttt 4140 ggaaatggaccatttggact gtgttacgac tacaagatac gtgtcaattg ttgctggccc 4200 atggataagtgtatcaccac tcccagccct ccaactacca ctcccagccc tccaccaacc 4260 acgacgaccacccttccacc aaccaccacc cccagccctc caaccaccac cacaaccacc 4320 cctccaccaaccaccacccc cagccctcca ataaccacca cgaccacccc tctaccaacc 4380 accactcccagccctccaat aagcaccaca accacccctc caccaaccac cactcccagc 4440 cctccaaccaccactcccag ccctccaacc accactccca gccctccaac aaccaccaca 4500 accacccctccaccaaccac cactcccagc cctccaatga ctacgcccat cactccacca 4560 gccagcactaccacccttcc accaaccacc actcccagcc ctccaacaac caccacaacc 4620 acccctccaccaaccaccac tcccagtcct ccaacgacta cgcccatcac tccaccaacc 4680 agcactactacccttccacc aaccaccact cccagccctc caccaaccac cacaaccacc 4740 cctccaccaaccaccactcc cagccctcca acaaccacca ctcccagtcc tccaacaatc 4800 accacaaccacccctccacc aaccaccact cccagccctc caacaacgac cacaaccacc 4860 cctccaccaaccaccactcc cagccctcca acgactacac ccatcactcc accaaccagc 4920 actaccacccttccaccaac caccactccc agccctccac caaccaccac aaccacccct 4980 ccaccaaccaccactcccag ccctccaaca accaccactc ccagccctcc aataaccacc 5040 acaaccacccctccaccaac caccactccc agctctccaa taaccaccac tcccagccct 5100 ccaacaaccaccatgaccac cccttcacca accaccaccc ccagctctcc aataaccacc 5160 acaaccaccccttcctcaac taccactccc agccctccac caaccaccat gaccacccct 5220 tcaccaaccaccactcccag ccctccaaca accaccatga ccacccttcc accaaccacc 5280 acttccagccctctaacaac tactcctcta cctccatcaa taactcctcc tacattttca 5340 ccattctcaacgacaacccc tactacccca tgcgtgcctc tctgcaattg gactggctgg 5400 ctggattctggaaaacccaa ctttcacaaa ccaggtggag acacagaatt gattggagac 5460 gtctgtggaccaggctgggc agctaacatc tcttgcagag ccaccatgta tcctgatgtt 5520 cccattggacagcttggaca aacagtggtg tgtgatgtct ctgtggggct gatatgcaaa 5580 aatgaagaccaaaagccagg tggggtcatc cctatggcct tctgcctcaa ctacgagatc 5640 aacgttcagtgctgtgagtg tgtcacccaa cccaccacca tgacaaccac caccacagag 5700 aacccaactccgccaaccac gacacccatc accaccacca ctacggtgac cccaacccca 5760 acacccaccggcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc 5820 ccaaccccaacacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 5880 acggtgaccccaaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 5940 accaccactacggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 6000 cccatcaccaccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 6060 accacgacacccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 6120 cagaccccaaccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 6180 accggcacacagaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 6240 ccaacacccaccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 6300 accccaaccccaacacccac cggcacacag accccaacca cgacacccat caccaccacc 6360 actacggtgaccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 6420 accaccaccactacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 6480 acacccatcaccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 6540 ccaaccacgacacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 6600 acacagaccccaaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 6660 cccaccggcacacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 6720 accccaacacccaccggcac acagacccca accacgacac ccatcaccac caccactacg 6780 gtgaccccaaccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc 6840 accactacggtgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 6900 atcaccaccaccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 6960 acgacacccatcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 7020 accccaaccacgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 7080 ggcacacagaccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca 7140 acacccaccggcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc 7200 ccaaccccaacacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 7260 acggtgaccccaaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 7320 accaccactacggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 7380 cccatcaccaccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 7440 accacgacacccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 7500 cagaccccaaccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 7560 accggcacacagaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 7620 ccaacacccaccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 7680 accccaaccccaacacccac cggcacacag accccaacca cgacacccat caccaccacc 7740 actacggtgaccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 7800 accaccaccactacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 7860 acacccatcaccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 7920 ccaaccacgacacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 7980 acacagaccccaaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 8040 cccaccggcacacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 8100 accccaacacccaccggcac acagacccca accacgacac ccatcaccac caccactacg 8160 gtgaccccaaccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc 8220 accactacggtgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 8280 atcaccaccaccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 8340 acgacacccatcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 8400 accccaaccacgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 8460 ggcacacagaccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca 8520 acacccaccggcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc 8580 ccaaccccaacacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 8640 acggtgaccccaaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 8700 accaccactacggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 8760 cccatcaccaccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 8820 accacgacacccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 8880 cagaccccaaccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 8940 accggcacacagaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 9000 ccaacacccaccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 9060 accccaaccccaacacccac cggcacacag accccaacca cgacacccat caccaccacc 9120 actacggtgaccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 9180 accaccaccactacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 9240 acacccatcaccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 9300 ccaaccacgacacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 9360 acacagaccccaaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 9420 cccaccggcacacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 9480 accccaacacccaccggcac acagacccca accacgacac ccatcaccac caccactacg 9540 gtgaccccaaccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc 9600 accactacggtgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 9660 atcaccaccaccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 9720 acgacacccatcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 9780 accccaaccacgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 9840 ggcacacagaccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca 9900 acacccaccggcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc 9960 ccaaccccaacacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 10020 acggtgaccccaaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 10080 accaccactacggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 10140 cccatcaccaccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 10200 accacgacacccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 10260 cagaccccaaccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 10320 accggcacacagaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 10380 ccaacacccaccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 10440 accccaaccccaacacccac cggcacacag accccaacca cgacacccat caccaccacc 10500 actacggtgaccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 10560 accaccaccactacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 10620 acacccatcaccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 10680 ccaaccacgacacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 10740 acacagaccccaaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 10800 cccaccggcacacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 10860 accccaacacccaccggcac acagacccca accacgacac ccatcaccac caccactacg 10920 gtgaccccaaccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc 10980 accactacggtgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 11040 atcaccaccaccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 11100 acgacacccatcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 11160 accccaaccacgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 11220 ggcacacagaccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca 11280 acacccaccggcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc 11340 ccaaccccaacacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 11400 acggtgaccccaaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 11460 accaccactacggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 11520 cccatcaccaccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 11580 accacgacacccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 11640 cagaccccaaccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 11700 accggcacacagaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 11760 ccaacacccaccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 11820 accccaaccccaacacccac cggcacacag accccaacca cgacacccat caccaccacc 11880 actacggtgaccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 11940 accaccaccactacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 12000 acacccatcaccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 12060 ccaaccacgacacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 12120 acacagaccccaaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 12180 cccaccggcacacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 12240 accccaacacccaccggcac acagacccca accacgacac ccatcaccac caccactacg 12300 gtgaccccaaccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc 12360 accactacggtgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 12420 atcaccaccaccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 12480 acgacacccatcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 12540 accccaaccacgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 12600 ggcacacagaccgggccccc cacccacaca agcacagcac cgattgctga gttgaccaca 12660 tccaatcctccgcctgagtc ctcaacccct cagacctctc ggtccacctc ttcccctctc 12720 acggagtcaaccacccttct gagtacccta ccacctgcca ttgagatgac cagcacggcc 12780 ccaccctccacacccacggc acccacgacc acgagcggag gccacacact gtctccaccg 12840 cccagcaccaccacgtcccc tccaggcacc cccactcgcg gtaccacgac cgggtcatct 12900 tcagcccccacccccagcac tgtgcagacg accaccacca gtgcctggac cccaacgccg 12960 accccactctccacacccag catcatcagg accacaggcc tgaggcccta cccttcctct 13020 gtgcttatctgctgtgtcct gaacgacacc tactacgcac caggtgagga ggtgtacaac 13080 ggcacatacggagacacctg ttatttcgtc aactgctcac tgagctgtac gttggagttc 13140 tataactggtcctgcccatc cacgccctcc ccaacaccca cgccctccaa gtcgacgccc 13200 acgccttccaagccatcgtc cacgccctcc aagccgacgc ccggcaccaa gccccccgag 13260 tgcccagactttgatcctcc cagacaggag aacgagactt ggtggctgtg cgactgcttc 13320 atggccacgtgcaagtacaa caacacggtg gagatcgtga aggtggagtg tgagccgccg 13380 cccatgcccacctgctccaa cggcctccaa cccgtgcgcg tcgaggaccc cgacggctgc 13440 tgctggcactgggagtgcga ctgctactgc acgggctggg gcgacccgca ctatgtcacc 13500 ttcgacggactctactacag ctaccagggc aactgcacct acgtgctggt ggaggagatc 13560 agcccctccgtggacaactt cggagtttac atcgacaact accactgcga tcccaacgac 13620 aaggtgtcctgtccccgcac cctcatcgtg cgccacgaga cccaggaggt gctgatcaag 13680 accgtgcatatgatgcccat gcaggtgcag gtgcaggtga acaggcaggc ggtggcactg 13740 ccctacaagaagtacgggct ggaggtgtac cagtctggca tcaactacgt ggtggacatc 13800 cccgagctgggtgtcctcgt ctcctacaat ggcctgtcct tctccgtcag gctgccctac 13860 caccggtttggcaacaacac caagggccag tgtggcacct gcaccaacac cacctccgac 13920 gactgcattctgcccagcgg ggagatcgtc tccaactgtg aggctgcggc tgaccagtgg 13980 ctggtgaacgacccctccaa gccacactgc ccccacagca gctccacgac caagcgcccg 14040 gccgtcactgtgcccggggg cggtaaaacg accccacaca aggactgcac cccatctccc 14100 ctctgccagctcatcaagga cagcctgttt gcccagtgcc acgcactggt gcccccgcag 14160 cactactacgatgcctgcgt gttcgacagc tgcttcatgc cgggctcgag cctggagtgc 14220 gccagtctgcaggcctacgc agccctctgt gcccagcaga acatctgcct cgactggcgg 14280 aaccacacgcatggggcctg cttggtggag tgcccatctc acagggagta ccaggcctgt 14340 ggccctgcagaagagcccac gtgcaaatcc agctcctccc agcagaacaa cacagtcctg 14400 gtggaaggctgcttctgtcc tgagggcacc atgaactacg ctcctggctt tgatgtctgc 14460 gtgaagacctgcggctgtgt gggacctgac aatgtgccca gagagtttgg ggagcacttc 14520 gagttcgactgcaagaactg tgtctgcctg gagggtggaa gtggcatcat ctgccaaccc 14580 aagaggtgcagccagaagcc cgttacccac tgcgtggaag acggcaccta cctcgccacg 14640 gaggtcaaccctgccgacac ctgctgcaac attaccgtct gcaagtgcaa caccagcctg 14700 tgcaaagagaagccctccgt gtgcccgctg ggattcgaag tgaagagcaa gatggtgcct 14760 ggaaggtgctgtcccttcta ctggtgtgag tccaaggggg tgtgtgttca cgggaatgct 14820 gagtaccagcccggttctcc agtttattcc tccaagtgcc aggactgcgt gtgcacggac 14880 aaggtggacaacaacaccct gctcaacgtc atcgcctgca cccacgtgcc ctgcaacacc 14940 tcctgcagccctggcttcga actcatggag gcccccgggg agtgctgtaa gaagtgtgaa 15000 cagacgcactgtatcatcaa acggcccgac aaccagcacg tcatcctgaa gcccggggac 15060 ttcaagagcgacccgaagaa caactgcaca ttcttcagct gcgtgaagat ccacaaccag 15120 ctcatctcgtccgtctccaa catcacctgc cccaactttg atgccagcat ttgcatcccg 15180 ggctccatcacattcatgcc caatggatgc tgcaagacct gcacccctcg caatgagacc 15240 agggtgccctgctccaccgt ccccgtcacc acggaggttt cgtacgccgg ctgcaccaag 15300 accgtcctcatgaatcattg ctccgggtcc tgcgggacat ttgtcatgta ctcggccaag 15360 gcccaggccctggaccacag ctgctcctgc tgcaaagagg agaaaaccag ccagcgtgag 15420 gtggtcctgagctgccccaa tggcggctcg ctgacacaca cctacaccca catcgagagc 15480 tgccagtgccaggacaccgt ctgcgggctc cccaccggca cctcccgccg ggcccggcgc 15540 tcccctaggcatctggggag cgggtgagcg gggtgggcac agcccccttc actgccctcg 15600 acagctttacctcccccgga ccctctgagc ctcctaagct cggcttcctc tcttcagata 15660 tttattgtctgagtctttgt tcagtccttg ctttccaata ataaactcag ggggacatgc 15720 <210> SEQID NO 14 <211> LENGTH: 15720 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 14 caacccacac cgcccctgcc agccaccatg gggctgccac tagcccgcctggcggctgtg 60 tgcctggccc tgtctttggc agggggctcg gagctccaga cagagggcagaacccgatac 120 cacggccgca acgtctgcag cacctggggc aacttccact acaagaccttcgacggggac 180 gtcttccgct tccccggcct ctgcgactac aacttcgcct ccgactgccgaggctcctac 240 aaggaatttg ctgtgcacct gaagcggggt ccgggccagg ctgaggcccccgccggggtg 300 gagtccatcc tgctgaccat caaggatgac accatctacc tcacccgccacctggctgtg 360 cttaacgggg ccgtggtcag caccccgcac tacagccccg ggctgctcattgagaagagc 420 gatgcctaca ccaaagtcta ctcccgcgcc ggcctcaccc tcatgtggaaccgggaggat 480 gcactcatgc tggagctgga cactaagttc cggaaccaca cctgtggcctctgcggggac 540 tacaacggcc tgcagagcta ttcagaattc ctctctgacg gcgtgctcttcagtcccctg 600 gagtttggga acatgcagaa gatcaaccag cccgatgtgg tgtgtgaggatcccgaggag 660 gaggtggccc ccgcatcctg ctccgagcac cgcgccgagt gtgagaggctgctgaccgcc 720 gaggccttcg cggactgtca ggacctggtg ccgctggagc cgtatctgcgcgcctgccag 780 caggaccgct gccggtgccc gggcggtgac acctgcgtct gcagcaccgtggccgagttc 840 tcccgccagt gctcccacgc cggcggccgg cccgggaact ggaggaccgccacgctctgc 900 cccaagacct gccccgggaa cctggtgtac ctggagagcg gctcgccctgcatggacacc 960 tgctcacacc tggaggtgag cagcctgtgc gaggagcacc gcatggacggctgtttctgc 1020 ccagaaggca ccgtatatga cgacatcggg gacagtggct gcgttcctgtgagccagtgc 1080 cactgcaggc tgcacggaca cctgtacaca ccgggccagg agatcaccaatgactgcgag 1140 cagtgtgtct gtaacgctgg ccgctgggtg tgcaaagacc tgccctgccccggcacctgt 1200 gccctggaag gcggctccca catcaccacc ttcgatggga agacgtacaccttccacggg 1260 gactgctact atgtcctggc caagggtgac cacaacgatt cctacgctctcctgggcgag 1320 ctggccccct gtggctccac agacaagcag acctgcctga agacggtggtgctgctggct 1380 gacaagaaga agaatgcggt ggtcttcaag tccgatggca gtgtactgctcaaccagctg 1440 caggtgaacc tgccccacgt gaccgcgagc ttctctgtct tccgcccgtcttcctaccac 1500 atcatggtga gcatggccat tggcgtccgg ctgcaggtgc agctggccccagtcatgcaa 1560 ctctttgtga cactggacca ggcctcccag gggcaggtgc agggcctctgcgggaacttc 1620 aacggcctgg aaggtgacga cttcaagacg gccagcgggc tggtggaggccacgggggcc 1680 ggctttgcca acacctggaa ggcacagtca acctgccatg acaagctggactggttggac 1740 gatccctgct ccctgaacat cgagagcgcc aactacgccg agcactggtgctccctcctg 1800 aagaagacag agaccccctt tggcaggtgc cactcggctg tggaccctgctgagtattac 1860 aagaggtgca aatatgacac gtgtaactgt cagaacaatg aggactgcctgtgcgccgcc 1920 ctgtcctcct acgcgcgcgc ctgcaccgcc aagggcgtca tgctgtggggctggcgggag 1980 catgtctgca acaaggatgt gggctcctgc cccaactcgc aggtcttcctgtacaacctg 2040 accacctgcc agcagacctg ccgctccctc tccgaggccg acagccactgtctcgagggc 2100 tttgcgcctg tggacggctg cggctgccct gaccacacct tcctggacgagaagggccgc 2160 tgcgtacccc tggccaagtg ctcctgttac caccgcggtc tctacctggaggcgggggat 2220 gtggtcgtca ggcaggaaga acgatgtgtg tgccgggatg ggcggctgcactgtaggcag 2280 atccggctga tcggccagag ctgcacggcc ccaaagatcc acatggactgcagcaacctg 2340 actgcactgg ccacctcgaa gccccgagcc ctcagctgcc agacgctggccgccggctat 2400 taccacacag agtgtgtcag tggctgtgtg tgccccgacg ggctgatggatgacggccgg 2460 ggtggctgcg tggtggagaa ggaatgccct tgcgtccata acaacgacctgtattcttcc 2520 ggcgccaaga tcaaggtgga ctgcaatacc tgcacctgca agagaggacgctgggtgtgc 2580 acccaggctg tgtgccatgg cacctgctcc atttacggga gtggccactacatcaccttt 2640 gatgggaagt actacgactt tgacggacac tgctcctacg tggctgttcaggactactgc 2700 ggccagaact cctcactggg ctcattcagc atcatcaccg agaacgtcccctgtggcact 2760 acgggcgtca cctgctccaa ggccatcaag atcttcatgg ggaggacggagctgaagttg 2820 gaagacaagc accgtgtggt gatccagcgt gatgagggtc accacgtggcctacaccacg 2880 cgggaggtgg gccagtacct ggtggtggag tccagcacgg gcatcatcgtcatctgggac 2940 aagaggacca ccgtgttcat caagctggct ccctcctaca agggcaccgtgtgtggcctg 3000 tgtgggaact ttgaccaccg ctccaacaac gacttcacca cgcgggaccacatggtggtg 3060 agcagcgagc tggacttcgg gaacagctgg aaggaggccc ccacctgcccagatgtgagc 3120 accaaccccg agccctgcag cctgaacccg caccgccgct cctgggccgagaagcagtgc 3180 agcatcctca aaagcagcgt gttcagcatc tgccacagca aggtggaccccaagcccttc 3240 tacgaggcct gtgtgcacga ctcgtgctcc tgtgacacgg gtggggactgtgagtgcttc 3300 tgctctgccg tggcctccta cgcccaggag tgtaccaaag agggggcctgcgtgttctgg 3360 aggacgccgg acctgtgccc catattctgc gactactaca accctccgcatgagtgtgag 3420 tggcactatg agccatgtgg gaaccggagc ttcgagacct gcaggaccatcaacggcatc 3480 cactccaaca tctccgtgtc ctacctggag ggctgctacc cccggtgccccaaggacagg 3540 cccatctatg aggaggatct gaagaagtgt gtcactgcag acaagtgtggctgctatgtc 3600 gaggacaccc actacccacc tggagcatcg gttcccaccg aggagacctgcaagtcctgc 3660 gtgtgtacca actcctccca agtcgtctgc aggccggagg aaggaaagattcttaaccag 3720 acccaggatg gcgccttctg ctactgggag atctgtggcc ccaacgggacggtggagaag 3780 cacttcaaca tctgttccat tacgacacgc ccgtccaccc tgaccaccttcaccaccatc 3840 accctcccca ccacccccac ctccttcacc actaccacca ccaccaccaccccgacctcc 3900 agcacagttt tatcaacaac tccgaagctg tgctgcctct ggtctgactggatcaatgag 3960 gaccacccca gcagtggcag cgacgacggt gaccgagaac catttgatggggtctgcggg 4020 gcccctgagg acatcgagtg caggtcggtc aaggatcccc acctcagcttggagcagcat 4080 ggccagaagg tgcagtgtga tgtctctgtt gggttcattt gcaagaatgaagaccagttt 4140 ggaaatggac catttggact gtgttacgac tacaagatac gtgtcaattgttgctggccc 4200 atggataagt gtatcaccac tcccagccct ccaactacca ctcccagccctccaccaacc 4260 acgacgacca cccttccacc aaccaccacc cccagccctc caaccaccaccacaaccacc 4320 cctccaccaa ccaccacccc cagccctcca ataaccacca cgaccacccctctaccaacc 4380 accactccca gccctccaat aagcaccaca accacccctc caccaaccaccactcccagc 4440 cctccaacca ccactcccag ccctccaacc accactccca gccctccaacaaccaccaca 4500 accacccctc caccaaccac cactcccagc cctccaatga ctacgcccatcactccacca 4560 gccagcacta ccacccttcc accaaccacc actcccagcc ctccaacaaccaccacaacc 4620 acccctccac caaccaccac tcccagtcct ccaacgacta cgcccatcactccaccaacc 4680 agcactacta cccttccacc aaccaccact cccagccctc caccaaccaccacaaccacc 4740 cctccaccaa ccaccactcc cagccctcca acaaccacca ctcccagtcctccaacaatc 4800 accacaacca cccctccacc aaccaccact cccagccctc caacaacgaccacaaccacc 4860 cctccaccaa ccaccactcc cagccctcca acgactacac ccatcactccaccaaccagc 4920 actaccaccc ttccaccaac caccactccc agccctccac caaccaccacaaccacccct 4980 ccaccaacca ccactcccag ccctccaaca accaccactc ccagccctccaataaccacc 5040 acaaccaccc ctccaccaac caccactccc agctctccaa taaccaccactcccagccct 5100 ccaacaacca ccatgaccac cccttcacca accaccaccc ccagctctccaataaccacc 5160 acaaccaccc cttcctcaac taccactccc agccctccac caaccaccatgaccacccct 5220 tcaccaacca ccactcccag ccctccaaca accaccatga ccacccttccaccaaccacc 5280 acttccagcc ctctaacaac tactcctcta cctccatcaa taactcctcctacattttca 5340 ccattctcaa cgacaacccc tactacccca tgcgtgcctc tctgcaattggactggctgg 5400 ctggattctg gaaaacccaa ctttcacaaa ccaggtggag acacagaattgattggagac 5460 gtctgtggac caggctgggc agctaacatc tcttgcagag ccaccatgtatcctgatgtt 5520 cccattggac agcttggaca aacagtggtg tgtgatgtct ctgtggggctgatatgcaaa 5580 aatgaagacc aaaagccagg tggggtcatc cctatggcct tctgcctcaactacgagatc 5640 aacgttcagt gctgtgagtg tgtcacccaa cccaccacca tgacaaccaccaccacagag 5700 aacccaactc cgccaaccac gacacccatc accaccacca ctacggtgaccccaacccca 5760 acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccactacggtgacc 5820 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcaccaccaccact 5880 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgacacccatcacc 5940 accaccacta cggtgacccc aaccccaaca cccaccggca cacagaccccaaccacgaca 6000 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcacacagacccca 6060 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacccaccggcaca 6120 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaaccccaacaccc 6180 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggtgaccccaacc 6240 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccaccactacggtg 6300 accccaaccc caacacccac cggcacacag accccaacca cgacacccatcaccaccacc 6360 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccacgacacccatc 6420 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagaccccaaccacg 6480 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccggcacacagacc 6540 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaacacccaccggc 6600 acacagaccc caaccacgac acccatcacc accaccacta cggtgaccccaaccccaaca 6660 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactacggtgacccca 6720 accccaacac ccaccggcac acagacccca accacgacac ccatcaccaccaccactacg 6780 gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacccatcaccacc 6840 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaaccacgacaccc 6900 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacacagaccccaacc 6960 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccaccggcacacag 7020 accccaacca cgacacccat caccaccacc actacggtga ccccaaccccaacacccacc 7080 ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgaccccaacccca 7140 acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccactacggtgacc 7200 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcaccaccaccact 7260 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgacacccatcacc 7320 accaccacta cggtgacccc aaccccaaca cccaccggca cacagaccccaaccacgaca 7380 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcacacagacccca 7440 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacccaccggcaca 7500 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaaccccaacaccc 7560 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggtgaccccaacc 7620 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccaccactacggtg 7680 accccaaccc caacacccac cggcacacag accccaacca cgacacccatcaccaccacc 7740 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccacgacacccatc 7800 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagaccccaaccacg 7860 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccggcacacagacc 7920 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaacacccaccggc 7980 acacagaccc caaccacgac acccatcacc accaccacta cggtgaccccaaccccaaca 8040 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactacggtgacccca 8100 accccaacac ccaccggcac acagacccca accacgacac ccatcaccaccaccactacg 8160 gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacccatcaccacc 8220 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaaccacgacaccc 8280 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacacagaccccaacc 8340 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccaccggcacacag 8400 accccaacca cgacacccat caccaccacc actacggtga ccccaaccccaacacccacc 8460 ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgaccccaacccca 8520 acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccactacggtgacc 8580 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcaccaccaccact 8640 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgacacccatcacc 8700 accaccacta cggtgacccc aaccccaaca cccaccggca cacagaccccaaccacgaca 8760 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcacacagacccca 8820 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacccaccggcaca 8880 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaaccccaacaccc 8940 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggtgaccccaacc 9000 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccaccactacggtg 9060 accccaaccc caacacccac cggcacacag accccaacca cgacacccatcaccaccacc 9120 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccacgacacccatc 9180 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagaccccaaccacg 9240 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccggcacacagacc 9300 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaacacccaccggc 9360 acacagaccc caaccacgac acccatcacc accaccacta cggtgaccccaaccccaaca 9420 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactacggtgacccca 9480 accccaacac ccaccggcac acagacccca accacgacac ccatcaccaccaccactacg 9540 gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacccatcaccacc 9600 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaaccacgacaccc 9660 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacacagaccccaacc 9720 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccaccggcacacag 9780 accccaacca cgacacccat caccaccacc actacggtga ccccaaccccaacacccacc 9840 ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgaccccaacccca 9900 acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccactacggtgacc 9960 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcaccaccaccact 10020 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgacacccatcacc 10080 accaccacta cggtgacccc aaccccaaca cccaccggca cacagaccccaaccacgaca 10140 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcacacagacccca 10200 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacccaccggcaca 10260 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaaccccaacaccc 10320 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggtgaccccaacc 10380 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccaccactacggtg 10440 accccaaccc caacacccac cggcacacag accccaacca cgacacccatcaccaccacc 10500 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccacgacacccatc 10560 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagaccccaaccacg 10620 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccggcacacagacc 10680 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaacacccaccggc 10740 acacagaccc caaccacgac acccatcacc accaccacta cggtgaccccaaccccaaca 10800 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactacggtgacccca 10860 accccaacac ccaccggcac acagacccca accacgacac ccatcaccaccaccactacg 10920 gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacccatcaccacc 10980 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaaccacgacaccc 11040 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacacagaccccaacc 11100 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccaccggcacacag 11160 accccaacca cgacacccat caccaccacc actacggtga ccccaaccccaacacccacc 11220 ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgaccccaacccca 11280 acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccactacggtgacc 11340 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcaccaccaccact 11400 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgacacccatcacc 11460 accaccacta cggtgacccc aaccccaaca cccaccggca cacagaccccaaccacgaca 11520 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcacacagacccca 11580 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacccaccggcaca 11640 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaaccccaacaccc 11700 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggtgaccccaacc 11760 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccaccactacggtg 11820 accccaaccc caacacccac cggcacacag accccaacca cgacacccatcaccaccacc 11880 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccacgacacccatc 11940 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagaccccaaccacg 12000 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccggcacacagacc 12060 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaacacccaccggc 12120 acacagaccc caaccacgac acccatcacc accaccacta cggtgaccccaaccccaaca 12180 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactacggtgacccca 12240 accccaacac ccaccggcac acagacccca accacgacac ccatcaccaccaccactacg 12300 gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacccatcaccacc 12360 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaaccacgacaccc 12420 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacacagaccccaacc 12480 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccaccggcacacag 12540 accccaacca cgacacccat caccaccacc actacggtga ccccaaccccaacacccacc 12600 ggcacacaga ccgggccccc cacccacaca agcacagcac cgattgctgagttgaccaca 12660 tccaatcctc cgcctgagtc ctcaacccct cagacctctc ggtccacctcttcccctctc 12720 acggagtcaa ccacccttct gagtacccta ccacctgcca ttgagatgaccagcacggcc 12780 ccaccctcca cacccacggc acccacgacc acgagcggag gccacacactgtctccaccg 12840 cccagcacca ccacgtcccc tccaggcacc cccactcgcg gtaccacgaccgggtcatct 12900 tcagccccca cccccagcac tgtgcagacg accaccacca gtgcctggaccccaacgccg 12960 accccactct ccacacccag catcatcagg accacaggcc tgaggccctacccttcctct 13020 gtgcttatct gctgtgtcct gaacgacacc tactacgcac caggtgaggaggtgtacaac 13080 ggcacatacg gagacacctg ttatttcgtc aactgctcac tgagctgtacgttggagttc 13140 tataactggt cctgcccatc cacgccctcc ccaacaccca cgccctccaagtcgacgccc 13200 acgccttcca agccatcgtc cacgccctcc aagccgacgc ccggcaccaagccccccgag 13260 tgcccagact ttgatcctcc cagacaggag aacgagactt ggtggctgtgcgactgcttc 13320 atggccacgt gcaagtacaa caacacggtg gagatcgtga aggtggagtgtgagccgccg 13380 cccatgccca cctgctccaa cggcctccaa cccgtgcgcg tcgaggaccccgacggctgc 13440 tgctggcact gggagtgcga ctgctactgc acgggctggg gcgacccgcactatgtcacc 13500 ttcgacggac tctactacag ctaccagggc aactgcacct acgtgctggtggaggagatc 13560 agcccctccg tggacaactt cggagtttac atcgacaact accactgcgatcccaacgac 13620 aaggtgtcct gtccccgcac cctcatcgtg cgccacgaga cccaggaggtgctgatcaag 13680 accgtgcata tgatgcccat gcaggtgcag gtgcaggtga acaggcaggcggtggcactg 13740 ccctacaaga agtacgggct ggaggtgtac cagtctggca tcaactacgtggtggacatc 13800 cccgagctgg gtgtcctcgt ctcctacaat ggcctgtcct tctccgtcaggctgccctac 13860 caccggtttg gcaacaacac caagggccag tgtggcacct gcaccaacaccacctccgac 13920 gactgcattc tgcccagcgg ggagatcgtc tccaactgtg aggctgcggctgaccagtgg 13980 ctggtgaacg acccctccaa gccacactgc ccccacagca gctccacgaccaagcgcccg 14040 gccgtcactg tgcccggggg cggtaaaacg accccacaca aggactgcaccccatctccc 14100 ctctgccagc tcatcaagga cagcctgttt gcccagtgcc acgcactggtgcccccgcag 14160 cactactacg atgcctgcgt gttcgacagc tgcttcatgc cgggctcgagcctggagtgc 14220 gccagtctgc aggcctacgc agccctctgt gcccagcaga acatctgcctcgactggcgg 14280 aaccacacgc atggggcctg cttggtggag tgcccatctc acagggagtaccaggcctgt 14340 ggccctgcag aagagcccac gtgcaaatcc agctcctccc agcagaacaacacagtcctg 14400 gtggaaggct gcttctgtcc tgagggcacc atgaactacg ctcctggctttgatgtctgc 14460 gtgaagacct gcggctgtgt gggacctgac aatgtgccca gagagtttggggagcacttc 14520 gagttcgact gcaagaactg tgtctgcctg gagggtggaa gtggcatcatctgccaaccc 14580 aagaggtgca gccagaagcc cgttacccac tgcgtggaag acggcacctacctcgccacg 14640 gaggtcaacc ctgccgacac ctgctgcaac attaccgtct gcaagtgcaacaccagcctg 14700 tgcaaagaga agccctccgt gtgcccgctg ggattcgaag tgaagagcaagatggtgcct 14760 ggaaggtgct gtcccttcta ctggtgtgag tccaaggggg tgtgtgttcacgggaatgct 14820 gagtaccagc ccggttctcc agtttattcc tccaagtgcc aggactgcgtgtgcacggac 14880 aaggtggaca acaacaccct gctcaacgtc atcgcctgca cccacgtgccctgcaacacc 14940 tcctgcagcc ctggcttcga actcatggag gcccccgggg agtgctgtaagaagtgtgaa 15000 cagacgcact gtatcatcaa acggcccgac aaccagcacg tcatcctgaagcccggggac 15060 ttcaagagcg acccgaagaa caactgcaca ttcttcagct gcgtgaagatccacaaccag 15120 ctcatctcgt ccgtctccaa catcacctgc cccaactttg atgccagcatttgcatcccg 15180 ggctccatca cattcatgcc caatggatgc tgcaagacct gcacccctcgcaatgagacc 15240 agggtgccct gctccaccgt ccccgtcacc acggaggttt cgtacgccggctgcaccaag 15300 accgtcctca tgaatcattg ctccgggtcc tgcgggacat ttgtcatgtactcggccaag 15360 gcccaggccc tggaccacag ctgctcctgc tgcaaagagg agaaaaccagccagcgtgag 15420 gtggtcctga gctgccccaa tggcggctcg ctgacacaca cctacacccacatcgagagc 15480 tgccagtgcc aggacaccgt ctgcgggctc cccaccggca cctcccgccgggcccggcgc 15540 tcccctaggc atctggggag cgggtgagcg gggtgggcac agcccccttcactgccctcg 15600 acagctttac ctcccccgga ccctctgagc ctcctaagct cggcttcctctcttcagata 15660 tttattgtct gagtctttgt tcagtccttg ctttccaata ataaactcagggggacatgc 15720 <210> SEQ ID NO 15 <211> LENGTH: 3697 <212> TYPE: DNA<213> ORGANISM: human <400> SEQUENCE: 15 agggagtgtt cccgggggagatactccagt cgtagcaaga gtctcgacca ctgaatggaa 60 gaaaaggact tttaaccaccattttgtgac ttacagaaag gaatttgaat aaagaaaact 120 atgatacttc aggcccatcttcactccctg tgtcttctta tgctttattt ggcaactgga 180 tatggccaag aggggaagtttagtggaccc ctgaaaccca tgacattttc tatttatgaa 240 ggccaagaac cgagtcaaattatattccag tttaaggcca atcctcctgc tgtgactttt 300 gaactaactg gggagacagacaacatattt gtgatagaac gggagggact tctgtattac 360 aacagagcct tggacagggaaacaagatct actcacaatc tccaggttgc agccctggac 420 gctaatggaa ttatagtggagggtccagtc cctatcacca tagaagtgaa ggacatcaac 480 gacaatcgac ccacgtttctccagtcaaag tacgaaggct cagtaaggca gaactctcgc 540 ccaggaaagc ccttcttgtatgtcaatgcc acagacctgg atgatccggc cactcccaat 600 ggccagcttt attaccagattgtcatccag cttcccatga tcaacaatgt catgtacttt 660 cagatcaaca acaaaacgggagccatctct cttacccgag agggatctca ggaattgaat 720 cctgctaaga atccttcctataatctggtg atctcagtga aggacatggg aggccagagt 780 gagaattcct tcagtgataccacatctgtg gatatcatag tgacagagaa tatttggaaa 840 gcaccaaaac ctgtggagatggtggaaaac tcaactgatc ctcaccccat caaaatcact 900 caggtgcggt ggaatgatcccggtgcacaa tattccttag ttgacaaaga gaagctgcca 960 agattcccat tttcaattgaccaggaagga gatatttacg tgactcagcc cttggaccga 1020 gaagaaaagg atgcatatgttttttatgca gttgcaaagg atgagtacgg aaaaccactt 1080 tcatatccgc tggaaattcatgtaaaagtt aaagatatta atgataatcc acctacatgt 1140 ccgtcaccag taaccgtatttgaggtccag gagaatgaac gactgggtaa cagtatcggg 1200 acccttactg cacatgacagggatgaagaa aatactgcca acagttttct aaactacagg 1260 attgtggagc aaactcccaaacttcccatg gatggactct tcctaatcca aacctatgct 1320 ggaatgttac agttagctaaacagtccttg aagaagcaag atactcctca gtacaactta 1380 acgatagagg tgtctgacaaagatttcaag accctttgtt ttgtgcaaat caacgttatt 1440 gatatcaatg atcagatccccatctttgaa aaatcagatt atggaaacct gactcttgct 1500 gaagacacaa acattgggtccaccatctta accatccagg ccactgatgc tgatgagcca 1560 tttactggga gttctaaaattctgtatcat atcataaagg gagacagtga gggacgcctg 1620 ggggttgaca cagatccccataccaacacc ggatatgtca taattaaaaa gcctcttgat 1680 tttgaaacag cagctgtttccaacattgtg ttcaaagcag aaaatcctga gcctctagtg 1740 tttggtgtga agtacaatgcaagttctttt gccaagttca cgcttattgt gacagatgtg 1800 aatgaagcac ctcaattttcccaacacgta ttccaagcga aagtcagtga ggatgtagct 1860 ataggcacta aagtgggcaatgtgactgcc aaggatccag aaggtctgga cataagctat 1920 tcactgaggg gagacacaagaggttggctt aaaattgacc acgtgactgg tgagatcttt 1980 agtgtggctc cattggacagagaagccgga agtccatatc gggtacaagt ggtggccaca 2040 gaagtagggg ggtcttccttgagctctgtg tcagagttcc acctgatcct tatggatgtg 2100 aatgacaacc ctcccaggctagccaaggac tacacgggct tgttcttctg ccatcccctc 2160 agtgcacctg gaagtctcattttcgaggct actgatgatg atcagcactt atttcggggt 2220 ccccatttta cattttccctcggcagtgga agcttacaaa acgactggga agtttccaaa 2280 atcaatggta ctcatgcccgactgtctacc aggcacacag agtttgagga gagggagtat 2340 gtcgtcttga tccgcatcaatgatgggggt cggccaccct tggaaggcat tgtttcttta 2400 ccagttacat tctgcagttgtgtggaagga agttgtttcc ggccagcagg tcaccagact 2460 gggataccca ctgtgggcatggcagttggt atactgctga ccacccttct ggtgattggt 2520 ataattttag cagttgtgtttatccgcata aagaaggata aaggcaaaga taatgttgaa 2580 agtgctcaag catctgaagtcaaacctctg agaagctgaa tttgaaaagg aatgtttgaa 2640 tttatatagc aagtgctatttcagcaacaa ccatctcatc ctattacttt tcatctaacg 2700 tgcattataa ttttttaaacagatattccc tcttgtcctt taatatttgc taaatatttc 2760 ttttttgagg tggagtcttgctctgtcgcc caggctggag tacagtggtg tgatcccagc 2820 tcactgcaac ctccgcctcctgggttcaca tgattctcct gcctcagctt cctaagtagc 2880 tgggtttaca ggcacccaccaccatgccca gctaattttt gtatttttaa tagagacggg 2940 gtttcgccat ttggccaggctggtcttgaa ctcctgacgt caagtgatct gcctgccttg 3000 gtctcccaat acaggcatgaaccactgcac ccacctactt agatatttca tgtgctatag 3060 acattagaga gatttttcatttttccatga catttttcct ctctgcaaat ggcttagcta 3120 cttgtgtttt tcccttttggggcaagacag actcattaaa tattctgtac attttttctt 3180 tatcaaggag atatatcagtgttgtctcat agaactgcct ggattccatt tatgtttttt 3240 ctgattccat cctgtgtccccttcatcctt gactcctttg gtatttcact gaatttcaaa 3300 catttgtcag agaagaaaaacgtgaggact caggaaaaat aaataaataa aagaacagcc 3360 ttttccctta gtattaacagaaatgtttct gtgtcattaa ccatctttaa tcaatgtgac 3420 atgttgctct ttggctgaaattcttcaact tggaaatgac acagacccac agaaggtgtt 3480 caaacacaac ctactctgcaaaccttggta aaggaaccag tcagctggcc agatttcctc 3540 actacctgcc atgcatacatgctgcgcatg ttttcttcat tcgtatgtta gtaaagtttt 3600 ggttattata tatttaacatgtggaagaaa acaagacatg aaaagagtgg tgacaaatca 3660 agaataaaca ctggttgtagtcagttttgt ttgttaa 3697 <210> SEQ ID NO 16 <211> LENGTH: 3697 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 16 agggagtgtt cccgggggagatactccagt cgtagcaaga gtctcgacca ctgaatggaa 60 gaaaaggact tttaaccaccattttgtgac ttacagaaag gaatttgaat aaagaaaact 120 atgatacttc aggcccatcttcactccctg tgtcttctta tgctttattt ggcaactgga 180 tatggccaag aggggaagtttagtggaccc ctgaaaccca tgacattttc tatttatgaa 240 ggccaagaac cgagtcaaattatattccag tttaaggcca atcctcctgc tgtgactttt 300 gaactaactg gggagacagacaacatattt gtgatagaac gggagggact tctgtattac 360 aacagagcct tggacagggaaacaagatct actcacaatc tccaggttgc agccctggac 420 gctaatggaa ttatagtggagggtccagtc cctatcacca tagaagtgaa ggacatcaac 480 gacaatcgac ccacgtttctccagtcaaag tacgaaggct cagtaaggca gaactctcgc 540 ccaggaaagc ccttcttgtatgtcaatgcc acagacctgg atgatccggc cactcccaat 600 ggccagcttt attaccagattgtcatccag cttcccatga tcaacaatgt catgtacttt 660 cagatcaaca acaaaacgggagccatctct cttacccgag agggatctca ggaattgaat 720 cctgctaaga atccttcctataatctggtg atctcagtga aggacatggg aggccagagt 780 gagaattcct tcagtgataccacatctgtg gatatcatag tgacagagaa tatttggaaa 840 gcaccaaaac ctgtggagatggtggaaaac tcaactgatc ctcaccccat caaaatcact 900 caggtgcggt ggaatgatcccggtgcacaa tattccttag ttgacaaaga gaagctgcca 960 agattcccat tttcaattgaccaggaagga gatatttacg tgactcagcc cttggaccga 1020 gaagaaaagg atgcatatgttttttatgca gttgcaaagg atgagtacgg aaaaccactt 1080 tcatatccgc tggaaattcatgtaaaagtt aaagatatta atgataatcc acctacatgt 1140 ccgtcaccag taaccgtatttgaggtccag gagaatgaac gactgggtaa cagtatcggg 1200 acccttactg cacatgacagggatgaagaa aatactgcca acagttttct aaactacagg 1260 attgtggagc aaactcccaaacttcccatg gatggactct tcctaatcca aacctatgct 1320 ggaatgttac agttagctaaacagtccttg aagaagcaag atactcctca gtacaactta 1380 acgatagagg tgtctgacaaagatttcaag accctttgtt ttgtgcaaat caacgttatt 1440 gatatcaatg atcagatccccatctttgaa aaatcagatt atggaaacct gactcttgct 1500 gaagacacaa acattgggtccaccatctta accatccagg ccactgatgc tgatgagcca 1560 tttactggga gttctaaaattctgtatcat atcataaagg gagacagtga gggacgcctg 1620 ggggttgaca cagatccccataccaacacc ggatatgtca taattaaaaa gcctcttgat 1680 tttgaaacag cagctgtttccaacattgtg ttcaaagcag aaaatcctga gcctctagtg 1740 tttggtgtga agtacaatgcaagttctttt gccaagttca cgcttattgt gacagatgtg 1800 aatgaagcac ctcaattttcccaacacgta ttccaagcga aagtcagtga ggatgtagct 1860 ataggcacta aagtgggcaatgtgactgcc aaggatccag aaggtctgga cataagctat 1920 tcactgaggg gagacacaagaggttggctt aaaattgacc acgtgactgg tgagatcttt 1980 agtgtggctc cattggacagagaagccgga agtccatatc gggtacaagt ggtggccaca 2040 gaagtagggg ggtcttccttgagctctgtg tcagagttcc acctgatcct tatggatgtg 2100 aatgacaacc ctcccaggctagccaaggac tacacgggct tgttcttctg ccatcccctc 2160 agtgcacctg gaagtctcattttcgaggct actgatgatg atcagcactt atttcggggt 2220 ccccatttta cattttccctcggcagtgga agcttacaaa acgactggga agtttccaaa 2280 atcaatggta ctcatgcccgactgtctacc aggcacacag agtttgagga gagggagtat 2340 gtcgtcttga tccgcatcaatgatgggggt cggccaccct tggaaggcat tgtttcttta 2400 ccagttacat tctgcagttgtgtggaagga agttgtttcc ggccagcagg tcaccagact 2460 gggataccca ctgtgggcatggcagttggt atactgctga ccacccttct ggtgattggt 2520 ataattttag cagttgtgtttatccgcata aagaaggata aaggcaaaga taatgttgaa 2580 agtgctcaag catctgaagtcaaacctctg agaagctgaa tttgaaaagg aatgtttgaa 2640 tttatatagc aagtgctatttcagcaacaa ccatctcatc ctattacttt tcatctaacg 2700 tgcattataa ttttttaaacagatattccc tcttgtcctt taatatttgc taaatatttc 2760 ttttttgagg tggagtcttgctctgtcgcc caggctggag tacagtggtg tgatcccagc 2820 tcactgcaac ctccgcctcctgggttcaca tgattctcct gcctcagctt cctaagtagc 2880 tgggtttaca ggcacccaccaccatgccca gctaattttt gtatttttaa tagagacggg 2940 gtttcgccat ttggccaggctggtcttgaa ctcctgacgt caagtgatct gcctgccttg 3000 gtctcccaat acaggcatgaaccactgcac ccacctactt agatatttca tgtgctatag 3060 acattagaga gatttttcatttttccatga catttttcct ctctgcaaat ggcttagcta 3120 cttgtgtttt tcccttttggggcaagacag actcattaaa tattctgtac attttttctt 3180 tatcaaggag atatatcagtgttgtctcat agaactgcct ggattccatt tatgtttttt 3240 ctgattccat cctgtgtccccttcatcctt gactcctttg gtatttcact gaatttcaaa 3300 catttgtcag agaagaaaaacgtgaggact caggaaaaat aaataaataa aagaacagcc 3360 ttttccctta gtattaacagaaatgtttct gtgtcattaa ccatctttaa tcaatgtgac 3420 atgttgctct ttggctgaaattcttcaact tggaaatgac acagacccac agaaggtgtt 3480 caaacacaac ctactctgcaaaccttggta aaggaaccag tcagctggcc agatttcctc 3540 actacctgcc atgcatacatgctgcgcatg ttttcttcat tcgtatgtta gtaaagtttt 3600 ggttattata tatttaacatgtggaagaaa acaagacatg aaaagagtgg tgacaaatca 3660 agaataaaca ctggttgtagtcagttttgt ttgttaa 3697 <210> SEQ ID NO 17 <211> LENGTH: 1597 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 17 aacaaactgc acccactgaactccgcagct agcatccaaa tcagcccttg agatttgagg 60 ccttggagac tcaggagttttgagagcaaa atgacaacac ccagaaattc agtaaatggg 120 actttcctgg cagagccaatgaaaggccct attgctatgc aatctggtcc aaaaccactc 180 ttcaggagga tgtcttcactggtgggcccc acgcaaagct tcttcatgag ggaatctaag 240 actttggggg ctgtccagattatgaatggg ctcttccaca ttgccctggg gggtcttctg 300 atgatcccag cagggatctatgcacccatc tgtgtgactg tgtggtaccc tctctgggga 360 ggcattatgt atattatttccggatcactc ctggcagcaa cggagaaaaa ctccaggaag 420 tgtttggtca aaggaaaaatgataatgaat tcattgagcc tctttgctgc catttctgga 480 atgattcttt caatcatggacatacttaat attaaaattt cccatttttt aaaaatggag 540 agtctgaatt ttattagagctcacacacca tatattaaca tatacaactg tgaaccagct 600 aatccctctg agaaaaactccccatctacc caatactgtt acagcataca atctctgttc 660 ttgggcattt tgtcagtgatgctgatcttt gccttcttcc aggaacttgt aatagctggc 720 atcgttgaga atgaatggaaaagaacgtgc tccagaccca aatctaacat agttctcctg 780 tcagcagaag aaaaaaaagaacagactatt gaaataaaag aagaagtggt tgggctaact 840 gaaacatctt cccaaccaaagaatgaagaa gacattgaaa ttattccaat ccaagaagag 900 gaagaagaag aaacagagacgaactttcca gaacctcccc aagatcagga atcctcacca 960 atagaaaatg acagctctccttaagtgatt tcttctgttt tctgtttcct tttttaaaca 1020 ttagtgttca tagcttccaagagacatgct gactttcatt tcttgaggta ctctgcacat 1080 acgcaccaca tctctatctggcctttgcat ggagtgacca tagctccttc tctcttacat 1140 tgaatgtaga gaatgtagccattgtagcag cttgtgttgt cacgcttctt cttttgagca 1200 actttcttac actgaagaaaggcagaatga gtgcttcaga atgtgatttc ctactaacct 1260 gttccttgga taggctttttagtatagtat ttttttttgt cattttctcc atcagcaacc 1320 agggagactg cacctgatggaaaagatata tgactgcttc atgacattcc taaactatct 1380 tttttttatt ccacatctacgtttttggtg gagtcccttt tgcatcattg ttttaaggat 1440 gataaaaaaa aaataacaactagggacaat acagaaccca ttccatttat ctttctacag 1500 ggctgacatt gtggcacattcttagagtta ccacacccca tgagggaagc tctaaatagc 1560 caacacccat ctgttttttgtaaaaacagc atagctt 1597 <210> SEQ ID NO 18 <211> LENGTH: 2907 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 18 gccatctggg cccaggccccatgccccgag gaggggtggt ctgaagccca ccagagcccc 60 ctgccagact gtctgcctcccttctgactg tggccgcttg gcatggccag caacagcagc 120 tcctgcccga cacctgggggcgggcacctc aatgggtacc cggtgcctcc ctacgccttc 180 ttcttccccc ctatgctgggtggactctcc ccgccaggcg ctctgaccac tctccagcac 240 cagcttccag ttagtggatatagcacacca tccccagcca ccattgagac ccagagcagc 300 agttctgaag agatagtgcccagccctccc tcgccacccc ctctaccccg catctacaag 360 ccttgctttg tctgtcaggacaagtcctca ggctaccact atggggtcag cgcctgtgag 420 ggctgcaagg gcttcttccgccgcagcatc cagaagaaca tggtgtacac gtgtcaccgg 480 gacaagaact gcatcatcaacaaggtgacc cggaaccgct gccagtactg ccgactgcag 540 aagtgctttg aagtgggcatgtccaaggag tctgtgagaa acgaccgaaa caagaagaag 600 aaggaggtgc ccaagcccgagtgctctgag agctacacgc tgacgccgga ggtgggggag 660 ctcattgaga aggtgcgcaaagcgcaccag gaaaccttcc ctgccctctg ccagctgggc 720 aaatacacta cgaacaacagctcagaacaa cgtgtctctc tggacattga cctctgggac 780 aagttcagtg aactctccaccaagtgcatc attaagactg tggagttcgc caagcagctg 840 cccggcttca ccaccctcaccatcgccgac cagatcaccc tcctcaaggc tgcctgcctg 900 gacatcctga tcctgcggatctgcacgcgg tacacgcccg agcaggacac catgaccttc 960 tcggacgggc tgaccctgaaccggacccag atgcacaacg ctggcttcgg ccccctcacc 1020 gacctggtct ttgccttcgccaaccagctg ctgcccctgg agatggatga tgcggagacg 1080 gggctgctca gcgccatctgcctcatctgc ggagaccgcc aggacctgga gcagccggac 1140 cgggtggaca tgctgcaggagccgctgctg gaggcgctaa aggtctacgt gcggaagcgg 1200 aggcccagcc gcccccacatgttccccaag atgctaatga agattactga cctgcgaagc 1260 atcagcgcca agggggctgagcgggtgatc acgctgaaga tggagatccc gggctccatg 1320 ccgcctctca tccaggaaatgttggagaac tcagagggcc tggacactct gagcggacag 1380 ccggggggtg gggggcgggacgggggtggc ctggcccccc cgccaggcag ctgtagcccc 1440 agcctcagcc ccagctccaacagaagcagc ccggccaccc actccccgtg accgcccacg 1500 ccacatggac acagccctcgccctccgccc cggcttttct ctgcctttct accgaccatg 1560 tgaccccgca ccagccctgcccccacctgc cctcccgggc agtactgggg accttccctg 1620 ggggacgggg agggaggaggcagcgactcc ttggacagag gcctgggccc tcagtggact 1680 gcctgctccc acagcctgggctgacgtcag aggccgaggc caggaactga gtgaggcccc 1740 tggtcctggg tctcaggatgggtcctgggg gcctcgtgtt catcaagaca cccctctgcc 1800 cagctcacca catcttcatcaccagcaaac gccaggactt ggctccccca tcctcagaac 1860 tcacaagcca ttgctccccagctggggaac ctcaacctcc cccctgcctc ggttggtgac 1920 agagggggtg ggacaggggcggggggttcc ccctgtacat accctgccat accaacccca 1980 ggtattaatt ctcgctggttttgtttttat tttaattttt ttgttttgat ttttttaata 2040 agaattttca ttttaagcacatttatactg aaggaatttg tgctgtgtat tggggggagc 2100 tggatccaga gctggagggggtgggtccgg gggagggagt ggctcggaag gggcccccac 2160 tctcctttca tgtccctgtgccccccagtt ctcctcctca gccttttcct cctcagtttt 2220 ctctttaaaa ctgtgaagtactaactttcc aaggcctgcc ttcccctccc tcccactgga 2280 gaagccgcca gcccctttctccctctgcct gaccactggg tgtggacggt gtggggcagc 2340 cctgaaagga caggctcctggccttggcac ttgcctgcac ccaccatgag gcatggagca 2400 gggcagagca agggccccgggacagagttt tcccagacct ggctcctcgg cagagctgcc 2460 tcccgtcagg gcccacatcatctaggctcc ccagccccca ctgtgaaggg gctggccagg 2520 ggcccgagct gcccccacccccggcctcag ccaccagcac ccccataggg cccccagaca 2580 ccacacacat gcgcgtgcgcacacacacaa acacacacac actggacagt agatgggccg 2640 acacacactt ggcccgagttcctccatttc cctggcctgc cccccacccc caacctgtcc 2700 cacccccgtg ccccctccttaccccgcagg acgggcctac aggggggtct cccctcaccc 2760 ctgcaccccc agctgggggagctggctctg ccccgacctc cttcaccagg ggttggggcc 2820 ccttcccctg gagcccgtgggtgcacctgt tactgttggg ctttccactg agatctactg 2880 gataaagaat aaagttctatttattct 2907 <210> SEQ ID NO 19 <211> LENGTH: 2907 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 19 gccatctggg cccaggcccc atgccccgaggaggggtggt ctgaagccca ccagagcccc 60 ctgccagact gtctgcctcc cttctgactgtggccgcttg gcatggccag caacagcagc 120 tcctgcccga cacctggggg cgggcacctcaatgggtacc cggtgcctcc ctacgccttc 180 ttcttccccc ctatgctggg tggactctccccgccaggcg ctctgaccac tctccagcac 240 cagcttccag ttagtggata tagcacaccatccccagcca ccattgagac ccagagcagc 300 agttctgaag agatagtgcc cagccctccctcgccacccc ctctaccccg catctacaag 360 ccttgctttg tctgtcagga caagtcctcaggctaccact atggggtcag cgcctgtgag 420 ggctgcaagg gcttcttccg ccgcagcatccagaagaaca tggtgtacac gtgtcaccgg 480 gacaagaact gcatcatcaa caaggtgacccggaaccgct gccagtactg ccgactgcag 540 aagtgctttg aagtgggcat gtccaaggagtctgtgagaa acgaccgaaa caagaagaag 600 aaggaggtgc ccaagcccga gtgctctgagagctacacgc tgacgccgga ggtgggggag 660 ctcattgaga aggtgcgcaa agcgcaccaggaaaccttcc ctgccctctg ccagctgggc 720 aaatacacta cgaacaacag ctcagaacaacgtgtctctc tggacattga cctctgggac 780 aagttcagtg aactctccac caagtgcatcattaagactg tggagttcgc caagcagctg 840 cccggcttca ccaccctcac catcgccgaccagatcaccc tcctcaaggc tgcctgcctg 900 gacatcctga tcctgcggat ctgcacgcggtacacgcccg agcaggacac catgaccttc 960 tcggacgggc tgaccctgaa ccggacccagatgcacaacg ctggcttcgg ccccctcacc 1020 gacctggtct ttgccttcgc caaccagctgctgcccctgg agatggatga tgcggagacg 1080 gggctgctca gcgccatctg cctcatctgcggagaccgcc aggacctgga gcagccggac 1140 cgggtggaca tgctgcagga gccgctgctggaggcgctaa aggtctacgt gcggaagcgg 1200 aggcccagcc gcccccacat gttccccaagatgctaatga agattactga cctgcgaagc 1260 atcagcgcca agggggctga gcgggtgatcacgctgaaga tggagatccc gggctccatg 1320 ccgcctctca tccaggaaat gttggagaactcagagggcc tggacactct gagcggacag 1380 ccggggggtg gggggcggga cgggggtggcctggcccccc cgccaggcag ctgtagcccc 1440 agcctcagcc ccagctccaa cagaagcagcccggccaccc actccccgtg accgcccacg 1500 ccacatggac acagccctcg ccctccgccccggcttttct ctgcctttct accgaccatg 1560 tgaccccgca ccagccctgc ccccacctgccctcccgggc agtactgggg accttccctg 1620 ggggacgggg agggaggagg cagcgactccttggacagag gcctgggccc tcagtggact 1680 gcctgctccc acagcctggg ctgacgtcagaggccgaggc caggaactga gtgaggcccc 1740 tggtcctggg tctcaggatg ggtcctgggggcctcgtgtt catcaagaca cccctctgcc 1800 cagctcacca catcttcatc accagcaaacgccaggactt ggctccccca tcctcagaac 1860 tcacaagcca ttgctcccca gctggggaacctcaacctcc cccctgcctc ggttggtgac 1920 agagggggtg ggacaggggc ggggggttccccctgtacat accctgccat accaacccca 1980 ggtattaatt ctcgctggtt ttgtttttattttaattttt ttgttttgat ttttttaata 2040 agaattttca ttttaagcac atttatactgaaggaatttg tgctgtgtat tggggggagc 2100 tggatccaga gctggagggg gtgggtccgggggagggagt ggctcggaag gggcccccac 2160 tctcctttca tgtccctgtg ccccccagttctcctcctca gccttttcct cctcagtttt 2220 ctctttaaaa ctgtgaagta ctaactttccaaggcctgcc ttcccctccc tcccactgga 2280 gaagccgcca gcccctttct ccctctgcctgaccactggg tgtggacggt gtggggcagc 2340 cctgaaagga caggctcctg gccttggcacttgcctgcac ccaccatgag gcatggagca 2400 gggcagagca agggccccgg gacagagttttcccagacct ggctcctcgg cagagctgcc 2460 tcccgtcagg gcccacatca tctaggctccccagccccca ctgtgaaggg gctggccagg 2520 ggcccgagct gcccccaccc ccggcctcagccaccagcac ccccataggg cccccagaca 2580 ccacacacat gcgcgtgcgc acacacacaaacacacacac actggacagt agatgggccg 2640 acacacactt ggcccgagtt cctccatttccctggcctgc cccccacccc caacctgtcc 2700 cacccccgtg ccccctcctt accccgcaggacgggcctac aggggggtct cccctcaccc 2760 ctgcaccccc agctggggga gctggctctgccccgacctc cttcaccagg ggttggggcc 2820 ccttcccctg gagcccgtgg gtgcacctgttactgttggg ctttccactg agatctactg 2880 gataaagaat aaagttctat ttattct 2907<210> SEQ ID NO 20 <211> LENGTH: 1347 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 20 atggatccca aatatttcat cttaattttg ttttgtggacacctgaacaa tacatttttt 60 tcaaagacag agacaattac aacagagaag cagtcacagcctaccttata cacatcatca 120 atgtcacagg tattggctaa ttctcaaaac acaacagggaatcctttggg tcaaccaaca 180 caattcagcg acactttttc tggacaatca atatcacctgccaaagtcac tgctggacaa 240 ccaacaccag ctgtctatac ctcttctgaa aaaccagaagcacatacttc tgctggacaa 300 ccacttgcct acaacaccaa acaaccaaca ccaatagccaacacctcctc ccagcaagcc 360 gtgttcacct ctgccagaca actaccatct gcccgtacttctaccacaca accaccaaag 420 tcatttgtct atacttttac tcaacaatca tcatctgtccagatcccttc tagaaaacaa 480 ataactgttc ataatccatc cacacaacca acatcaactgtcaaaaattc acctaggagt 540 acaccaggat ttatcttaga tactaccagt aacaaacaaaccccacaaaa aaacaattat 600 aattcaatag ctgccatact aattggtgta cttctgacttctatgttggt agctataatc 660 atcattgtac tttggaaatg cttaaggaaa ccagttttaaatgatcaaaa ttgggcaggt 720 agatctccat ttgctgatgg agaaacccct gacatttgtatggataacat cagagaaaat 780 gaaatatcca caaaacgtac atcaatcatt tcacttacaccctggaaacc aagcaaaagc 840 acacttttag cagatgactt agaaattaag ttgtttgaatcaagtgaaaa cattgaagac 900 tccaacaacc ccaaaacaga gaaaataaaa gatcaagtaaatggtacatc agaagatagt 960 gctgatggtt caacagttgg aactgctgtt tcttcttcagatgatgcaga tctgcctcca 1020 ccacctcccc ttctggattt ggaaggacag gaaagtaaccaatctgacaa acccacaatg 1080 acaattgtat ctcctcttcc aaatgattct actagtctccctccatctct ggactgtctc 1140 aatcaagact gtggagatca taaatctgag ataatacaatcatttccacc gcttgactca 1200 cttaacttgc ccctgccacc agtagatttt atgaaaaaccaagaagattc caaccttgag 1260 atccagtgtc aggagttctc tattcctccc aactctgatcaagatcttaa tgaatccctg 1320 ccacctccac ctgcagaact gttataa 1347 <210> SEQID NO 21 <211> LENGTH: 2170 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 21 ctgagggctc atccctctgc agagcgcggg gtcaccggga ggagacgccatgacgcccgc 60 cctcacagcc ctgctctgcc ttgggctgag tctgggcccc aggacccgcgtgcaggcagg 120 gcccttcccc aaacccaccc tctgggctga gccaggctct gtgatcagctgggggagccc 180 cgtgaccatc tggtgtcagg ggagcctgga ggcccaggag taccgactggataaagaggg 240 aagcccagag cccttggaca gaaataaccc actggaaccc aagaacaaggccagattctc 300 catcccatcc atgacagagc accatgcggg gagataccgc tgccactattacagctctgc 360 aggctggtca gagcccagcg accccctgga gctggtgatg acaggattctacaacaaacc 420 caccctctca gccctgccca gccctgtggt ggcctcaggg gggaatatgaccctccgatg 480 tggctcacag aagggatatc accattttgt tctgatgaag gaaggagaacaccagctccc 540 ccggaccctg gactcacagc agctccacag tggggggttc caggccctgttccctgtggg 600 ccccgtgaac cccagccaca ggtggaggtt cacatgctat tactattatatgaacacccc 660 ccaggtgtgg tcccacccca gtgaccccct ggagattctg ccctcaggcgtgtctaggaa 720 gccctccctc ctgaccctgc agggccctgt cctggcccct gggcagagcctgaccctcca 780 gtgtggctct gatgtcggct acgacagatt tgttctgtat aaggagggggaacgtgactt 840 cctccagcgc cctggccagc agccccaggc tgggctctcc caggccaacttcaccctggg 900 ccctgtgagc ccctcccacg ggggccagta caggtgctat ggtgcacacaacctctcctc 960 cgagtggtcg gcccccagcg accccctgaa catcctgatg gcaggacagatctatgacac 1020 cgtctccctg tcagcacagc cgggccccac agtggcctca ggagagaacgtgaccctgct 1080 gtgtcagtca tggtggcagt ttgacacttt ccttctgacc aaagaaggggcagcccatcc 1140 cccactgcgt ctgagatcaa tgtacggagc tcataagtac caggctgaattccccatgag 1200 tcctgtgacc tcagcccacg cggggaccta caggtgctac ggctcatacagctccaaccc 1260 ccacctgctg tctttcccca gtgagcccct ggaactcatg gtctcaggacactctggagg 1320 ctccagcctc ccacccacag ggccgccctc cacacctggt ctgggaagatacctggaggt 1380 tttgattggg gtctcggtgg ccttcgtcct gctgctcttc ctcctcctcttcctcctcct 1440 ccgacgtcag cgtcacagca aacacaggac atctgaccag agaaagactgatttccagcg 1500 tcctgcaggg gctgcggaga cagagcccaa ggacaggggc ctgctgaggaggtccagccc 1560 agctgctgac gtccaggaag aaaacctcta tgctgccgtg aaggacacacagtctgagga 1620 cagggtggag ctggacagtc agagcccaca cgatgaagac ccccaggcagtgacgtatgc 1680 cccggtgaaa cactccagtc ctaggagaga aatggcctct cctccctcctcactgtctgg 1740 ggaattcctg gacacaaagg acagacaggt ggaagaggac aggcagatggacactgaggc 1800 tgctgcatct gaagcctccc aggatgtgac ctacgcccag ctgcacagcttgacccttag 1860 acggaaggca actgagcctc ctccatccca ggaaggggaa cctccagctgagcccagcat 1920 ctacgccact ctggccatcc actagcccgg ggggtacgca gaccccacactcagcagaag 1980 gagactcagg actgctgaag gcacgggagc tgcccccagt ggacaccagtgaaccccagt 2040 cagcctggac ccctaacaca gaccatgagg agacgctggg aacttgtgggactcacctga 2100 ctcaaagatg actaatatcg tcccattttg gaaataaagc aacagacttctcaacaatca 2160 atgagttaat 2170 <210> SEQ ID NO 22 <211> LENGTH: 1453<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 22 gggagtgcatccgccccaac ccttttcccc ctcgtctcct gtgagaattc cccgtcggat 60 acgagcagcgtggccgttgg ctgcctcgca caggacttcc ttcccgactc catcactttc 120 tcctggaaatacaagaacaa ctctgacatc agcagcaccc ggggcttccc atcagtcctg 180 agagggggcaagtacgcagc cacctcacag gtgctgctgc cttccaagga cgtcatgcag 240 ggcacagacgaacacgtggt gtgcaaagtc cagcacccca acggcaacaa agaaaagaac 300 gtgcctcttccagtgattgc cgagctgcct cccaaagtga gcgtcttcgt cccaccccgc 360 gacggcttcttcggcaaccc ccgcaagtcc aagctcatct gccaggccac gggtttcagt 420 ccccggcagattcaggtgtc ctggctgcgc gaggggaagc aggtggggtc tggcgtcacc 480 acggaccaggtgcaggctga ggccaaagag tctgggccca cgacctacaa ggtgaccagc 540 acactgaccatcaaagagag cgactggctc agccagagca tgttcacctg ccgcgtggat 600 cacaggggcctgaccttcca gcagaatgcg tcctccatgt gtgtccccga tcaagacaca 660 gccatccgggtcttcgccat ccccccatcc tttgccagca tcttcctcac caagtccacc 720 aagttgacctgcctggtcac agacctgacc acctatgaca gcgtgaccat ctcctggacc 780 cgccagaatggcgaagctgt gaaaacccac accaacatct ccgagagcca ccccaatgcc 840 actttcagcgccgtgggtga ggccagcatc tgcgaggatg actggaattc cggggagagg 900 ttcacgtgcaccgtgaccca cacagacctg ccctcgccac tgaagcagac catctcccgg 960 cccaagggggtggccctgca caggcccgat gtctacttgc tgccaccagc ccgggagcag 1020 ctgaacctgcgggagtcggc caccatcacg tgcctggtga cgggcttctc tcccgcggac 1080 gtcttcgtgcagtggatgca gagggggcag cccttgtccc cggagaagta tgtgaccagc 1140 gccccaatgcctgagcccca ggccccaggc cggtacttcg cccacagcat cctgaccgtg 1200 tccgaagaggaatggaacac gggggagacc tacacctgcg tggtggccca tgaggccctg 1260 cccaacagggtcaccgagag gaccgtggac aagtccaccg gtaaacccac cctgtacaac 1320 gtgtccctggtcatgtccga cacagctggc acctgctact gaccctgctg gcctgcccac 1380 aggctcggggcggctggccg ctctgtgtgt gcatgcaaac taacccgtgt caacggggtg 1440 agatgttgcatct 1453 <210> SEQ ID NO 23 <211> LENGTH: 1192 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 23 cagatccatc aggtccaagc tgtgttgactaccactgctt ttcccttcgt ctcaattatg 60 tcttggaaga aggctttgcg gatccctggaggccttcggg tagcaactgt gaccttgatg 120 ctggcgatgc tgagcacccc ggtggctgagggcagagact ctcccgagga tttcgtgtac 180 cagtttaagg gcatgtgcta cttcaccaacgggacggagc gcgtgcgtct tgtgaccaga 240 tacatctata accgagagga gtacgcacgcttcgacagcg acgtgggggt gtatcgggcg 300 gtgacgccgc tggggccgcc tgacgccgagtactggaaca gccagaagga agtcctggag 360 aggacccggg cggagttgga cacggtgtgcagacacaact accagttgga gctccgcacg 420 accttgcagc ggcgagtgga gcccacagtgaccatctccc catccaggac agaggccctc 480 aaccaccaca acctgctggt ctgctcagtgacagatttct atccagccca gatcaaagtc 540 cggtggtttc ggaatgacca ggaggagacaactggcgttg tgtccacccc ccttattagg 600 aacggtgact ggaccttcca gatcctggtgatgctggaaa tgactcccca gcgtggagac 660 gtctacacct gccacgtgga gcaccccagcctccagaacc ccatcatcgt ggagtggcgg 720 gctcagtctg aatctgccca gagcaagatgctgagtggca ttggaggctt cgtgctgggg 780 ctgatcttcc tcgggctggg ccttattatccatcacagga gtcagaaagg gctcctgcac 840 tgactcctga gactatttta actgggattggttatcactt ttctgtaacg cctgcttgtc 900 cctgcccaga attcccagct gcctgtgtcagcctgtcccc cgagatcaga gtcctaccgt 960 ggctgtcacg cagccaccag gtcatctcctttcatcccca cctcaaggct gatggctgtg 1020 accctgcttc ctgcactgac ccagagcctctgcctgtgca cggccagctg cgtctactga 1080 ggccccaagg ggtttctgtt tctattctctcctcagactg ctcaagagaa gcacatgaaa 1140 accattacct gactttagag cttttttacataattaaaca tgatcctgag tt 1192 <210> SEQ ID NO 24 <211> LENGTH: 2048<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 24 atgtgaaggcacaagctgct gttatataca acagagtgaa ctgagcatca gtcagaaaaa 60 gtctatgtttgcagaaatac agatccaaga caaagacagg atgggcactg ctggaaaagt 120 tattaaatgcaaagcagctg tgctttggga gcagaagcaa cccttctcca ttgaggaaat 180 agaagttgccccaccaaaga ctaaagaagt tcgcattaag attttggcca caggaatctg 240 tcgcacagatgaccatgtga taaaaggaac aatggtgtcc aagtttccag tgattgtggg 300 acatgaggcaactgggattg tagagagcat tggagaagga gtgactacag tgaaaccagg 360 tgacaaagtcatccctctct ttctgccaca atgtagagaa tgcaatgctt gtcgcaaccc 420 agatggcaacctttgcatta ggagcgatat tactggtcgt ggagtactgg ctgatggcac 480 caccagatttacatgcaagg gcaaaccagt acaccacttc atgaacacca gtacatttac 540 cgagtacacagtggtggatg aatcttctgt tgctaagatt gatgatgcag ctcctcctga 600 gaaagtctgtttaattggct gtgggttttc cactggatat ggcgctgctg ttaaaactgg 660 caaggtcaaacctggttcca cttgcgtcgt ctttggcctg ggaggagttg gcctgtcagt 720 catcatgggctgtaagtcag ctggtgcatc taggatcatt gggattgacc tcaacaaaga 780 caaatttgagaaggccatgg ctgtaggtgc cactgagtgt atcagtccca aggactctac 840 caaacccatcagtgaggtgc tgtcagaaat gacaggcaac aacgtgggat acacctttga 900 agttattgggcatcttgaaa ccatgattga tgccctggca tcctgccaca tgaactatgg 960 gaccagcgtggttgtaggag ttcctccatc agccaagatg ctcacctatg acccgatgtt 1020 gctcttcactggacgcacat ggaagggatg tgtctttgga ggtttgaaaa gcagagatga 1080 tgtcccaaaactagtgactg agttcctggc aaagaaattt gacctggacc agttgataac 1140 tcatgttttaccatttaaaa aaatcagtga aggatttgag ctgctcaatt caggacaaag 1200 cattcgaacggtcctgacgt tttgagatcc aaagtggcag gaggtctgtg ttgtcatggt 1260 gaactggagtttctcttgtg agagttccct catctgaaat catgtatctg tctcacaaat 1320 acaagcataagtagaagatt tgttgaagac atagaaccct tataaagaat tattaacctt 1380 tataaacatttaaagtcttg tgagcacctg ggaattagta taataacaat gttaatattt 1440 ttgatttacattttgtaagg ctataattgt atcttttaag aaaacataca cttggatttc 1500 tatgttgaaatggagatttt taagagtttt aaccagctgc tgcagatata taactcaaaa 1560 cagatatagcgtataaagat atagtaaatg catctcccag agtaatattc acttaacaca 1620 ttgaaactattattttttag atttgaatat aaatgtattt tttaaacact tgttatgagt 1680 taacttggattacattttga aatcagttca ttccatgatg catattactg gattagatta 1740 agaaagacagaaaagattaa gggacgggca catttttcaa cgattaagaa tcatcattac 1800 ataacttggtgaaactgaaa aagtatatca tatgggtaca caaggctatt tgccagcata 1860 tattaatattttagaaaata ttccttttgt aatactgaat ataaacatag agctagagtc 1920 atattatcatacttatcata atgttcaatt tgatacagta gaattgcaag tccctaagtc 1980 cctattcactgtgcttagta gtgactccat ttaataaaaa gtgtttttag tttttaacaa 2040 ctaaaccg2048 <210> SEQ ID NO 25 <211> LENGTH: 2048 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 25 atgtgaaggc acaagctgct gttatatacaacagagtgaa ctgagcatca gtcagaaaaa 60 gtctatgttt gcagaaatac agatccaagacaaagacagg atgggcactg ctggaaaagt 120 tattaaatgc aaagcagctg tgctttgggagcagaagcaa cccttctcca ttgaggaaat 180 agaagttgcc ccaccaaaga ctaaagaagttcgcattaag attttggcca caggaatctg 240 tcgcacagat gaccatgtga taaaaggaacaatggtgtcc aagtttccag tgattgtggg 300 acatgaggca actgggattg tagagagcattggagaagga gtgactacag tgaaaccagg 360 tgacaaagtc atccctctct ttctgccacaatgtagagaa tgcaatgctt gtcgcaaccc 420 agatggcaac ctttgcatta ggagcgatattactggtcgt ggagtactgg ctgatggcac 480 caccagattt acatgcaagg gcaaaccagtacaccacttc atgaacacca gtacatttac 540 cgagtacaca gtggtggatg aatcttctgttgctaagatt gatgatgcag ctcctcctga 600 gaaagtctgt ttaattggct gtgggttttccactggatat ggcgctgctg ttaaaactgg 660 caaggtcaaa cctggttcca cttgcgtcgtctttggcctg ggaggagttg gcctgtcagt 720 catcatgggc tgtaagtcag ctggtgcatctaggatcatt gggattgacc tcaacaaaga 780 caaatttgag aaggccatgg ctgtaggtgccactgagtgt atcagtccca aggactctac 840 caaacccatc agtgaggtgc tgtcagaaatgacaggcaac aacgtgggat acacctttga 900 agttattggg catcttgaaa ccatgattgatgccctggca tcctgccaca tgaactatgg 960 gaccagcgtg gttgtaggag ttcctccatcagccaagatg ctcacctatg acccgatgtt 1020 gctcttcact ggacgcacat ggaagggatgtgtctttgga ggtttgaaaa gcagagatga 1080 tgtcccaaaa ctagtgactg agttcctggcaaagaaattt gacctggacc agttgataac 1140 tcatgtttta ccatttaaaa aaatcagtgaaggatttgag ctgctcaatt caggacaaag 1200 cattcgaacg gtcctgacgt tttgagatccaaagtggcag gaggtctgtg ttgtcatggt 1260 gaactggagt ttctcttgtg agagttccctcatctgaaat catgtatctg tctcacaaat 1320 acaagcataa gtagaagatt tgttgaagacatagaaccct tataaagaat tattaacctt 1380 tataaacatt taaagtcttg tgagcacctgggaattagta taataacaat gttaatattt 1440 ttgatttaca ttttgtaagg ctataattgtatcttttaag aaaacataca cttggatttc 1500 tatgttgaaa tggagatttt taagagttttaaccagctgc tgcagatata taactcaaaa 1560 cagatatagc gtataaagat atagtaaatgcatctcccag agtaatattc acttaacaca 1620 ttgaaactat tattttttag atttgaatataaatgtattt tttaaacact tgttatgagt 1680 taacttggat tacattttga aatcagttcattccatgatg catattactg gattagatta 1740 agaaagacag aaaagattaa gggacgggcacatttttcaa cgattaagaa tcatcattac 1800 ataacttggt gaaactgaaa aagtatatcatatgggtaca caaggctatt tgccagcata 1860 tattaatatt ttagaaaata ttccttttgtaatactgaat ataaacatag agctagagtc 1920 atattatcat acttatcata atgttcaatttgatacagta gaattgcaag tccctaagtc 1980 cctattcact gtgcttagta gtgactccatttaataaaaa gtgtttttag tttttaacaa 2040 ctaaaccg 2048 <210> SEQ ID NO 26<211> LENGTH: 2816 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE:26 tcgttgatat caaagacagt tgaaggaaat gaattttgaa acttcacggt gtgccaccct 60acagtactgc cctgaccctt acatccagcg tttcgtagaa acccagctca tttctcttgg 120aaagaaagtt attaccgatc caccatgtcc cagagcacac agacaaatga attcctcagt 180ccagaggttt tccagcatat ctgggatttt ctggaacagc ctatatgttc agttcagccc 240attgacttga actttgtgga tgaaccatca gaagatggtg cgacaaacaa gattgagatt 300agcatggact gtatccgcat gcaggactcg gacctgagtg accccatgtg gccacagtac 360acgaacctgg ggctcctgaa cagcatggac cagcagattc agaacggctc ctcgtccacc 420agtccctata acacagacca cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag 480cccagctcca ccttcgatgc tctctctcca tcacccgcca tcccctccaa caccgactac 540ccaggcccgc acagtttcga cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc 600tggacgtatt ccactgaact gaagaaactc tactgccaaa ttgcaaagac atgccccatc 660cagatcaagg tgatgacccc acctcctcag ggagctgtta tccgcgccat gcctgtctac 720aaaaaagctg agcacgtcac ggaggtggtg aagcggtgcc ccaaccatga gctgagccgt 780gaattcaacg agggacagat tgcccctcct agtcatttga ttcgagtaga ggggaacagc 840catgcccagt atgtagaaga tcccatcaca ggaagacaga gtgtgctggt accttatgag 900ccaccccagg ttggcactga attcacgaca gtcttgtaca atttcatgtg taacagcagt 960tgtgttggag ggatgaaccg ccgtccaatt ttaatcattg ttactctgga aaccagagat 1020gggcaagtcc tgggccgacg ctgctttgag gcccggatct gtgcttgccc aggaagagac 1080aggaaggcgg atgaagatag catcagaaag cagcaagttt cggacagtac aaagaacggt 1140gatggtacga agcgcccgtt tcgtcagaac acacatggta tccagatgac atccatcaag 1200aaacgaagat ccccagatga tgaactgtta tacttaccag tgaggggccg tgagacttat 1260gaaatgctgt tgaagatcaa agagtccctg gaactcatgc agtaccttcc tcagcacaca 1320attgaaacgt acaggcaaca gcaacagcag cagcaccagc acttacttca gaaacatctc 1380ctttcagcct gcttcaggaa tgagcttgtg gagccccgga gagaaactcc aaaacaatct 1440gacgtcttct ttagacattc caagccccca aaccgatcag tgtacccata gagccctatc 1500tctatatttt aagtgtgtgt gttgtatttc catgtgtata tgtgagtgtg tgtgtgtgta 1560tgtgtgtgcg tgtgtatcta gccctcataa acaggacttg aagacacttt ggctcagaga 1620cccaactgct caaaggcaca aagccactag tgagagaatc ttttgaaggg actcaaacct 1680ttacaagaaa ggatgttttc tgcagatttt gtatccttag accggccatt ggtgggtgag 1740gaaccactgt gtttgtctgt gagctttctg ttgtttcctg ggagggaggg gtcaggtggg 1800gaaaggggca ttaagatgtt tattggaacc cttttctgtc ttcttctgtt gtttttctaa 1860aattcacagg gaagcttttg agcaggtctc aaacttaaga tgtcttttta agaaaaggag 1920aaaaaagttg ttattgtctg tgcataagta agttgtaggt gactgagaga ctcagtcaga 1980cccttttaat gctggtcatg taataatatt gcaagtagta agaaacgaag gtgtcaagtg 2040tactgctggg cagcgaggtg atcattacca aaagtaatca actttgtggg tggagagttc 2100tttgtgagaa cttgcattat ttgtgtcctc ccctcatgtg taggtagaac atttcttaat 2160gctgtgtacc tgcctctgcc actgtatgtt ggcatctgtt atgctaaagt ttttcttgta 2220catgaaaccc tggaagacct actacaaaaa aactgttgtt tggcccccat agcaggtgaa 2280ctcattttgt gcttttaata gaaagacaaa tccaccccag taatattgcc cttacgtagt 2340tgtttaccat tattcaaagc tcaaaataga atttgaagcc ctctcacaaa atctgtgatt 2400aatttgctta attagagctt ctatccctca agcctaccta ccataaaacc agccatatta 2460ctgatactgt tcagtgcatt tagccaggag acttacgttt tgagtaagtg agatccaagc 2520agacgtgtta aaatcagcac tcctggactg gaaattaaag attgaaaggg tagactactt 2580ttcttttttt tactcaaaag tttagagaat ctctgtttct ttccatttta aaaacatatt 2640ttaagataat agcataaaga ctttaaaaat gttcctcccc tccatcttcc cacacccagt 2700caccagcact gtattttctg tcaccaagac aatgatttct tgttattgag gctgttgctt 2760ttgtggatgt gtgattttaa ttttcaataa acttttgcat cttggtttaa aagaaa 2816 <210>SEQ ID NO 27 <211> LENGTH: 2816 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 27 tcgttgatat caaagacagt tgaaggaaat gaattttgaaacttcacggt gtgccaccct 60 acagtactgc cctgaccctt acatccagcg tttcgtagaaacccagctca tttctcttgg 120 aaagaaagtt attaccgatc caccatgtcc cagagcacacagacaaatga attcctcagt 180 ccagaggttt tccagcatat ctgggatttt ctggaacagcctatatgttc agttcagccc 240 attgacttga actttgtgga tgaaccatca gaagatggtgcgacaaacaa gattgagatt 300 agcatggact gtatccgcat gcaggactcg gacctgagtgaccccatgtg gccacagtac 360 acgaacctgg ggctcctgaa cagcatggac cagcagattcagaacggctc ctcgtccacc 420 agtccctata acacagacca cgcgcagaac agcgtcacggcgccctcgcc ctacgcacag 480 cccagctcca ccttcgatgc tctctctcca tcacccgccatcccctccaa caccgactac 540 ccaggcccgc acagtttcga cgtgtccttc cagcagtcgagcaccgccaa gtcggccacc 600 tggacgtatt ccactgaact gaagaaactc tactgccaaattgcaaagac atgccccatc 660 cagatcaagg tgatgacccc acctcctcag ggagctgttatccgcgccat gcctgtctac 720 aaaaaagctg agcacgtcac ggaggtggtg aagcggtgccccaaccatga gctgagccgt 780 gaattcaacg agggacagat tgcccctcct agtcatttgattcgagtaga ggggaacagc 840 catgcccagt atgtagaaga tcccatcaca ggaagacagagtgtgctggt accttatgag 900 ccaccccagg ttggcactga attcacgaca gtcttgtacaatttcatgtg taacagcagt 960 tgtgttggag ggatgaaccg ccgtccaatt ttaatcattgttactctgga aaccagagat 1020 gggcaagtcc tgggccgacg ctgctttgag gcccggatctgtgcttgccc aggaagagac 1080 aggaaggcgg atgaagatag catcagaaag cagcaagtttcggacagtac aaagaacggt 1140 gatggtacga agcgcccgtt tcgtcagaac acacatggtatccagatgac atccatcaag 1200 aaacgaagat ccccagatga tgaactgtta tacttaccagtgaggggccg tgagacttat 1260 gaaatgctgt tgaagatcaa agagtccctg gaactcatgcagtaccttcc tcagcacaca 1320 attgaaacgt acaggcaaca gcaacagcag cagcaccagcacttacttca gaaacatctc 1380 ctttcagcct gcttcaggaa tgagcttgtg gagccccggagagaaactcc aaaacaatct 1440 gacgtcttct ttagacattc caagccccca aaccgatcagtgtacccata gagccctatc 1500 tctatatttt aagtgtgtgt gttgtatttc catgtgtatatgtgagtgtg tgtgtgtgta 1560 tgtgtgtgcg tgtgtatcta gccctcataa acaggacttgaagacacttt ggctcagaga 1620 cccaactgct caaaggcaca aagccactag tgagagaatcttttgaaggg actcaaacct 1680 ttacaagaaa ggatgttttc tgcagatttt gtatccttagaccggccatt ggtgggtgag 1740 gaaccactgt gtttgtctgt gagctttctg ttgtttcctgggagggaggg gtcaggtggg 1800 gaaaggggca ttaagatgtt tattggaacc cttttctgtcttcttctgtt gtttttctaa 1860 aattcacagg gaagcttttg agcaggtctc aaacttaagatgtcttttta agaaaaggag 1920 aaaaaagttg ttattgtctg tgcataagta agttgtaggtgactgagaga ctcagtcaga 1980 cccttttaat gctggtcatg taataatatt gcaagtagtaagaaacgaag gtgtcaagtg 2040 tactgctggg cagcgaggtg atcattacca aaagtaatcaactttgtggg tggagagttc 2100 tttgtgagaa cttgcattat ttgtgtcctc ccctcatgtgtaggtagaac atttcttaat 2160 gctgtgtacc tgcctctgcc actgtatgtt ggcatctgttatgctaaagt ttttcttgta 2220 catgaaaccc tggaagacct actacaaaaa aactgttgtttggcccccat agcaggtgaa 2280 ctcattttgt gcttttaata gaaagacaaa tccaccccagtaatattgcc cttacgtagt 2340 tgtttaccat tattcaaagc tcaaaataga atttgaagccctctcacaaa atctgtgatt 2400 aatttgctta attagagctt ctatccctca agcctacctaccataaaacc agccatatta 2460 ctgatactgt tcagtgcatt tagccaggag acttacgttttgagtaagtg agatccaagc 2520 agacgtgtta aaatcagcac tcctggactg gaaattaaagattgaaaggg tagactactt 2580 ttcttttttt tactcaaaag tttagagaat ctctgtttctttccatttta aaaacatatt 2640 ttaagataat agcataaaga ctttaaaaat gttcctcccctccatcttcc cacacccagt 2700 caccagcact gtattttctg tcaccaagac aatgatttcttgttattgag gctgttgctt 2760 ttgtggatgt gtgattttaa ttttcaataa acttttgcatcttggtttaa aagaaa 2816 <210> SEQ ID NO 28 <211> LENGTH: 3803 <212> TYPE:DNA <213> ORGANISM: human <400> SEQUENCE: 28 ccatggtagg agcgctcgcctcgctgcggt gcccgctgag gccatgccgg ggccccggcg 60 ccccgctggc tcccgcctgcgcctgctcct gctcctgctg ctgccgccgc tgctgctgct 120 gctccggggc agccacgcgggcaacctgac ggtagccgtg gtactgccgc tggccaatac 180 ctcgtacccc tggtcgtgggcgcgcgtggg acccgccgtg gagctggccc tggcccaggt 240 gaaggcgcgc cccgacttgctgccgggctg gacggtccgc acggtgctgg gcagcagcga 300 aaacgcgctg ggcgtctgctccgacaccgc agcgcccctg gccgcggtgg acctcaagtg 360 ggagcacaac cccgctgtgttcctgggccc cggctgcgtg tacgccgccg ccccagtggg 420 gcgcttcacc gcgcactggcgggtcccgct gctgaccgcc ggcgccccgg cgctgggctt 480 cggtgtcaag gacgagtatgcgctgaccac ccgcgcgggg cccagctacg ccaagctggg 540 ggacttcgtg gcggcgctgcaccgacggct gggctgggag cgccaagcgc tcatgctcta 600 cgcctaccgg ccgggtgacgaagagcactg cttcttcctc gtggaggggc tgttcatgcg 660 ggtccgcgac cgcctcaatattacggtgga ccacctggag ttcgccgagg acgacctcag 720 ccactacacc aggctgctgcggaccatgcc gcgcaaaggc cgagttatct acatctgcag 780 ctcccctgat gccttcagaaccctcatgct cctggccctg gaagctggct tgtgtgggga 840 ggactacgtt ttcttccacctggatatctt tgggcaaagc ctgcaaggtg gacagggccc 900 tgctccccgc aggccctgggagagagggga tgggcaggat gtcagtgccc gccaggcctt 960 tcaggctgcc aaaatcattacatataaaga cccagataat cccgagtact tggaattcct 1020 gaagcagtta aaacacctggcctatgagca gttcaacttc accatggagg atggcctggt 1080 gaacaccatc ccagcatccttccacgacgg gctcctgctc tatatccagg cagtgacgga 1140 gactctggca catgggggaactgttactga tggggagaac atcactcagc ggatgtggaa 1200 ccgaagcttt caaggtgtgacaggatacct gaaaattgat agcagtggcg atcgggaaac 1260 agacttctcc ctctgggatatggatcccga gaatggtgcc ttcagggttg tactgaacta 1320 caatgggact tcccaagagctggtggctgt gtcggggcgc aaactgaact ggcccctggg 1380 gtaccctcct cctgacatccccaaatgtgg ctttgacaac gaagacccag catgcaacca 1440 agatcacctt tccaccctggaggtgctggc tttggtgggc agcctctcct tgctcggcat 1500 tctgattgtc tccttcttcatatacaggaa gatgcagctg gagaaggaac tggcctcgga 1560 gctgtggcgg gtgcgctgggaggacgttga gcccagtagc cttgagaggc acctgcggag 1620 tgcaggcagc cggctgaccctgagcgggag aggctccaat tacggctccc tgctaaccac 1680 agagggccag ttccaagtctttgccaagac agcatattat aagggcaacc tcgtggctgt 1740 gaaacgtgtg aaccgtaaacgcattgagct gacacgaaaa gtcctgtttg aactgaagca 1800 tatgcgggat gtgcagaatgaacacctgac caggtttgtg ggagcctgca ccgacccccc 1860 caatatctgc atcctcacagagtactgtcc ccgtgggagc ctgcaggaca ttctggagaa 1920 tgagagcatc accctggactggatgttccg gtactcactc accaatgaca tcgtcaaggg 1980 catgctgttt ctacacaatggggctatctg ttcccatggg aacctcaagt catccaactg 2040 cgtggtagat gggcgctttgtgctcaagat caccgactat gggctggaga gcttcaggga 2100 cctggaccca gagcaaggacacaccgttta tgccaaaaag ctgtggacgg cccctgagct 2160 cctgcgaatg gcttcaccccctgtgcgggg ctcccaggct ggtgacgtat acagctttgg 2220 gatcatcctt caggagattgccctgaggag tggggtcttc cacgtggaag gtttggacct 2280 gagccccaaa gagatcatcgagcgggtgac tcggggtgag cagcccccct tccggccctc 2340 cctggccctg cagagtcacctggaggagtt ggggctgctc atgcagcggt gctgggctga 2400 ggacccacag gagaggccaccattccagca gatccgcctg acgttgcgca aatttaacag 2460 ggagaacagc agcaacatcctggacaacct gctgtcccgc atggagcagt acgcgaacaa 2520 tctggaggaa ctggtggaggagcggaccca ggcatacctg gaggagaagc gcaaggctga 2580 ggccctgctc taccagatcctgcctcactc agtggctgag cagctgaagc gtggggagac 2640 ggtgcaggcc gaagcctttgacagtgttac catctacttc agtgacattg tgggtttcac 2700 agcgctgtcg gcggagagcacacccatgca ggtggtgacc ctgctcaatg acctgtacac 2760 ttgctttgat gctgtcatagacaactttga tgtgtacaag gtggagacaa ttggcgatgc 2820 ctacatggtg gtgtcagggctccctgtgcg gaacgggcgg ctacacgcct gcgaggtagc 2880 ccgcatggcc ctggcactgctggatgctgt gcgctccttc cgaatccgcc accggcccca 2940 ggagcagctg cgcttgcgcattggcatcca cacaggacct gtgtgtgctg gagtggtggg 3000 actgaagatg ccccgttactgtctctttgg ggatacagtc aacacagcct caagaatgga 3060 gtctaatggg gaagccctgaagatccactt gtcttctgag accaaggctg tcctggagga 3120 gtttggtggt ttcgagctggagcttcgagg ggatgtagaa atgaagggca aaggcaaggt 3180 tcggacctac tggctccttggggagagggg gagtagcacc cgaggctgac ctgcctcctc 3240 tcctatccct ccacacctcccctaccctgt gccagaagca acagaggtgc caggcctcag 3300 cctcacccac agcagccccatcgccaaagg atggaagtaa tttgaatagc tcaggtgtgc 3360 tgaccccagt gaagacaccagataggacct ctgagagggg actggcatgg ggggatctca 3420 gagcttacag gctgagccaagcccacggcc atgcacaggg acactcacac aggcacacgc 3480 acctgctctc cacctggactcaggccgggc tgggctgtgg atccttgatc ccctcccctc 3540 cccatgctct cctccctcagccttgctacc ctgtgactta ctgggaggag agtcacctga 3600 aggggaacat gaaaagagactaggtgaaga gagggcaggg gagcccacat ctggggctgg 3660 cccacaatac ctgctcccccgaccccctcc acccagcagt agacacagtg cacaggggag 3720 aagaggggtg gcgcagaagggttgggggcc tgtatgcctt gcttctacca tgagcagaga 3780 caattaaaat ctttattccagtg 3803 <210> SEQ ID NO 29 <211> LENGTH: 3803 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 29 ccatggtagg agcgctcgcc tcgctgcggtgcccgctgag gccatgccgg ggccccggcg 60 ccccgctggc tcccgcctgc gcctgctcctgctcctgctg ctgccgccgc tgctgctgct 120 gctccggggc agccacgcgg gcaacctgacggtagccgtg gtactgccgc tggccaatac 180 ctcgtacccc tggtcgtggg cgcgcgtgggacccgccgtg gagctggccc tggcccaggt 240 gaaggcgcgc cccgacttgc tgccgggctggacggtccgc acggtgctgg gcagcagcga 300 aaacgcgctg ggcgtctgct ccgacaccgcagcgcccctg gccgcggtgg acctcaagtg 360 ggagcacaac cccgctgtgt tcctgggccccggctgcgtg tacgccgccg ccccagtggg 420 gcgcttcacc gcgcactggc gggtcccgctgctgaccgcc ggcgccccgg cgctgggctt 480 cggtgtcaag gacgagtatg cgctgaccacccgcgcgggg cccagctacg ccaagctggg 540 ggacttcgtg gcggcgctgc accgacggctgggctgggag cgccaagcgc tcatgctcta 600 cgcctaccgg ccgggtgacg aagagcactgcttcttcctc gtggaggggc tgttcatgcg 660 ggtccgcgac cgcctcaata ttacggtggaccacctggag ttcgccgagg acgacctcag 720 ccactacacc aggctgctgc ggaccatgccgcgcaaaggc cgagttatct acatctgcag 780 ctcccctgat gccttcagaa ccctcatgctcctggccctg gaagctggct tgtgtgggga 840 ggactacgtt ttcttccacc tggatatctttgggcaaagc ctgcaaggtg gacagggccc 900 tgctccccgc aggccctggg agagaggggatgggcaggat gtcagtgccc gccaggcctt 960 tcaggctgcc aaaatcatta catataaagacccagataat cccgagtact tggaattcct 1020 gaagcagtta aaacacctgg cctatgagcagttcaacttc accatggagg atggcctggt 1080 gaacaccatc ccagcatcct tccacgacgggctcctgctc tatatccagg cagtgacgga 1140 gactctggca catgggggaa ctgttactgatggggagaac atcactcagc ggatgtggaa 1200 ccgaagcttt caaggtgtga caggatacctgaaaattgat agcagtggcg atcgggaaac 1260 agacttctcc ctctgggata tggatcccgagaatggtgcc ttcagggttg tactgaacta 1320 caatgggact tcccaagagc tggtggctgtgtcggggcgc aaactgaact ggcccctggg 1380 gtaccctcct cctgacatcc ccaaatgtggctttgacaac gaagacccag catgcaacca 1440 agatcacctt tccaccctgg aggtgctggctttggtgggc agcctctcct tgctcggcat 1500 tctgattgtc tccttcttca tatacaggaagatgcagctg gagaaggaac tggcctcgga 1560 gctgtggcgg gtgcgctggg aggacgttgagcccagtagc cttgagaggc acctgcggag 1620 tgcaggcagc cggctgaccc tgagcgggagaggctccaat tacggctccc tgctaaccac 1680 agagggccag ttccaagtct ttgccaagacagcatattat aagggcaacc tcgtggctgt 1740 gaaacgtgtg aaccgtaaac gcattgagctgacacgaaaa gtcctgtttg aactgaagca 1800 tatgcgggat gtgcagaatg aacacctgaccaggtttgtg ggagcctgca ccgacccccc 1860 caatatctgc atcctcacag agtactgtccccgtgggagc ctgcaggaca ttctggagaa 1920 tgagagcatc accctggact ggatgttccggtactcactc accaatgaca tcgtcaaggg 1980 catgctgttt ctacacaatg gggctatctgttcccatggg aacctcaagt catccaactg 2040 cgtggtagat gggcgctttg tgctcaagatcaccgactat gggctggaga gcttcaggga 2100 cctggaccca gagcaaggac acaccgtttatgccaaaaag ctgtggacgg cccctgagct 2160 cctgcgaatg gcttcacccc ctgtgcggggctcccaggct ggtgacgtat acagctttgg 2220 gatcatcctt caggagattg ccctgaggagtggggtcttc cacgtggaag gtttggacct 2280 gagccccaaa gagatcatcg agcgggtgactcggggtgag cagcccccct tccggccctc 2340 cctggccctg cagagtcacc tggaggagttggggctgctc atgcagcggt gctgggctga 2400 ggacccacag gagaggccac cattccagcagatccgcctg acgttgcgca aatttaacag 2460 ggagaacagc agcaacatcc tggacaacctgctgtcccgc atggagcagt acgcgaacaa 2520 tctggaggaa ctggtggagg agcggacccaggcatacctg gaggagaagc gcaaggctga 2580 ggccctgctc taccagatcc tgcctcactcagtggctgag cagctgaagc gtggggagac 2640 ggtgcaggcc gaagcctttg acagtgttaccatctacttc agtgacattg tgggtttcac 2700 agcgctgtcg gcggagagca cacccatgcaggtggtgacc ctgctcaatg acctgtacac 2760 ttgctttgat gctgtcatag acaactttgatgtgtacaag gtggagacaa ttggcgatgc 2820 ctacatggtg gtgtcagggc tccctgtgcggaacgggcgg ctacacgcct gcgaggtagc 2880 ccgcatggcc ctggcactgc tggatgctgtgcgctccttc cgaatccgcc accggcccca 2940 ggagcagctg cgcttgcgca ttggcatccacacaggacct gtgtgtgctg gagtggtggg 3000 actgaagatg ccccgttact gtctctttggggatacagtc aacacagcct caagaatgga 3060 gtctaatggg gaagccctga agatccacttgtcttctgag accaaggctg tcctggagga 3120 gtttggtggt ttcgagctgg agcttcgaggggatgtagaa atgaagggca aaggcaaggt 3180 tcggacctac tggctccttg gggagagggggagtagcacc cgaggctgac ctgcctcctc 3240 tcctatccct ccacacctcc cctaccctgtgccagaagca acagaggtgc caggcctcag 3300 cctcacccac agcagcccca tcgccaaaggatggaagtaa tttgaatagc tcaggtgtgc 3360 tgaccccagt gaagacacca gataggacctctgagagggg actggcatgg ggggatctca 3420 gagcttacag gctgagccaa gcccacggccatgcacaggg acactcacac aggcacacgc 3480 acctgctctc cacctggact caggccgggctgggctgtgg atccttgatc ccctcccctc 3540 cccatgctct cctccctcag ccttgctaccctgtgactta ctgggaggag agtcacctga 3600 aggggaacat gaaaagagac taggtgaagagagggcaggg gagcccacat ctggggctgg 3660 cccacaatac ctgctccccc gaccccctccacccagcagt agacacagtg cacaggggag 3720 aagaggggtg gcgcagaagg gttgggggcctgtatgcctt gcttctacca tgagcagaga 3780 caattaaaat ctttattcca gtg 3803<210> SEQ ID NO 30 <211> LENGTH: 2970 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 30 ggggtaagga gttcaaggca gcgcccacac ccgggggctctccgcaaccc gaccgcctgt 60 ccgctccccc acttcccgcc ctccctccca cctactcattcacccaccca cccacccaga 120 gccgggacgg cagcccaggc gcccgggccc cgccgtctcctcgccgcgat cctggacttc 180 ctcttgctgc aggacccggc ttccacgtgt gtcccggagccggcgtctca gcacacgctc 240 cgctccgggc ctgggtgcct acagcagcca gagcagcagggagtccggga cccgggcggc 300 atctgggcca agttaggcgc cgccgaggcc agcgctgaacgtctccaggg ccggaggagc 360 cgcggggcgt ccgggtctga gcctcagcaa atgggctccgacgtgcggga cctgaacgcg 420 ctgctgcccg ccgtcccctc cctgggtggc ggcggcggctgtgccctgcc tgtgagcggc 480 gcggcgcagt gggcgccggt gctggacttt gcgcccccgggcgcttcggc ttacgggtcg 540 ttgggcggcc ccgcgccgcc accggctccg ccgccacccccgccgccgcc gcctcactcc 600 ttcatcaaac aggagccgag ctggggcggc gcggagccgcacgaggagca gtgcctgagc 660 gccttcactg tccacttttc cggccagttc actggcacagccggagcctg tcgctacggg 720 cccttcggtc ctcctccgcc cagccaggcg tcatccggccaggccaggat gtttcctaac 780 gcgccctacc tgcccagctg cctcgagagc cagcccgctattcgcaatca gggttacagc 840 acggtcacct tcgacgggac gcccagctac ggtcacacgccctcgcacca tgcggcgcag 900 ttccccaacc actcattcaa gcatgaggat cccatgggccagcagggctc gctgggtgag 960 cagcagtact cggtgccgcc cccggtctat ggctgccacacccccaccga cagctgcacc 1020 ggcagccagg ctttgctgct gaggacgccc tacagcagtgacaatttata ccaaatgaca 1080 tcccagcttg aatgcatgac ctggaatcag atgaacttaggagccacctt aaagggccac 1140 agcacagggt acgagagcga taaccacaca acgcccatcctctgcggagc ccaatacaga 1200 atacacacgc acggtgtctt cagaggcatt caggatgtgcgacgtgtgcc tggagtagcc 1260 ccgactcttg tacggtcggc atctgagacc agtgagaaacgccccttcat gtgtgcttac 1320 ccaggctgca ataagagata ttttaagctg tcccacttacagatgcacag caggaagcac 1380 actggtgaga aaccatacca gtgtgacttc aaggactgtgaacgaaggtt ttctcgttca 1440 gaccagctca aaagacacca aaggagacat acaggtgtgaaaccattcca gtgtaaagct 1500 tgtcagcgaa agttctcccg gtccgaccac ctgaagacccacaccaggac tcatacaggt 1560 gaaaagccct tcagctgtcg gtggccaagt tgtcagaaaaagtttgcccg gtcagatgaa 1620 ttagtccgcc atcacaacat gcatcagaga aacatgaccaaactccagct ggcgctttga 1680 ggggtctccc tcggggaccg ttcagtgtcc caggcagcacagtgtgtgaa ctgctttcaa 1740 gtctgactct ccactcctcc tcactaaaaa ggaaacttcagttgatcttc ttcatccaac 1800 ttccaagaca agataccggt gcttctggaa actaccaggtgtgcctggaa gagttggtct 1860 ctgccctgcc tacttttagt tgactcacag gccctggagaagcagctaac aatgtctggt 1920 tagttaaaag cccattgcca tttggtctgg attttctactgtaagaagag ccatagctga 1980 tcatgtcccc ctgacccttc ccttcttttt ttatgctcgttttcgctggg gatggaatta 2040 ttgtaccatt ttctatcatg gaatatttat aggccagggcatgtgtatgt gtctgctaat 2100 gtaaactttg tcatggtttc catttactaa cagcaacagcaagaaataaa tcagagagca 2160 aggcatcggg ggtgaatctt gtctaacatt cccgaggtcagccaggctgc taacctggaa 2220 agcaggatgt agttctgcca ggcaactttt aaagctcatgcatttcaagc agctgaagaa 2280 agaatcagaa ctaaccagta cctctgtata gaaatctaaaagaattttac cattcagtta 2340 attcaatgtg aacactggca cactgctctt aagaaactatgaagatctga gatttttttg 2400 tgtatgtttt tgactctttt gagtggtaat catatgtgtctttatagatg tacatacctc 2460 cttgcacaaa tggaggggaa ttcattttca tcactgggagtgtccttagt gtataaaaac 2520 catgctggta tatggcttca agttgtaaaa atgaaagtgactttaaaaga aaatagggga 2580 tggtccagga tctccactga taagactgtt tttaagtaacttaaggacct ttgggtctac 2640 aagtatatgt gaaaaaaatg agacttactg ggtgaggaaatccattgttt aaagatggtc 2700 gtgtgtgtgt gtgtgtgtgt gtgtgtgttg tgttgtgttttgttttttaa gggagggaat 2760 ttattattta ccgttgcttg aaattactgt gtaaatatatgtctgataat gatttgctct 2820 ttgacaacta aaattaggac tgtataagta ctagatgcatcactgggtgt tgatcttaca 2880 agatattgat gataacactt aaaattgtaa cctgcatttttcactttgct ctcaattaaa 2940 gtctattcaa aaggaaaaaa aaaaaaaaaa 2970 <210>SEQ ID NO 31 <211> LENGTH: 2422 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 31 gtcagcctcc cttccaccgc catattgggc cactaaaaaaagggggctcg tcttttcggg 60 gtgtttttct ccccctcccc tgtccccgct tgctcacggctctgcgactc cgacgccggc 120 aaggtttgga gagcggctgg gttcgcggga cccgcgggcttgcacccgcc cagactcgga 180 cgggctttgc caccctctcc gcttgcctgg tcccctctcctctccgccct cccgctcgcc 240 agtccatttg atcagcggag actcggcggc cgggccggggcttccccgca gcccctgcgc 300 gctcctagag ctcgggccgt ggctcgtcgg ggtctgtgtcttttggctcc gagggcagtc 360 gctgggcttc cgagaggggt tcgggccgcg taggggcgctttgttttgtt cggttttgtt 420 tttttgagag tgcgagagag gcggtcgtgc agacccgggagaaagatgtc aaacgtgcga 480 gtgtctaacg ggagccctag cctggagcgg atggacgccaggcaggcgga gcaccccaag 540 ccctcggcct gcaggaacct cttcggcccg gtggaccacgaagagttaac ccgggacttg 600 gagaagcact gcagagacat ggaagaggcg agccagcgcaagtggaattt cgattttcag 660 aatcacaaac ccctagaggg caagtacgag tggcaagaggtggagaaggg cagcttgccc 720 gagttctact acagaccccc gcggcccccc aaaggtgcctgcaaggtgcc ggcgcaggag 780 agccaggatg tcagcgggag ccgcccggcg gcgcctttaattggggctcc ggctaactct 840 gaggacacgc atttggtgga cccaaagact gatccgtcggacagccagac ggggttagcg 900 gagcaatgcg caggaataag gaagcgacct gcaaccgacgattcttctac tcaaaacaaa 960 agagccaaca gaacagaaga aaatgtttca gacggttccccaaatgccgg ttctgtggag 1020 cagacgccca agaagcctgg cctcagaaga cgtcaaacgtaaacagctcg aattaagaat 1080 atgtttcctt gtttatcaga tacatcactg cttgatgaagcaaggaagat atacatgaaa 1140 attttaaaaa tacatatcgc tgacttcatg gaatggacatcctgtataag cactgaaaaa 1200 caacaacaca ataacactaa aattttaggc actcttaaatgatctgcctc taaaagcgtt 1260 ggatgtagca ttatgcaatt aggtttttcc ttatttgcttcattgtacta cctgtgtata 1320 tagtttttac cttttatgta gcacataaac tttggggaagggagggcagg gtggggctga 1380 ggaactgacg tggagcgggg tatgaagagc ttgctttgatttacagcaag tagataaata 1440 tttgacttgc atgaagagaa gcaattttgg ggaagggtttgaattgtttt ctttaaagat 1500 gtaatgtccc tttcagagac agctgatact tcatttaaaaaaatcacaaa aatttgaaca 1560 ctggctaaag ataattgcta tttattttta caagaagtttattctcattt gggagatctg 1620 gtgatctccc aagctatcta aagtttgtta gatagctgcatgtggctttt ttaaaaaagc 1680 aacagaaacc tatcctcact gccctcccca gtctctcttaaagttggaat ttaccagtta 1740 attactcagc agaatggtga tcactccagg tagtttggggcaaaaatccg aggtgcttgg 1800 gagttttgaa tgttaagaat tgaccatctg cttttattaaatttgttgac aaaattttct 1860 cattttcttt tcacttcggg ctgtgtaaac acagtcaaaataattctaaa tccctcgata 1920 tttttaaaga tctgtaagta acttcacatt aaaaaatgaaatatttttta atttaaagct 1980 tactctgtcc atttatccac aggaaagtgt tatttttaaaggaaggttca tgtagagaaa 2040 agcacacttg taggataagt gaaatggata ctacatctttaaacagtatt tcattgcctg 2100 tgtatggaaa aaccatttga agtgtacctg tgtacataactctgtaaaaa cactgaaaaa 2160 ttatactaac ttatttatgt taaaagattt tttttaatctagacaatata caagccaaag 2220 tggcatgttt tgtgcatttg taaatgctgt gttgggtagaataggttttc ccctcttttg 2280 ttaaataata tggctatgct taaaaggttg catactgagccaagtataat tttttgtaat 2340 gtgtgaaaaa gatgccaatt attgttacac attaagtaatcaataaagaa aacttccata 2400 gctaaaaaaa aaaaaaaaaa aa 2422 <210> SEQ ID NO32 <211> LENGTH: 1181 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 32 ggcacgaggc ccgggccccc caaagtcccg gccgggccga gggtcggcggccgccggcgg 60 gccgggcccg cgcacagcgc ccgcatgtac aacatgatgg agacggagctgaagccgccg 120 ggcccgcagc aaacttcggg gggcggcggc ggcaactcca ccgcggcggcggccggcggc 180 aaccagaaaa acagcccgga ccgcgtcaag cggcccatga atgccttcatggtgtggtcc 240 cgcgggcagc ggcgcaagat ggcccaggag aaccccaaga tgcacaactcggagatcagc 300 aagcgcctgg gcgccgagtg gaaacttttg tcggagacgg agaagcggccgttcatcgac 360 gaggctaagc ggctgcgagc gctgcacatg aaggagcacc cggattataaataccggccc 420 cggcggaaaa ccaagacgct catgaagaag gataagtaca cgctgcccggcgggctgctg 480 gcccccggcg gcaatagcat ggcgagcggg gtcggggtgg gcgccggcctgggcgcgggc 540 gtgaaccagc gcatggacag ttacgcgcac atgaacggct ggagcaacggcagctacagc 600 atgatgcagg accagctggg ctacccgcag cacccgggcc tcaatgcgcacggcgcagcg 660 cagatgcagc ccatgcaccg ctacgacgtg agcgccctgc agtacaactccatgaccagc 720 tcgcagacct acatgaacgg ctcgcccacc tacagcatgt cctactcgcagcagggcacc 780 cctggcatgg ctcttggctc catgggttcg gtggtcaagt ccgaggccagctccagcccc 840 cctgtggtta cctcttcctc ccactccagg gcgccctgcc aggccggggacctccgggac 900 atgatcagca tgtatctccc cggcgccgag gtgccggaac ccgccgcccccagcagactt 960 cacatgtccc agcactacca gagcggcccg gtgcccggca cggccattaacggcacactg 1020 cccctctcac acatgtgagg gccggacagc gaactggagg ggggagaaattttcaaagaa 1080 aaacgaggga aatgggaggg gtgcaaaaga ggagagtaag aaacagcatggagaaaaccc 1140 ggtacgctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 1181 <210>SEQ ID NO 33 <211> LENGTH: 1305 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 33 ggggccccgc gccggcccgc gccctgccca gtgcggcctccttccacccg ccgctgcctg 60 gcccgcgccg tccggccgag ctgcccggcg ggctggtccccgcgcccgag ccgcccggcc 120 gggaccccga acaaggccga gatgacttcc aaggaggacggcaaggcggc gccgggggag 180 gagcggcgcc gcagcccgct ggaccacctg cctccgcctgccaactccaa caagccagac 240 gccgttcagc atcgaggaca tcctcaacaa gccgtctgtgcggagaagtt actcgctgcg 300 tggggcggcg cacctgctgg ccgccgcgga caagcacgcgcagggcggct tgccctggcg 360 ggccgcgcgc tgctctcgaa gacctcgccg ctgtgcgcgctggaggagct cgccagcaag 420 acgtttaagg ggctggaggt cagcgttctg caggcagccgaaggccgcga cggtatgacc 480 atctttgggc agcggcagac ccctaagaag cggcgaaagtcgcgcacggc cttcaccaac 540 caccagatct atgaattgga aaagcgcttt ctataccagaagtacctgtc ccccgccgat 600 cgcgaccaaa tcgcgcagca gctgggcctc accaacgcgcaagtcatcac ctggttccag 660 aatcggcgcg ctaagctcaa gcgggaactg gaggagatgaaggccgacgt ggagtccccc 720 aagaaactgg gccccagcgg gcagatggac atcgtggcgctggccgaact cgagcagaac 780 tcggaggcca cagccggcgg tggcggcggc tgcggcagggccaagtcgag gcccggctct 840 ccggtcctcc ccccaggcgc cccgaaggcc cccgggcgctgcgccctgca gctctcgcct 900 gcctctccgc tcacggacca gccggccagc agccaggactgctcggagga cgaggaagac 960 gaagagatcg acgtggacga ttgagcggcg ccccgggtcttccgccgccc tgggctccta 1020 gcgctcgaaa gcccaacgcc tcccggaccg gaccgccgaggggagctggg acctcctctg 1080 ccactcccgc ctcctcccct gtccccggac tcggctcctggcagccgcct cttccctctc 1140 gaagcaataa acccaggctg gccggccggg ccggccgccaccagcggcct ccgccgcccc 1200 ggaagccctc gccgagcaat tctgtatggc ttctatataaatatttaaac ctatatagcg 1260 ggttctcccc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaaaaaaa 1305 <210> SEQ ID NO 34 <211> LENGTH: 1926 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 34 gctggagcat cccgctctgg tgccgctgcagccggcagag atggttgagc tcatgttccc 60 gctgttgctc ctccttctgc ccttccttctgtatatggct gcgccccaaa tcaggaaaat 120 gctgtccagt ggggtgtgta catcaactgttcagcttcct gggaaagtag ttgtggtcac 180 aggagctaat acaggtatcg ggaaggagacagccaaagag ctggctcaga gaggagctcg 240 agtatattta gcttgccggg atgtggaaaagggggaattg gtggccaaag agatccagac 300 cacgacaggg aaccagcagg tgttggtgcggaaactggac ctgtctgata ctaagtctat 360 tcgagctttt gctaagggct tcttagctgaggaaaagcac ctccacgttt tgatcaacaa 420 tgcaggagtg atgatgtgtc cgtactcgaagacagcagat ggctttgaga tgcacatagg 480 agtcaaccac ttgggtcact tcctcctaacccatctgctg ctagagaaac taaaggaatc 540 agccccatca aggatagtaa atgtgtcttccctcgcacat cacctgggaa ggatccactt 600 ccataacctg cagggcgaga aattctacaatgcaggcctg gcctactgtc acagcaagct 660 agccaacatc ctcttcaccc aggaactggcccggagacta aaaggctctg gcgttacgac 720 gtattctgta caccctggca cagtccaatctgaactggtt cggcactcat ctttcatgag 780 atggatgtgg tggcttttct cctttttcatcaagactcct cagcagggag cccagaccag 840 cctgcactgt gccttaacag aaggtcttgagattctaagt gggaatcatt tcagtgactg 900 tcatgtggca tgggtctctg cccaagctcgtaatgagact atagcaaggc ggctgtggga 960 cgtcagttgt gacctgctgg gcctcccaatagactaacag gcagtgcagt tggacccaag 1020 agaagactgc agcagactac acagtacttcttgtcaaaat gattctcctt caaggttttc 1080 aaaaccttta gcacaaagag agcaaaaccttccagccttg cctgcttggt gtccagttaa 1140 aactcagtgt actgccagat tcgtctaaatgtctgtcatg tccagattta ctttgcttct 1200 gttactgcca gagttactag agatatcataataggataag aagaccctca tatgacctgc 1260 acagctcatt ttccttctga aagaaactactacctaggag aatctaagct atagcaggga 1320 tgatttatgc aaatttgaac tagcttctttgttcacaatt cagttcctcc caaccaacca 1380 gtcttcactt caagagggcc acactgcaacctcagcttaa catgaataac aaagactggc 1440 tcaggagcag ggcttgccca ggcatggtggatcaccggag tcagtagttc aagaccagcc 1500 tggccaacat ggtgaaaccc cacctctactaaaaattgtg tatatctttg tgtgtcttcc 1560 tgtttatgtg tgccaaggga gtattttcacaaagttcaaa acagccacaa taatcagaga 1620 tggagcaaac cagtgccatc cagtctttatgcaaatgaaa tgctgcaaag ggaagcagat 1680 tctgtatatg ttggtaacta cccaccaagagcacatgggt agcagggaag aagtaaaaaa 1740 agagaaggag aatactggaa gataatgcacaaaatgaagg gactagttaa ggattaacta 1800 gccctttaag gattaactag ttaaggattaatagcaaaag acattaaata tgctaacata 1860 gctatggagg aattgagggc aagcacccaggactgatgag gtcttaacaa aaaccagtgt 1920 ggcaaa 1926 <210> SEQ ID NO 35<211> LENGTH: 1195 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE:35 ccgagactca cggtcaagct aaggcgaaga gtgggtggct gaagccatac tattttatag 60aattaatgga aagcagaaaa gacatcacaa accaagaaga actttggaaa atgaagccta 120ggagaaattt agaagaagac gattatttgc ataaggacac gggagagacc agcatgctaa 180aaagacctgt gcttttgcat ttgcaccaaa cagcccatgc tgatgaattt gactgccctt 240cagaacttca gcacacacag gaactctttc cacagtggca cttgccaatt aaaatagctg 300ctattatagc atctctgact tttctttaca ctcttctgag ggaagtaatt caccctttag 360caacttccca tcaacaatat ttttataaaa ttccaatcct ggtcatcaac aaagtcttgc 420caatggtttc catcactctc ttggcattgg tttacctgcc aggtgtgata gcagcaattg 480tccaacttca taatggaacc aagtataaga agtttccaca ttggttggat aagtggatgt 540taacaagaaa gcagtttggg cttctcagtt tcttttttgc tgtactgcat gcaatttata 600gtctgtctta cccaatgagg cgatcctaca gatacaagtt gctaaactgg gcatatcaac 660aggtccaaca aaataaagaa gatgcctgga ttgagcatga tgtttggaga atggagattt 720atgtgtctct gggaattgtg ggattggcaa tactggctct gttggctgtg acatctattc 780catctgtgag tgactctttg acatggagag aatttcacta tattcagagc aagctaggaa 840ttgtttccct tctactgggc acaatacacg cattgatttt tgcctggaat aagtggatag 900atataaaaca atttgtatgg tatacacctc caacttttat gatagctgtt ttccttccaa 960ttgttgtcct gatatttaaa agcatactat tcctgccatg cttgaggaag aagatactga 1020agattagaca tggttgggaa gacgtcacca aaattaacaa aactgagata tgttcccagt 1080tgtagaatta ctgtttacac acatttttgt tcaatattga tatattttat caccaacatt 1140tcaagtttgt atttgttaat aaaatgatta ttcaaggaaa aaaaaaaaaa aaaaa 1195 <210>SEQ ID NO 36 <211> LENGTH: 3414 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 36 gcttacacag tatggccggc gacattagct agcgctcgctctactctctc taacgggaaa 60 gcagcggaat acaagagact gaactgtatc tgcctctatttccaaaagac tcacgttcaa 120 ctttcgctca cacaaagccg ggaaaatttt attagtcctttttttaaaaa aagttaatat 180 aaaattatag caaaaaaaaa aaggaacctg aactttagtaacacagctgg aacaatcgca 240 gcggcggcgg cagcggcggg agaagaggtt taatttagttgattttctgt ggttgttggt 300 tgttcgctag tctcacggtg atggaagctg cacattttttcgaagggacc gagaagctgc 360 tggaggtttg gttctcccgg cagcagcccg acgcaaaccaaggatctggg gatcttcgca 420 ctatcccaag atctgagtgg gacatacttt tgaaggatgtgcaatgttca atcataagtg 480 tgacaaaaac tgacaagcag gaagcttatg tactcagtgagagtagcatg tttgtctcca 540 agagacgttt cattttgaag acatgtggta ccaccctcttgctgaaagca ctggttcccc 600 tgttgaagct tgctagggat tacagtgggt ttgactcaattcaaagcttc ttttattctc 660 gtaagaattt catgaagcct tctcaccaag ggtacccacaccggaatttc caggaagaaa 720 tagagtttct taatgcaatt ttcccaaatg gagcaggatattgtatggga cgtatgaatt 780 ctgactgttg gtacttatat actctggatt tcccagagagtcgggtaatc agtcagccag 840 atcaaacctt ggaaattctg atgagtgagc ttgacccagcagttatggac cagttctaca 900 tgaaagatgg tgttactgca aaggatgtca ctcgtgagagtggaattcgt gacctgatac 960 caggttctgt cattgatgcc acaatgttca atccttgtgggtattcgatg aatggaatga 1020 aatcggatgg aacttattgg actattcaca tcactccagaaccagaattt tcttatgtta 1080 gctttgaaac aaacttaagt cagacctcct atgatgacctgatcaggaaa gttgtagaag 1140 tcttcaagcc aggaaaattt gtgaccacct tgtttgttaatcagagttct aaatgtcgca 1200 cagtgcttgc ttcgccccag aagattgaag gttttaagcgtcttgattgc cagagtgcta 1260 tgttcaatga ttacaatttt gtttttacca gttttgctaagaagcagcaa caacagcaga 1320 gttgattaag aaaaatgaag aaaaaacgca aaaagagaacacatgtagaa ggtggtggat 1380 gctttctaga tgtcgatgct gggggcagtg ctttccataaccaccactgt gtagttgcag 1440 aaagccctag atgtaatgat agtgtaatca ttttgaattgtatgcattat tatatcaagg 1500 agttagatat cttgcatgaa tgctctcttc tgtgtttaggtattctctgc cactcttgct 1560 gtgaaattga agtggatgta gaaaaaacct tttactatatgaaactttac aacacttgtg 1620 aaagcaactc aatttggttt atgcacagtg taatatttctccaagtatca tccaaaattc 1680 cccacagaca aggctttcgt cctcattagg tgttggcctcagcctaaccc tctaggactg 1740 ttctattaaa ttgctgccag aattttacat ccagttacctccactttcta gaacatattc 1800 tttactaatg ttattgaaac caatttctac ttcatactgatgtttttgga aacagcaatt 1860 aaagtttttc ttccatagtt gagtccttag aaaatgattccagttactca ttttgcatat 1920 tgctatttaa cattattgga ccctgcattt atagtcctttgatttcttcc ctctccctgg 1980 tgtctccccc aagaccccaa ataaagcaat accctgttaacactgtgggt ttatatacta 2040 attctatacc ccagatgggg aattaggggg gagatggtccctgggcttaa tattctttaa 2100 agggcatggg aatttagcct ctcttttatt gtaatgtgctcttttggaaa atagttggtt 2160 agcagggaga ccagagttgt agattgagat tgggtgtactggctgttctg tggaaaacat 2220 acattctgtg ttcctcgaat aagtgaaatt gagcttctaatgagatgcac ccctttacta 2280 acttgatgat gatataaaat tcatttttat ttagttaattaccagagaga tttagcataa 2340 ttttgcttct ggattcagta aatcaagtca gcttggatcattcaccttaa cttttccttt 2400 agcagccctt tccactagtt tcccattaag tagtgttctataaactttga tccaaagcag 2460 aatcaatgtc ttttccatct cgtgacttaa agttctgtgactgtgatgca tgtgagtgtt 2520 ccgacttcat ctgttcctct taactacggt gtttcccttaccgatcggca ttcataggat 2580 gaaatgaatg actgtcccag aatgagaatt tgtccagattattcagataa acatcataaa 2640 gagaataaca ttataaataa gtagaatatg aataaatagaataataaaat tccaaaatac 2700 tcaatgggaa atgactagta atataggctt tcaagagttggtacctttac gtatatttgc 2760 agattctctg ggattttaag gaactgagaa aacagaaaagttgactaaat tttatatttc 2820 ttgtcctcta aatattttga taatttctgg attgatgcagtgatgttttt cgttccttgt 2880 atttataaat gaaaaccttt ttttggtgtt tctaaacctaaaatctactt ggtttgaaat 2940 caagtggttg gaacactgtt tgacttttat ttgaagcatgttgttgattg aaaatttcat 3000 tgaggaagtt ttcaatcagt gtgatcagtt tgattctgtaatgagcacag cacctaatat 3060 tttgaggagc tctgttttga ggaccaatgc ttaaggtggaccttgttgct aaacaatatc 3120 ccaatagatt tgttgacttg aggtctggtt tggttttgtttttgttttgt tttggttttg 3180 ttttgtttcc caatagaatt aagaattcta atgttgaaaaactgtataaa tttttatggg 3240 acaaagccta gaaaagagaa atgtagtttg aatcataatctaaatcatcg tatgatagga 3300 aggaaaagtt ttggtgccat aatttctcct ttcactggtgttggacttaa atcagttgaa 3360 atgtatttct gtaccacaat ttacgcttca ataaaagtttaattgtctag tgag 3414 <210> SEQ ID NO 37 <211> LENGTH: 3287 <212> TYPE:DNA <213> ORGANISM: human <400> SEQUENCE: 37 agactgaggc ggaggcagccccgcgccgcg ccggacccga gcatatttca ttttctgtca 60 ttggactttg agccattagaaccatgagca actacagtgt gtcactggtt ggcccagctc 120 cttggggttt ccggctgcagggcggtaagg atttcaacat gcctctgaca atctctagtc 180 taaaagatgg cggcaaggcagcccaggcaa atgtaagaat aggcgatgtg gttctcagca 240 ttgatggaat aaatgcacaaggaatgactc atcttgaagc ccagaataag attaagggtt 300 gtacaggctc tttgaatatgactctgcaaa gagcatctgc tgcacccaag cctgagccgg 360 ttcctgttca aaagggagaacctaaagaag tagttaaacc tgtgcccatt acatctcctg 420 ctgtgtccaa agtcacttccacaaacaaca tggcctacaa taaggcacca cggccttttg 480 gttctgtgtc ttcaccaaaagtcacatcca tcccatcacc atcgtctgcc ttcaccccag 540 cccatgcgac cacctcatcacatgcttccc cttcacccgt ggctgccgtc actcctcccc 600 tgttcgctgc atctggactgcatgctaatg ccaatcttag tgctgaccag tctccatctg 660 cactgagcgc tggtaaaactgcagttaatg tcccacggca gcccacagtc accagcgtgt 720 gttccgagac ttctcaggagctagcagagg gacagagaag aggatcccag ggtgacagta 780 aacagcaaaa tggcccaccaagaaaacaca ttgtggagcg ctatacagag ttttatcatg 840 tacccactca cagtgatgccagcaagaaga gactgattga ggatactgaa gactggcgtc 900 caagaactgg aacaactcagtctcgctctt tccgaatcct tgcccagatc actgggactg 960 aacatttgaa agaatctgaagccgataata caaagaaggc aaataactct caggagcctt 1020 ctccgcagtt ggcttccttggtagcttcca cacggagcat gcccgagagc ctggacagcc 1080 caacctctgg cagaccaggggttaccagcc tcacaactgc agctgccttc aagcctgtag 1140 gatccactgg cgtcatcaagtcaccaagct ggcaacggcc aaaccaagga gtaccttcca 1200 ctggaagaat ctcaaacagcgctacttact caggatcagt ggcaccagcc aactcagctt 1260 tgggacaaac ccagccaagtgaccaggaca ctttagtgca aagagctgag cacattccag 1320 cagggaaacg aactccgatgtgcgcccatt gtaaccaggt catcagagga ccattcttag 1380 tggcactggg gaaatcttggcacccagaag aattcaactg cgctcactgc aaaaatacaa 1440 tggcctacat tggatttgtagaggagaaag gagccctgta ttgtgagctg tgctatgaga 1500 aattctttgc ccctgaatgtggtcgatgcc aaaggaagat ccttggagaa gtcatcaatg 1560 cgttgaaaca aacttggcatgtttcctgtt ttgtgtgtgt agcctgtgga aagcccattc 1620 ggaacaatgt ttttcacttggaggatggtg aaccctactg tgagactgat tattatgccc 1680 tctttggtac tatatgccatggatgtgaat ttcccataga agctggtgac atgttcctgg 1740 aagctctggg ctacacctggcatgacactt gctttgtatg ctcagtgtgt tgtgaaagtt 1800 tggaaggtca gacctttttctccaagaagg acaagcccct gtgtaagaaa catgctcatt 1860 ctgtgaattt ttgaaagtcaacagttcagg agaagagaag gaatttgaag agaaaaagga 1920 aaattaaaat tactaattaatttttagatt caatatttat atggagtttt gaaaaataat 1980 agtggccctg aaggaataaattccagcttt aaaaaccaag tctgaggaaa tatttggctt 2040 cataaagtaa agagacggtttggcatttat tattactttt tcctgtattt tatgcccata 2100 aaataagctt tataaaaaccaatttcctga tggactatta aattcatctt agaataaatt 2160 agtgaagaat ttaattttagaataaataat ccaatctgaa ataattatac cttctttcct 2220 tgttaggtag ttatgagtaaatctgcaaaa ggcaatgaaa atgccttaaa ttttatcaat 2280 aacagaatta ttgtatttaaaaaaaaacta atacttatct ttaaaatagt aaataggatt 2340 ttaaacagag aattttatcagtaataggtg tcagttttta aaaaattgct tgtaggctga 2400 gcgcggtggc tcacgcctgtaatcccagca ctttgggagg ccaaggtggg tggaccacat 2460 gaggtcagga gtttgagatcagcctggcca acatggtgaa accccatctc tactaaaaat 2520 acaaaaatta gccggacgcagtggcacgcg cctgtaatcc cagctactca agaggctgag 2580 gcacgagaat cacttgaacccgggagggag aggttgcagt gagccaagat cgtaccactg 2640 cactccagcc tgggtgacagagtgagactc cgtctccaaa aaaaaacttt gcttgtatat 2700 tatttttgcc ttacagtggatcattctagt aggaaaggac aataagattt tttatcaaaa 2760 tgtgtcatgc cagtaagagatgttatattc ttttcttatt tcttccccac ccaaaaataa 2820 gctaccatat agcttataagtctcaaattt ttgcctttta ctaaaatgtg attgtttctg 2880 ttcattgtgt atgcttcatcacctatatta ggcaaattcc attttttccc ttgcgctaag 2940 gtaaagattt aattaaataattttggcctc tcatagtttt ctctctcttt aaagagaata 3000 aatagagggc caggtgtggtggctcacgcc tgtgatccca gcactttggg aggccaagac 3060 gggcggatca tgaggtcaagagatcaagat catcctggcc aacatggtga aaccctgtct 3120 ctactaaaaa tacaaaaatgagctgggcat ggtggggcgt gcctgtagtc ccatgtactt 3180 gggaggctga ggcaggaaaattcttgaacc caggagacgg aagttgcagt gagctgagat 3240 cacaccactg cactccagcctggtgacaga gcaagactcc ggctctt 3287 <210> SEQ ID NO 38 <211> LENGTH: 1254<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 38 atggcagtggagaccacggt ccacactcac ctctctgcgt ctccaccgca gggctctccc 60 tacgaccacacacccggcat ggcgggctcc ttggggtacc atccttacgc ggcgcccctg 120 ggatcgtacccttacgggga cccagcgtac cggaagaacg ccacaaggga cgccacggct 180 accctcaaggcctggctcaa cgagcaccgc aagaacccct accccaccaa gggcgagaag 240 atcatgctggccatcatcac caagatgacc ctcacccagg tgtccacctg gttcgccaac 300 gcgcgccggcgcctcaagaa agagaataaa atgacgtgga cgccgcggaa ccgcagcgag 360 gacgaggaagaggaggagaa cattgacctg gagaagaacg acgaggacga gccccagaag 420 cccgaggacaagggcgaccc cgagggcccc gaagcaggag gagctgagca gaaggcggct 480 tcgggctgcgaacggcttca gggaccaccc acccctgcag gcaaggagac ggagggcagc 540 ctcagcgactcggattttaa ggagccgccc tcggagggcc gcctcgacgc gctgcagggc 600 cccccccgcaccggcgggcc ctccccggct gggccagcgg cggcgcggct ggcggaggac 660 ccggcccctcactaccccgc cggagcgccg gcgcccggcc cgcatccagc cgcgggcgag 720 gtgcctccgggtcccggcgg gccctcggtt atccattcgc cgcctccgcc gccgcctcct 780 gcggtgctcgccaagcccaa actgtggtct ttggcagaga tcgccacatt gtcggacaag 840 gtcaaggacgggggcggcgg gaacgagggc tctccatgcc caccgtgtcc cgggcccata 900 gccgggcaagccctaggagg cagccgggcg tcgccggccc cggcgccgtc acgctcgccc 960 tcggcgcagtgtccttttcc aggcgggacg gtgctgtccc ggcctctcta ctacaccgcg 1020 cccttctatcccggctacac gaactatggc tccttcggac accttcatgg ccacccgggg 1080 cccgggccaggccccacaac cggtccgggg tctcatttca atggattaaa ccagaccgtg 1140 ttgaaccgagcggacgcttt ggctaaagac ccgaaaatgt tgcggagcca gtctcagcta 1200 gacctgtgcaaagactctcc ctatgaattg aagaaaggta tgtccgacat ttaa 1254 <210> SEQ ID NO 39<211> LENGTH: 2560 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE:39 gaattccggc cagaagaaat ctggcctcgg aacacgccat tctccgcgcc gcttccaata 60accactaaca tccctaacga gcatccgagc cgagggctct gctcggaaat cgtcctggcc 120caactcggcc cttcgagctc tcgaagatta ccgcatctat tttttttttc ttttttttct 180tttcctagcg cagataaagt gagcccggaa agggaaggag ggggcgggga caccattgcc 240ctgaaagaat aaataagtaa ataaacaaac tggctcctcg ccgcagctgg acgcggtcgg 300ttgagtccag gttgggtcgg acctgaaccc ctaaaagcgg aaccgcctcc cgccctcgcc 360atcccggagc tgagtcgccg gcggcggtgg ctgctgccag acccggagtt tcctctttca 420ctggatggag ctgaactttg ggcggccaga gcagcacagc tgtccgggga tcgctgcacg 480ctgagctccc tcggcaagac ccagcggcgg ctcgggattt ttttgggggg gcggggacca 540gccccgcgcc ggcaccatgt tcctggcgac cctgtacttc gcgctgccgc tcttggactt 600gctcctgtcg gccgaagtga gcggcggaga ccgcctggat tgcgtgaaag ccagtgatca 660gtgcctgaag gagcagagct gcagcaccaa gtaccgcacg ctaaggcagt gcgtggcggg 720caaggagacc aacttcagcc tggcatccgg cctggaggcc aaggatgagt gccgcagcgc 780catggaggcc ctgaagcaga agtcgctcta caactgccgc tgcaagcggg gtatgaagaa 840ggagaagaac tgcctgcgca tttactggag catgtaccag agcctgcagg gaaatgatct 900gctggaggat tccccatatg aaccagttaa cagcagattg tcagatatat tccgggtggt 960cccattcata tcagatgttt ttcagcaagt ggagcacatt cccaaaggga acaactgcct 1020ggatgcagcg aaggcctgca acctcgacga catttgcaag aagtacaggt cggcgtacat 1080caccccgtgc accaccagcg tgtccaacga tgtctgcaac cgccgcaagt gccacaaggc 1140cctccggcag ttctttgaca aggtcccggc caagcacagc tacggaatgc tcttctgctc 1200ctgccgggac atcgcctgca cagagcggag gcgacagacc atcgtgcctg tgtgctccta 1260tgaagagagg gagaagccca actgtttgaa tttgcaggac tcctgcaaga cgaattacat 1320ctgcagatct cgccttgcgg atttttttac caactgccag ccagagtcaa ggtctgtcag 1380cagctgtcta aaggaaaact acgctgactg cctcctcgcc tactcggggc ttattggcac 1440agtcatgacc cccaactaca tagactccag tagcctcagt gtggccccat ggtgtgactg 1500cagcaacagt gggaacgacc tagaagagtg cttgaaattt ttgaatttct tcaaggacaa 1560tacatgtctt aaaaatgcaa ttcaagcctt tggcaatggc tccgatgtga ccgtgtggca 1620gccagccttc ccagtacaga ccaccactgc cactaccacc actgccctcc gggttaagaa 1680caagcccctg gggccagcag ggtctgagaa tgaaattccc actcatgttt tgccaccgtg 1740tgcaaattta caggcacaga agctgaaatc caatgtgtcg ggcaatacac acctctgtat 1800ttccaatggt aattatgaaa aagaaggtct cggtgcttcc agccacataa ccacaaaatc 1860aatggctgct cctccaagct gtggtctgag cccactgctg gtcctggtgg taaccgctct 1920gtccacccta ttatctttaa cagaaacatc atagctgcat taaaaaaata caatatggac 1980atgtaaaaag acaaaaacca agttatctgt ttcctgttct cttgtatagc tgaaattcca 2040gtttaggagc tcagttgaga aacagttcca ttcaactgga acattttttt ttttcctttt 2100aagaaagctt cttgtgatcc ttcggggctt ctgtgaaaaa cctgatgcag tgctccatcc 2160aaactcagaa ggctttggga tatgctgtat tttaaaggga cagtttgtaa cttgggctgt 2220aaagcaaact ggggctgtgt tttcgatgat gatgatcatc atgatcatga tgattttaac 2280agttttactt ctggcctttc ctagctagag aaggagttaa tatttctaag gtaactccca 2340tatctccttt aatgacattg atttctaatg atataaattt cagcctacat tgatgccaag 2400cttttttgcc acaaagaaga ttcttaccaa gagtgggctt tgtggaaaca gctggtactg 2460atgttcacct ttatatatgt actagcattt tccacgctga tgtttatgta ctgtaaacag 2520ttctgcactc ttgtacaaaa gaaaaaacca cccggaattc 2560 <210> SEQ ID NO 40<211> LENGTH: 2560 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE:40 gaattccggc cagaagaaat ctggcctcgg aacacgccat tctccgcgcc gcttccaata 60accactaaca tccctaacga gcatccgagc cgagggctct gctcggaaat cgtcctggcc 120caactcggcc cttcgagctc tcgaagatta ccgcatctat tttttttttc ttttttttct 180tttcctagcg cagataaagt gagcccggaa agggaaggag ggggcgggga caccattgcc 240ctgaaagaat aaataagtaa ataaacaaac tggctcctcg ccgcagctgg acgcggtcgg 300ttgagtccag gttgggtcgg acctgaaccc ctaaaagcgg aaccgcctcc cgccctcgcc 360atcccggagc tgagtcgccg gcggcggtgg ctgctgccag acccggagtt tcctctttca 420ctggatggag ctgaactttg ggcggccaga gcagcacagc tgtccgggga tcgctgcacg 480ctgagctccc tcggcaagac ccagcggcgg ctcgggattt ttttgggggg gcggggacca 540gccccgcgcc ggcaccatgt tcctggcgac cctgtacttc gcgctgccgc tcttggactt 600gctcctgtcg gccgaagtga gcggcggaga ccgcctggat tgcgtgaaag ccagtgatca 660gtgcctgaag gagcagagct gcagcaccaa gtaccgcacg ctaaggcagt gcgtggcggg 720caaggagacc aacttcagcc tggcatccgg cctggaggcc aaggatgagt gccgcagcgc 780catggaggcc ctgaagcaga agtcgctcta caactgccgc tgcaagcggg gtatgaagaa 840ggagaagaac tgcctgcgca tttactggag catgtaccag agcctgcagg gaaatgatct 900gctggaggat tccccatatg aaccagttaa cagcagattg tcagatatat tccgggtggt 960cccattcata tcagatgttt ttcagcaagt ggagcacatt cccaaaggga acaactgcct 1020ggatgcagcg aaggcctgca acctcgacga catttgcaag aagtacaggt cggcgtacat 1080caccccgtgc accaccagcg tgtccaacga tgtctgcaac cgccgcaagt gccacaaggc 1140cctccggcag ttctttgaca aggtcccggc caagcacagc tacggaatgc tcttctgctc 1200ctgccgggac atcgcctgca cagagcggag gcgacagacc atcgtgcctg tgtgctccta 1260tgaagagagg gagaagccca actgtttgaa tttgcaggac tcctgcaaga cgaattacat 1320ctgcagatct cgccttgcgg atttttttac caactgccag ccagagtcaa ggtctgtcag 1380cagctgtcta aaggaaaact acgctgactg cctcctcgcc tactcggggc ttattggcac 1440agtcatgacc cccaactaca tagactccag tagcctcagt gtggccccat ggtgtgactg 1500cagcaacagt gggaacgacc tagaagagtg cttgaaattt ttgaatttct tcaaggacaa 1560tacatgtctt aaaaatgcaa ttcaagcctt tggcaatggc tccgatgtga ccgtgtggca 1620gccagccttc ccagtacaga ccaccactgc cactaccacc actgccctcc gggttaagaa 1680caagcccctg gggccagcag ggtctgagaa tgaaattccc actcatgttt tgccaccgtg 1740tgcaaattta caggcacaga agctgaaatc caatgtgtcg ggcaatacac acctctgtat 1800ttccaatggt aattatgaaa aagaaggtct cggtgcttcc agccacataa ccacaaaatc 1860aatggctgct cctccaagct gtggtctgag cccactgctg gtcctggtgg taaccgctct 1920gtccacccta ttatctttaa cagaaacatc atagctgcat taaaaaaata caatatggac 1980atgtaaaaag acaaaaacca agttatctgt ttcctgttct cttgtatagc tgaaattcca 2040gtttaggagc tcagttgaga aacagttcca ttcaactgga acattttttt ttttcctttt 2100aagaaagctt cttgtgatcc ttcggggctt ctgtgaaaaa cctgatgcag tgctccatcc 2160aaactcagaa ggctttggga tatgctgtat tttaaaggga cagtttgtaa cttgggctgt 2220aaagcaaact ggggctgtgt tttcgatgat gatgatcatc atgatcatga tgattttaac 2280agttttactt ctggcctttc ctagctagag aaggagttaa tatttctaag gtaactccca 2340tatctccttt aatgacattg atttctaatg atataaattt cagcctacat tgatgccaag 2400cttttttgcc acaaagaaga ttcttaccaa gagtgggctt tgtggaaaca gctggtactg 2460atgttcacct ttatatatgt actagcattt tccacgctga tgtttatgta ctgtaaacag 2520ttctgcactc ttgtacaaaa gaaaaaacca cccggaattc 2560 <210> SEQ ID NO 41<211> LENGTH: 2439 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE:41 cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttc ttctgctcac 60cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcag acctgggccc 120gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgc gggactggct 180gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagt gtgacgcgtg 240cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgc tccactgcgc 300gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcg gccgctgcgg 360cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtca acgagtgcaa 420cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggt tccgctgcga 480ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctgg ctttcgccaa 540ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaac ataactgcgt 600ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgt gccagcccgg 660cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttct gccccgacgg 720ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatg gctcgcggtc 780gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcg acactgacct 840agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgta aggacaactg 900cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcg gagacgcctg 960cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcc cgctggtgcg 1020gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcg acaactgccg 1080gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcg atgcgtgcga 1140cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgcccta gggtacccaa 1200ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgaca actgtcccca 1260gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatg cttgtgacag 1320cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtc ccacggtgcc 1380taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcg acgacgacga 1440cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgccta accccggcca 1500ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttg atgcagacaa 1560ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctca ccgacttcag 1620ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgacc ccaactgggt 1680ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccag gcctggctgt 1740gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtga acacggtcac 1800ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagct tctacgtggt 1860catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtg ctgtggccga 1920gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaac agctgcggaa 1980cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtgga aggacccgcg 2040aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcacc ggccccaagt 2100gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgaca gcaacgtggt 2160cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctccc aggagaacat 2220catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggact atgagaccca 2280tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagc caccctcacc 2340gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagg gggaagtgag 2400aagggctcag agaggacaaa ataaagtgtg tgtgcaggg 2439 <210> SEQ ID NO 42 <211>LENGTH: 2439 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 42cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttc ttctgctcac 60cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcag acctgggccc 120gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgc gggactggct 180gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagt gtgacgcgtg 240cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgc tccactgcgc 300gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcg gccgctgcgg 360cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtca acgagtgcaa 420cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggt tccgctgcga 480ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctgg ctttcgccaa 540ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaac ataactgcgt 600ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgt gccagcccgg 660cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttct gccccgacgg 720ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatg gctcgcggtc 780gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcg acactgacct 840agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgta aggacaactg 900cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcg gagacgcctg 960cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcc cgctggtgcg 1020gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcg acaactgccg 1080gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcg atgcgtgcga 1140cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgcccta gggtacccaa 1200ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgaca actgtcccca 1260gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatg cttgtgacag 1320cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtc ccacggtgcc 1380taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcg acgacgacga 1440cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgccta accccggcca 1500ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttg atgcagacaa 1560ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctca ccgacttcag 1620ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgacc ccaactgggt 1680ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccag gcctggctgt 1740gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtga acacggtcac 1800ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagct tctacgtggt 1860catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtg ctgtggccga 1920gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaac agctgcggaa 1980cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtgga aggacccgcg 2040aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcacc ggccccaagt 2100gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgaca gcaacgtggt 2160cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctccc aggagaacat 2220catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggact atgagaccca 2280tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagc caccctcacc 2340gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagg gggaagtgag 2400aagggctcag agaggacaaa ataaagtgtg tgtgcaggg 2439 <210> SEQ ID NO 43 <211>LENGTH: 1385 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 43ctccagccat tggtgtctgt gtcattacta atagagtctt gtaaacactc gttaatcacg 60gaagccgccg gcctggggct ccgcacgcca gcctgtgcgg gtcttccccg cctctgcagc 120ctagtgggaa ggaggtggga ggaaagaagg aagaaaggga gggagggagg aggcaggcca 180gagggaggga ccgcctcgga ggcagaagag ccgcgaggag ccagcggagc accgcgggct 240ggggcgcagc cacccgccgc tcctcgagtc ccctcgcccc tttcccttcg tgccccccgg 300cagcctccag cgtcggtccc caggcagcat ggtgaggtct gctcccggtc cctcgccacc 360atgtacgtga gctacctcct ggacaaggac gtgagcatgt accctagctc cgtgcgccac 420tctggcggcc tcaacctggc gccgcagaac ttcgtcagcc ccccgcagta cccggactac 480ggcggttacc acgtggcggc cgcagctgca gcggcagcga acttggacag cgcgcagtcc 540ccggggccat cctggccggc agcgtatggc gccccactcc gggaggactg gaatggctac 600gcgcccggag gcgccgcggc cgccgccaac gccgtggctc acggcctcaa cggtggctcc 660ccggccgcag ccatgggcta cagcagcccc gcagactacc atccgcacca ccacccgcat 720caccacccgc accacccggc cgcggcgcct tcctgcgctt ctgggctgct gcaaacgctc 780aaccccggcc ctcctgggcc cgccgccacc gctgccgccg agcagctgtc tcccggcggc 840cagcggcgga acctgtgcga gtggatgcgg aagccggcgc agcagtccct cggcagccaa 900gtgaaaacca ggacgaaaga caaatatcga gtggtgtaca cggaccacca gcggctggag 960ctggagaagg agtttcacta cagtcgctac atcaccatcc ggaggaaagc cgagctagcc 1020gccacgctgg ggctctctga gaggcaggtt aaaatctggt ttcagaaccg cagagcaaag 1080gagaggaaaa tcaacaagaa gaagttgcag cagcaacagc agcagcagcc accacagccg 1140cctccgccgc caccacagcc tccccagcct cagccaggtc ctctgagaag tgtcccagag 1200cccttgagtc cggtgtcttc cctgcaagcc tcagtgtctg gctctgtccc tggggttctg 1260gggccaactg ggggggtgct aaaccccacc gtcacccagt gacccaccgg ggttctgcag 1320cggcagagca attccaggct gagccatgag gagcgtggac tctgctagac tcctcaggag 1380agacc 1385 <210> SEQ ID NO 44 <211> LENGTH: 4098 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 44 ggtggcctct gtggccgtcc aggctagcggcggcccgcag gcggcgggga gaaagactct 60 ctcacctggt cttgcggctg tggccaccgccggccagggg tgtggagggc gtgctgccgg 120 agacgtccgc cgggctctgc agttccgccgggggtcgggc agctatggag ccgcggccca 180 cggcgccctc ctccggcgcc ccgggactggccggggtcgg ggagacgccg tcagccgctg 240 cgctggccgc agccagggtg gaactgcccggcacggctgt gccctcggtg ccggaggatg 300 ctgcgcccgc gagccgggac ggcggcggggtccgcgatga gggccccgcg gcggccgggg 360 acgggctggg cagacccttg gggcccaccccgagccagag ccgtttccag gtggacctgg 420 tttccgagaa cgccgggcgg gccgctgctgcggcggcggc ggcggcggcg gcagcggcgg 480 cggctggtgc tggggcgggg gccaagcagacccccgcgga cggggaagcc agcggcgaga 540 gcgagccagc taaaggcagc gaggaagccaagggccgctt ccgcgtgaac ttcgtggacc 600 cagctgcctc ctcgtcggct gaagacagcctgtcagatgc tgccggggtc ggagtcgacg 660 ggcccaacgt gagcttccag aacggcggggacacggtgct gagcgagggc agcagcctgc 720 actccggcgg cggcggcggc agtgggcaccaccagcacta ctattatgat acccacacca 780 acacctacta cctgcgcacc ttcggccacaacaccatgga cgctgtgccc aggatcgatc 840 actaccggca cacagccgcg cagctgggcgagaagctgct ccggcctagc ctggcggagc 900 tccacgacga gctggaaaag gaaccttttgaggatggctt tgcaaatggg gaagaaagta 960 ctccaaccag agatgctgtg gtcacgtatactgcagaaag taaaggagtc gtgaagtttg 1020 gctggatcaa gggtgtatta gtacgttgtatgttaaacat ttggggtgtg atgcttttca 1080 ttagattgtc atggattgtg ggtcaagctggaataggtct atcagtcctt gtaataatga 1140 tggccactgt tgtgacaact atcacaggattgtctacttc agcaatagca actaatggat 1200 ttgtaagagg aggaggagca tattatttaatatctagaag tctagggcca gaatttggtg 1260 gtgcaattgg tctaatcttc gcctttgccaacgctgttgc agttgctatg tatgtggttg 1320 gatttgcaga aaccgtggtg gagttgcttaaggaacattc catacttatg atagatgaaa 1380 tcaatgatat ccgaattatt ggagccattacagtcgtgat tcttttaggt atctcagtag 1440 ctggaatgga gtgggaagca aaagctcagattgttctttt ggtgatccta cttcttgcta 1500 ttggtgattt cgtcatagga acatttatcccactggagag caagaagcca aaagggtttt 1560 ttggttataa atctgaaata tttaatgagaactttgggcc cgattttcga gaggaagaga 1620 ctttcttttc tgtatttgcc atcttttttcctgctgcaac tggtattctg gctggagcaa 1680 atatctcagg tgatcttgca gatcctcagtcagccatacc caaaggaaca ctcctagcca 1740 ttttaattac tacattggtt tacgtaggaattgcagtatc tgtaggttct tgtgttgttc 1800 gagatgccac tggaaacgtt aatgacactatcgtaacaga gctaacaaac tgtacttctg 1860 cagcctgcaa attaaacttt gatttttcatcttgtgaaag cagtccttgt tcctatggcc 1920 taatgaacaa cttccaggta atgagtatggtgtcaggatt tacaccacta atttctgcag 1980 gtatattttc agccactctt tcttcagcattagcatccct agtgagtgct cccaaaatat 2040 ttcaggctct atgtaaggac aacatctacccagctttcca gatgtttgct aaaggttatg 2100 ggaaaaataa tgaacctctt cgtggctacatcttaacatt cttaattgca cttggattca 2160 tcttaattgc tgaactgaat gttattgcaccaattatctc aaacttcttc cttgcatcat 2220 atgcattgat caatttttca gtattccatgcatcacttgc aaaatctcca ggatggcgtc 2280 ctgcattcaa atactacaac atgtggatatcacttcttgg agcaattctt tgttgcatag 2340 taatgttcgt cattaactgg tgggctgcattgctaacata tgtgatagtc cttgggctgt 2400 atatttatgt tacctacaaa aaaccagatgtgaattgggg atcctctaca caagccctga 2460 cttacctgaa tgcactgcag cattcaattcgtctttctgg agtggaagac cacgtgaaaa 2520 actttaggcc acagtgtctt gttatgacaggtgctccaaa ctcacgtcca gctttacttc 2580 atcttgttca tgatttcaca aaaaatgttggtttgatgat ctgtggccat gtacatatgg 2640 gtcctcgaag acaagccatg aaagagatgtccatcgatca agccaaatat cagcgatggc 2700 ttattaagaa caaaatgaag gcattttatgctccagtaca tgcagatgac ttgagagaag 2760 gtgcacagta tttgatgcag gctgctggtcttggtcgtat gaagccaaac acacttgtcc 2820 ttggatttaa gaaagattgg ttgcaagcagatatgaggga tgtggatatg tatataaact 2880 tatttcatga tgcttttgac atacaatatggagtagtggt tattcgccta aaagaaggtc 2940 tggatatatc tcatcttcaa ggacaagaagaattattgtc atcacaagag aaatctcctg 3000 gcaccaagga tgtggtagta agtgtggaatatagtaaaaa gtccgattta gatacttcca 3060 aaccactcag tgaaaaacca attacacacaaagttgagga agaggatggc aagactgcaa 3120 ctcaaccact gttgaaaaaa gaatccaaaggccctattgt gcctttaaat gtagctgacc 3180 aaaagcttct tgaagctagt acacagtttcagaaaaaaca aggaaagaat actattgatg 3240 tctggtggct ttttgatgat ggaggtttgaccttattgat accttacctt ctgacgacca 3300 agaaaaaatg gaaagactgt aagatcagagtattcattgg tggaaagata aacagaatag 3360 accatgaccg gagagcgatg gctactttgcttagcaagtt ccggatagac ttttctgata 3420 tcatggttct aggagatatc aataccaaaccaaagaaaga aaatattata gcttttgagg 3480 aaatcattga gccatacaga cttcatgaagatgataaaga gcaagatatt gcagataaaa 3540 tgaaagaaga tgaaccatgg cgaataacagataatgagct tgaactttat aagaccaaga 3600 cataccggca gatcaggtta aatgagttattaaaggaaca ttcaagcaca gctaatatta 3660 ttgtcatgag tctcccagtt gcacgaaaaggtgctgtgtc tagtgctctc tacatggcat 3720 ggttagaagc tctatctaag gacctaccaccaatcctcct agttcgtggg aatcatcaga 3780 gtgtccttac cttctattca taaatgttctatacagtgga cagccctcca gaatggtact 3840 tcagtgccta gtgtagtaac ctgaaatcttcaatgacaca ttaacatcac aatggcgaat 3900 ggtgactttt ctttcacgat ttcattaatttgaaagcaca caggaaagct tgctccattg 3960 ataacgtgta tggagacttc ggttttagtcaattccatat ctcaatctta atggtgattc 4020 ttctctgttg aactgaagtt tgtgagagtagttttccttt gctacttgaa tagcaataaa 4080 agcgtgttaa ctttttgg 4098 <210> SEQID NO 45 <211> LENGTH: 4098 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 45 ggtggcctct gtggccgtcc aggctagcgg cggcccgcag gcggcggggagaaagactct 60 ctcacctggt cttgcggctg tggccaccgc cggccagggg tgtggagggcgtgctgccgg 120 agacgtccgc cgggctctgc agttccgccg ggggtcgggc agctatggagccgcggccca 180 cggcgccctc ctccggcgcc ccgggactgg ccggggtcgg ggagacgccgtcagccgctg 240 cgctggccgc agccagggtg gaactgcccg gcacggctgt gccctcggtgccggaggatg 300 ctgcgcccgc gagccgggac ggcggcgggg tccgcgatga gggccccgcggcggccgggg 360 acgggctggg cagacccttg gggcccaccc cgagccagag ccgtttccaggtggacctgg 420 tttccgagaa cgccgggcgg gccgctgctg cggcggcggc ggcggcggcggcagcggcgg 480 cggctggtgc tggggcgggg gccaagcaga cccccgcgga cggggaagccagcggcgaga 540 gcgagccagc taaaggcagc gaggaagcca agggccgctt ccgcgtgaacttcgtggacc 600 cagctgcctc ctcgtcggct gaagacagcc tgtcagatgc tgccggggtcggagtcgacg 660 ggcccaacgt gagcttccag aacggcgggg acacggtgct gagcgagggcagcagcctgc 720 actccggcgg cggcggcggc agtgggcacc accagcacta ctattatgatacccacacca 780 acacctacta cctgcgcacc ttcggccaca acaccatgga cgctgtgcccaggatcgatc 840 actaccggca cacagccgcg cagctgggcg agaagctgct ccggcctagcctggcggagc 900 tccacgacga gctggaaaag gaaccttttg aggatggctt tgcaaatggggaagaaagta 960 ctccaaccag agatgctgtg gtcacgtata ctgcagaaag taaaggagtcgtgaagtttg 1020 gctggatcaa gggtgtatta gtacgttgta tgttaaacat ttggggtgtgatgcttttca 1080 ttagattgtc atggattgtg ggtcaagctg gaataggtct atcagtccttgtaataatga 1140 tggccactgt tgtgacaact atcacaggat tgtctacttc agcaatagcaactaatggat 1200 ttgtaagagg aggaggagca tattatttaa tatctagaag tctagggccagaatttggtg 1260 gtgcaattgg tctaatcttc gcctttgcca acgctgttgc agttgctatgtatgtggttg 1320 gatttgcaga aaccgtggtg gagttgctta aggaacattc catacttatgatagatgaaa 1380 tcaatgatat ccgaattatt ggagccatta cagtcgtgat tcttttaggtatctcagtag 1440 ctggaatgga gtgggaagca aaagctcaga ttgttctttt ggtgatcctacttcttgcta 1500 ttggtgattt cgtcatagga acatttatcc cactggagag caagaagccaaaagggtttt 1560 ttggttataa atctgaaata tttaatgaga actttgggcc cgattttcgagaggaagaga 1620 ctttcttttc tgtatttgcc atcttttttc ctgctgcaac tggtattctggctggagcaa 1680 atatctcagg tgatcttgca gatcctcagt cagccatacc caaaggaacactcctagcca 1740 ttttaattac tacattggtt tacgtaggaa ttgcagtatc tgtaggttcttgtgttgttc 1800 gagatgccac tggaaacgtt aatgacacta tcgtaacaga gctaacaaactgtacttctg 1860 cagcctgcaa attaaacttt gatttttcat cttgtgaaag cagtccttgttcctatggcc 1920 taatgaacaa cttccaggta atgagtatgg tgtcaggatt tacaccactaatttctgcag 1980 gtatattttc agccactctt tcttcagcat tagcatccct agtgagtgctcccaaaatat 2040 ttcaggctct atgtaaggac aacatctacc cagctttcca gatgtttgctaaaggttatg 2100 ggaaaaataa tgaacctctt cgtggctaca tcttaacatt cttaattgcacttggattca 2160 tcttaattgc tgaactgaat gttattgcac caattatctc aaacttcttccttgcatcat 2220 atgcattgat caatttttca gtattccatg catcacttgc aaaatctccaggatggcgtc 2280 ctgcattcaa atactacaac atgtggatat cacttcttgg agcaattctttgttgcatag 2340 taatgttcgt cattaactgg tgggctgcat tgctaacata tgtgatagtccttgggctgt 2400 atatttatgt tacctacaaa aaaccagatg tgaattgggg atcctctacacaagccctga 2460 cttacctgaa tgcactgcag cattcaattc gtctttctgg agtggaagaccacgtgaaaa 2520 actttaggcc acagtgtctt gttatgacag gtgctccaaa ctcacgtccagctttacttc 2580 atcttgttca tgatttcaca aaaaatgttg gtttgatgat ctgtggccatgtacatatgg 2640 gtcctcgaag acaagccatg aaagagatgt ccatcgatca agccaaatatcagcgatggc 2700 ttattaagaa caaaatgaag gcattttatg ctccagtaca tgcagatgacttgagagaag 2760 gtgcacagta tttgatgcag gctgctggtc ttggtcgtat gaagccaaacacacttgtcc 2820 ttggatttaa gaaagattgg ttgcaagcag atatgaggga tgtggatatgtatataaact 2880 tatttcatga tgcttttgac atacaatatg gagtagtggt tattcgcctaaaagaaggtc 2940 tggatatatc tcatcttcaa ggacaagaag aattattgtc atcacaagagaaatctcctg 3000 gcaccaagga tgtggtagta agtgtggaat atagtaaaaa gtccgatttagatacttcca 3060 aaccactcag tgaaaaacca attacacaca aagttgagga agaggatggcaagactgcaa 3120 ctcaaccact gttgaaaaaa gaatccaaag gccctattgt gcctttaaatgtagctgacc 3180 aaaagcttct tgaagctagt acacagtttc agaaaaaaca aggaaagaatactattgatg 3240 tctggtggct ttttgatgat ggaggtttga ccttattgat accttaccttctgacgacca 3300 agaaaaaatg gaaagactgt aagatcagag tattcattgg tggaaagataaacagaatag 3360 accatgaccg gagagcgatg gctactttgc ttagcaagtt ccggatagacttttctgata 3420 tcatggttct aggagatatc aataccaaac caaagaaaga aaatattatagcttttgagg 3480 aaatcattga gccatacaga cttcatgaag atgataaaga gcaagatattgcagataaaa 3540 tgaaagaaga tgaaccatgg cgaataacag ataatgagct tgaactttataagaccaaga 3600 cataccggca gatcaggtta aatgagttat taaaggaaca ttcaagcacagctaatatta 3660 ttgtcatgag tctcccagtt gcacgaaaag gtgctgtgtc tagtgctctctacatggcat 3720 ggttagaagc tctatctaag gacctaccac caatcctcct agttcgtgggaatcatcaga 3780 gtgtccttac cttctattca taaatgttct atacagtgga cagccctccagaatggtact 3840 tcagtgccta gtgtagtaac ctgaaatctt caatgacaca ttaacatcacaatggcgaat 3900 ggtgactttt ctttcacgat ttcattaatt tgaaagcaca caggaaagcttgctccattg 3960 ataacgtgta tggagacttc ggttttagtc aattccatat ctcaatcttaatggtgattc 4020 ttctctgttg aactgaagtt tgtgagagta gttttccttt gctacttgaatagcaataaa 4080 agcgtgttaa ctttttgg 4098 <210> SEQ ID NO 46 <211>LENGTH: 3311 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 46tgctaatgct tttggtacaa atggatgtgg aatataattg aatattttct tgtttaaggg 60gagcatgaag aggtgttgag gttatgtcaa gcatctggca cagctgaagg cagatggaaa 120tatttacaag tacgcaattt gagactaaga tattgttatc attctcctat tgaagacaag 180agcaatagta aaacacatca ggtcaggggg ttaaagacct gtgataaacc acttccgata 240agttggaaac gtgtgtctat attttcatat ctgtatatat ataatggtaa agaaagacac 300cttcgtaacc cgcattttcc aaagagagga atcacaggga gatgtacagc aatggggcca 360tttaagagtt ctgtgttcat cttgattctt caccttctag aaggggccct gagtaattca 420ctcattcagc tgaacaacaa tggctatgaa ggcattgtcg ttgcaatcga ccccaatgtg 480ccagaagatg aaacactcat tcaacaaata aaggacatgg tgacccaggc atctctgtat 540ctgtttgaag ctacaggaaa gcgattttat ttcaaaaatg ttgccatttt gattcctgaa 600acatggaaga caaaggctga ctatgtgaga ccaaaacttg agacctacaa aaatgctgat 660gttctggttg ctgagtctac tcctccaggt aatgatgaac cctacactga gcagatgggc 720aactgtggag agaagggtga aaggatccac ctcactcctg atttcattgc aggaaaaaag 780ttagctgaat atggaccaca aggtaaggca tttgtccatg agtgggctca tctacgatgg 840ggagtatttg acgagtacaa taatgatgag aaattctact tatccaatgg aagaatacaa 900gcagtaagat gttcagcagg tattactggt acaaatgtag taaagaagtg tcagggaggc 960agctgttaca ccaaaagatg cacattcaat aaagttacag gactctatga aaaaggatgt 1020gagtttgttc tccaatcccg ccagacggag aaggcttcta taatgtttgc acaacatgtt 1080gattctatag ttgaattctg tacagaacaa aaccacaaca aagaagctcc aaacaagcaa 1140aatcaaaaat gcaatctccg aagcacatgg gaagtgatcc gtgattctga ggactttaag 1200aaaaccactc ctatgacaac acagccacca aatcccacct tctcattgct gcagattgga 1260caaagaattg tgtgtttagt ccttgacaaa tctggaagca tggcgactgg taaccgcctc 1320aatcgactga atcaagcagg ccagcttttc ctgctgcaga cagttgagct ggggtcctgg 1380gttgggatgg tgacatttga cagtgctgcc catgtacaaa gtgaactcat acagataaac 1440agtggcagtg acagggacac actcgccaaa agattacctg cagcagcttc aggagggacg 1500tccatctgca gcgggcttcg atcggcattt actgtgatta ggaagaaata tccaactgat 1560ggatctgaaa ttgtgctgct gacggatggg gaagacaaca ctataagtgg gtgctttaac 1620gaggtcaaac aaagtggtgc catcatccac acagtcgctt tggggccctc tgcagctcaa 1680gaactagagg agctgtccaa aatgacagga ggtttacaga catatgcttc agatcaagtt 1740cagaacaatg gcctcattga tgcttttggg gccctttcat caggaaatgg agctgtctct 1800cagcgctcca tccagcttga gagtaaggga ttaaccctcc agaacagcca gtggatgaat 1860ggcacagtga tcgtggacag caccgtggga aaggacactt tgtttcttat cacctggaca 1920acgcagcctc cccaaatcct tctctgggat cccagtggac agaagcaagg tggctttgta 1980gtggacaaaa acaccaaaat ggcctacctc caaatcccag gcattgctaa ggttggcact 2040tggaaataca gtctgcaagc aagctcacaa accttgaccc tgactgtcac gtcccgtgcg 2100tccaatgcta ccctgcctcc aattacagtg acttccaaaa cgaacaagga caccagcaaa 2160ttccccagcc ctctggtagt ttatgcaaat attcgccaag gagcctcccc aattctcagg 2220gccagtgtca cagccctgat tgaatcagtg aatggaaaaa cagttacctt ggaactactg 2280gataatggag caggtgctga tgctactaag gatgacggtg tctactcaag gtatttcaca 2340acttatgaca cgaatggtag atacagtgta aaagtgcggg ctctgggagg agttaacgca 2400gccagacgga gagtgatacc ccagcagagt ggagcactgt acatacctgg ctggattgag 2460aatgatgaaa tacaatggaa tccaccaaga cctgaaatta ataaggatga tgttcaacac 2520aagcaagtgt gtttcagcag aacatcctcg ggaggctcat ttgtggcttc tgatgtccca 2580aatgctccca tacctgatct cttcccacct ggccaaatca ccgacctgaa ggcggaaatt 2640cacgggggca gtctcattaa tctgacttgg acagctcctg gggatgatta tgaccatgga 2700acagctcaca agtatatcat tcgaataagt acaagtattc ttgatctcag agacaagttc 2760aatgaatctc ttcaagtgaa tactactgct ctcatcccaa aggaagccaa ctctgaggaa 2820gtctttttgt ttaaaccaga aaacattact tttgaaaatg gcacagatct tttcattgct 2880attcaggctg ttgataaggt cgatctgaaa tcagaaatat ccaacattgc acgagtatct 2940ttgtttattc ctccacagac tccgccagag acacctagtc ctgatgaaac gtctgctcct 3000tgtcctaata ttcatatcaa cagcaccatt cctggcattc acattttaaa aattatgtgg 3060aagtggatag gagaactgca gctgtcaata gcctagggct gaatttttgt cagataaata 3120aaataaatca ttcatccttt ttttgattat aaaattttct aaaatgtatt ttagacttcc 3180tgtagggggc gatatactaa atgtatatag tacatttata ctaaatgtat tcctgtaggg 3240ggcgatatac taaatgtatt ttagacttcc tgtagggggc gataaaataa aatgctaaac 3300aactgggtaa a 3311 <210> SEQ ID NO 47 <211> LENGTH: 3311 <212> TYPE: DNA<213> ORGANISM: human <400> SEQUENCE: 47 tgctaatgct tttggtacaaatggatgtgg aatataattg aatattttct tgtttaaggg 60 gagcatgaag aggtgttgaggttatgtcaa gcatctggca cagctgaagg cagatggaaa 120 tatttacaag tacgcaatttgagactaaga tattgttatc attctcctat tgaagacaag 180 agcaatagta aaacacatcaggtcaggggg ttaaagacct gtgataaacc acttccgata 240 agttggaaac gtgtgtctatattttcatat ctgtatatat ataatggtaa agaaagacac 300 cttcgtaacc cgcattttccaaagagagga atcacaggga gatgtacagc aatggggcca 360 tttaagagtt ctgtgttcatcttgattctt caccttctag aaggggccct gagtaattca 420 ctcattcagc tgaacaacaatggctatgaa ggcattgtcg ttgcaatcga ccccaatgtg 480 ccagaagatg aaacactcattcaacaaata aaggacatgg tgacccaggc atctctgtat 540 ctgtttgaag ctacaggaaagcgattttat ttcaaaaatg ttgccatttt gattcctgaa 600 acatggaaga caaaggctgactatgtgaga ccaaaacttg agacctacaa aaatgctgat 660 gttctggttg ctgagtctactcctccaggt aatgatgaac cctacactga gcagatgggc 720 aactgtggag agaagggtgaaaggatccac ctcactcctg atttcattgc aggaaaaaag 780 ttagctgaat atggaccacaaggtaaggca tttgtccatg agtgggctca tctacgatgg 840 ggagtatttg acgagtacaataatgatgag aaattctact tatccaatgg aagaatacaa 900 gcagtaagat gttcagcaggtattactggt acaaatgtag taaagaagtg tcagggaggc 960 agctgttaca ccaaaagatgcacattcaat aaagttacag gactctatga aaaaggatgt 1020 gagtttgttc tccaatcccgccagacggag aaggcttcta taatgtttgc acaacatgtt 1080 gattctatag ttgaattctgtacagaacaa aaccacaaca aagaagctcc aaacaagcaa 1140 aatcaaaaat gcaatctccgaagcacatgg gaagtgatcc gtgattctga ggactttaag 1200 aaaaccactc ctatgacaacacagccacca aatcccacct tctcattgct gcagattgga 1260 caaagaattg tgtgtttagtccttgacaaa tctggaagca tggcgactgg taaccgcctc 1320 aatcgactga atcaagcaggccagcttttc ctgctgcaga cagttgagct ggggtcctgg 1380 gttgggatgg tgacatttgacagtgctgcc catgtacaaa gtgaactcat acagataaac 1440 agtggcagtg acagggacacactcgccaaa agattacctg cagcagcttc aggagggacg 1500 tccatctgca gcgggcttcgatcggcattt actgtgatta ggaagaaata tccaactgat 1560 ggatctgaaa ttgtgctgctgacggatggg gaagacaaca ctataagtgg gtgctttaac 1620 gaggtcaaac aaagtggtgccatcatccac acagtcgctt tggggccctc tgcagctcaa 1680 gaactagagg agctgtccaaaatgacagga ggtttacaga catatgcttc agatcaagtt 1740 cagaacaatg gcctcattgatgcttttggg gccctttcat caggaaatgg agctgtctct 1800 cagcgctcca tccagcttgagagtaaggga ttaaccctcc agaacagcca gtggatgaat 1860 ggcacagtga tcgtggacagcaccgtggga aaggacactt tgtttcttat cacctggaca 1920 acgcagcctc cccaaatccttctctgggat cccagtggac agaagcaagg tggctttgta 1980 gtggacaaaa acaccaaaatggcctacctc caaatcccag gcattgctaa ggttggcact 2040 tggaaataca gtctgcaagcaagctcacaa accttgaccc tgactgtcac gtcccgtgcg 2100 tccaatgcta ccctgcctccaattacagtg acttccaaaa cgaacaagga caccagcaaa 2160 ttccccagcc ctctggtagtttatgcaaat attcgccaag gagcctcccc aattctcagg 2220 gccagtgtca cagccctgattgaatcagtg aatggaaaaa cagttacctt ggaactactg 2280 gataatggag caggtgctgatgctactaag gatgacggtg tctactcaag gtatttcaca 2340 acttatgaca cgaatggtagatacagtgta aaagtgcggg ctctgggagg agttaacgca 2400 gccagacgga gagtgataccccagcagagt ggagcactgt acatacctgg ctggattgag 2460 aatgatgaaa tacaatggaatccaccaaga cctgaaatta ataaggatga tgttcaacac 2520 aagcaagtgt gtttcagcagaacatcctcg ggaggctcat ttgtggcttc tgatgtccca 2580 aatgctccca tacctgatctcttcccacct ggccaaatca ccgacctgaa ggcggaaatt 2640 cacgggggca gtctcattaatctgacttgg acagctcctg gggatgatta tgaccatgga 2700 acagctcaca agtatatcattcgaataagt acaagtattc ttgatctcag agacaagttc 2760 aatgaatctc ttcaagtgaatactactgct ctcatcccaa aggaagccaa ctctgaggaa 2820 gtctttttgt ttaaaccagaaaacattact tttgaaaatg gcacagatct tttcattgct 2880 attcaggctg ttgataaggtcgatctgaaa tcagaaatat ccaacattgc acgagtatct 2940 ttgtttattc ctccacagactccgccagag acacctagtc ctgatgaaac gtctgctcct 3000 tgtcctaata ttcatatcaacagcaccatt cctggcattc acattttaaa aattatgtgg 3060 aagtggatag gagaactgcagctgtcaata gcctagggct gaatttttgt cagataaata 3120 aaataaatca ttcatcctttttttgattat aaaattttct aaaatgtatt ttagacttcc 3180 tgtagggggc gatatactaaatgtatatag tacatttata ctaaatgtat tcctgtaggg 3240 ggcgatatac taaatgtattttagacttcc tgtagggggc gataaaataa aatgctaaac 3300 aactgggtaa a 3311 <210>SEQ ID NO 48 <211> LENGTH: 3697 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 48 agggagtgtt cccgggggag atactccagt cgtagcaagagtctcgacca ctgaatggaa 60 gaaaaggact tttaaccacc attttgtgac ttacagaaaggaatttgaat aaagaaaact 120 atgatacttc aggcccatct tcactccctg tgtcttcttatgctttattt ggcaactgga 180 tatggccaag aggggaagtt tagtggaccc ctgaaacccatgacattttc tatttatgaa 240 ggccaagaac cgagtcaaat tatattccag tttaaggccaatcctcctgc tgtgactttt 300 gaactaactg gggagacaga caacatattt gtgatagaacgggagggact tctgtattac 360 aacagagcct tggacaggga aacaagatct actcacaatctccaggttgc agccctggac 420 gctaatggaa ttatagtgga gggtccagtc cctatcaccatagaagtgaa ggacatcaac 480 gacaatcgac ccacgtttct ccagtcaaag tacgaaggctcagtaaggca gaactctcgc 540 ccaggaaagc ccttcttgta tgtcaatgcc acagacctggatgatccggc cactcccaat 600 ggccagcttt attaccagat tgtcatccag cttcccatgatcaacaatgt catgtacttt 660 cagatcaaca acaaaacggg agccatctct cttacccgagagggatctca ggaattgaat 720 cctgctaaga atccttccta taatctggtg atctcagtgaaggacatggg aggccagagt 780 gagaattcct tcagtgatac cacatctgtg gatatcatagtgacagagaa tatttggaaa 840 gcaccaaaac ctgtggagat ggtggaaaac tcaactgatcctcaccccat caaaatcact 900 caggtgcggt ggaatgatcc cggtgcacaa tattccttagttgacaaaga gaagctgcca 960 agattcccat tttcaattga ccaggaagga gatatttacgtgactcagcc cttggaccga 1020 gaagaaaagg atgcatatgt tttttatgca gttgcaaaggatgagtacgg aaaaccactt 1080 tcatatccgc tggaaattca tgtaaaagtt aaagatattaatgataatcc acctacatgt 1140 ccgtcaccag taaccgtatt tgaggtccag gagaatgaacgactgggtaa cagtatcggg 1200 acccttactg cacatgacag ggatgaagaa aatactgccaacagttttct aaactacagg 1260 attgtggagc aaactcccaa acttcccatg gatggactcttcctaatcca aacctatgct 1320 ggaatgttac agttagctaa acagtccttg aagaagcaagatactcctca gtacaactta 1380 acgatagagg tgtctgacaa agatttcaag accctttgttttgtgcaaat caacgttatt 1440 gatatcaatg atcagatccc catctttgaa aaatcagattatggaaacct gactcttgct 1500 gaagacacaa acattgggtc caccatctta accatccaggccactgatgc tgatgagcca 1560 tttactggga gttctaaaat tctgtatcat atcataaagggagacagtga gggacgcctg 1620 ggggttgaca cagatcccca taccaacacc ggatatgtcataattaaaaa gcctcttgat 1680 tttgaaacag cagctgtttc caacattgtg ttcaaagcagaaaatcctga gcctctagtg 1740 tttggtgtga agtacaatgc aagttctttt gccaagttcacgcttattgt gacagatgtg 1800 aatgaagcac ctcaattttc ccaacacgta ttccaagcgaaagtcagtga ggatgtagct 1860 ataggcacta aagtgggcaa tgtgactgcc aaggatccagaaggtctgga cataagctat 1920 tcactgaggg gagacacaag aggttggctt aaaattgaccacgtgactgg tgagatcttt 1980 agtgtggctc cattggacag agaagccgga agtccatatcgggtacaagt ggtggccaca 2040 gaagtagggg ggtcttcctt gagctctgtg tcagagttccacctgatcct tatggatgtg 2100 aatgacaacc ctcccaggct agccaaggac tacacgggcttgttcttctg ccatcccctc 2160 agtgcacctg gaagtctcat tttcgaggct actgatgatgatcagcactt atttcggggt 2220 ccccatttta cattttccct cggcagtgga agcttacaaaacgactggga agtttccaaa 2280 atcaatggta ctcatgcccg actgtctacc aggcacacagagtttgagga gagggagtat 2340 gtcgtcttga tccgcatcaa tgatgggggt cggccacccttggaaggcat tgtttcttta 2400 ccagttacat tctgcagttg tgtggaagga agttgtttccggccagcagg tcaccagact 2460 gggataccca ctgtgggcat ggcagttggt atactgctgaccacccttct ggtgattggt 2520 ataattttag cagttgtgtt tatccgcata aagaaggataaaggcaaaga taatgttgaa 2580 agtgctcaag catctgaagt caaacctctg agaagctgaatttgaaaagg aatgtttgaa 2640 tttatatagc aagtgctatt tcagcaacaa ccatctcatcctattacttt tcatctaacg 2700 tgcattataa ttttttaaac agatattccc tcttgtcctttaatatttgc taaatatttc 2760 ttttttgagg tggagtcttg ctctgtcgcc caggctggagtacagtggtg tgatcccagc 2820 tcactgcaac ctccgcctcc tgggttcaca tgattctcctgcctcagctt cctaagtagc 2880 tgggtttaca ggcacccacc accatgccca gctaatttttgtatttttaa tagagacggg 2940 gtttcgccat ttggccaggc tggtcttgaa ctcctgacgtcaagtgatct gcctgccttg 3000 gtctcccaat acaggcatga accactgcac ccacctacttagatatttca tgtgctatag 3060 acattagaga gatttttcat ttttccatga catttttcctctctgcaaat ggcttagcta 3120 cttgtgtttt tcccttttgg ggcaagacag actcattaaatattctgtac attttttctt 3180 tatcaaggag atatatcagt gttgtctcat agaactgcctggattccatt tatgtttttt 3240 ctgattccat cctgtgtccc cttcatcctt gactcctttggtatttcact gaatttcaaa 3300 catttgtcag agaagaaaaa cgtgaggact caggaaaaataaataaataa aagaacagcc 3360 ttttccctta gtattaacag aaatgtttct gtgtcattaaccatctttaa tcaatgtgac 3420 atgttgctct ttggctgaaa ttcttcaact tggaaatgacacagacccac agaaggtgtt 3480 caaacacaac ctactctgca aaccttggta aaggaaccagtcagctggcc agatttcctc 3540 actacctgcc atgcatacat gctgcgcatg ttttcttcattcgtatgtta gtaaagtttt 3600 ggttattata tatttaacat gtggaagaaa acaagacatgaaaagagtgg tgacaaatca 3660 agaataaaca ctggttgtag tcagttttgt ttgttaa 3697<210> SEQ ID NO 49 <211> LENGTH: 3697 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 49 agggagtgtt cccgggggag atactccagt cgtagcaagagtctcgacca ctgaatggaa 60 gaaaaggact tttaaccacc attttgtgac ttacagaaaggaatttgaat aaagaaaact 120 atgatacttc aggcccatct tcactccctg tgtcttcttatgctttattt ggcaactgga 180 tatggccaag aggggaagtt tagtggaccc ctgaaacccatgacattttc tatttatgaa 240 ggccaagaac cgagtcaaat tatattccag tttaaggccaatcctcctgc tgtgactttt 300 gaactaactg gggagacaga caacatattt gtgatagaacgggagggact tctgtattac 360 aacagagcct tggacaggga aacaagatct actcacaatctccaggttgc agccctggac 420 gctaatggaa ttatagtgga gggtccagtc cctatcaccatagaagtgaa ggacatcaac 480 gacaatcgac ccacgtttct ccagtcaaag tacgaaggctcagtaaggca gaactctcgc 540 ccaggaaagc ccttcttgta tgtcaatgcc acagacctggatgatccggc cactcccaat 600 ggccagcttt attaccagat tgtcatccag cttcccatgatcaacaatgt catgtacttt 660 cagatcaaca acaaaacggg agccatctct cttacccgagagggatctca ggaattgaat 720 cctgctaaga atccttccta taatctggtg atctcagtgaaggacatggg aggccagagt 780 gagaattcct tcagtgatac cacatctgtg gatatcatagtgacagagaa tatttggaaa 840 gcaccaaaac ctgtggagat ggtggaaaac tcaactgatcctcaccccat caaaatcact 900 caggtgcggt ggaatgatcc cggtgcacaa tattccttagttgacaaaga gaagctgcca 960 agattcccat tttcaattga ccaggaagga gatatttacgtgactcagcc cttggaccga 1020 gaagaaaagg atgcatatgt tttttatgca gttgcaaaggatgagtacgg aaaaccactt 1080 tcatatccgc tggaaattca tgtaaaagtt aaagatattaatgataatcc acctacatgt 1140 ccgtcaccag taaccgtatt tgaggtccag gagaatgaacgactgggtaa cagtatcggg 1200 acccttactg cacatgacag ggatgaagaa aatactgccaacagttttct aaactacagg 1260 attgtggagc aaactcccaa acttcccatg gatggactcttcctaatcca aacctatgct 1320 ggaatgttac agttagctaa acagtccttg aagaagcaagatactcctca gtacaactta 1380 acgatagagg tgtctgacaa agatttcaag accctttgttttgtgcaaat caacgttatt 1440 gatatcaatg atcagatccc catctttgaa aaatcagattatggaaacct gactcttgct 1500 gaagacacaa acattgggtc caccatctta accatccaggccactgatgc tgatgagcca 1560 tttactggga gttctaaaat tctgtatcat atcataaagggagacagtga gggacgcctg 1620 ggggttgaca cagatcccca taccaacacc ggatatgtcataattaaaaa gcctcttgat 1680 tttgaaacag cagctgtttc caacattgtg ttcaaagcagaaaatcctga gcctctagtg 1740 tttggtgtga agtacaatgc aagttctttt gccaagttcacgcttattgt gacagatgtg 1800 aatgaagcac ctcaattttc ccaacacgta ttccaagcgaaagtcagtga ggatgtagct 1860 ataggcacta aagtgggcaa tgtgactgcc aaggatccagaaggtctgga cataagctat 1920 tcactgaggg gagacacaag aggttggctt aaaattgaccacgtgactgg tgagatcttt 1980 agtgtggctc cattggacag agaagccgga agtccatatcgggtacaagt ggtggccaca 2040 gaagtagggg ggtcttcctt gagctctgtg tcagagttccacctgatcct tatggatgtg 2100 aatgacaacc ctcccaggct agccaaggac tacacgggcttgttcttctg ccatcccctc 2160 agtgcacctg gaagtctcat tttcgaggct actgatgatgatcagcactt atttcggggt 2220 ccccatttta cattttccct cggcagtgga agcttacaaaacgactggga agtttccaaa 2280 atcaatggta ctcatgcccg actgtctacc aggcacacagagtttgagga gagggagtat 2340 gtcgtcttga tccgcatcaa tgatgggggt cggccacccttggaaggcat tgtttcttta 2400 ccagttacat tctgcagttg tgtggaagga agttgtttccggccagcagg tcaccagact 2460 gggataccca ctgtgggcat ggcagttggt atactgctgaccacccttct ggtgattggt 2520 ataattttag cagttgtgtt tatccgcata aagaaggataaaggcaaaga taatgttgaa 2580 agtgctcaag catctgaagt caaacctctg agaagctgaatttgaaaagg aatgtttgaa 2640 tttatatagc aagtgctatt tcagcaacaa ccatctcatcctattacttt tcatctaacg 2700 tgcattataa ttttttaaac agatattccc tcttgtcctttaatatttgc taaatatttc 2760 ttttttgagg tggagtcttg ctctgtcgcc caggctggagtacagtggtg tgatcccagc 2820 tcactgcaac ctccgcctcc tgggttcaca tgattctcctgcctcagctt cctaagtagc 2880 tgggtttaca ggcacccacc accatgccca gctaatttttgtatttttaa tagagacggg 2940 gtttcgccat ttggccaggc tggtcttgaa ctcctgacgtcaagtgatct gcctgccttg 3000 gtctcccaat acaggcatga accactgcac ccacctacttagatatttca tgtgctatag 3060 acattagaga gatttttcat ttttccatga catttttcctctctgcaaat ggcttagcta 3120 cttgtgtttt tcccttttgg ggcaagacag actcattaaatattctgtac attttttctt 3180 tatcaaggag atatatcagt gttgtctcat agaactgcctggattccatt tatgtttttt 3240 ctgattccat cctgtgtccc cttcatcctt gactcctttggtatttcact gaatttcaaa 3300 catttgtcag agaagaaaaa cgtgaggact caggaaaaataaataaataa aagaacagcc 3360 ttttccctta gtattaacag aaatgtttct gtgtcattaaccatctttaa tcaatgtgac 3420 atgttgctct ttggctgaaa ttcttcaact tggaaatgacacagacccac agaaggtgtt 3480 caaacacaac ctactctgca aaccttggta aaggaaccagtcagctggcc agatttcctc 3540 actacctgcc atgcatacat gctgcgcatg ttttcttcattcgtatgtta gtaaagtttt 3600 ggttattata tatttaacat gtggaagaaa acaagacatgaaaagagtgg tgacaaatca 3660 agaataaaca ctggttgtag tcagttttgt ttgttaa 3697<210> SEQ ID NO 50 <211> LENGTH: 3803 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 50 ccatggtagg agcgctcgcc tcgctgcggt gcccgctgaggccatgccgg ggccccggcg 60 ccccgctggc tcccgcctgc gcctgctcct gctcctgctgctgccgccgc tgctgctgct 120 gctccggggc agccacgcgg gcaacctgac ggtagccgtggtactgccgc tggccaatac 180 ctcgtacccc tggtcgtggg cgcgcgtggg acccgccgtggagctggccc tggcccaggt 240 gaaggcgcgc cccgacttgc tgccgggctg gacggtccgcacggtgctgg gcagcagcga 300 aaacgcgctg ggcgtctgct ccgacaccgc agcgcccctggccgcggtgg acctcaagtg 360 ggagcacaac cccgctgtgt tcctgggccc cggctgcgtgtacgccgccg ccccagtggg 420 gcgcttcacc gcgcactggc gggtcccgct gctgaccgccggcgccccgg cgctgggctt 480 cggtgtcaag gacgagtatg cgctgaccac ccgcgcggggcccagctacg ccaagctggg 540 ggacttcgtg gcggcgctgc accgacggct gggctgggagcgccaagcgc tcatgctcta 600 cgcctaccgg ccgggtgacg aagagcactg cttcttcctcgtggaggggc tgttcatgcg 660 ggtccgcgac cgcctcaata ttacggtgga ccacctggagttcgccgagg acgacctcag 720 ccactacacc aggctgctgc ggaccatgcc gcgcaaaggccgagttatct acatctgcag 780 ctcccctgat gccttcagaa ccctcatgct cctggccctggaagctggct tgtgtgggga 840 ggactacgtt ttcttccacc tggatatctt tgggcaaagcctgcaaggtg gacagggccc 900 tgctccccgc aggccctggg agagagggga tgggcaggatgtcagtgccc gccaggcctt 960 tcaggctgcc aaaatcatta catataaaga cccagataatcccgagtact tggaattcct 1020 gaagcagtta aaacacctgg cctatgagca gttcaacttcaccatggagg atggcctggt 1080 gaacaccatc ccagcatcct tccacgacgg gctcctgctctatatccagg cagtgacgga 1140 gactctggca catgggggaa ctgttactga tggggagaacatcactcagc ggatgtggaa 1200 ccgaagcttt caaggtgtga caggatacct gaaaattgatagcagtggcg atcgggaaac 1260 agacttctcc ctctgggata tggatcccga gaatggtgccttcagggttg tactgaacta 1320 caatgggact tcccaagagc tggtggctgt gtcggggcgcaaactgaact ggcccctggg 1380 gtaccctcct cctgacatcc ccaaatgtgg ctttgacaacgaagacccag catgcaacca 1440 agatcacctt tccaccctgg aggtgctggc tttggtgggcagcctctcct tgctcggcat 1500 tctgattgtc tccttcttca tatacaggaa gatgcagctggagaaggaac tggcctcgga 1560 gctgtggcgg gtgcgctggg aggacgttga gcccagtagccttgagaggc acctgcggag 1620 tgcaggcagc cggctgaccc tgagcgggag aggctccaattacggctccc tgctaaccac 1680 agagggccag ttccaagtct ttgccaagac agcatattataagggcaacc tcgtggctgt 1740 gaaacgtgtg aaccgtaaac gcattgagct gacacgaaaagtcctgtttg aactgaagca 1800 tatgcgggat gtgcagaatg aacacctgac caggtttgtgggagcctgca ccgacccccc 1860 caatatctgc atcctcacag agtactgtcc ccgtgggagcctgcaggaca ttctggagaa 1920 tgagagcatc accctggact ggatgttccg gtactcactcaccaatgaca tcgtcaaggg 1980 catgctgttt ctacacaatg gggctatctg ttcccatgggaacctcaagt catccaactg 2040 cgtggtagat gggcgctttg tgctcaagat caccgactatgggctggaga gcttcaggga 2100 cctggaccca gagcaaggac acaccgttta tgccaaaaagctgtggacgg cccctgagct 2160 cctgcgaatg gcttcacccc ctgtgcgggg ctcccaggctggtgacgtat acagctttgg 2220 gatcatcctt caggagattg ccctgaggag tggggtcttccacgtggaag gtttggacct 2280 gagccccaaa gagatcatcg agcgggtgac tcggggtgagcagcccccct tccggccctc 2340 cctggccctg cagagtcacc tggaggagtt ggggctgctcatgcagcggt gctgggctga 2400 ggacccacag gagaggccac cattccagca gatccgcctgacgttgcgca aatttaacag 2460 ggagaacagc agcaacatcc tggacaacct gctgtcccgcatggagcagt acgcgaacaa 2520 tctggaggaa ctggtggagg agcggaccca ggcatacctggaggagaagc gcaaggctga 2580 ggccctgctc taccagatcc tgcctcactc agtggctgagcagctgaagc gtggggagac 2640 ggtgcaggcc gaagcctttg acagtgttac catctacttcagtgacattg tgggtttcac 2700 agcgctgtcg gcggagagca cacccatgca ggtggtgaccctgctcaatg acctgtacac 2760 ttgctttgat gctgtcatag acaactttga tgtgtacaaggtggagacaa ttggcgatgc 2820 ctacatggtg gtgtcagggc tccctgtgcg gaacgggcggctacacgcct gcgaggtagc 2880 ccgcatggcc ctggcactgc tggatgctgt gcgctccttccgaatccgcc accggcccca 2940 ggagcagctg cgcttgcgca ttggcatcca cacaggacctgtgtgtgctg gagtggtggg 3000 actgaagatg ccccgttact gtctctttgg ggatacagtcaacacagcct caagaatgga 3060 gtctaatggg gaagccctga agatccactt gtcttctgagaccaaggctg tcctggagga 3120 gtttggtggt ttcgagctgg agcttcgagg ggatgtagaaatgaagggca aaggcaaggt 3180 tcggacctac tggctccttg gggagagggg gagtagcacccgaggctgac ctgcctcctc 3240 tcctatccct ccacacctcc cctaccctgt gccagaagcaacagaggtgc caggcctcag 3300 cctcacccac agcagcccca tcgccaaagg atggaagtaatttgaatagc tcaggtgtgc 3360 tgaccccagt gaagacacca gataggacct ctgagaggggactggcatgg ggggatctca 3420 gagcttacag gctgagccaa gcccacggcc atgcacagggacactcacac aggcacacgc 3480 acctgctctc cacctggact caggccgggc tgggctgtggatccttgatc ccctcccctc 3540 cccatgctct cctccctcag ccttgctacc ctgtgacttactgggaggag agtcacctga 3600 aggggaacat gaaaagagac taggtgaaga gagggcaggggagcccacat ctggggctgg 3660 cccacaatac ctgctccccc gaccccctcc acccagcagtagacacagtg cacaggggag 3720 aagaggggtg gcgcagaagg gttgggggcc tgtatgccttgcttctacca tgagcagaga 3780 caattaaaat ctttattcca gtg 3803 <210> SEQ IDNO 51 <211> LENGTH: 3803 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 51 ccatggtagg agcgctcgcc tcgctgcggt gcccgctgag gccatgccggggccccggcg 60 ccccgctggc tcccgcctgc gcctgctcct gctcctgctg ctgccgccgctgctgctgct 120 gctccggggc agccacgcgg gcaacctgac ggtagccgtg gtactgccgctggccaatac 180 ctcgtacccc tggtcgtggg cgcgcgtggg acccgccgtg gagctggccctggcccaggt 240 gaaggcgcgc cccgacttgc tgccgggctg gacggtccgc acggtgctgggcagcagcga 300 aaacgcgctg ggcgtctgct ccgacaccgc agcgcccctg gccgcggtggacctcaagtg 360 ggagcacaac cccgctgtgt tcctgggccc cggctgcgtg tacgccgccgccccagtggg 420 gcgcttcacc gcgcactggc gggtcccgct gctgaccgcc ggcgccccggcgctgggctt 480 cggtgtcaag gacgagtatg cgctgaccac ccgcgcgggg cccagctacgccaagctggg 540 ggacttcgtg gcggcgctgc accgacggct gggctgggag cgccaagcgctcatgctcta 600 cgcctaccgg ccgggtgacg aagagcactg cttcttcctc gtggaggggctgttcatgcg 660 ggtccgcgac cgcctcaata ttacggtgga ccacctggag ttcgccgaggacgacctcag 720 ccactacacc aggctgctgc ggaccatgcc gcgcaaaggc cgagttatctacatctgcag 780 ctcccctgat gccttcagaa ccctcatgct cctggccctg gaagctggcttgtgtgggga 840 ggactacgtt ttcttccacc tggatatctt tgggcaaagc ctgcaaggtggacagggccc 900 tgctccccgc aggccctggg agagagggga tgggcaggat gtcagtgcccgccaggcctt 960 tcaggctgcc aaaatcatta catataaaga cccagataat cccgagtacttggaattcct 1020 gaagcagtta aaacacctgg cctatgagca gttcaacttc accatggaggatggcctggt 1080 gaacaccatc ccagcatcct tccacgacgg gctcctgctc tatatccaggcagtgacgga 1140 gactctggca catgggggaa ctgttactga tggggagaac atcactcagcggatgtggaa 1200 ccgaagcttt caaggtgtga caggatacct gaaaattgat agcagtggcgatcgggaaac 1260 agacttctcc ctctgggata tggatcccga gaatggtgcc ttcagggttgtactgaacta 1320 caatgggact tcccaagagc tggtggctgt gtcggggcgc aaactgaactggcccctggg 1380 gtaccctcct cctgacatcc ccaaatgtgg ctttgacaac gaagacccagcatgcaacca 1440 agatcacctt tccaccctgg aggtgctggc tttggtgggc agcctctccttgctcggcat 1500 tctgattgtc tccttcttca tatacaggaa gatgcagctg gagaaggaactggcctcgga 1560 gctgtggcgg gtgcgctggg aggacgttga gcccagtagc cttgagaggcacctgcggag 1620 tgcaggcagc cggctgaccc tgagcgggag aggctccaat tacggctccctgctaaccac 1680 agagggccag ttccaagtct ttgccaagac agcatattat aagggcaacctcgtggctgt 1740 gaaacgtgtg aaccgtaaac gcattgagct gacacgaaaa gtcctgtttgaactgaagca 1800 tatgcgggat gtgcagaatg aacacctgac caggtttgtg ggagcctgcaccgacccccc 1860 caatatctgc atcctcacag agtactgtcc ccgtgggagc ctgcaggacattctggagaa 1920 tgagagcatc accctggact ggatgttccg gtactcactc accaatgacatcgtcaaggg 1980 catgctgttt ctacacaatg gggctatctg ttcccatggg aacctcaagtcatccaactg 2040 cgtggtagat gggcgctttg tgctcaagat caccgactat gggctggagagcttcaggga 2100 cctggaccca gagcaaggac acaccgttta tgccaaaaag ctgtggacggcccctgagct 2160 cctgcgaatg gcttcacccc ctgtgcgggg ctcccaggct ggtgacgtatacagctttgg 2220 gatcatcctt caggagattg ccctgaggag tggggtcttc cacgtggaaggtttggacct 2280 gagccccaaa gagatcatcg agcgggtgac tcggggtgag cagccccccttccggccctc 2340 cctggccctg cagagtcacc tggaggagtt ggggctgctc atgcagcggtgctgggctga 2400 ggacccacag gagaggccac cattccagca gatccgcctg acgttgcgcaaatttaacag 2460 ggagaacagc agcaacatcc tggacaacct gctgtcccgc atggagcagtacgcgaacaa 2520 tctggaggaa ctggtggagg agcggaccca ggcatacctg gaggagaagcgcaaggctga 2580 ggccctgctc taccagatcc tgcctcactc agtggctgag cagctgaagcgtggggagac 2640 ggtgcaggcc gaagcctttg acagtgttac catctacttc agtgacattgtgggtttcac 2700 agcgctgtcg gcggagagca cacccatgca ggtggtgacc ctgctcaatgacctgtacac 2760 ttgctttgat gctgtcatag acaactttga tgtgtacaag gtggagacaattggcgatgc 2820 ctacatggtg gtgtcagggc tccctgtgcg gaacgggcgg ctacacgcctgcgaggtagc 2880 ccgcatggcc ctggcactgc tggatgctgt gcgctccttc cgaatccgccaccggcccca 2940 ggagcagctg cgcttgcgca ttggcatcca cacaggacct gtgtgtgctggagtggtggg 3000 actgaagatg ccccgttact gtctctttgg ggatacagtc aacacagcctcaagaatgga 3060 gtctaatggg gaagccctga agatccactt gtcttctgag accaaggctgtcctggagga 3120 gtttggtggt ttcgagctgg agcttcgagg ggatgtagaa atgaagggcaaaggcaaggt 3180 tcggacctac tggctccttg gggagagggg gagtagcacc cgaggctgacctgcctcctc 3240 tcctatccct ccacacctcc cctaccctgt gccagaagca acagaggtgccaggcctcag 3300 cctcacccac agcagcccca tcgccaaagg atggaagtaa tttgaatagctcaggtgtgc 3360 tgaccccagt gaagacacca gataggacct ctgagagggg actggcatggggggatctca 3420 gagcttacag gctgagccaa gcccacggcc atgcacaggg acactcacacaggcacacgc 3480 acctgctctc cacctggact caggccgggc tgggctgtgg atccttgatcccctcccctc 3540 cccatgctct cctccctcag ccttgctacc ctgtgactta ctgggaggagagtcacctga 3600 aggggaacat gaaaagagac taggtgaaga gagggcaggg gagcccacatctggggctgg 3660 cccacaatac ctgctccccc gaccccctcc acccagcagt agacacagtgcacaggggag 3720 aagaggggtg gcgcagaagg gttgggggcc tgtatgcctt gcttctaccatgagcagaga 3780 caattaaaat ctttattcca gtg 3803 <210> SEQ ID NO 52 <211>LENGTH: 1155 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 52atggattgca gtaacggatc ggcagagtgt accggagaag gaggatcaaa agaggtggtg 60gggactttta aggctaaaga cctaatagtc acaccagcta ccattttaaa ggaaaaacca 120gaccccaata atctggtttt tggaactgtg ttcacggatc atatgctgac ggtggagtgg 180tcctcagagt ttggatggga gaaacctcat atcaagcctc ttcagaacct gtcattgcac 240cctggctcat cagctttgca ctatgcagtg gaattatttg aaggattgaa ggcatttcga 300ggagtagata ataaaattcg actgtttcag ccaaacctca acatggatag aatgtatcgc 360tctgctgtga gggcaactct gccggtattt gacaaagaag agctcttaga gtgtattcaa 420cagcttgtga aattggatca agaatgggtc ccatattcaa catctgctag tctgtatatt 480cgtcctgcat tcattggaac tgagccttct cttggagtca agaagcctac caaagccctg 540ctctttgtac tcttgagccc agtgggacct tatttttcaa gtggaacctt taatccagtg 600tccctgtggg ccaatcccaa gtatgtaaga gcctggaaag gtggaactgg ggactgcaag 660atgggaggga attacggctc atctcttttt gcccaatgtg aagacgtaga taatgggtgt 720cagcaggtcc tgtggctcta tggcagagac catcagatca ctgaagtggg aactatgaat 780ctttttcttt actggataaa tgaagatgga gaagaagaac tggcaactcc tccactagat 840ggcatcattc ttccaggagt gacaaggcgg tgcattctgg acctggcaca tcagtggggt 900gaatttaagg tgtcagagag atacctcacc atggatgact tgacaacagc cctggagggg 960aacagagtga gagagatgtt tagctctggt acagcctgtg ttgtttgccc agtttctgat 1020atactgtaca aaggcgagac aatacacatt ccaactatgg agaatggtcc taagctggca 1080agccgcatct tgagcaaatt aactgatatc cagtatggaa gagaagagag cgactggaca 1140attgtgctat cctga 1155 <210> SEQ ID NO 53 <211> LENGTH: 2511 <212> TYPE:DNA <213> ORGANISM: human <400> SEQUENCE: 53 cttttcacac tggccttaaagaggatatat tagaagttga agtaggaagg gagccagaga 60 ggccgatggc gcaaaggtacgacgatctac cccattacgg gggcatggat ggagtaggca 120 tcccctccac gatgtatggggacccgcatg cagccaggtc catgcagccg gtccaccacc 180 tgaaccacgg gcctcctctgcactcgcatc agtacccgca cacagctcat accaacgcca 240 tggcccccag catgggctcctctgtcaatg acgctttaaa gagagataaa gatgccattt 300 atggacaccc cctcttccctctcttagcac tgatttttga gaaatgtgaa ttagctactt 360 gtaccccccg cgagccgggggtggcgggcg gggacgtctg ctcgtcagag tcattcaatg 420 aagatatagc cgtgttcgccaaacagattc gcgcagaaaa acctctattt tcttctaatc 480 cagaactgga taacttgatgattcaagcca tacaagtatt aaggtttcat ctattggaat 540 tagagaaggt acacgaattatgtgacaatt tctgccaccg gtatattagc tgtttgaaag 600 ggaaaatgcc tatcgatttggtgatagacg atagagaagg aggatcaaaa tcagacagtg 660 aagatataac aagatcagcaaatctaactg accagccctc ttggaacaga gatcatgatg 720 acacggcatc tactcgttcaggaggaaccc caggcccttc cagcggtggc cacacgtcac 780 acagtgggga caacagcagtgagcaaggtg atggcttgga caacagtgta gcttccccca 840 gcacaggtga cgatgatgaccctgataagg acaaaaagcg tcacaaaaag cgtggcatct 900 ttcccaaagt agccacaaatatcatgaggg cgtggctgtt ccagcatcta acacaccctt 960 acccttctga agaacagaaaaagcagttgg cacaagacac gggactcacc atccttcaag 1020 tgaacaattg gtttattaatgcccggagaa gaatagtgca gcccatgata gaccagtcca 1080 accgagcagt aagtcaaggaacaccttata atcctgatgg acagcccatg ggaggtttcg 1140 taatggacgg tcagcaacatatgggaatta gagcaccagg acctatgagt ggaatgggca 1200 tgaatatggg catggaggggcagtggcact acatgtaacc ttcatctagt taaccaatcg 1260 caaagcaagg gggaaggctgcaaagtatgc caggggagta tgtagcccgg ggtggtccaa 1320 tgggtgtgag tatgggacagccaagttata cccaacccca gatgcccccc catcctgctc 1380 agctgcgtca tgggccccccatgcatacgt acattcctgg acaccctcac cacccaacag 1440 tgatgatgca tggaggaccgccccaccctg gaatgccaat gtcagcatca agccccacag 1500 ttcttaatac aggagacccaacaatgagtg gacaagtcat ggacattcat gctcagtagc 1560 ttaagggaat atgcattgtctgcaatggtg actgatttca aatcatgttt tttctgcaat 1620 gactgtggag ttccattcttggcatctact ctggaccaag gagcatccct aattcttcat 1680 agggaccttt aaaaagcaggaaataccaac tgaagtcaat ttgggggaca tgctaaataa 1740 ctatataaga cattaagagaacaaagagtg aaatattgta aatgctatta tactgttatc 1800 catattacgt tgtttcttatagatttttta aaaaaaatgt gaaatttttc cacactatgt 1860 gtgttgtttc catagctcttcacttcctcc agaagcctcc ttacattaaa aagccttaca 1920 gttatcctgc aagggacaggaaggtctgat ttgcaggatt tttagagcat taaaataact 1980 atcaggcaga agaatctttcttctcgccta ggatttcagc catgcgcgcg ctctctctct 2040 ttctctctct tttcctctctctccctcttt ctagcctggg gcttgaattt gcatgtctaa 2100 ttcatttact caccatatttgaattggcct gaacagatgt aaatcgggaa ggatgggaaa 2160 aactgcagtc atcaacaatgattaatcagc tgttgcaggc agtgtcttaa ggagactggt 2220 aggaggaggc atggaaaccaaaaggccgtg tgtttagaag cctaattgtc acatcaagca 2280 tcattgtccc catgcaacaaccaccacctt atacatcact tcctgtttta agcagctcta 2340 aaacatagac tgaagatttatttttaatat gttgacttta tttctgagca aagcatcggt 2400 catgtgtgta ttttttcatagtcccacctt ggagcattta tgtagacatt gtaaataaat 2460 tttgtgcaaa aaggactggaaaaatgaact gtattattgc aatttttttt t 2511 <210> SEQ ID NO 54 <211> LENGTH:1887 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 54 tcgcccaattccgggctcag acactgggct cccagctggg gactgctcca tggccatgga 60 gatagacagcaggcctgggg ggctccccgg cagtagctgc aacctaggtg cagcccgaga 120 acacatgcaggcggtcaccc gaaactacat cacccacccc cgtgtcacct acaggactgt 180 gtgcagcgtgaacgggcccc tggtggtgct ggaccgggtc aagtttgccc agtatgcgga 240 gatcgtccacttcaccctcc cagatgggac tcagaggagc gggcaggtgc ttgaggtggc 300 tggcaccaaggcgattgttc aggtgtttga agggacatca gggatcgatg ccaggaagac 360 cacttgcgaatttacagggg acatcctacg aactccggtg tcagaggaca tgctgggtcg 420 ggttttcaatggctccggca agcccattga caaggggcca gtggtcatgg cggaggactt 480 tctggatatcaatggccagc ccatcaaccc gcactcccgc atctaccccg aggagatgat 540 tcagacgggcatttctccta ttgacgtcat gaacagcatt gcccgcggcc agaagatccc 600 catcttctcagcagccgggc tcccccacaa tgagattgcc gctcagatct gccgccaggc 660 ggggctggtgaagaagtcca aggctgtgct ggattaccat gacgacaact tcgccatcgt 720 ctttgcagccatgggggtga acatggagac agccagattc ttcaagtctg actttgagca 780 gaatggaaccatggggaacg tctgcctctt cctgaacttg gccaatgacc ccacgatcga 840 gcggatcatcaccccgcgcc tggcgctgac cactgctgaa ttccttgcct accagtgtga 900 gaagcatgtgctggtcatac tgacggacat gagttcctat gcagaggcct tgcgggaggt 960 ctctgctgctagagaggagg tgcctgggcg ccgagggttt cctggatata tgtacacaga 1020 cctggccaccatctacgagc gggcgggccg tgtggagggt cggggaggat ccatcacaca 1080 gatccccatcctcaccatgc ccaacgacga tatcacccac cctatcccag acttgacggg 1140 cttcatcacagagggacaga tctacgtgga cagacagctt cacaacagac agatctaccc 1200 ccccatcaacgtgctccctt ccctgtcgcg gctgatgaag tcagccattg gggaaggcat 1260 gacaagaaaggaccatggag atgtctccaa ccagctgtac gcctgctatg ccatcgggaa 1320 ggacgtgcaggccatgaagg cagtagttgg ggaggaggcg ctcacctctg aggacctgct 1380 ctacctggaattcctgcaga agtttgagaa gaacttcatc aatcagggcc cctacgagaa 1440 ccgctcgatgttcgagtcgc tggaccttag ctggaagctg ctgcgcatct tccccaagga 1500 gatgctgaagcgcattccgc aggccgtgat cgacgagttc tattcccgcg aggggcggct 1560 gcaggacctcgcgcctgaca ctgcgctcta gccccgcgcg ccgtggcacc ccaacaccgg 1620 caggaacctaccctcggctc ccgggtctcc ccgtccctcg ccacccctaa ccagcggctt 1680 tcgcgccgccctccgccctc cgtggctccg aggtggtggg gggcgccgca gtcatccctt 1740 tcctcgctcgattccttttc ccgcgctcca tgcctccccc tcagctcccg gtgctgcgga 1800 agaactgaaggttcatgcct actctgacgg gagcatctgt attttttatg ttaaaagccc 1860 acaaaataaaaataaaaatg aactgag 1887 <210> SEQ ID NO 55 <211> LENGTH: 1506 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 55 aggcggacaa agcccgattgttcctgggcc ctttccccat cgcgcctggg cctgctcccc 60 agcccggggc aggggcgggggccagtgtgg tgacacacgc tgtagctgtc tccccggctg 120 gctggctcgc tctctcctggggacacagag gtcggcaggc agcacacaga gggacctacg 180 ggcagctgtt ccttcccccgactcaagaat ccccggaggc ccggaggcct gcagcaggag 240 cggccatgaa gaagctgatggtggtgctga gtctgattgc tgcagcctgg gcagaggagc 300 agaataagtt ggtgcatggcggaccctgcg acaagacatc tcacccctac caagctgccc 360 tctacacctc gggccacttgctctgtggtg gggtccttat ccatccactg tgggtcctca 420 cagctgccca ctgcaaaaaaccgaatcttc aggtcttcct ggggaagcat aaccttcggc 480 aaagggagag ttcccaggagcagagttctg ttgtccgggc tgtgatccac cctgactatg 540 atgccgccag ccatgaccaggacatcatgc tgttgcgcct ggcacgccca gccaaactct 600 ctgaactcat ccagccccttcccctggaga gggactgctc agccaacacc accagctgcc 660 acatcctggg ctggggcaagacagcagatg gtgatttccc tgacaccatc cagtgtgcat 720 acatccacct ggtgtcccgtgaggagtgtg agcatgccta ccctggccag atcacccaga 780 acatgttgtg tgctggggatgagaagtacg ggaaggattc ctgccagggt gattctgggg 840 gtccgctggt atgtggagaccacctccgag gccttgtgtc atggggtaac atcccctgtg 900 gatcaaagga gaagccaggagtctacacca acgtctgcag atacacgaac tggatccaaa 960 aaaccattca ggccaagtgaccctgacatg tgacatctac ctcccgacct accaccccac 1020 tggctggttc cagaacgtctctcacctaga ccttgcctcc cctcctctcc tgcccagctc 1080 tgaccctgat gcttaataaacgcagcgacg tgagggtcct gattctccct ggttttaccc 1140 cagctccatc cttgcatcactggggaggac gtgatgagtg aggacttggg tcctcggtct 1200 tacccccacc actaagagaatacaggaaaa tcccttctag gcatctcctc tccccaaccc 1260 ttccacacgt ttgatttcttcctgcagagg cccagccacg tgtctggaat cccagctccg 1320 ctgcttactg tcggtgtccccttgggatgt acctttcttc actgcagatt tctcacctgt 1380 aagatgaaga taaggatgatacagtctcca tcaggcagtg gctgttggaa agatttaaga 1440 tttcacacct atgacatacatgggatagca cctgggccgc catgcactca ataaagaatg 1500 tatttt 1506 <210> SEQID NO 56 <211> LENGTH: 2907 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 56 gccatctggg cccaggcccc atgccccgag gaggggtggt ctgaagcccaccagagcccc 60 ctgccagact gtctgcctcc cttctgactg tggccgcttg gcatggccagcaacagcagc 120 tcctgcccga cacctggggg cgggcacctc aatgggtacc cggtgcctccctacgccttc 180 ttcttccccc ctatgctggg tggactctcc ccgccaggcg ctctgaccactctccagcac 240 cagcttccag ttagtggata tagcacacca tccccagcca ccattgagacccagagcagc 300 agttctgaag agatagtgcc cagccctccc tcgccacccc ctctaccccgcatctacaag 360 ccttgctttg tctgtcagga caagtcctca ggctaccact atggggtcagcgcctgtgag 420 ggctgcaagg gcttcttccg ccgcagcatc cagaagaaca tggtgtacacgtgtcaccgg 480 gacaagaact gcatcatcaa caaggtgacc cggaaccgct gccagtactgccgactgcag 540 aagtgctttg aagtgggcat gtccaaggag tctgtgagaa acgaccgaaacaagaagaag 600 aaggaggtgc ccaagcccga gtgctctgag agctacacgc tgacgccggaggtgggggag 660 ctcattgaga aggtgcgcaa agcgcaccag gaaaccttcc ctgccctctgccagctgggc 720 aaatacacta cgaacaacag ctcagaacaa cgtgtctctc tggacattgacctctgggac 780 aagttcagtg aactctccac caagtgcatc attaagactg tggagttcgccaagcagctg 840 cccggcttca ccaccctcac catcgccgac cagatcaccc tcctcaaggctgcctgcctg 900 gacatcctga tcctgcggat ctgcacgcgg tacacgcccg agcaggacaccatgaccttc 960 tcggacgggc tgaccctgaa ccggacccag atgcacaacg ctggcttcggccccctcacc 1020 gacctggtct ttgccttcgc caaccagctg ctgcccctgg agatggatgatgcggagacg 1080 gggctgctca gcgccatctg cctcatctgc ggagaccgcc aggacctggagcagccggac 1140 cgggtggaca tgctgcagga gccgctgctg gaggcgctaa aggtctacgtgcggaagcgg 1200 aggcccagcc gcccccacat gttccccaag atgctaatga agattactgacctgcgaagc 1260 atcagcgcca agggggctga gcgggtgatc acgctgaaga tggagatcccgggctccatg 1320 ccgcctctca tccaggaaat gttggagaac tcagagggcc tggacactctgagcggacag 1380 ccggggggtg gggggcggga cgggggtggc ctggcccccc cgccaggcagctgtagcccc 1440 agcctcagcc ccagctccaa cagaagcagc ccggccaccc actccccgtgaccgcccacg 1500 ccacatggac acagccctcg ccctccgccc cggcttttct ctgcctttctaccgaccatg 1560 tgaccccgca ccagccctgc ccccacctgc cctcccgggc agtactggggaccttccctg 1620 ggggacgggg agggaggagg cagcgactcc ttggacagag gcctgggccctcagtggact 1680 gcctgctccc acagcctggg ctgacgtcag aggccgaggc caggaactgagtgaggcccc 1740 tggtcctggg tctcaggatg ggtcctgggg gcctcgtgtt catcaagacacccctctgcc 1800 cagctcacca catcttcatc accagcaaac gccaggactt ggctcccccatcctcagaac 1860 tcacaagcca ttgctcccca gctggggaac ctcaacctcc cccctgcctcggttggtgac 1920 agagggggtg ggacaggggc ggggggttcc ccctgtacat accctgccataccaacccca 1980 ggtattaatt ctcgctggtt ttgtttttat tttaattttt ttgttttgatttttttaata 2040 agaattttca ttttaagcac atttatactg aaggaatttg tgctgtgtattggggggagc 2100 tggatccaga gctggagggg gtgggtccgg gggagggagt ggctcggaaggggcccccac 2160 tctcctttca tgtccctgtg ccccccagtt ctcctcctca gccttttcctcctcagtttt 2220 ctctttaaaa ctgtgaagta ctaactttcc aaggcctgcc ttcccctccctcccactgga 2280 gaagccgcca gcccctttct ccctctgcct gaccactggg tgtggacggtgtggggcagc 2340 cctgaaagga caggctcctg gccttggcac ttgcctgcac ccaccatgaggcatggagca 2400 gggcagagca agggccccgg gacagagttt tcccagacct ggctcctcggcagagctgcc 2460 tcccgtcagg gcccacatca tctaggctcc ccagccccca ctgtgaaggggctggccagg 2520 ggcccgagct gcccccaccc ccggcctcag ccaccagcac ccccatagggcccccagaca 2580 ccacacacat gcgcgtgcgc acacacacaa acacacacac actggacagtagatgggccg 2640 acacacactt ggcccgagtt cctccatttc cctggcctgc cccccacccccaacctgtcc 2700 cacccccgtg ccccctcctt accccgcagg acgggcctac aggggggtctcccctcaccc 2760 ctgcaccccc agctggggga gctggctctg ccccgacctc cttcaccaggggttggggcc 2820 ccttcccctg gagcccgtgg gtgcacctgt tactgttggg ctttccactgagatctactg 2880 gataaagaat aaagttctat ttattct 2907 <210> SEQ ID NO 57<211> LENGTH: 2907 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE:57 gccatctggg cccaggcccc atgccccgag gaggggtggt ctgaagccca ccagagcccc 60ctgccagact gtctgcctcc cttctgactg tggccgcttg gcatggccag caacagcagc 120tcctgcccga cacctggggg cgggcacctc aatgggtacc cggtgcctcc ctacgccttc 180ttcttccccc ctatgctggg tggactctcc ccgccaggcg ctctgaccac tctccagcac 240cagcttccag ttagtggata tagcacacca tccccagcca ccattgagac ccagagcagc 300agttctgaag agatagtgcc cagccctccc tcgccacccc ctctaccccg catctacaag 360ccttgctttg tctgtcagga caagtcctca ggctaccact atggggtcag cgcctgtgag 420ggctgcaagg gcttcttccg ccgcagcatc cagaagaaca tggtgtacac gtgtcaccgg 480gacaagaact gcatcatcaa caaggtgacc cggaaccgct gccagtactg ccgactgcag 540aagtgctttg aagtgggcat gtccaaggag tctgtgagaa acgaccgaaa caagaagaag 600aaggaggtgc ccaagcccga gtgctctgag agctacacgc tgacgccgga ggtgggggag 660ctcattgaga aggtgcgcaa agcgcaccag gaaaccttcc ctgccctctg ccagctgggc 720aaatacacta cgaacaacag ctcagaacaa cgtgtctctc tggacattga cctctgggac 780aagttcagtg aactctccac caagtgcatc attaagactg tggagttcgc caagcagctg 840cccggcttca ccaccctcac catcgccgac cagatcaccc tcctcaaggc tgcctgcctg 900gacatcctga tcctgcggat ctgcacgcgg tacacgcccg agcaggacac catgaccttc 960tcggacgggc tgaccctgaa ccggacccag atgcacaacg ctggcttcgg ccccctcacc 1020gacctggtct ttgccttcgc caaccagctg ctgcccctgg agatggatga tgcggagacg 1080gggctgctca gcgccatctg cctcatctgc ggagaccgcc aggacctgga gcagccggac 1140cgggtggaca tgctgcagga gccgctgctg gaggcgctaa aggtctacgt gcggaagcgg 1200aggcccagcc gcccccacat gttccccaag atgctaatga agattactga cctgcgaagc 1260atcagcgcca agggggctga gcgggtgatc acgctgaaga tggagatccc gggctccatg 1320ccgcctctca tccaggaaat gttggagaac tcagagggcc tggacactct gagcggacag 1380ccggggggtg gggggcggga cgggggtggc ctggcccccc cgccaggcag ctgtagcccc 1440agcctcagcc ccagctccaa cagaagcagc ccggccaccc actccccgtg accgcccacg 1500ccacatggac acagccctcg ccctccgccc cggcttttct ctgcctttct accgaccatg 1560tgaccccgca ccagccctgc ccccacctgc cctcccgggc agtactgggg accttccctg 1620ggggacgggg agggaggagg cagcgactcc ttggacagag gcctgggccc tcagtggact 1680gcctgctccc acagcctggg ctgacgtcag aggccgaggc caggaactga gtgaggcccc 1740tggtcctggg tctcaggatg ggtcctgggg gcctcgtgtt catcaagaca cccctctgcc 1800cagctcacca catcttcatc accagcaaac gccaggactt ggctccccca tcctcagaac 1860tcacaagcca ttgctcccca gctggggaac ctcaacctcc cccctgcctc ggttggtgac 1920agagggggtg ggacaggggc ggggggttcc ccctgtacat accctgccat accaacccca 1980ggtattaatt ctcgctggtt ttgtttttat tttaattttt ttgttttgat ttttttaata 2040agaattttca ttttaagcac atttatactg aaggaatttg tgctgtgtat tggggggagc 2100tggatccaga gctggagggg gtgggtccgg gggagggagt ggctcggaag gggcccccac 2160tctcctttca tgtccctgtg ccccccagtt ctcctcctca gccttttcct cctcagtttt 2220ctctttaaaa ctgtgaagta ctaactttcc aaggcctgcc ttcccctccc tcccactgga 2280gaagccgcca gcccctttct ccctctgcct gaccactggg tgtggacggt gtggggcagc 2340cctgaaagga caggctcctg gccttggcac ttgcctgcac ccaccatgag gcatggagca 2400gggcagagca agggccccgg gacagagttt tcccagacct ggctcctcgg cagagctgcc 2460tcccgtcagg gcccacatca tctaggctcc ccagccccca ctgtgaaggg gctggccagg 2520ggcccgagct gcccccaccc ccggcctcag ccaccagcac ccccataggg cccccagaca 2580ccacacacat gcgcgtgcgc acacacacaa acacacacac actggacagt agatgggccg 2640acacacactt ggcccgagtt cctccatttc cctggcctgc cccccacccc caacctgtcc 2700cacccccgtg ccccctcctt accccgcagg acgggcctac aggggggtct cccctcaccc 2760ctgcaccccc agctggggga gctggctctg ccccgacctc cttcaccagg ggttggggcc 2820ccttcccctg gagcccgtgg gtgcacctgt tactgttggg ctttccactg agatctactg 2880gataaagaat aaagttctat ttattct 2907 <210> SEQ ID NO 58 <211> LENGTH: 5026<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 58 agaggaggaaattgttcctc gtctgataag acaacagtgg agaaaggacg catgctgttt 60 cttagggacacggctgactt ccagatatga ccatgtattt gtggcttaaa ctcttggcat 120 ttggctttgcctttctggac acagaagtat ttgtgacagg gcaaagccca acaccttccc 180 ccactggattgactacagca aagatgccca gtgttccact ttcaagtgac cccttaccta 240 ctcacaccactgcattctca cccgcaagca cctttgaaag agaaaatgac ttctcagaga 300 ccacaacttctcttagtcca gacaatactt ccacccaagt atccccggac tctttggata 360 atgctagtgcttttaatacc acaggtgttt catcagtaca gacgcctcac cttcccacgc 420 acgcagactcgcagacgccc tctgctggaa ctgacacgca gacattcagc ggctccgccg 480 ccaatgcaaaactcaaccct accccaggca gcaatgctat ctcagatgtc ccaggagaga 540 ggagtacagccagcaccttt cctacagacc cagtttcccc attgacaacc accctcagcc 600 ttgcacaccacagctctgct gccttacctg cacgcacctc caacaccacc atcacagcga 660 acacctcagatgcctacctt aatgcctctg aaacaaccac tctgagccct tctggaagcg 720 ctgtcatttcaaccacaaca atagctacta ctccatctaa gccaacatgt gatgaaaaat 780 atgcaaacatcactgtggat tacttatata acaaggaaac taaattattt acagcaaagc 840 taaatgttaatgagaatgtg gaatgtggaa acaatacttg cacaaacaat gaggtgcata 900 accttacagaatgtaaaaat gcgtctgttt ccatatctca taattcatgt actgctcctg 960 ataagacattaatattagat gtgccaccag gggttgaaaa gtttcagtta catgattgta 1020 cacaagttgaaaaagcagat actactattt gtttaaaatg gaaaaatatt gaaaccttta 1080 cttgtgatacacagaatatt acctacagat ttcagtgtgg taatatgata tttgataata 1140 aagaaattaaattagaaaac cttgaacccg aacatgagta taagtgtgac tcagaaatac 1200 tctataataaccacaagttt actaacgcaa gtaaaattat taaaacagat tttgggagtc 1260 caggagagcctcagattatt ttttgtagaa gtgaagctgc acatcaagga gtaattacct 1320 ggaatccccctcaaagatca tttcataatt ttaccctctg ttatataaaa gagacagaaa 1380 aagattgcctcaatctggat aaaaacctga tcaaatatga tttgcaaaat ttaaaacctt 1440 atacgaaatatgttttatca ttacatgcct acatcattgc aaaagtgcaa cgtaatggaa 1500 gtgctgcaatgtgtcatttc acaactaaaa gtgctcctcc aagccaggtc tggaacatga 1560 ctgtctccatgacatcagat aatagtatgc atgtcaagtg taggcctccc agggaccgta 1620 atggcccccatgaacgttac catttggaag ttgaagctgg aaatactctg gttagaaatg 1680 agtcgcataagaattgcgat ttccgtgtaa aagatcttca atattcaaca gactacactt 1740 ttaaggcctattttcacaat ggagactatc ctggagaacc ctttatttta catcattcaa 1800 catcttataattctaaggca ctgatagcat ttctggcatt tctgattatt gtgacatcaa 1860 tagccctgcttgttgttctc tacaaaatct atgatctaca taagaaaaga tcctgcaatt 1920 tagatgaacagcaggagctt gttgaaaggg atgatgaaaa acaactgatg aatgtggagc 1980 caatccatgcagatattttg ttggaaactt ataagaggaa gattgctgat gaaggaagac 2040 tttttctggctgaatttcag agcatcccgc gggtgttcag caagtttcct ataaaggaag 2100 ctcgaaagccctttaaccag aataaaaacc gttatgttga cattcttcct tatgattata 2160 accgtgttgaactctctgag ataaacggag atgcagggtc aaactacata aatgccagct 2220 atattgatggtttcaaagaa cccaggaaat acattgctgc acaaggtccc agggatgaaa 2280 ctgttgatgatttctggagg atgatttggg aacagaaagc cacagttatt gtcatggtca 2340 ctcgatgtgaagaaggaaac aggaacaagt gtgcagaata ctggccgtca atggaagagg 2400 gcactcgggcttttggagat gttgttgtaa agatcaacca gcacaaaaga tgtccagatt 2460 acatcattcagaaattgaac attgtaaata aaaaagaaaa agcaactgga agagaggtga 2520 ctcacattcagttcaccagc tggccagacc acggggtgcc tgaggatcct cacttgctcc 2580 tcaaactgagaaggagagtg aatgccttca gcaatttctt cagtggtccc attgtggtgc 2640 actgcagtgctggtgttggg cgcacaggaa cctatatcgg aattgatgcc atgctagaag 2700 gcctggaagccgagaacaaa gtggatgttt atggttatgt tgtcaagcta aggcgacaga 2760 gatgcctgatggttcaagta gaggcccagt acatcttgat ccatcaggct ttggtggaat 2820 acaatcagtttggagaaaca gaagtgaatt tgtctgaatt acatccatat ctacataaca 2880 tgaagaaaagggatccaccc agtgagccgt ctccactaga ggctgaattc cagagacttc 2940 cttcatataggagctggagg acacagcaca ttggaaatca agaagaaaat aaaagtaaaa 3000 acaggaattctaatgtcatc ccatatgact ataacagagt gccacttaaa catgagctgg 3060 aaatgagtaaagagagtgag catgattcag atgaatcctc tgatgatgac agtgattcag 3120 aggaaccaagcaaatacatc aatgcatctt ttataatgag ctactggaaa cctgaagtga 3180 tgattgctgctcagggacca ctgaaggaga ccattggtga cttttggcag atgatcttcc 3240 aaagaaaagtcaaagttatt gttatgctga cagaactgaa acatggagac caggaaatct 3300 gtgctcagtactggggagaa ggaaagcaaa catatggaga tattgaagtt gacctgaaag 3360 acacagacaaatcttcaact tatacccttc gtgtctttga actgagacat tccaagagga 3420 aagactctcgaactgtgtac cagtaccaat atacaaactg gagtgtggag cagcttcctg 3480 cagaacccaaggaattaatc tctatgattc aggtcgtcaa acaaaaactt ccccagaaga 3540 attcctctgaagggaacaag catcacaaga gtacacctct actcattcac tgcagggatg 3600 gatctcagcaaacgggaata ttttgtgctt tgttaaatct cttagaaagt gcggaaacag 3660 aagaggtagtggatattttt caagtggtaa aagctctacg caaagctagg ccaggcatgg 3720 tttccacattcgagcaatat caattcctat atgacgtcat tgccagcacc taccctgctc 3780 agaatggacaagtaaagaaa aacaaccatc aagaagataa aattgaattt gataatgaag 3840 tggacaaagtaaagcaggat gctaattgtg ttaatccact tggtgcccca gaaaagctcc 3900 ctgaagcaaaggaacaggct gaaggttctg aacccacgag tggcactgag gggccagaac 3960 attctgtcaatggtcctgca agtccagctt taaatcaagg ttcataggaa aagacataaa 4020 tgaggaaactccaaacctcc tgttagctgt tatttctatt tttgtagaag taggaagtga 4080 aaataggtatacagtggatt aattaaatgc agcgaaccaa tatttgtaga agggttatat 4140 tttactactgtggaaaaata tttaagatag ttttgccaga acagtttgta cagacgtatg 4200 cttattttaaaattttatct cttattcagt aaaaaacaac ttctttgtaa tcgttatgtg 4260 tgtatatgtatgtgtgtatg ggtgtgtgtt tgtgtgagag acagagaaag agagagaatt 4320 ctttcaagtgaatctaaaag cttttgcttt tcctttgttt ttatgaagaa aaaatacatt 4380 ttatattagaagtgttaact tagcttgaag gatctgtttt taaaaatcat aaactgtgtg 4440 cagactcaataaaatcatgt acatttctga aatgacctca agatgtcctc cttgttctac 4500 tcatatatatctatcttata tacttactat tttacttcta gagatagtac ataaaggtgg 4560 tatgtgtgtgtatgctacta caaaaaagtt gttaactaaa ttaacattgg gaaatcttat 4620 attccatatattagcattta gtccaatgtc tttttaagct tatttaatta aaaaatttcc 4680 agtgagcttatcatgctgtc tttacatggg gttttcaatt ttgcatgctc gattattccc 4740 tgtacaatatttaaaattta ttgcttgata cttttgacaa caaattaggt tttgtacaat 4800 tgaacttaaataaatgtcat taaaataaat aaatgcaata tgtattaata ttcattgtat 4860 aaaaatagaagaatacaaac atatttgtta aatatttaca tatgaaattt aatatagcta 4920 tttttatggaatttttcatt gatatgaaaa atatgatatt gcatatgcat agttcccatg 4980 ttaaatcccattcataactt tcattaaagc atttactttg aatttc 5026 <210> SEQ ID NO 59 <211>LENGTH: 624 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 59ggcgggccgc tcccacttcg gcacgagggg cacgaggtaa atcttttctg cttactgaaa 60aggaagagtc tgatgattag ttactgatcc tctttgcatt tgtaaagctt tggagatatt 120gaatcatgtt accatttctg tttttttcca ccctgttttc ttccatattt actgaagctc 180agaagcagta ttgggtctgc aactcatccg atgcaagtat ttcatacacc tactgtgata 240aaatgcaata cccaatttca attaatgtta acccctgtat agaattgaaa ggatccaaag 300gattattgca cattttctac attccaagga gagatttaaa gcaattatat ttcaatctct 360atataactgt caacaccatg aatcttccaa agcgcaaaga agttatttgc cgaggatctg 420atgacgatta ctctttttgc agagctctga agggagagac tgtgaataca acaatatcat 480tctccttcaa gggaataaaa ttttctaagg gaaaatacaa atgtgttgtt gaagctattt 540ctgggagccc agaagaaatg ctcttttgct tggagtttgt catcctacac caacctaatt 600caaattagaa taaattgagt attt 624 <210> SEQ ID NO 60 <211> LENGTH: 2088<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 60 gaattcggcacgagcgcgcg gcgaatctca acgctgcgcc gtctgcgggc gcttccgggc 60 caccagtttctctgctttcc accctggcgc cccccagccc tggctcccca gctgcgctgc 120 cccgggcgtccacgccctgc gggcttagcg ggttcagtgg gctcaatctg cgcagcgcca 180 cctccatgttgaccaagcct ctacaggggc ctcccgcgcc ccccgggacc cccacgccgc 240 cgccaggaggcaaggatcgg gaagcgttcg aggccgagta tcgactcggc cccctcctgg 300 gtaaggggggctttggcacc gtcttcgcag gacaccgcct cacagatcga ctccaggtgg 360 ccatcaaagtgattccccgg aatcgtgtgc tgggctggtc ccccttgtca gactcagtca 420 catgcccactcgaagtcgca ctgctatgga aagtgggtgc aggtggtggg caccctggcg 480 tgatccgcctgcttgactgg tttgagacac aggaaggctt catgctggtc ctcgagcggc 540 ctttgcccgcccaggatctc tttgactata tcacagagaa gggcccactg ggtgaaggcc 600 caagccgctgcttctttggc caagtagtgg cagccatcca gcactgccat tcccgtggag 660 ttgtccatcgtgacatcaag gatgagaaca tcctgataga cctacgccgt ggctgtgcca 720 aactcattgattttggttct ggtgccctgc ttcatgatga accctacact gactttgatg 780 ggacaagggtgtacagcccc ccagagtgga tctctcgaca ccagtaccat gcactcccgg 840 ccactgtctggtcactgggc atcctcctct atgacatggt gtgtggggac attccctttg 900 agagggaccaggagattctg gaagctgagc tccacttccc agcccatgtc tccccagact 960 gctgtgccctaatccgccgg tgcctggccc ccaaaccttc ttcccgaccc tcactggaag 1020 agatcctgctggacccctgg atgcaaacac cagccgagga tgttacccct caacccctcc 1080 aaaggaggccctgccccttt ggcctggtcc ttgctaccct aagcctggcc tggcctggcc 1140 tggcccccaatggtcagaag agccatccca tggccatgtc acagggatag atggacattt 1200 gttgacttggttttacaggt cattaccagt cattaaagtc cagtattact aaggtaaggg 1260 attgaggatcaggggttaga agacataaac caagtttgcc cagttccctt cccaatccta 1320 caaaggagccttcctcccag aacctgtggt ccctgatttt ggagggggaa cttcttgctt 1380 ctcattttgctaaggaagtt tattttggtg aagttgttcc cattttgagc cccgggactc 1440 ttattttgatgatgtgtcac cccacattgg cacctcctac taccaccaca caaacttagt 1500 tcatatgcttttacttgggc aagggtgctt tccttccaat accccagtag cttttatttt 1560 agtaaagggaccctttcccc tagcctaggg tcccatattg ggtcaagctg cttacctgcc 1620 tcagcccaggattttttatt ttgggggagg taatgccctg ttgttacccc aaggcttctt 1680 tttttttttttttttttttg ggtgagggga ccctactttg ttatcccaag tgctcttatt 1740 ctggtgagaagaaccttaat tccataattt gggaaggaat ggaagatgga caccaccgga 1800 caccaccagacaataggatg ggatggatgg ttttttgggg gatgggctag gggaaataag 1860 gcttgctgtttgttttcctg gggcgctccc tccaattttg cagatttttg caacctcctc 1920 ctgagccgggattgtccaat tactaaaatg taaataatca cgtattgtgg ggaggggagt 1980 tccaagtgtgccctcctttt ttttcctgcc tggattattt aaaaagccat gtgtggaaac 2040 ccactatttaataaaagtaa tagaatcaga aaaaaaaaaa aaaaaaaa 2088 <210> SEQ ID NO 61 <211>LENGTH: 2270 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 61ctcctccagc ctctcacact ctcctcagct ctctcatctc ctggaaccat ggccagcaca 60tccaccacca tcaggagcca cagcagcagc cgccggggtt tcagtgccaa ctcagccagg 120ctccctgggg tcagccgctc tggcttcagc agcgtctccg tgtcccgctc caggggcagt 180ggtggcctgg gtggtgcatg tggaggagct ggctttggca gccgcagtct gtatggcctg 240gggggctcca agaggatctc cattggaggg ggcagctgtg ccatcagtgg cggctatggc 300agcagagccg gaggcagcta tggctttggt ggcgccggga gtggatttgg tttcggtggt 360ggagccggca ttggctttgg tctgggtggt ggagccggcc ttgctggtgg ctttgggggc 420cctggcttcc ctgtgtgccc ccctggaggc atccaagagg tcaccgtcaa ccagagtctc 480ctgactcccc tcaacctgca aatcgatccc accatccagc gggtgcgggc tgaggagcgt 540gaacagatca agaccctcaa caacaagttt gcctccttca tcgacaaggt gcggttcctg 600gagcagcaga acaaggttct ggaaacaaag tggaccctgc tgcaggagca gggcaccaag 660actgtgaggc agaacctgga gccgttgttc gagcagtaca tcaacaacct caggaggcag 720ctggacagca ttgtcgggga acggggccgc ctggactcag agctcagagg catgcaggac 780ctggtggagg acttcaagaa caaatatgag gatgaaatca acaagcgcac agcagcagag 840aatgaatttg tgactctgaa gaaggatgtg gatgctgcct acatgaacaa ggttgaactg 900caagccaagg cagacactct cacagacgag atcaacttcc tgagagcctt gtatgatgca 960gagctgtccc agatgcagac ccacatctca gacacatctg tggtgctgtc catggacaac 1020aaccgcaacc tggacctgga cagcatcatc gctgaggtca aggcccaata tgaggagatt 1080gctcagagaa gccgggctga ggctgagtcc tggtaccaga ccaagtacga ggagctgcag 1140gtcacagcag gcagacatgg ggacgacctg cgcaacacca agcaggagat tgctgagatc 1200aaccgcatga tccagaggct gagatctgag atcgaccacg tcaagaagca gtgcgccaac 1260ctgcaggccg ccattgctga tgctgagcag cgtggggaga tggccctcaa ggatgccaag 1320aacaagctgg aagggctgga ggatgccctg cagaaggcca agcaggacct ggcccggctg 1380ctgaaggagt accaggagct gatgaatgtc aagctggccc tggacgtgga gatcgccacc 1440taccgcaagc tgctggaggg tgaggagtgc aggctgaatg gcgaaggcgt tggacaagtc 1500aacatctctg tggtgcagtc caccgtctcc agtggctatg gcggtgccag tggtgtcggc 1560agtggcttag gcctgggtgg aggaagcagc tactcctatg gcagtggtct tggcgttgga 1620ggtggcttca gttccagcag tggcagagcc attgggggtg gcctcagctc tgttggaggc 1680ggcagttcca ccatcaagta caccaccacc tcctcctcca gcaggaagag ctataagcac 1740taaagtgcgt ctgctagctc tcggtcccac agtcctcagg cccctctctg gctgcagagc 1800cctctcctca ggttgcctgt cctctcctgg cctccagtct cccctgctgt cccaggtaga 1860gctggggatg aatgcttagt gccctcactt cttctctctc tctctatacc atctgagcac 1920ccattgctca ccatcagatc aacctctgat tttacatcat gatgtaatca ccactggagc 1980ttcactgtta ctaaattatt aatttcttgc ctccagtgtt ctatctctga ggctgagcat 2040tataagaaaa tgacctctgc tccttttcat tgcagaaaat tgccaggggc ttatttcaga 2100acaacttcca cttactttcc actggctctc aaactctcta acttataagt gttgtgaacc 2160cccacccagg cagtatccat gaaagcacaa gtgactagtc ctatgatgta caaagcctgt 2220atctctgtga tgatttctgt gctcttcact gtttgcaatt gctaaataaa 2270 <210> SEQ IDNO 62 <211> LENGTH: 2048 <211> TYPE: DNA <212> ORGANISM: human <400>SEQUENCE: 62 atgtgaaggc acaagctgct gttatataca acagagtgaa ctgagcatcagtcagaaaaa 60 gtctatgttt gcagaaatac agatccaaga caaagacagg atgggcactgctggaaaagt 120 tattaaatgc aaagcagctg tgctttggga gcagaagcaa cccttctccattgaggaaat 180 agaagttgcc ccaccaaaga ctaaagaagt tcgcattaag attttggccacaggaatctg 240 tcgcacagat gaccatgtga taaaaggaac aatggtgtcc aagtttccagtgattgtggg 300 acatgaggca actgggattg tagagagcat tggagaagga gtgactacagtgaaaccagg 360 tgacaaagtc atccctctct ttctgccaca atgtagagaa tgcaatgcttgtcgcaaccc 420 agatggcaac ctttgcatta ggagcgatat tactggtcgt ggagtactggctgatggcac 480 caccagattt acatgcaagg gcaaaccagt acaccacttc atgaacaccagtacatttac 540 cgagtacaca gtggtggatg aatcttctgt tgctaagatt gatgatgcagctcctcctga 600 gaaagtctgt ttaattggct gtgggttttc cactggatat ggcgctgctgttaaaactgg 660 caaggtcaaa cctggttcca cttgcgtcgt ctttggcctg ggaggagttggcctgtcagt 720 catcatgggc tgtaagtcag ctggtgcatc taggatcatt gggattgacctcaacaaaga 780 caaatttgag aaggccatgg ctgtaggtgc cactgagtgt atcagtcccaaggactctac 840 caaacccatc agtgaggtgc tgtcagaaat gacaggcaac aacgtgggatacacctttga 900 agttattggg catcttgaaa ccatgattga tgccctggca tcctgccacatgaactatgg 960 gaccagcgtg gttgtaggag ttcctccatc agccaagatg ctcacctatgacccgatgtt 1020 gctcttcact ggacgcacat ggaagggatg tgtctttgga ggtttgaaaagcagagatga 1080 tgtcccaaaa ctagtgactg agttcctggc aaagaaattt gacctggaccagttgataac 1140 tcatgtttta ccatttaaaa aaatcagtga aggatttgag ctgctcaattcaggacaaag 1200 cattcgaacg gtcctgacgt tttgagatcc aaagtggcag gaggtctgtgttgtcatggt 1260 gaactggagt ttctcttgtg agagttccct catctgaaat catgtatctgtctcacaaat 1320 acaagcataa gtagaagatt tgttgaagac atagaaccct tataaagaattattaacctt 1380 tataaacatt taaagtcttg tgagcacctg ggaattagta taataacaatgttaatattt 1440 ttgatttaca ttttgtaagg ctataattgt atcttttaag aaaacatacacttggatttc 1500 tatgttgaaa tggagatttt taagagtttt aaccagctgc tgcagatatataactcaaaa 1560 cagatatagc gtataaagat atagtaaatg catctcccag agtaatattcacttaacaca 1620 ttgaaactat tattttttag atttgaatat aaatgtattt tttaaacacttgttatgagt 1680 taacttggat tacattttga aatcagttca ttccatgatg catattactggattagatta 1740 agaaagacag aaaagattaa gggacgggca catttttcaa cgattaagaatcatcattac 1800 ataacttggt gaaactgaaa aagtatatca tatgggtaca caaggctatttgccagcata 1860 tattaatatt ttagaaaata ttccttttgt aatactgaat ataaacatagagctagagtc 1920 atattatcat acttatcata atgttcaatt tgatacagta gaattgcaagtccctaagtc 1980 cctattcact gtgcttagta gtgactccat ttaataaaaa gtgtttttagtttttaacaa 2040 ctaaaccg 2048 <210> SEQ ID NO 63 <211> LENGTH: 2048<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 63 atgtgaaggcacaagctgct gttatataca acagagtgaa ctgagcatca gtcagaaaaa 60 gtctatgtttgcagaaatac agatccaaga caaagacagg atgggcactg ctggaaaagt 120 tattaaatgcaaagcagctg tgctttggga gcagaagcaa cccttctcca ttgaggaaat 180 agaagttgccccaccaaaga ctaaagaagt tcgcattaag attttggcca caggaatctg 240 tcgcacagatgaccatgtga taaaaggaac aatggtgtcc aagtttccag tgattgtggg 300 acatgaggcaactgggattg tagagagcat tggagaagga gtgactacag tgaaaccagg 360 tgacaaagtcatccctctct ttctgccaca atgtagagaa tgcaatgctt gtcgcaaccc 420 agatggcaacctttgcatta ggagcgatat tactggtcgt ggagtactgg ctgatggcac 480 caccagatttacatgcaagg gcaaaccagt acaccacttc atgaacacca gtacatttac 540 cgagtacacagtggtggatg aatcttctgt tgctaagatt gatgatgcag ctcctcctga 600 gaaagtctgtttaattggct gtgggttttc cactggatat ggcgctgctg ttaaaactgg 660 caaggtcaaacctggttcca cttgcgtcgt ctttggcctg ggaggagttg gcctgtcagt 720 catcatgggctgtaagtcag ctggtgcatc taggatcatt gggattgacc tcaacaaaga 780 caaatttgagaaggccatgg ctgtaggtgc cactgagtgt atcagtccca aggactctac 840 caaacccatcagtgaggtgc tgtcagaaat gacaggcaac aacgtgggat acacctttga 900 agttattgggcatcttgaaa ccatgattga tgccctggca tcctgccaca tgaactatgg 960 gaccagcgtggttgtaggag ttcctccatc agccaagatg ctcacctatg acccgatgtt 1020 gctcttcactggacgcacat ggaagggatg tgtctttgga ggtttgaaaa gcagagatga 1080 tgtcccaaaactagtgactg agttcctggc aaagaaattt gacctggacc agttgataac 1140 tcatgttttaccatttaaaa aaatcagtga aggatttgag ctgctcaatt caggacaaag 1200 cattcgaacggtcctgacgt tttgagatcc aaagtggcag gaggtctgtg ttgtcatggt 1260 gaactggagtttctcttgtg agagttccct catctgaaat catgtatctg tctcacaaat 1320 acaagcataagtagaagatt tgttgaagac atagaaccct tataaagaat tattaacctt 1380 tataaacatttaaagtcttg tgagcacctg ggaattagta taataacaat gttaatattt 1440 ttgatttacattttgtaagg ctataattgt atcttttaag aaaacataca cttggatttc 1500 tatgttgaaatggagatttt taagagtttt aaccagctgc tgcagatata taactcaaaa 1560 cagatatagcgtataaagat atagtaaatg catctcccag agtaatattc acttaacaca 1620 ttgaaactattattttttag atttgaatat aaatgtattt tttaaacact tgttatgagt 1680 taacttggattacattttga aatcagttca ttccatgatg catattactg gattagatta 1740 agaaagacagaaaagattaa gggacgggca catttttcaa cgattaagaa tcatcattac 1800 ataacttggtgaaactgaaa aagtatatca tatgggtaca caaggctatt tgccagcata 1860 tattaatattttagaaaata ttccttttgt aatactgaat ataaacatag agctagagtc 1920 atattatcatacttatcata atgttcaatt tgatacagta gaattgcaag tccctaagtc 1980 cctattcactgtgcttagta gtgactccat ttaataaaaa gtgtttttag tttttaacaa 2040 ctaaaccg2048 <210> SEQ ID NO 64 <211> LENGTH: 2816 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 64 tcgttgatat caaagacagt tgaaggaaatgaattttgaa acttcacggt gtgccaccct 60 acagtactgc cctgaccctt acatccagcgtttcgtagaa acccagctca tttctcttgg 120 aaagaaagtt attaccgatc caccatgtcccagagcacac agacaaatga attcctcagt 180 ccagaggttt tccagcatat ctgggattttctggaacagc ctatatgttc agttcagccc 240 attgacttga actttgtgga tgaaccatcagaagatggtg cgacaaacaa gattgagatt 300 agcatggact gtatccgcat gcaggactcggacctgagtg accccatgtg gccacagtac 360 acgaacctgg ggctcctgaa cagcatggaccagcagattc agaacggctc ctcgtccacc 420 agtccctata acacagacca cgcgcagaacagcgtcacgg cgccctcgcc ctacgcacag 480 cccagctcca ccttcgatgc tctctctccatcacccgcca tcccctccaa caccgactac 540 ccaggcccgc acagtttcga cgtgtccttccagcagtcga gcaccgccaa gtcggccacc 600 tggacgtatt ccactgaact gaagaaactctactgccaaa ttgcaaagac atgccccatc 660 cagatcaagg tgatgacccc acctcctcagggagctgtta tccgcgccat gcctgtctac 720 aaaaaagctg agcacgtcac ggaggtggtgaagcggtgcc ccaaccatga gctgagccgt 780 gaattcaacg agggacagat tgcccctcctagtcatttga ttcgagtaga ggggaacagc 840 catgcccagt atgtagaaga tcccatcacaggaagacaga gtgtgctggt accttatgag 900 ccaccccagg ttggcactga attcacgacagtcttgtaca atttcatgtg taacagcagt 960 tgtgttggag ggatgaaccg ccgtccaattttaatcattg ttactctgga aaccagagat 1020 gggcaagtcc tgggccgacg ctgctttgaggcccggatct gtgcttgccc aggaagagac 1080 aggaaggcgg atgaagatag catcagaaagcagcaagttt cggacagtac aaagaacggt 1140 gatggtacga agcgcccgtt tcgtcagaacacacatggta tccagatgac atccatcaag 1200 aaacgaagat ccccagatga tgaactgttatacttaccag tgaggggccg tgagacttat 1260 gaaatgctgt tgaagatcaa agagtccctggaactcatgc agtaccttcc tcagcacaca 1320 attgaaacgt acaggcaaca gcaacagcagcagcaccagc acttacttca gaaacatctc 1380 ctttcagcct gcttcaggaa tgagcttgtggagccccgga gagaaactcc aaaacaatct 1440 gacgtcttct ttagacattc caagcccccaaaccgatcag tgtacccata gagccctatc 1500 tctatatttt aagtgtgtgt gttgtatttccatgtgtata tgtgagtgtg tgtgtgtgta 1560 tgtgtgtgcg tgtgtatcta gccctcataaacaggacttg aagacacttt ggctcagaga 1620 cccaactgct caaaggcaca aagccactagtgagagaatc ttttgaaggg actcaaacct 1680 ttacaagaaa ggatgttttc tgcagattttgtatccttag accggccatt ggtgggtgag 1740 gaaccactgt gtttgtctgt gagctttctgttgtttcctg ggagggaggg gtcaggtggg 1800 gaaaggggca ttaagatgtt tattggaacccttttctgtc ttcttctgtt gtttttctaa 1860 aattcacagg gaagcttttg agcaggtctcaaacttaaga tgtcttttta agaaaaggag 1920 aaaaaagttg ttattgtctg tgcataagtaagttgtaggt gactgagaga ctcagtcaga 1980 cccttttaat gctggtcatg taataatattgcaagtagta agaaacgaag gtgtcaagtg 2040 tactgctggg cagcgaggtg atcattaccaaaagtaatca actttgtggg tggagagttc 2100 tttgtgagaa cttgcattat ttgtgtcctcccctcatgtg taggtagaac atttcttaat 2160 gctgtgtacc tgcctctgcc actgtatgttggcatctgtt atgctaaagt ttttcttgta 2220 catgaaaccc tggaagacct actacaaaaaaactgttgtt tggcccccat agcaggtgaa 2280 ctcattttgt gcttttaata gaaagacaaatccaccccag taatattgcc cttacgtagt 2340 tgtttaccat tattcaaagc tcaaaatagaatttgaagcc ctctcacaaa atctgtgatt 2400 aatttgctta attagagctt ctatccctcaagcctaccta ccataaaacc agccatatta 2460 ctgatactgt tcagtgcatt tagccaggagacttacgttt tgagtaagtg agatccaagc 2520 agacgtgtta aaatcagcac tcctggactggaaattaaag attgaaaggg tagactactt 2580 ttcttttttt tactcaaaag tttagagaatctctgtttct ttccatttta aaaacatatt 2640 ttaagataat agcataaaga ctttaaaaatgttcctcccc tccatcttcc cacacccagt 2700 caccagcact gtattttctg tcaccaagacaatgatttct tgttattgag gctgttgctt 2760 ttgtggatgt gtgattttaa ttttcaataaacttttgcat cttggtttaa aagaaa 2816 <210> SEQ ID NO 65 <211> LENGTH: 2816<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 65 tcgttgatatcaaagacagt tgaaggaaat gaattttgaa acttcacggt gtgccaccct 60 acagtactgccctgaccctt acatccagcg tttcgtagaa acccagctca tttctcttgg 120 aaagaaagttattaccgatc caccatgtcc cagagcacac agacaaatga attcctcagt 180 ccagaggttttccagcatat ctgggatttt ctggaacagc ctatatgttc agttcagccc 240 attgacttgaactttgtgga tgaaccatca gaagatggtg cgacaaacaa gattgagatt 300 agcatggactgtatccgcat gcaggactcg gacctgagtg accccatgtg gccacagtac 360 acgaacctggggctcctgaa cagcatggac cagcagattc agaacggctc ctcgtccacc 420 agtccctataacacagacca cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag 480 cccagctccaccttcgatgc tctctctcca tcacccgcca tcccctccaa caccgactac 540 ccaggcccgcacagtttcga cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc 600 tggacgtattccactgaact gaagaaactc tactgccaaa ttgcaaagac atgccccatc 660 cagatcaaggtgatgacccc acctcctcag ggagctgtta tccgcgccat gcctgtctac 720 aaaaaagctgagcacgtcac ggaggtggtg aagcggtgcc ccaaccatga gctgagccgt 780 gaattcaacgagggacagat tgcccctcct agtcatttga ttcgagtaga ggggaacagc 840 catgcccagtatgtagaaga tcccatcaca ggaagacaga gtgtgctggt accttatgag 900 ccaccccaggttggcactga attcacgaca gtcttgtaca atttcatgtg taacagcagt 960 tgtgttggagggatgaaccg ccgtccaatt ttaatcattg ttactctgga aaccagagat 1020 gggcaagtcctgggccgacg ctgctttgag gcccggatct gtgcttgccc aggaagagac 1080 aggaaggcggatgaagatag catcagaaag cagcaagttt cggacagtac aaagaacggt 1140 gatggtacgaagcgcccgtt tcgtcagaac acacatggta tccagatgac atccatcaag 1200 aaacgaagatccccagatga tgaactgtta tacttaccag tgaggggccg tgagacttat 1260 gaaatgctgttgaagatcaa agagtccctg gaactcatgc agtaccttcc tcagcacaca 1320 attgaaacgtacaggcaaca gcaacagcag cagcaccagc acttacttca gaaacatctc 1380 ctttcagcctgcttcaggaa tgagcttgtg gagccccgga gagaaactcc aaaacaatct 1440 gacgtcttctttagacattc caagccccca aaccgatcag tgtacccata gagccctatc 1500 tctatattttaagtgtgtgt gttgtatttc catgtgtata tgtgagtgtg tgtgtgtgta 1560 tgtgtgtgcgtgtgtatcta gccctcataa acaggacttg aagacacttt ggctcagaga 1620 cccaactgctcaaaggcaca aagccactag tgagagaatc ttttgaaggg actcaaacct 1680 ttacaagaaaggatgttttc tgcagatttt gtatccttag accggccatt ggtgggtgag 1740 gaaccactgtgtttgtctgt gagctttctg ttgtttcctg ggagggaggg gtcaggtggg 1800 gaaaggggcattaagatgtt tattggaacc cttttctgtc ttcttctgtt gtttttctaa 1860 aattcacagggaagcttttg agcaggtctc aaacttaaga tgtcttttta agaaaaggag 1920 aaaaaagttgttattgtctg tgcataagta agttgtaggt gactgagaga ctcagtcaga 1980 cccttttaatgctggtcatg taataatatt gcaagtagta agaaacgaag gtgtcaagtg 2040 tactgctgggcagcgaggtg atcattacca aaagtaatca actttgtggg tggagagttc 2100 tttgtgagaacttgcattat ttgtgtcctc ccctcatgtg taggtagaac atttcttaat 2160 gctgtgtacctgcctctgcc actgtatgtt ggcatctgtt atgctaaagt ttttcttgta 2220 catgaaaccctggaagacct actacaaaaa aactgttgtt tggcccccat agcaggtgaa 2280 ctcattttgtgcttttaata gaaagacaaa tccaccccag taatattgcc cttacgtagt 2340 tgtttaccattattcaaagc tcaaaataga atttgaagcc ctctcacaaa atctgtgatt 2400 aatttgcttaattagagctt ctatccctca agcctaccta ccataaaacc agccatatta 2460 ctgatactgttcagtgcatt tagccaggag acttacgttt tgagtaagtg agatccaagc 2520 agacgtgttaaaatcagcac tcctggactg gaaattaaag attgaaaggg tagactactt 2580 ttcttttttttactcaaaag tttagagaat ctctgtttct ttccatttta aaaacatatt 2640 ttaagataatagcataaaga ctttaaaaat gttcctcccc tccatcttcc cacacccagt 2700 caccagcactgtattttctg tcaccaagac aatgatttct tgttattgag gctgttgctt 2760 ttgtggatgtgtgattttaa ttttcaataa acttttgcat cttggtttaa aagaaa 2816 <210> SEQ ID NO66 <211> LENGTH: 5838 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 66 ccgggcaggt ggctcatgct cgggagcgtg gttgagcggc tggcgcggttgtcctggagc 60 aggggcgcag gaattctgat gtgaaactaa cagtctgtga gccctggaacctccgctcag 120 agaagatgaa ggatatcgac ataggaaaag agtatatcat ccccagtcctgggtatagaa 180 gtgtgaggga gagaaccagc acttctggga cgcacagaga ccgtgaagattccaagttca 240 ggagaactcg accgttggaa tgccaagatg ccttggaaac agcagcccgagccgagggcc 300 tctctcttga tgcctccatg cattctcagc tcagaatcct ggatgaggagcatcccaagg 360 gaaagtacca tcatggcttg agtgctctga agcccatccg gactacttccaaacaccagc 420 acccagtgga caatgctggg cttttttcct gtatgacttt ttcgtggctttcttctctgg 480 cccgtgtggc ccacaagaag ggggagctct caatggaaga cgtgtggtctctgtccaagc 540 acgagtcttc tgacgtgaac tgcagaagac tagagagact gtggcaagaagagctgaatg 600 aagttgggcc agacgctgct tccctgcgaa gggttgtgtg gatcttctgccgcaccaggc 660 tcatcctgtc catcgtgtgc ctgatgatca cgcagctggc tggcttcagtggaccagcct 720 tcatggtgaa acacctcttg gagtataccc aggcaacaga gtctaacctgcagtacagct 780 tgttgttagt gctgggcctc ctcctgacgg aaatcgtgcg gtcttggtcgcttgcactga 840 cttgggcatt gaattaccga accggtgtcc gcttgcgggg ggccatcctaaccatggcat 900 ttaagaagat ccttaagtta aagaacatta aagagaaatc cctgggtgagctcatcaaca 960 tttgctccaa cgatgggcag agaatgtttg aggcagcagc cgttggcagcctgctggctg 1020 gaggacccgt tgttgccatc ttaggcatga tttataatgt aattattctgggaccaacag 1080 gcttcctggg atcagctgtt tttatcctct tttacccagc aatgatgtttgcatcacggc 1140 tcacagcata tttcaggaga aaatgcgtgg ccgccacgga tgaacgtgtccagaagatga 1200 atgaagttct tacttacatt aaatttatca aaatgtatgc ctgggtcaaagcattttctc 1260 agagtgttca aaaaatccgc gaggaggagc gtcggatatt ggaaaaagccgggtacttcc 1320 agggtatcac tgtgggtgtg gctcccattg tggtggtgat tgccagcgtggtgaccttct 1380 ctgttcatat gaccctgggc ttcgatctga cagcagcaca ggctttcacagtggtgacag 1440 tcttcaattc catgactttt gctttgaaag taacaccgtt ttcagtaaagtccctctcag 1500 aagcctcagt ggctgttgac agatttaaga gtttgtttct aatggaagaggttcacatga 1560 taaagaacaa accagccagt cctcacatca agatagagat gaaaaatgccaccttggcat 1620 gggactcctc ccactccagt atccagaact cgcccaagct gacccccaaaatgaaaaaag 1680 acaagagggc ttccaggggc aagaaagaga aggtgaggca gctgcagcgcactgagcatc 1740 aggcggtgct ggcagagcag aaaggccacc tcctcctgga cagtgacgagcggcccagtc 1800 ccgaagagga agaaggcaag cacatccacc tgggccacct gcgcttacagaggacactgc 1860 acagcatcga tctggagatc caagagggta aactggttgg aatctgcggcagtgtgggaa 1920 gtggaaaaac ctctctcatt tcagccattt taggccagat gacgcttctagagggcagca 1980 ttgcaatcag tggaaccttc gcttatgtgg cccagcaggc ctggatcctcaatgctactc 2040 tgagagacaa catcctgttt gggaaggaat atgatgaaga aagatacaactctgtgctga 2100 acagctgctg cctgaggcct gacctggcca ttcttcccag cagcgacctgacggagattg 2160 gagagcgagg agccaacctg agcggtgggc agcgccagag gatcagccttgcccgggcct 2220 tgtatagtga caggagcatc tacatcctgg acgaccccct cagtgccttagatgcccatg 2280 tgggcaacca catcttcaat agtgctatcc ggaaacatct caagtccaagacagttctgt 2340 ttgttaccca ccagttacag tacctggttg actgtgatga agtgatcttcatgaaagagg 2400 gctgtattac ggaaagaggc acccatgagg aactgatgaa tttaaatggtgactatgcta 2460 ccatttttaa taacctgttg ctgggagaga caccgccagt tgagatcaattcaaaaaagg 2520 aaaccagtgg ttcacagaag aagtcacaag acaagggtcc taaaacaggatcagtaaaga 2580 aggaaaaagc agtaaagcca gaggaagggc agcttgtgca gctggaagagaaagggcagg 2640 gttcagtgcc ctggtcagta tatggtgtct acatccaggc tgctgggggccccttggcat 2700 tcctggttat tatggccctt ttcatgctga atgtaggcag caccgccttcagcacctggt 2760 ggttgagtta ctggatcaag caaggaagcg ggaacaccac tgtgactcgagggaacgaga 2820 cctcggtgag tgacagcatg aaggacaatc ctcatatgca gtactatgccagcatctacg 2880 ccctctccat ggcagtcatg ctgatcctga aagccattcg aggagttgtctttgtcaagg 2940 gcacgctgcg agcttcctcc cggctgcatg acgagctttt ccgaaggatccttcgaagcc 3000 ctatgaagtt ttttgacacg acccccacag ggaggattct caacaggttttccaaagaca 3060 tggatgaagt tgacgtgcgg ctgccgttcc aggccgagat gttcatccagaacgttatcc 3120 tggtgttctt ctgtgtggga atgatcgcag gagtcttccc gtggttccttgtggcagtgg 3180 ggccccttgt catcctcttt tcagtcctgc acattgtctc cagggtcctgattcgggagc 3240 tgaagcgtct ggacaatatc acgcagtcac ctttcctctc ccacatcacgtccagcatac 3300 agggccttgc caccatccac gcctacaata aagggcagga gtttctgcacagataccagg 3360 agctgctgga tgacaaccaa gctccttttt ttttgtttac gtgtgcgatgcggtggctgg 3420 ctgtgcggct ggacctcatc agcatcgccc tcatcaccac cacggggctgatgatcgttc 3480 ttatgcacgg gcagattccc ccagcctatg cgggtctcgc catctcttatgctgtccagt 3540 taacggggct gttccagttt acggtcagac tggcatctga gacagaagctcgattcacct 3600 cggtggagag gatcaatcac tacattaaga ctctgtcctt ggaagcacctgccagaatta 3660 agaacaaggc tccctcccct gactggcccc aggagggaga ggtgacctttgagaacgcag 3720 agatgaggta ccgagaaaac ctccctcttg tcctaaagaa agtatccttcacgatcaaac 3780 ctaaagagaa gattggcatt gtggggcgga caggatcagg gaagtcctcgctggggatgg 3840 ccctcttccg tctggtggag ttatctggag gctgcatcaa gattgatggagtgagaatca 3900 gtgatattgg ccttgccgac ctccgaagca aactctctat cattcctcaagagccggtgc 3960 tgttcagtgg cactgtcaga tcaaatttgg accccttcaa ccagtacactgaagaccaga 4020 tttgggatgc cctggagagg acacacatga aagaatgtat tgctcagctacctctgaaac 4080 ttgaatctga agtgatggag aatggggata acttctcagt gggggaacggcagctcttgt 4140 gcatagctag agccctgctc cgccactgta agattctgat tttagatgaagccacagctg 4200 ccatggacac agagacagac ttattgattc aagagaccat ccgagaagcatttgcagact 4260 gtaccatgct gaccattgcc catcgcctgc acacggttct aggctccgataggattatgg 4320 tgctggccca gggacaggtg gtggagtttg acaccccatc ggtccttctgtccaacgaca 4380 gttcccgatt ctatgccatg tttgctgctg cagagaacaa ggtcgctgtcaagggctgac 4440 tcctccctgt tgacgaagtc tcttttcttt agagcattgc cattccctgcctggggcggg 4500 cccctcatcg cgtcctccta ccgaaacctt gcctttctcg attttatctttcgcacagca 4560 gttccggatt ggcttgtgtg tttcactttt agggagagtc atattttgattattgtattt 4620 attccatatt catgtaaaca aaatttagtt tttgttctta attgcactctaaaaggttca 4680 gggaaccgtt attataattg tatcagaggc ctataatgaa gctttatacgtgtagctata 4740 tctatatata attctgtaca tagcctatat ttacagtgaa aatgtaagctgtttatttta 4800 tattaaaata agcactgtgc taataacagt gcatattcct ttctatcatttttgtacagt 4860 ttgctgtact agagatctgg ttttgctatt agactgtagg aagagtagcatttcattctt 4920 ctctagctgg tggtttcacg gtgccaggtt ttctgggtgt ccaaaggaagacgtgtggca 4980 atagtgggcc ctccgacagc cccctctgcc gcctccccac agccgctccaggggtggctg 5040 gagacgggtg ggcggctgga gaccatgcag agcgccgtga gttctcagggctcctgcctt 5100 ctgtcctggt gtcacttact gtttctgtca ggagagcagc ggggcgaagcccaggcccct 5160 tttcactccc tccatcaaga atggggatca cagagacatt cctccgagccggggagtttc 5220 tttcctgcct tcttcttttt gctgttgttt ctaaacaaga atcagtctatccacagagag 5280 tcccactgcc tcaggttcct atggctggcc actgcacaga gctctccagctccaagacct 5340 gttggttcca agccctggag ccaactgctg ctttttgagg tggcactttttcatttgcct 5400 attcccacac ctccacagtt cagtggcagg gctcaggatt tcgtgggtctgttttccttt 5460 ctcaccgcag tcgtcgcaca gtctctctct ctctctcccc tcaaagtctgcaactttaag 5520 cagctcttgc taatcagtgt ctcacactgg cgtagaagtt tttgtactgtaaagagacct 5580 acctcaggtt gctggttgct gtgtggtttg gtgtgttccc gcaaaccccctttgtgctgt 5640 ggggctggta gctcaggtgg gcgtggtcac tgctgtcatc agttgaatggtcagcgttgc 5700 atgtcgtgac caactagaca ttctgtcgcc ttagcatgtt tgctgaacaccttgtggaag 5760 caaaaatctg aaaatgtgaa taaaattatt ttggattttg taaaaaaaaaaaaaaaaaaa 5820 aaaaaaaaaa aaaaaaaa 5838 <210> SEQ ID NO 67 <211>LENGTH: 6841 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 67gccggagggc gcccgagggg ccccgggccg cggcgctcag ggcccgggcg gccggcggcg 60gccccggggc tggggggagt ccagcccgga tattgagtgc agccattgag aaaagccaaa 120ctcttgtgtg tgcgcgtctc gatagccccc aagatggccg ccaatgtggg atcgatgttt 180caatattgga agcgatttga tctacggcga ctccagaagg agcttaattc cgtcgcttct 240gagctgtctg cacggcagga ggagagtgaa cattctcata aacatttaat tgaactccgc 300cgggaattta agaaaaatgt acctgaggaa atcagagaga tggtggctcc tgtattaaaa 360agcttccaag ccgaggtggt ggcccttagt aagagaagtc aggaggcgga ggctgctttt 420ctgagtgttt acaagcaatt aattgaagca ccagaccccg tgcctgtgtt tgaggcggca 480cgcagcctag acgacagact gcagcccccc agctttgacc ccagtgggca gccccggcga 540gacctccaca cttcgtggaa gaggaacccc gagctcctca gccccaaaga gcagagagag 600gggacgtcgc ctgccgggcc cacgctgacc gagggaagcc gcctcccagg cattcccggg 660aaagccctcc tgacagaaac cttgctgcag agaaatgagg cggaaaaaca aaagggcctt 720caagaagtac agatcacttt ggcggccaga ctgggggagg cagaggagaa aatcaaagtc 780ctacattcag cgctaaaggc tacgcaggca gagctgctag agctgcggcg gaagtacgac 840gaggaggcag catccaaggc agatgaagtc ggcctgatca tgaccaacct ggagaaagct 900aatcagcgag ctgaggctgc ccagcgggag gtggaaagtc tccgggaaca gctggcctct 960gtcaacagct ccatccgcct ggcttgctgc tctccccagg ggcccagtgg ggataaggtg 1020aacttcactc tgtgctcggg ccctcggctg gaggccgcgc tggcctccaa ggacagggag 1080atcctgcggc tgctgaagga cgtgcagcac ctccagagct cactgcagga gctggaggag 1140gcatccgcca accagatcgc cgacctggag cggcagctca cggccaagtc cgaggccata 1200gaaaagctgg aagagaagct ccaggcccag tctgactatg aggaaattaa aacggagctg 1260agcatcctga aagccatgaa gctggcctcc agcacctgca gcctccccca gggcatggcc 1320aagcctgaag actcactgct tattgcaaag gaggccttct tccccacgca gaaattcctt 1380ctggagaagc ccagcctcct ggccagccct gaggaagacc catcagagga cgattccatc 1440aaggattcac tgggcacgga gcagtcctac ccctcccctc agcagctccc acctccacca 1500gggccagaag accccctgtc tcccagcccc gggcagcccc tgctgggccc cagcttgggg 1560cctgacggca ctcggacttt ctcgctgtcc cccttcccca gcctggcatc aggggagaga 1620ctgatgatgc ccccagccgc cttcaaggga gaggcgggcg gcctgctggt gttcccccca 1680gccttctatg gcgccaagcc ccccacagcc cctgccaccc cggcccctgg ccctgagcca 1740ctgggcggtc ctgagcccgc ggatggtggt gggggcggag cggcggggcc cggggcagag 1800gaggagcagc tggacacggc agagatcgcc ttccaggtga aggagcagct gctgaaacac 1860aacatcgggc agcgggtgtt tgggcattac gtgctggggc tgtcgcaggg ctcggtcagc 1920gagatcctag cccggcccaa gccctggcgc aagctcacgg tgaagggcaa ggagcccttc 1980atcaagatga agcagttcct gtcggatgag cagaatgtac tggcgctcag gaccatccaa 2040gtgcggcagc gaggcagcat caccccgaga atccgcacgc ctgagacagg ctcagacgac 2100gccatcaaga gcattctaga gcaggccaag aaggagatcg agtcgcagaa gggcggcgag 2160cccaagacct cggtggcccc gctgagcatc gccaacggca cgacccccgc cagcacctcg 2220gaggacgcca tcaagagcat cctggagcag gcacgccgtg agatgcaggc gcaacagcag 2280gcgctgctgg agatggaggt ggcgcccagg ggccgctcgg tgcccccctc gcccccggag 2340cggccatcac tggccaccgc gagccagaac ggggccccgg ccttggtgaa gcaggaggag 2400ggcagcgggg gccccgcgca ggcgccgctc ccggtcctgt cccccgccgc cttcgtgcag 2460agcatcatcc gcaaggtcaa gtccgagatc ggcgacgccg gctacttcga ccaccactgg 2520gcctccgacc gcggcctgct cagccgcccc tacgcctccg tgtcgccctc gctgtcctcc 2580tcctcctcct ctggctactc tggccagccc aacggccgcg cctggccccg cggggacgag 2640gcccctgtgc cccccgagga cgaggcggcg gcaggggcgg aggacgaacc ccccaggacg 2700ggcgagctca aggctgaggg cgcgacggcc gaggcgggcg cgcggctgcc ctactacccg 2760gcctacgtgc cgcgcaccct gaagcccacc gtgccgccgc tgacccccga gcagtacgag 2820ctgtacatgt accgtgaggt agacacgctg gagctcaccc gccaggtcaa ggagaagctg 2880gccaagaacg gcatctgcca gaggatcttc ggggagaagg tgctgggcct gtcacagggc 2940agcgtgagcg acatgctgtc ccggccgaag ccatggagca agctgacgca gaaggggcgg 3000gagcccttca tccgcatgca gctgtggctc tctgaccagc tcggccaggc agtgggccag 3060cagcctggtg cctcccaggc cagtcccaca gaaccaaggt cctcaccatc cccacccccc 3120agccccacag agcctgagaa gagctcccag gagccgttga gcctgtccct ggagagcagc 3180aaggagaacc agcagccaga gggccgctcc agctcctcgt tgagcgggaa gatgtactca 3240ggcagccagg ccccaggggg catccaggag atcgtggcca tgtcccccga gctggacacg 3300tactccatca ccaagagggt gaaggaggtc ctcacagaca acaatctagg gcagcggctg 3360tttggggaaa gcatcctggg tctgacacag ggctccgtgt ctgacctgct gtcccggccc 3420aaaccctggc acaagctgag cctgaagggg cgggagcctt ttgtccgcat gcagctgtgg 3480ctcaatgacc cccataacgt ggagaagctg agggatatga agaagctgga gaagaaagcc 3540tacctgaaac gtcgctatgg cctcatcagc accggctcag acagtgagtc cccggccacc 3600cgctcagagt gccccagccc ctgcctgcag ccccaggacc tgagcctcct gcagatcaag 3660aagccccggg tggtgctggc acccgaggag aaggaggcac tgcggaaggc ctatcagctg 3720gaaccctacc cctcgcagca gaccatcgag ctcctctcct tccagctcaa cctcaagacc 3780aacaccgtca tcaactggtt ccacaactac aggtcccgga tgcgccggga gatgttggtg 3840gaggggaccc aggatgagcc agaccttgat ccaagcgggg gtcctggaat cctaccgcca 3900ggccactccc acccagaccc caccccgcag agccctgact ctgagactga ggaccagaag 3960ccaaccgtga aggaactgga gcttcaggag ggccctgagg agaacagcac acccctgacc 4020acccaggaca aggcccaagt gaggatcaag caggaacaga tggaggagga tgctgaggaa 4080gaggcaggca gccagcccca ggactcaggg gagctggaca aaggccaagg tccccccaaa 4140gaggagcatc ccgaccctcc gggtaatgat ggactcccaa aagtggctcc cgggcccctc 4200cttccaggtg gatccacccc agactgtccc tcacttcatc cccaacagga gagtgaggcc 4260ggggagcgac ttcacccgga ccctttaagt tttaagtcag cctcagagtc ctcacgctgc 4320agcctggagg tgtcactgaa ctcgccctcg gccgcctcct caccaggcct catgatgtct 4380gtgtcacctg tcccctcctc ctcagctccc atctccccat ccccacctgg cgccccccct 4440gccaaagtgc cgagtgccag ccccactgct gacatggctg gagccttgca ccccagtgcc 4500aaggtgaacc ccaacttgca gcggcggcat gagaagatgg ccaatctgaa caacatcatt 4560taccgactag agcgggctgc caatcgggag gaggccctgg agtgggagtt ctgaaggcag 4620ggtgaggggg caagggacat accctggtaa ctaccttcct tctcgcactt actctcctca 4680acaggatggg gtaagggagg gaggaactca accatcaaaa tgtggacagc aatgttatgc 4740cgtttacgtt ttttgttgta atcctagttc tatgaagctg tgtgagcagg tgggtcaaat 4800gccattgcct ccacttttct gcacccccct gctcctcttc accctgaccc ctctgcagga 4860ggcagaagca aaatggcacc acatattcac ctgaaaactc caaactcttt tagaaaaata 4920aataaatatt tatagacctc ttttagatat tttaataaag gatcctttgg aatttatccc 4980agctgatgct gttttgatat tacagagagt tataaaatca ggatgctgtc acaactgttg 5040cgaagtatac actgaagttg tgtcgttttt gccactagat gagattaaaa gaagacaatt 5100attcaaagcc atcacaaaac actataagac tgaccaaaat ttagataacc tttgaaccac 5160gatttttttc cacatctgtc tgtgagacac agcgcaatgc tactgccctt ccagaaactg 5220tgctaaaaag agaaagtcca aaagactcta aacaaaaacc tcgacgccgt tgaggatgtg 5280tttcattctg gtggtctgtt ttgcaagctt gataacagaa tgtccgtgcc attgtaaatg 5340ttgtagagat gtgggccgtg gcccaaccgt cctatatgag atgtagcatg gtacagaaca 5400aactgcttac acaggtctca ctagttagaa acctgtgggc catggaggtc agacatccat 5460cttgtccatc tataggcaag aagtgtttcc agatcctttg gaaaggtggg catggggcag 5520gtgcttggag agtggcgttt gagccagagc gaccccattt cccgtgtgaa ccataggcac 5580aacccaggaa gtttccccac ttgtaggagt gtgggtattc cagagcaaga ctgtggccac 5640catcttcccc tcttggtgtt ttccgaaagt gacagtgttg gtcatcccat gaccactgaa 5700gcttagtaac cagcgccaaa aagtagattc atcaaactag agaccccagc tccccttctc 5760gccatcttct ttctcaagtt gaccgtggtg ctgtttctgg aaggcatctg caactccaag 5820tccatgcaga actctggaag gccaagttca tcgcagcatg ttcaccatat cccagcctcc 5880aaatctatcc tcctaccttc caacgcatga cctgttgggg agcagagact taacccccaa 5940ctcagaggaa cccttcctcc agcgtctttg gcatggtttc tagggtgaga gttcccaatt 6000tggatagaac ggccaccata ttggttactg aatctctctc ccttgttttt attacgtttc 6060ctttttcaaa ctgtccatgg gaaggctgaa ttgagtgact ccccagaatg aagatgagaa 6120ggtgaatata atcaatgcca atgtaatgcc agcgggtgag atggccgatg gaggtttcaa 6180agatgtagct agcattttga aaccatatgg gcaaaacccg gcaaccagaa ggggacagat 6240aaggaccgtt ccagaaatcc caactctcac acccagccca ggctgcagtc tccacaccaa 6300acagtcaaca aaacacaaac cctgaaggaa aaccttttcc atacacccag gctatgcatt 6360gaagagtttt ccactgtata catttttatc cagatgaagg tatttttata ttttgacaat 6420aggaaacagt gaccattttc agagtaatca aatctggaac aaatgaaaca tcttttagcc 6480accaccaccc tgttgcaatt aagacaaccg tgggggaaca caccactttt tactgttgaa 6540accaacacaa cgttgaaatc caggcttata cgcagactcc gattcctaga gaactaaatt 6600tggctttagt gtgacgggat ttgattaagc acttagtata gtcttttgaa cacggaaatc 6660ctgttgtact taaagctagc ggacccgtga acaactttgt caggttcacg tcctataacg 6720gttaaaaaac acacacacac atacacaaac cgtttctatg agagattgat gaactttgtt 6780taaaatttta aaaaaaggaa cacgttctgt aaacgagtcg ctaaatacag aattgtataa 6840 t6841 <210> SEQ ID NO 68 <211> LENGTH: 1181 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 68 ggcacgaggc ccgggccccc caaagtcccggccgggccga gggtcggcgg ccgccggcgg 60 gccgggcccg cgcacagcgc ccgcatgtacaacatgatgg agacggagct gaagccgccg 120 ggcccgcagc aaacttcggg gggcggcggcggcaactcca ccgcggcggc ggccggcggc 180 aaccagaaaa acagcccgga ccgcgtcaagcggcccatga atgccttcat ggtgtggtcc 240 cgcgggcagc ggcgcaagat ggcccaggagaaccccaaga tgcacaactc ggagatcagc 300 aagcgcctgg gcgccgagtg gaaacttttgtcggagacgg agaagcggcc gttcatcgac 360 gaggctaagc ggctgcgagc gctgcacatgaaggagcacc cggattataa ataccggccc 420 cggcggaaaa ccaagacgct catgaagaaggataagtaca cgctgcccgg cgggctgctg 480 gcccccggcg gcaatagcat ggcgagcggggtcggggtgg gcgccggcct gggcgcgggc 540 gtgaaccagc gcatggacag ttacgcgcacatgaacggct ggagcaacgg cagctacagc 600 atgatgcagg accagctggg ctacccgcagcacccgggcc tcaatgcgca cggcgcagcg 660 cagatgcagc ccatgcaccg ctacgacgtgagcgccctgc agtacaactc catgaccagc 720 tcgcagacct acatgaacgg ctcgcccacctacagcatgt cctactcgca gcagggcacc 780 cctggcatgg ctcttggctc catgggttcggtggtcaagt ccgaggccag ctccagcccc 840 cctgtggtta cctcttcctc ccactccagggcgccctgcc aggccgggga cctccgggac 900 atgatcagca tgtatctccc cggcgccgaggtgccggaac ccgccgcccc cagcagactt 960 cacatgtccc agcactacca gagcggcccggtgcccggca cggccattaa cggcacactg 1020 cccctctcac acatgtgagg gccggacagcgaactggagg ggggagaaat tttcaaagaa 1080 aaacgaggga aatgggaggg gtgcaaaagaggagagtaag aaacagcatg gagaaaaccc 1140 ggtacgctca aaaaaaaaaa aaaaaaaaaaaaaaaaaaaa a 1181 <210> SEQ ID NO 69 <211> LENGTH: 4729 <212> TYPE: DNA<213> ORGANISM: human <400> SEQUENCE: 69 gctgctctcg ttcgcttggctcagctcagc tcagctcagc gcagctccgc ggccgccaag 60 ccgaggcggg cacggtctccgagtcgcgga cgccagctcc gagctccctc tctccgccgc 120 gcctccgcca ggtcgcgccttcgtcgggac cacttcgggc aggagtcgcg tggcgaaggc 180 ctgcggccgc ggcacaaagttgggggccgc gaagatgagg ctgtccccgg cgcccctgaa 240 gctgagccgg actccggcactgctggccct ggcgctgccc ctggccgcgg cgctggcctt 300 ctccgacgag accctggacaaagtgcccaa gtcagagggc tactgcagcc gtatcctgcg 360 cgcccagggc acgcggcgcgagggctacac cgagttcagc ctccgcgtgg agggcgaccc 420 cgacttctac aagccgggaaccagctaccg cgtaacactt tcagctgctc ctccctccta 480 cttcagagga ttcacattaattgccctcag agagaacaga gagggtgata aggaagaaga 540 ccatgctggg accttccagatcatagacga agaagaaact cagtttatga gcaattgccc 600 tgttgcagtc actgaaagcactccacggag gaggacccgg atccaggtgt tttggatagc 660 accaccagcg ggaacaggctgcgtgattct gaaggccagc atcgtacaaa aacgcattat 720 ttattttcaa gatgagggctctctgaccaa gaaactttgt gaacaagatt ccacatttga 780 tggggtgact gacaaacccatcttagactg ctgtgcctgc ggaactgcca agtacagact 840 cacattttat gggaattggtccgagaagac acacccaaag gattaccctc gtcgggccaa 900 ccactggtct gcgatcatcggaggatccca ctccaagaat tatgtactgt gggaatatgg 960 aggatatgcc agcgaaggcgtcaaacaagt tgcagaattg ggctcacccg tgaaaatgga 1020 ggaagaaatt cgacaacagagtgatgaggt cctcaccgtc atcaaagcca aagcccagtg 1080 gccagcctgg cagcctctcaacgtgagagc agcaccttca gctgaatttt ccgtggacag 1140 aacgcgccat ttaatgtccttcctgaccat gatgggccct agtcccgact ggaacgtagg 1200 cttatctgca gaagatctgtgcaccaagga atgtggctgg gtccagaagg tggtgcaaga 1260 cctgattccc tgggacgctggcaccgacag cggggtgacc tatgagtcac ccaacaaacc 1320 caccattccc caggagaaaatccggcccct gaccagcctg gaccatcctc agagtccttt 1380 ctatgaccca gagggtgggtccatcactca agtagccaga gttgtcatcg agagaatcgc 1440 acggaagggt gaacaatgcaatattgtacc tgacaatgtc gatgatattg tagctgacct 1500 ggctccagaa gagaaagatgaagatgacac ccctgaaacc tgcatctact ccaactggtc 1560 cccatggtcc gcctgcagctcctccacctg tgacaaaggc aagaggatgc gacagcgcat 1620 gctgaaagca cagctggacctcagcgtccc ctgccctgac acccaggact tccagccctg 1680 catgggccct ggctgcagtgacgaagacgg ccccacctgc accatgtccg agtggatcac 1740 ctggtcgccc tgcagcatctcctgcggcat gggcatgagg tcccgggaga ggtatgtgaa 1800 gcagttcccg gaggacggctccgtgtgcac gctgcccact gaggaaacgg agaagtgcac 1860 ggtcaacgag gagtgctctcccagcagctg cctgatgacc gagtggggcg agtgggacga 1920 gtacagcgcc acctgcggcatgggcatgaa gaagcggcac cgcatgatca agatgaaccc 1980 cgcagatggc tccatgtgcaaagccgagac atcacaggca gagaagcgca tgatgccaga 2040 gtgccacacc atcccatgcttgctgtcccc atggtccgag tggagtgact gcagcgtgac 2100 ctgcgggaag ggcatgcgaacccgacagcg gatgctcaag tctctggcag aacttggaga 2160 ctgcaatgag gatctggagcaggtggagaa gtgcatgctc cctgaatgcc ccattgactg 2220 tgagctcacc gagtggtcccagtggtcgga atgtaacaag tcatgtggga aaggccacgt 2280 gattcgaacc cggatgatccaaatggagcc tcagtttgga ggtgcaccct gcccagagac 2340 tgtgcagcga aaaaagtgccgcatccgaaa atgccttcga aatccatcca tccaaaagct 2400 acgctggagg gaggcccgagagagccggcg gagtgagcag ctgaaggaag agtctgaagg 2460 ggagcagttc ccaggttgtaggatgcgccc atggacggcc tggtcagaat gcaccaaact 2520 gtgcggaggt ggaattcaggaacgttacat gactgtaaag aagagattca aaagctccca 2580 gtttaccagc tgcaaagacaagaaggagat cagagcatgc aatgttcatc cttgttagca 2640 agggtacgag ttccccagggctgcactcta gattccagag tcaccaatgg ctggattatt 2700 tgcttgttta agacaatttaaattgtgtac gctagttttc atttttgcag tgtggttcgc 2760 ccagtagtct tgtggatgccagagacatcc tttctgaata cttcttgatg ggtacaggct 2820 gagtggggcg ccctcacctccagccagcct cttcctgcag aggagtagtg tcagccacct 2880 tgtactaagc tgaaacatgtccctctggag cttccacctg gccagggagg acggagactt 2940 tgacctactc cacatggagaggcaaccatg tctggaagtg actatgcctg agtcccaggg 3000 tgcggcaggt aggaaacattcacagatgaa gacagcagat tccccacatt ctcatctttg 3060 gcctgttcaa tgaaaccattgtttgcccat ctcttcttag tggaacttta ggtctctttt 3120 caagtctcct cagtcatcaatagttcctgg ggaaaaacag agctggtaga cttgaagagg 3180 agcattgatg ttgggtggcttttgttcttt cactgagaaa ttcggaatac atttgtctca 3240 cccctgatat tggttcctgatgccccccca acaaaaataa ataaataaat tatggctgct 3300 ttatttaaat ataaggtagctagtttttac acctgagata aataataagc ttagagtgta 3360 tttttccctt gcttttgggggttcagagga gtatgtacaa ttcttctggg aagccagcct 3420 tctgaacttt ttggtactaaatccttattg gaaccaagac aaaggaagca aaattggtct 3480 ctttagagac caatttgcctaaattttaaa atcttcctac acacatctag acgttcaagt 3540 ttgcaaatca gtttttagcaagaaaacatt tttgctatac aaacattttg ctaagtctgc 3600 ccaaagcccc cccaatgcattccttcaaca aaatacaatc tctgtacttt aaagttattt 3660 tagtcatgaa attttatatgcagagagaaa aagttaccga gacagaaaac aaatctaagg 3720 gaaaggaata ttatgggattaagctgagca agcaattctg gtggaaagtc aaacctgtca 3780 gtgctccaca ccagggctgtggtcctccca gacatgcata ggaatggcca caggtttaca 3840 ctgccttccc agcaattataagcacaccag attcagggag actgaccacc aagggatagt 3900 gtaaaaggac attttctcagttgggtccat cagcagtttt tcttcctgca tttattgttg 3960 aaaactattg tttcatttcttcttttatag gccttattac tgcttaatcc aaatgtgtac 4020 cattggtgag acacatacaatgctctgaat acactacgaa tttgtattaa acacatcaga 4080 atatttccaa atacaacatagtatagtcct gaatatgtac ttttaacaca agagagacta 4140 ttcaataaaa actcactgggtctttcatgt ctttaagcta agtaagtgtt cagaaggttc 4200 ttttttatat tgtcctccacctccatcatt ttcaataaaa gatagggctt ttgctccctt 4260 gttcttggag ggaccattattacatctctg aactaccttt gtatccaaca tgttttaaat 4320 ccttaaatga attgctttctcccaaaaaaa gcacagtata aagaaacaca agatttaatt 4380 atttttctac ttggggggaaaaaagtcctc atgtagaagc acccactttt gcaatgttgt 4440 tctaagctat ctatctaactctcagcccat gataaagttc cttaagctgg tgattcctaa 4500 tcaaggacaa gccaccctagtgtctcatgt ttgtatttgg tcccagttgg gtacatttta 4560 aaatcctgat tttggagacttaaaaccagg ttaatggcta agaatgggta acatgactct 4620 tgttggattg ttattttttgtttgcaatgg ggaatttata agaagcatca agtctctttc 4680 ttaccaaagt cttgttaggtggtttatagt tcttttggct aacaaatca 4729 <210> SEQ ID NO 70 <211> LENGTH:443 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 70 tttttttttttttttccatt aacccaacac aagtttattt actaagtcaa gtcaaactga 60 ggagtatttgtttctttggt agttggtaga caaagaatac atatacatat tctatttccc 120 attaagcattcgatcatgtt acaaaacaat ggcctagaga actatcattg aagatttacc 180 aaatctgcctgaagcaaaat gtgataaact gcagaaatgg tggagaatga cactggaagt 240 cataaagttgattctcaaac acgggtttga actgcatagg accgcttata tgcatatttt 300 gataaatatattgaaaattt ttttggaaat ttgcaacaat ttaaaaaact tgcagatgca 360 ccatgtagcttagaaatact gaaaaactaa gaaaaaggtg tgtcatgaat tcatataata 420 tatgtagacactagtctatt tta 443 <210> SEQ ID NO 71 <211> LENGTH: 2432 <212> TYPE: DNA<213> ORGANISM: human <400> SEQUENCE: 71 ggcgagtggc gagtggcgagtgtcaggggg gcggccggcg ggggcggggc ggccggagga 60 ggcgttggca gcgggctcggacccacgcgg cgccgcggcc cgcctggcct gcagcgctcc 120 cacccccggc ggcggcacgatgccctttga cttcaggagg tttgacatct acaggaaggt 180 gcccaaggac cttacgcagccaacgtacac cggggccatt atctccatct gctgctgcct 240 cttcatcctc ttcctcttcctctcggagct caccggattt ataacgacag aagttgtgaa 300 cgagctctat gtcgatgacccagacaagga cagcggtggc aagatcgacg tcagtctgaa 360 catcagttta cccaatctgcactgcgagtt ggttgggctt gacattcagg atgagatggg 420 caggcacgaa gtgggccacatcgacaactc catgaagatc ccgctgaaca atggggcagg 480 ctgccgcttc gaggggcagttcagcatcaa caaggtcccc ggcaacttcc acgtgtccac 540 acacagtgcc acagcccagccacagaaccc agacatgacg catgtcatcc acaagctctc 600 ctttggggac acgctacaggtccagaacat ccacggagct ttcaatgctc tcgggggagc 660 agacagactc acctccaaccccctggcctc ccacgactac atcctgaaga ttgtgcccac 720 ggtttatgag gacaagagtggcaagcagcg gtactcctac cagtacacgg tggccaacaa 780 ggaatacgtc gcctacagccacacgggccg catcatccct gcaatctggt tccgctacga 840 cctcagcccc atcacggtcaagtacacaga gagacggcag ccgctgtaca gattcatcac 900 cacgatctgt gccatcattggcgggacctt caccgtcgcc ggcatcctgg actcatgcat 960 cttcacagcc tctgaggcctggaagaagat ccagctgggc aagatgcatt gacgccacac 1020 ccagcctaat ggccgaggaccctgggcatc gccagccttg cctccagtgc cctgtctcct 1080 ttggccctca atctggtcccaaatctggct gtgtcccaaa gggtgtgtgg gaagtggggg 1140 gaaagtagag gatggctcgatgttttgcag ctacctcttt tccccgtgtt tctttttaga 1200 caaattacac tgcctgaagttgcagttccc ctttccctgg ggagccccaa gaacagagtc 1260 aggcaagggg tggggagtccagggatcttg gggacccctc ctaggagagc tgcagtctct 1320 tccctcaggg gaacatcccagaatgcatat cgatcagctc tcagccaggc ttcgacaatc 1380 tcgcagcccc cactaggtggacacattaat gatttggttt ctcccctggg cagccaacct 1440 gccccagagg caccagacctgggctttcag ctttgggacc aggctgccca aaggtactcc 1500 tttatacacc cggcaccttccacgaaagat ggtacttccc aagcaagccc ctatgatttg 1560 tcactataga tggaaccctgacttctgccc catcccttcc tgcccaacct agaacccagg 1620 cctcaagtct ttaccccacccctttcttgt tcttccaaga agcagatgcc cagttgctca 1680 gcagcagcgg tagagacttgaatctgccca ccagtcacaa ggcgggtcac agattcctct 1740 tcctctcttc tcctcgttcctctgaaccct ccaccaatgt gcctcagcct gtgtgctgtg 1800 tggcaacagc attctggttcccactgccaa gatctcccac cactctgctg ggatctgcag 1860 tggcagggag tgggggttgtgtaaagggga agtcatcttt tgagatccag atagacatgg 1920 tttgtgcact tacgtccagatgggaagcat ccttcctgca accctaaaat aatcatgcag 1980 cctctcagac ggacgccatcggtcccaagg ccttaggtgg aggaagcaaa gcaggccagg 2040 cctgtcctgt ccgtggacctctaccttctg gactccctac gggtgcagag cacttgggtt 2100 tctctacagc catcgtggcccacttgacac tgtgctcctc catcagctgg tcacatgcca 2160 acacgttccc agcccctgaggcagctccag ggtgccccac ctgctcctga ggtgggtccc 2220 taccctgctg ctcctcttcatcctttccct tttgtcctga aagggaggag caatggtcca 2280 ggcattaatt ccacccagggaattttagct atgccctcat gtcccaggga gagagccaca 2340 cgcctgtttt ccatttatagcaagattgtt tgcatacttt tgtaatgaag gggagtgtcc 2400 agtggaagga tttttaaaattatcttatgg at 2432 <210> SEQ ID NO 72 <211> LENGTH: 2782 <212> TYPE: DNA<213> ORGANISM: human <400> SEQUENCE: 72 gcggccgcgg cggggcggcgcgggaaccgg gccccggggg gagtcggccg ggctgctgct 60 gctgctgctc caggtgctgccgcccggggc tacggcaggg ccgggacgcc ggggcacgcg 120 gggcgctggc ggcggcggcgtctgctggcc cggcgcggcc ccagcctttc cccgggacgc 180 gcggctgctg ctgctcctgccgccgctgcc gccactgtcg ccgccgccgc cgagctccgc 240 gcccgcagcc tccgcctcccggatggacgc tctgccccgc agcgggctga acctgaagga 300 ggagccgctg ctgcccgccggcctgggctc agtgcgctcc tggatgcagg gcgcgggcat 360 cctggacgcc agcaccgcggcgcagagtgg cgtgggtctg gcacgagcac attttgagaa 420 gcagcctccc tccaacctcaggaaatccaa cttcttccac ttcgtgctgg ccatgtacga 480 ccggcagggg cagcccgtggaggtggagcg cacagccttc atcgacttcg tggaaaagga 540 ccgagagccc ggggcggaaaagactaacaa tgggatccat taccgcctcc ggctggtgta 600 taacaatgga ctgcggacagagcaagacct ctacgtgcgt ctcatcgact ccatgtccaa 660 acaggccatc atctatgaggggcaggacaa gaaccccgaa atgtgccgag tgctgctcac 720 ccatgagatc atgtgcagccggtgctgtga ccggaagagc tgtggcaacc ggaatgagac 780 gccctcagac cccgtcatcattgacaggtt cttcctcaag ttcttcctca aatgcaacca 840 gaactgcctg aagaatgcggggaatcccag agacatgcgc cgcttccagg tggtggtgtc 900 cacgacggtg agcgtggacggacacgtgct ggccgtgtcc gacaacatgt ttgtgcacaa 960 caactccaag catggccgcagggcgcgccg cctggacccc tccgaagctg ccaccccctg 1020 catcaaggcc atcagccccggggagggctg gaccacgggc ggcgccaccg tcattgtcat 1080 cggcgacaac ttcttcgacgggttgcaggt cgtgttcgga aacgtgctcg tgtggagcga 1140 gctcatcacg ccccacgccatccgggtgca gacgcccccg cggcacatcc ccggggtggt 1200 ggaggtgacc ctctcctacaagtccaagca gttttgcaag ggatgccccg gccgctttgt 1260 ctacacagct ctgaacgagcccaccattga ctacggattc cagaggctac agaaagtcat 1320 tcccagacac cccggagaccccgagaggct gcccaaggaa gtgctgctga agcgggcggc 1380 cgacttggca gaagccctgtacggagtgcc cggcagtaac caggagctgc tcctgaagcg 1440 cgcggcggac gtggccgaggctctgtacag caccccccgc gcacccgggc cgctcgcacc 1500 cctggccccg agccacccacactccgccgt cgtgggcatc aacgccttca gcagcccgct 1560 ggccatcgcc gtcggggacgccaccccggg gcccgagccg ggctacgcgc gcagctgcag 1620 cagcgcgtcc ccccgcgggttcgcgcccag ccccggctcg cagcagagcg gctacggcgg 1680 cggcctcgga gctggcctgggcggctacgg cgcgccgggc gtggccggcc tcggcgtgcc 1740 tgggtccccc agcttcctcaatggctccac cgccacctcg cccttcgcca aggagcgcct 1800 tcgcccccgt gctgcgccccccaagctccc caccccaggc ctgccccaga gcccacggag 1860 aggggcttcc agaccagtcttttgaggatt ctgacaagtt ccactctcca gcccgggggc 1920 ttcagggcct ggcatactcctaattacggt ctgcagctgt tcccatggag cccggactgg 1980 aggtccctct gggattcacagccacacccc ggatggtggc acagacagat gcagggccag 2040 ggccatgggc ggacctcaacccgtgagctg aacggggaga ggccttcacc ccatgctcaa 2100 gcctccccgc tagcagccccacaggcttct ctcgcctccc tgtcttgggg tagtcagaag 2160 ccccagcact gtgcagatgctcttggcagg acagcatcgc agggaggtgc tgggattctg 2220 ggcctcactg tctgggtcttggttcctctg aaagagatgg atcttgtgca gaccagggtt 2280 gttgagtgag gggagcgtgggatggggacc gtgggaaaga ggacagctca gggagaagtg 2340 acctggaaag gtcctgtttgcatctgaccc atctcaactg gcccagcatc ccaacttctc 2400 tgcagcgaaa gggtggcgccccgcagcctc gggaggcctg cccaggctcc cgtggagctt 2460 ccaacagctg cttggccccgcagctgcccc cacttccttt gagacctgca ctctcatgct 2520 tgccgcatca tgcctccctgtgggggcttt gggcatggag gaggcagaag agggggtgcc 2580 aggcctcctg tatttggggtcttcccccag tggatgtctc atggactctg gccccacaca 2640 ctcacaatga ctctggctggccccacgcag cgggcccagc cgccccccag gtggcctcac 2700 attctgctct gctaagtttggagaaaacag aacaataaac cagatgcagg tggtgcccgc 2760 ccggcctctc acctgcctcctt 2782 <210> SEQ ID NO 73 <211> LENGTH: 1722 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 73 ggggaaaaga gctaggaaag agctgcaaagcagtgtgggc tttttccctt tttttgctcc 60 ttttcattac ccctcctccg ttttcacccttctccggact tcgcgtagaa cctgcgaatt 120 tcgaagagga ggtggcaaag tgggagaaaagaggtgttag ggtttggggt ttttttgttt 180 ttgtttttgt tttttaattt cttgatttcaacattttctc ccaccctctc ggctgcagcc 240 aacgcctctt acctgttctg cggcgccgcgcaccgctggc agctgagggt tagaaagcgg 300 ggtgtatttt agattttaag caaaaattttaaagataaat ccatttttct ctcccacccc 360 caacgccatc tccactgcat ccgatctcattatttcggtg gttgcttggg ggtgaacaat 420 tttgtggctt tttttcccct ataattctgacccgctcagg cttgagggtt tctccggcct 480 ccgctcactg cgtgcacctg gcgctgccctgcttccccca acctgttgca aggctttaat 540 tcttgcaact gggacctgct cgcaggcaccccagccctcc acctctctct acatttttgc 600 aagtgtctgg gggagggcac ctgctctacctgccagaaat tttaaaacaa aaacaaaaac 660 aaaaaaatct ccgggggccc tcttggcccctttatccctg cactctcgct ctcctgcccc 720 accccgaggt aaagggggcg actaagagaagatggtgttg ctcaccgcgg tcctcctgct 780 gctggccgcc tatgcggggc cggcccagagcctgggctcc ttcgtgcact gcgagccctg 840 cgacgagaaa gccctctcca tgtgcccccccagccccctg ggctgcgagc tggtcaagga 900 gccgggctgc ggctgctgca tgacctgcgccctggccgag gggcagtcgt gcggcgtcta 960 caccgagcgc tgcgcccagg ggctgcgctgcctcccccgg caggacgagg agaagccgct 1020 gcacgccctg ctgcacggcc gcggggtttgcctcaacgaa aagagctacc gcgagcaagt 1080 caagatcgag agagactccc gtgagcacgaggagcccacc acctctgaga tggccgagga 1140 gacctactcc cccaagatct tccggcccaaacacacccgc atctccgagc tgaaggctga 1200 agcagtgaag aaggaccgca gaaagaagctgacccagtcc aagtttgtcg ggggagccga 1260 gaacactgcc cacccccgga tcatctctgcacctgagatg agacaggagt ctgagcaggg 1320 cccctgccgc agacacatgg aggcttccctgcaggagctc aaagccagcc cacgcatggt 1380 gccccgtgct gtgtacctgc ccaattgtgaccgcaaagga ttctacaaga gaaagcagtg 1440 caaaccttcc cgtggccgca agcgtggcatctgctggtgc gtggacaagt acgggatgaa 1500 gctgccaggc atggagtacg ttgacggggactttcagtgc cacaccttcg acagcagcaa 1560 cgttgagtga tgcgtccccc cccaacctttccctcacccc ctcccacccc cagccccgac 1620 tccagccagc gcctccctcc accccaggacgccactcatt tcatctcatt taagggaaaa 1680 atatatatct atctatttga ggaaaaaaaaaaaaaaaaaa aa 1722 <210> SEQ ID NO 74 <211> LENGTH: 2626 <212> TYPE: DNA<213> ORGANISM: human <400> SEQUENCE: 74 gggtacggct gcgagaagacgacagaaggg gatgtcacct gctttatttc tggctttggc 60 ctgtggtctg tgatacccatcctgcttgat gttctgcaga atggcacttg actgctgggc 120 atgcatgaag ttaagggcaagaaacagtat gccatgtgtt ctgtaccatc atgtgtctct 180 tcttgcttct gggcccttctactggtgaac tttcatcaag atctgcgcca tgccgtgtca 240 ctatcaagcc attaagttttgtctgggttg ctgtcagccc cagttggctt cctggtcaac 300 aaggacctca agaactgcctgtggaccgag gccccctacc agtgcatgag acacacacct 360 accctcccca gctttccaggaaccctactg gctgccagac tgatgggcgg gctggtatgt 420 gtggacatgt gttcactgtcattatgctgt ggctccaggt gagggtgagg actgggccta 480 tatagaatcc agataccattgtcaacttcc cttattcccg tctaagatgt gagcagagtg 540 ccatagtagg ggttctgggaagaggtattt ctgatttgtg ggcctctgct tgcttgactt 600 caggtcactt atacttcttattttgcttgc ctgccttcat ccctcatttc ctccctctca 660 ttcttctttc ctccctccctttcctggtag cctcctttcc tccccttctg ccttcccctt 720 ccttctttcc ttattcttttttattttgtt taaatagtac cacagagaaa acaactgaaa 780 aaccacattt ttctacatacagctggggag gtagctgaga acttggcact gcgcacacat 840 actaggttga aagagagttgaggaaaccag aaggccaagt ggatctgctg gcaaaccctg 900 aacctgtctc ctgcgcttgctctacagttc tgaagttgaa aatcgttttc atgcctagca 960 tctgcttgag ttataaaccccaaggcagcc atgtcataga ctagtgttta ctcttgtttt 1020 gactttgttt taatgcttcctaagacccaa gtgcctcctg ctgtttcctc ctttgtggta 1080 gcctctggcc atctggacctcaatccccag ctttcccact ttcagcagtc ctttgctctc 1140 tttgcttcta cctcaaatagccccaggagt gggctttagt ctccaatatg gagcatctca 1200 agcttctcct gggggatggggattgggatg ggcggaatct gttttggatc tccgggttat 1260 ttccagtggg tgtaaaagcagagctgggcc tttccctctc ttatccctga gggtgggtaa 1320 gaaggactgt atctacacctgttcttccct accttctctt ttgttaggga ggcctcattc 1380 taagttcctc aagagagtccttggcttaaa gctgtagcaa gggtgtgcta ggtgggggat 1440 ttggagcaaa accgtcgagtaggcatgata ctggtatgga gtgggcctgc aaaatcagac 1500 agaaatggct tgagaagccgcagggggagc atgcctgtct ctcagtgata gagtatggga 1560 gggacctccc tagcttggaaaatgagaatt gaaggggtta tgaacaaata ggatgcctag 1620 ttgaggatgt tcccaaagttttgtccaatc ttatcattag tagattttat aagccacaga 1680 gacaaaccag aaacggaataatgttacttt ggatgcttta tttttttgtt ctaggtgtgg 1740 ctttgtacat gcagaagaatgctatatgct gcacattttg cctttaaagt cttacgactt 1800 tccccatttt agtctaatgggaagatacag atgtgcaagt ctgctttttt gttttttgtt 1860 attatttttt tttttgctctgtgttatgga cattttcaga catgcacaga agtggagagg 1920 atggtccttg gaccccatgtgtccatcacc tagctgcatc acttatcagc tatggtcaac 1980 ctggtttcat ctgtatctctctcttttcac ctgtattgtt tattgaaaat ccaagacact 2040 atgccaatgc aaccgtgactactttgggag attggtagtc tcttttgatg gtgatagtga 2100 tggggtgcac tatcataatcacatcaggtc tgctttttgc ttttaatgtt aactaatgaa 2160 gttccagaga tgggccttagaaatgtgttt taagaattaa caaggagtct caaaaagaaa 2220 tgagagggat gcttcctttcccttgcatct acaaaacaag agagagactg ttctgttgta 2280 aaactctttc aaaaattctgatatggtaag gtacttgaga cccttcacca gaatgtcaat 2340 ctttttttct gtgtaacatggaaacttgtg tgaccattag cattgttatc agcttgtact 2400 ggtctcataa ctctggttttggaagaataa tttggaaatt gttgctgtgt tctgtgaaaa 2460 taacctcccc aaaataattagtaactggtt gttctacttg gtaatttgac accctgttaa 2520 taacgcaatt atttctgtgttcttaaacag tataaatagt tgtaagtttg catgcatgat 2580 ggaaaaataa aaacctgtatctctgtcaaa aaaaaaaaaa aaaaaa 2626 <210> SEQ ID NO 75 <211> LENGTH: 3337<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 75 gtcgagcctctagcccgccc gggtttcctt cgcagtcgcg caccgacgct caaacgcgcg 60 ctccaacccgcagcctcctc ctgcctcacc gcccgaagat ggcggctctc aaactcctct 120 cctccgggcttcggctctgc gcctctgccc gcggatctgg ggcaacctgg tacaagggat 180 gtgtttgttccttttccacc agtgctcatc gccataccaa gttttataca gatccagtag 240 aagctgtaaaagacatccct gatggtgcca cggttttggt tggtggtttt gggctatgtg 300 gaattccagagaatcttata gatgctttac tgaaaactgg agtaaaagga ctaactgcag 360 tcagcaacaatgcaggggtt gacaattttg gtttggggct tttgcttcgg tcgaagcaga 420 taaaacgcatggtctcttca tatgtgggag aaaatgcaga atttgaacga cagtacttat 480 ctggtgaattagaagtggag ctgacaccac agggcacact tgcagagagg atccgtgcag 540 gcggggctggagttcctgca ttttacaccc caacagggta tgggaccctg gtacaagaag 600 gaggatcgcccatcaaatac aacaaagatg gcagtgttgc cattgccagt aagccaagag 660 aggtgagggagttcaatggt cagcacttta ttttggagga agcaattaca ggggattttg 720 ctttggtgaaagcctggaag gcggaccgag caggaaacgt gattttcagg aaaagtgcaa 780 ggaatttcaacttgccaatg tgcaaagctg cagaaaccac agtggtagag gttgaagaaa 840 ttgtggatattggagcattt gctccagaag acatccatat tcctcagatt tatgtacatc 900 gccttataaagggagaaaaa tatgagaaaa gaattgagcg tttatcaatc cggaaagagg 960 gagatggggaagccaaatct gctaaacctg gagatgacgt aagggaacga atcatcaaga 1020 gggccgctcttgagtttgag gatggcatgt atgctaattt gggcatagga atccctctcc 1080 tggccagcaattttatcagc ccaaatataa ctgttcatct tcaaagtgaa aatggagttc 1140 tgggtttgggtccatatcca cgacaacatg aagctgatgc agatctcatc aatgcaggca 1200 aggaaacagttactattctt ccaggagcct cttttttctc cagcgatgaa tcatttgcaa 1260 tgattagaggtggacacgtc gatctgacaa tgctaggagc gatgcaggtt tccaaatatg 1320 gtgacctggctaactggatg atacctggga agatggtgaa aggaatggga ggtgctatgg 1380 atttagtgtccagtgcgaaa accaaagtgg tggtcaccat ggagcattct gcaaagggaa 1440 atgcacataaaatcatggag aaatgtacat taccattgac tggaaagcaa tgtgtcaacc 1500 gcattattactgaaaaggct gtgtttgatg tggacaagaa gaaagggttg actctgattg 1560 agctctgggaaggcctgaca gtggatgacg tacaaaagag tactgggtgt gattttgcag 1620 tttcaccaaaactcatgcca atgcagcaga tcgcaaattg aaatatggat atttgtacca 1680 ggctgcgtgtttttcatttt aaacacacaa gatttaattg aaaggacatc aataatcata 1740 attgtgtatttaacaggtgg ttttttatta gttttcttgt gtttcagact ttatgcagcc 1800 atataaactgttctctaggc atgctgtgac attttaataa aaagcaaaag gagcatttat 1860 aattatctcatttgttaagg ctgagaaggt tgtttttata ataggtaatt atattgaatg 1920 cattttcactgaatatggta tgtatgctaa attatatgaa cctttcccca agaagggccc 1980 tagaaattgatgtggctttc ctcttaaata ttaattatta gtcctgaaag aaagataaca 2040 tatgtgatttttgtggttag gagagttgct gtcatgattg ttttttcttc agcctcctct 2100 gacttttcttttggggcttc agattttatg attacatctt gtccccctag aacatccccc 2160 ttcctcccatactgctttta aacagatgcc caagaaggca agcaggaatg cctcttgtgg 2220 gggagggcagggagaaataa ctagttcaaa ccaactatct atctatgctt tgcaaagact 2280 aaggcgtattataggaagag ggctagaaac ctaactgatt cttctcagtt ttctcatttt 2340 aaaacagcccagtattcctt tgtatcctca agggtccttg agaatacttc tgttattgaa 2400 accctgtgggctacttgtac tgtacctcct ctcaagccaa gaagggctgt gggataattt 2460 accatgaatccttagtagca atgacagcag agttaaaaaa taaaaggtgt tttactttca 2520 ggctcttgttttggttcaga ggagatttta aatattgaat gacacttcta cagaacaacg 2580 gtttttcttctgccaaggct acttccttta acgaagtgcc tttaattcag ccttatccaa 2640 ctagggaaaataatgttgga caagtctagg atttgaagag tcagtgaact tttagtgtca 2700 gggaataaacatggtgggta gattaggttt gaaaaaaact tccttagagg tatttattct 2760 caatacctgacaggggccca tgggaatgac ttcagaagca tcccggataa tagatgggta 2820 aaaagtctaggcaccctgaa gaacaggtga gacagctggc ctctggacag aggtaggcat 2880 agtacagtacgatatatcat tcctctggtc ctaaatatac aaacttattc atgtttttag 2940 gtgatgatggtcattgaaac tcacttcttt tcaggtgtag ctacaattgt gtaatgtaca 3000 atattagagaaaggacaggc tttttatgag taacacacac catatataaa acagcctttc 3060 tggctgaccacatggttaaa tgcatacctt cccagtactg gggggaaaat gacccttctt 3120 agaatgtgcaagttccatag agtaatatat tgatatgatt ttgaaaagaa ttgttgatag 3180 ttacatcttcaaacttatca ttccagtatg catctttaag ataatgtgat tctaagtaga 3240 tgactttatattcttgatta aagagtgcta tacatgttaa gaaatgcatt aaggaataca 3300 ataaatattctaaactgatg aaaaaaaaaa aaaaaaa 3337 <210> SEQ ID NO 76 <211> LENGTH: 2460<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 76 aaagtcaaaccccgacaccg cggcgggccg gtgagctcac tagctgaccc ggcaggtcag 60 gatctggcttagcggcgccg cgagctccag tgcgcgcacc cgtggccgcc tcccagccct 120 ctttgccggacgagctctgg gccgccacaa gactaaggaa tggccacccc gcccaagaga 180 agctgcccgtctttctcagc cagctctgag gggacccgca tcaagaaaat ctccatcgaa 240 gggaacatcgctgcagggaa gtcaacattt gtgaatatcc ttaaacaatt gtgtgaagat 300 tgggaagtggttcctgaacc tgttgccaga tggtgcaatg ttcaaagtac tcaagatgaa 360 tttgaggaacttacaatgtc tcagaaaaat ggtgggaatg ttcttcagat gatgtatgag 420 aaacctgaacgatggtcttt taccttccaa acatatgcct gtctcagtcg aataagagct 480 cagcttgcctctctgaatgg caagctcaaa gatgcagaga aacctgtatt attttttgaa 540 cgatctgtgtatagtgacag gtatattttt gcatctaatt tgtatgaatc tgaatgcatg 600 aatgagacagagtggacaat ttatcaagac tggcatgact ggatgaataa ccaatttggc 660 caaagccttgaattggatgg aatcatttat cttcaagcca ctccagagac atgcttacat 720 agaatatatttacggggaag aaatgaagag caaggcattc ctcttgaata tttagagaag 780 cttcattataaacatgaaag ctggctcctg cataggacac tgaaaaccaa cttcgattat 840 cttcaagaggtgcctatctt aacactggat gttaatgaag actttaaaga caaatatgaa 900 agtctggttgaaaaggtcaa agagtttttg agtactttgt gatcttgctg aagactacag 960 gcagccaaatggttccagat acttcagctt tgtgtatctt cgtaacttca tattaatata 1020 agtttctttagaaaacccaa gtttttaatc gtttttgttt taaggaaaaa agatttttaa 1080 aatgaatcttatgcaaaact ttttgatcag tttcttttct tttgtttttt ttttaaaaaa 1140 gacatttaaagacaaagaca ttatttctca tagcaggaaa tgtagaggta gatggttcca 1200 gtatcagcatagtgactaaa ctacattata aaagatccag cttccttctg tcattcccct 1260 cttttgtcttcctcagcagg ttggcttttt tccctggtgc ctctcacttc gttggtgacc 1320 agtttcttaaactgaaagct ttaatgttac atagtaaatg gtagtgtgtc ctgtgtaaat 1380 tagtgtacctattaaaagtt gcaaagtgga attaaaggaa tccctagaat aaggattctg 1440 aagttttattttaaattatt atcttcttaa cagtttagtc ccacctctta cttcctgcct 1500 cagtctgctttctctactgt ctggattaat taggcagcct gctataaagt taaagtcaca 1560 catttctattttgcaaacac tgtgattact ctttgctttg tagtttgctt tgctttgtag 1620 ggttctgcttttaagttttt ctctttttca gacaaattac tgataaaaat gatattgctc 1680 tatatgtaatatatcctgaa agcattattt tttgttgaat aggaaataaa attaatgaag 1740 acagaggctagaaagcatcc attaattaat gagacacact taactactta tctctaaacc 1800 atctatgtgaatatttgtaa aaataatgaa tggactcatc ttagttctgt atataaatat 1860 attttctttctagtttgttt agttaaggtg tgcagtgttt ttcctgtgta ttaaaccttt 1920 ccattttacgttttagaaaa ttttatgtat tttaaaataa ggggaagagt cattttcacc 1980 tttaaactactatttttctt tccaagtcat ttttgttttt ggtttcttat tcaaagatga 2040 taatttagtggattaaccag tccagacgca ctgatctttg caaaggagac ttaatttcaa 2100 atctgtaattaccatacata aactgtctca ttatacgtat gcattttttt agtttgtttt 2160 tgtttggtataaattaattt gttaattaaa tatttcttaa gtataaacct tatgaactac 2220 agtggagctacactcattga aatgtaattt cagttctaaa aagatgtaat aatcatttta 2280 gaattaaaatttattctact tttaaataaa ttatgaatat taaaggtgaa aattgtataa 2340 attactttgattccatttta agtggagaca tatttcagtg atttttagta acctttaaaa 2400 atgtataatgacttttaaaa tttgtagaat tgaaaagacg ctaataaaaa tttattattt 2460 <210> SEQ IDNO 77 <211> LENGTH: 7680 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 77 gcggacactc ctctcggctc ctccccggca gcggcggcgg ctcggagcgggctccggggc 60 tcgggtgcag cggccagcgg gcctggcggc gaggattacc cggggaagtggttgtctcct 120 ggctggagcc gcgagacggg cgctcagggc gcggggccgg cggcggcgaacgagaggacg 180 gactctggcg gccgggtcgt tggccggggg agcgcgggca ccgggcgagcaggccgcgtc 240 gcgctcacca tggtcagcta ctgggacacc ggggtcctgc tgtgcgcgctgctcagctgt 300 ctgcttctca caggatctag ttcaggttca aaattaaaag atcctgaactgagtttaaaa 360 ggcacccagc acatcatgca agcaggccag acactgcatc tccaatgcaggggggaagca 420 gcccataaat ggtctttgcc tgaaatggtg agtaaggaaa gcgaaaggctgagcataact 480 aaatctgcct gtggaagaaa tggcaaacaa ttctgcagta ctttaaccttgaacacagct 540 caagcaaacc acactggctt ctacagctgc aaatatctag ctgtacctacttcaaagaag 600 aaggaaacag aatctgcaat ctatatattt attagtgata caggtagacctttcgtagag 660 atgtacagtg aaatccccga aattatacac atgactgaag gaagggagctcgtcattccc 720 tgccgggtta cgtcacctaa catcactgtt actttaaaaa agtttccacttgacactttg 780 atccctgatg gaaaacgcat aatctgggac agtagaaagg gcttcatcatatcaaatgca 840 acgtacaaag aaatagggct tctgacctgt gaagcaacag tcaatgggcatttgtataag 900 acaaactatc tcacacatcg acaaaccaat acaatcatag atgtccaaataagcacacca 960 cgcccagtca aattacttag aggccatact cttgtcctca attgtactgctaccactccc 1020 ttgaacacga gagttcaaat gacctggagt taccctgatg aaaaaaataagagagcttcc 1080 gtaaggcgac gaattgacca aagcaattcc catgccaaca tattctacagtgttcttact 1140 attgacaaaa tgcagaacaa agacaaagga ctttatactt gtcgtgtaaggagtggacca 1200 tcattcaaat ctgttaacac ctcagtgcat atatatgata aagcattcatcactgtgaaa 1260 catcgaaaac agcaggtgct tgaaaccgta gctggcaagc ggtcttaccggctctctatg 1320 aaagtgaagg catttccctc gccggaagtt gtatggttaa aagatgggttacctgcgact 1380 gagaaatctg ctcgctattt gactcgtggc tactcgttaa ttatcaaggacgtaactgaa 1440 gaggatgcag ggaattatac aatcttgctg agcataaaac agtcaaatgtgtttaaaaac 1500 ctcactgcca ctctaattgt caatgtgaaa ccccagattt acgaaaaggccgtgtcatcg 1560 tttccagacc cggctctcta cccactgggc agcagacaaa tcctgacttgtaccgcatat 1620 ggtatccctc aacctacaat caagtggttc tggcacccct gtaaccataatcattccgaa 1680 gcaaggtgtg acttttgttc caataatgaa gagtccttta tcctggatgctgacagcaac 1740 atgggaaaca gaattgagag catcactcag cgcatggcaa taatagaaggaaagaataag 1800 atggctagca ccttggttgt ggctgactct agaatttctg gaatctacatttgcatagct 1860 tccaataaag ttgggactgt gggaagaaac ataagctttt atatcacagatgtgccaaat 1920 gggtttcatg ttaacttgga aaaaatgccg acggaaggag aggacctgaaactgtcttgc 1980 acagttaaca agttcttata cagagacgtt acttggattt tactgcggacagttaataac 2040 agaacaatgc actacagtat tagcaagcaa aaaatggcca tcactaaggagcactccatc 2100 actcttaatc ttaccatcat gaatgtttcc ctgcaagatt caggcacctatgcctgcaga 2160 gccaggaatg tatacacagg ggaagaaatc ctccagaaga aagaaattacaatcagagat 2220 caggaagcac catacctcct gcgaaacctc agtgatcaca cagtggccatcagcagttcc 2280 accactttag actgtcatgc taatggtgtc cccgagcctc agatcacttggtttaaaaac 2340 aaccacaaaa tacaacaaga gcctggaatt attttaggac caggaagcagcacgctgttt 2400 attgaaagag tcacagaaga ggatgaaggt gtctatcact gcaaagccaccaaccagaag 2460 ggctctgtgg aaagttcagc atacctcact gttcaaggaa cctcggacaagtctaatctg 2520 gagctgatca ctctaacatg cacctgtgtg gctgcgactc tcttctggctcctattaacc 2580 ctccttatcc gaaaaatgaa aaggtcttct tctgaaataa agactgactacctatcaatt 2640 ataatggacc cagatgaagt tcctttggat gagcagtgtg agcggctcccttatgatgcc 2700 agcaagtggg agtttgcccg ggagagactt aaactgggca aatcacttggaagaggggct 2760 tttggaaaag tggttcaagc atcagcattt ggcattaaga aatcacctacgtgccggact 2820 gtggctgtga aaatgctgaa agagggggcc acggccagcg agtacaaagctctgatgact 2880 gagctaaaaa tcttgaccca cattggccac catctgaacg tggttaacctgctgggagcc 2940 tgcaccaagc aaggagggcc tctgatggtg attgttgaat actgcaaatatggaaatctc 3000 tccaactacc tcaagagcaa acgtgactta ttttttctca acaaggatgcagcactacac 3060 atggagccta agaaagaaaa aatggagcca ggcctggaac aaggcaagaaaccaagacta 3120 gatagcgtca ccagcagcga aagctttgcg agctccggct ttcaggaagataaaagtctg 3180 agtgatgttg aggaagagga ggattctgac ggtttctaca aggagcccatcactatggaa 3240 gatctgattt cttacagttt tcaagtggcc agaggcatgg agttcctgtcttccagaaag 3300 tgcattcatc gggacctggc agcgagaaac attcttttat ctgagaacaacgtggtgaag 3360 atttgtgatt ttggccttgc ccgggatatt tataagaacc ccgattatgtgagaaaagga 3420 gatactcgac ttcctctgaa atggatggct cccgaatcta tctttgacaaaatctacagc 3480 accaagagcg acgtgtggtc ttacggagta ttgctgtggg aaatcttctccttaggtggg 3540 tctccatacc caggagtaca aatggatgag gacttttgca gtcgcctgagggaaggcatg 3600 aggatgagag ctcctgagta ctctactcct gaaatctatc agatcatgctggactgctgg 3660 cacagagacc caaaagaaag gccaagattt gcagaacttg tggaaaaactaggtgatttg 3720 cttcaagcaa atgtacaaca ggatggtaaa gactacatcc caatcaatgccatactgaca 3780 ggaaatagtg ggtttacata ctcaactcct gccttctctg aggacttcttcaaggaaagt 3840 atttcagctc cgaagtttaa ttcaggaagc tctgatgatg tcagatatgtaaatgctttc 3900 aagttcatga gcctggaaag aatcaaaacc tttgaagaac ttttaccgaatgccacctcc 3960 atgtttgatg actaccaggg cgacagcagc actctgttgg cctctcccatgctgaagcgc 4020 ttcacctgga ctgacagcaa acccaaggcc tcgctcaaga ttgacttgagagtaaccagt 4080 aaaagtaagg agtcggggct gtctgatgtc agcaggccca gtttctgccattccagctgt 4140 gggcacgtca gcgaaggcaa gcgcaggttc acctacgacc acgctgagctggaaaggaaa 4200 atcgcgtgct gctccccgcc cccagactac aactcggtgg tcctgtactccaccccaccc 4260 atctagagtt tgacacgaag ccttatttct agaagcacat gtgtatttatacccccagga 4320 aactagcttt tgccagtatt atgcatatat aagtttacac ctttatctttccatgggagc 4380 cagctgcttt ttgtgatttt tttaatagtg cttttttttt ttgactaacaagaatgtaac 4440 tccagataga gaaatagtga caagtgaaga acactactgc taaatcctcatgttactcag 4500 tgttagagaa atccttccta aacccaatga cttccctgct ccaacccccgccacctcagg 4560 gcacgcagga ccagtttgat tgaggagctg cactgatcac ccaatgcatcacgtacccca 4620 ctgggccagc cctgcagccc aaaacccagg gcaacaagcc cgttagccccaggggatcac 4680 tggctggcct gagcaacatc tcgggagtcc tctagcaggc ctaagacatgtgaggaggaa 4740 aaggaaaaaa agcaaaaagc aagggagaaa agagaaaccg ggagaaggcatgagaaagaa 4800 tttgagacgc accatgtggg cacggagggg gacggggctc agcaatgccatttcagtggc 4860 ttcccagctc tgacccttct acatttgagg gcccagccag gagcagatggacagcgatga 4920 ggggacattt tctggattct gggaggcaag aaaaggacaa atatcttttttggaactaaa 4980 gcaaatttta gacctttacc tatggaagtg gttctatgtc cattctcattcgtggcatgt 5040 tttgatttgt agcactgagg gtggcactca actctgagcc catacttttggctcctctag 5100 taagatgcac tgaaaactta gccagagtta ggttgtctcc aggccatgatggccttacac 5160 tgaaaatgtc acattctatt ttgggtatta atatatagtc cagacacttaactcaatttc 5220 ttggtattat tctgttttgc acagttagtt gtgaaagaaa gctgagaagaatgaaaatgc 5280 agtcctgagg agagttttct ccatatcaaa acgagggctg atggaggaaaaaggtcaata 5340 aggtcaaggg aagaccccgt ctctatacca accaaaccaa ttcaccaacacagttgggac 5400 ccaaaacaca ggaagtcagt cacgtttcct tttcatttaa tggggattccactatctcac 5460 actaatctga aaggatgtgg aagagcatta gctggcgcat attaagcactttaagctcct 5520 tgagtaaaaa ggtggtatgt aatttatgca aggtatttct ccagttgggactcaggatat 5580 tagttaatga gccatcacta gaagaaaagc ccattttcaa ctgctttgaaacttgcctgg 5640 ggtctgagca tgatgggaat agggagacag ggtaggaaag ggcgcctactcttcagggtc 5700 taaagatcaa gtgggccttg gatcgctaag ctggctctgt ttgatgctatttatgcaagt 5760 tagggtctat gtatttagga tgcgcctact cttcagggtc taaagatcaagtgggccttg 5820 gatcgctaag ctggctctgt ttgatgctat ttatgcaagt tagggtctatgtatttagga 5880 tgtctgcacc ttctgcagcc agtcagaagc tggagaggca acagtggattgctgcttctt 5940 ggggagaaga gtatgcttcc ttttatccat gtaatttaac tgtagaacctgagctctaag 6000 taaccgaaga atgtatgcct ctgttcttat gtgccacatc cttgtttaaaggctctctgt 6060 atgaagagat gggaccgtca tcagcacatt ccctagtgag cctactggctcctggcagcg 6120 gcttttgtgg aagactcact agccagaaga gaggagtggg acagtcctctccaccaagat 6180 ctaaatccaa acaaaagcag gctagagcca gaagagagga caaatctttgttgttcctct 6240 tctttacaca tacgcaaacc acctgtgaca gctggcaatt ttataaatcaggtaactgga 6300 aggaggttaa actcagaaaa aagaagacct cagtcaattc tctacttttttttttttttt 6360 tccaaatcag ataatagccc agcaaatagt gataacaaat aaaaccttagctgttcatgt 6420 cttgatttca ataattaatt cttaatcatt aagagaccat aataaatactccttttcaag 6480 agaaaagcaa aaccattaga attgttactc agctccttca aactcaggtttgtagcatac 6540 atgagtccat ccatcagtca aagaatggtt ccatctggag tcttaatgtagaaagaaaaa 6600 tggagacttg taataatgag ctagttacaa agtgcttgtt cattaaaatagcactgaaaa 6660 ttgaaacatg aattaactga taatattcca atcatttgcc atttatgacaaaaatggttg 6720 gcactaacaa agaacgagca cttcctttca gagtttctga gataatgtacgtggaacagt 6780 ctgggtggaa tggggctgaa accatgtgca agtctgtgtc ttgtcagtccaagaagtgac 6840 accgagatgt taattttagg gacccgtgcc ttgtttccta gcccacaagaatgcaaacat 6900 caaacagata ctcgctagcc tcatttaaat tgattaaagg aggagtgcatctttggccga 6960 cagtggtgta actgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtgtgtgggtgtg 7020 ggtgtatgtg tgttttgtgc ataactattt aaggaaactg gaattttaaagttactttta 7080 tacaaaccaa gaatatatgc tacagatata agacagacat ggtttggtcctatatttcta 7140 gtcatgatga atgtattttg tataccatct tcatataata tacttaaaaatatttcttaa 7200 ttgggatttg taatcgtacc aacttaattg ataaacttgg caactgcttttatgttctgt 7260 ctccttccat aaatttttca aaatactaat tcaacaaaga aaaagctcttttttttccta 7320 aaataaactc aaatttatcc ttgtttagag cagagaaaaa ttaagaaaaactttgaaatg 7380 gtctcaaaaa attgctaaat attttcaatg gaaaactaaa tgttagtttagctgattgta 7440 tggggttttc gaacctttca ctttttgttt gttttaccta tttcacaactgtgtaaattg 7500 ccaataattc ctgtccatga aaatgcaaat tatccagtgt agatatatttgaccatcacc 7560 ctatggatat tggctagttt tgcctttatt aagcaaattc atttcagcctgaatgtctgc 7620 ctatatattc tctgctcttt gtattctcct ttgaacccgt taaaacatcctgtggcactc 7680 <210> SEQ ID NO 78 <211> LENGTH: 3160 <212> TYPE: DNA<213> ORGANISM: human <400> SEQUENCE: 78 attctcgccg cgcccgggcggacgatccag cgaacagccc cgcttctaac ccgagatgct 60 gctgccggcg cccgcgctccgccgcgccct gctgtcccgc ccctggaccg gggccggcct 120 gcggtggaag cacacctcctccctgaaggt ggccaacgag cccgtcttag ccttcacgca 180 gggcagccct gagcgagatgccctgcaaaa ggccttgaag gacctgaagg gccggatgga 240 agccatccca tgcgtggtgggggatgagga ggtgtggacg tcggacgtgc agtaccaagt 300 gtcgcctttt aaccatggacataaggtggc caagttctgt tatgcagaca agagcctgct 360 caacaaagcc attgaggctgccctggctgc ccggaaagag tgggacctga agcctattgc 420 agaccgggcc cagatcttcctgaaggcggc agacatgctg agtgggccgc gcagggctga 480 gatcctcgcc aagaccatggtgggacaggg taagaccgtg atccaagcgg agattgacgc 540 tgcagcggaa ctcatcgacttcttccggtt caatgccaag tatgcggtgg agctggaggg 600 gcagcagccc atcagcgtgcccccgagcac caacagcacg gtgtaccggg gtctggaggg 660 cttcgtggcg gccatctcgccctttaactt cactgcaatc ggcggcaacc tggcgggggc 720 accggccctg atgggcaacgtggtcctatg gaagcccagt gacactgcca tgctggccag 780 ctatgctgtc taccgcatccttcgggaggc tggcctgccc cccaacatca tccagtttgt 840 gccagctgat gggcccctatttggggacac tgtcaccagc tcagagcacc tctgtggcat 900 caacttcaca ggcagtgtgcccaccttcaa acacctgtgg aagcaggtgg cccagaacct 960 ggaccggttc cacaccttcccacgcctggc tggagagtgc ggcggaaaga acttccactt 1020 cgtgcaccgc tcggccgacgtggagagcgt ggtgagcggg accctccgct cagccttcga 1080 gtacggtggc cagaagtgttccgcctgctc gcgtctctac gtgccgcact cgctgtggcc 1140 gcagatcaaa gggcggctgctggaggagca cagtcggatc aaagtgggcg accctgcaga 1200 ggattttggg accttcttctctgcagtgat tgatgccaag tcctttgccc gtatcaagaa 1260 gtggctggag cacgcgcgctcctcgcccag cctcaccatc ctggctgggg gcaagtgtga 1320 tgactccgtg ggctactttgtggagccctg catcgtggag agcaaggacc ctcaggagcc 1380 catcatgaag gaggagatcttcgggcctgt actgtctgtg tacgtctacc cggacgacaa 1440 gtacaaggag acgctgcagctggttgacag caccaccagc tatggcctca cgggggcagt 1500 gttctcccag gataaggacgtcgtgcagga ggccacaaag gtgctgagga atgctgccgg 1560 caacttctac atcaacgacaagtccactgg ctcgatagtg ggccagcagc cctttggggg 1620 ggcccgagcc tctggaaccaatgacaagcc agggggccca cactacatcc tgcgctggac 1680 gtcgccgcag gtcatcaaggagacacataa gcccctgggg gactggagct acgcgtacat 1740 gcagtgagcc cctctcgggctccaccgtcc agctgtctgt ccgtccaggt ggccgacctc 1800 actgcacaga ccccactccagcccctccac cccttcttca tgcacagctg cctttctata 1860 atccgggctt gactcccttcttaccactgt attctggcct ctcccatgcc tcaggctctg 1920 gtttgagatc gtgctggggaggaacatggc cactacccct tatcccatcg gccatgtggg 1980 aggtatgacc ctggtgcctggcaggttctc cctctgccct ccactgggcc cagtggctca 2040 gggacctggg gaaaggagatggagcagctc ttgggatcct ttggggaaaa ggaggccatt 2100 ctgggcccct tggcaaacctcaccactcac agaggctcct ggccttgatc cctgcccctc 2160 caggtgtcca gggtaaagtgtaactcagac tgacctgtgg ggcacagggg gcaccagctg 2220 gccttgccct ctctggtctgggctgtctac cttcctcact gtatctttgc ccagacccac 2280 ctgggccagt aggcccctgtccccagccac acaccttaga tgctggcatg ccttactcca 2340 ggtgcctgtg tttggccgaggcctgtgtga ttcccggtct gcaccacatg gcggggttgg 2400 ggggccgctg gaggccacctgccaaggcgt gggatgggat ggtcctgccg gtttaggccg 2460 tgattctgga aaaccttggatgggccttcg tcctatgtca gccttccctt tgatcctcag 2520 gccctacctg tagagacctccactcctaga gccagtctca gggtctggga tttccctgca 2580 ggagctcagc caccactgtgccatggtgac acaggccaag gcagacattg gccctccctt 2640 ctcccagccc ccagaggcctggccttgggt tcgtcagcat gggccgagga cgttgcctgt 2700 agaatcctcc tctgcctgggagtggctctg tgtggaccag tccctcactg gcccattctt 2760 tttttgacgc agccaatctgtgaccacgat tcctcccaca gatgcctcct gcttggattc 2820 tgagtggtca gagatctgtaaagcatgact ttcaaggatg gttcttaggg gactgtgaaa 2880 gtgttgggtc ttcctccaggatgcctgcat gggaccccac ccggagctgg tgtggccatt 2940 ccccaagtgc cactggcccatggatggggg tgggtgctgg tgccagctgg gctgggtgtg 3000 ggttctgtgt ccttccaggatatgtgtcat ttcccatgag gggccggggc aggtggctgg 3060 gtgggggcac aggctggagtattcttagtt ctactggttc tacactgtga ggtggcaatg 3120 ggatttgctc agatgccacccaataaaatg cctgttactt 3160 <210> SEQ ID NO 79 <211> LENGTH: 1546 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 79 cacggccgga gagacgcggaggaggagaca tgagccggcg ggcgcccaga cggagcggcc 60 gtgacgcttt cgcgctgcagccgcgcgccc cgaccccgga gcgctgaccc ctggccccac 120 gcagctccgc gcccgggccggagagcgcaa ctcggcttcc agacccgccg cgcatgctgt 180 ccccggactg agccgggcagccagcctccc acggacgccc ggacggccgg ccggccagca 240 gtgagcgagc ttccccgcaccggccaggcg cctcctgcac agcggctgcc gccccgcagc 300 ccctgcgcca gcccggagggcgcagcgctc gggaggagcc gcgcggggcg ctgatgccgc 360 agggcgcgcc gcggagcgccccggagcagc agagtctgca gcagcagcag ccggcgagga 420 gggagcagca gcagcggcggcggcggcggc ggcggcggcg gaggcgcccg gtcccggccg 480 cgcggagcgg acatgtgcaggctgggctag gagccgccgc ctccctcccg cccagcgatg 540 tattcagcgc cctccgcctgcacttgcctg tgtttacact tcctgctgct gtgcttccag 600 gtacaggtgc tggttgccgaggagaacgtg gacttccgca tccacgtgga gaaccagacg 660 cgggctcggg acgatgtgagccgtaagcag ctgcggctgt accagctcta cagccggacc 720 agtgggaaac acatccaggtcctgggccgc aggatcagtg cccgcggcga ggatggggac 780 aagtatgccc agctcctagtggagacagac accttcggta gtcaagtccg gatcaagggc 840 aaggagacgg aattctacctgtgcatgaac cgcaaaggca agctcgtggg gaagcccgat 900 ggcaccagca aggagtgtgtgttcatcgag aaggttctgg agaacaacta cacggccctg 960 atgtcggcta agtactccggctggtacgtg ggcttcacca agaaggggcg gccgcggaag 1020 ggccccaaga cccgggagaaccagcaggac gtgcatttca tgaagcgcta ccccaagggg 1080 cagccggagc ttcagaagcccttcaagtac acgacggtga ccaagaggtc ccgtcggatc 1140 cggcccacac accctgcctaggccaccccg ccgcggcccc tcaggtcgcc ctggccacac 1200 tcacactccc agaaaactgcatcagaggaa tatttttaca tgaaaaataa ggaagaagct 1260 ctatttttgt acattgtgtttaaaagaaga caaaaactga accaaaactc ttggggggag 1320 gggtgataag gattttattgttgacttgaa acccccgatg acaaaagact cacgcaaagg 1380 gactgtagtc aacccacaggtgcttgtctc tctctaggaa cagacaactc taaactcgtc 1440 cccagaggag gacttgaatgaggaaaccaa cactttgaga aaccaaagtc ctttttccca 1500 aaggttctga aaggaaaaaaaaaaaaaaac aaaaaaaaaa aaaaaa 1546 <210> SEQ ID NO 80 <211> LENGTH: 2819<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 80 ctgggcccagctcccccgag aggtggtcgg atcctctggg ctgctcggtc gatgcctgtg 60 ccactgacgtccaggcatga ggtggttcct gccctggacg ctggcagcag tgacagcagc 120 agccgccagcaccgtcctgg ccacggccct ctctccagcc cctacgacca tggactttac 180 cccagctccactggaggaca cctcctcacg cccccaattc tgcaagtggc catgtgagtg 240 cccgccatccccaccccgct gcccgctggg ggtcagcctc atcacagatg gctgtgagtg 300 ctgtaagatgtgcgctcagc agcttgggga caactgcacg gaggctgcca tctgtgaccc 360 ccaccggggcctctactgtg actacagcgg ggaccgcccg aggtacgcaa taggagtgtg 420 tgcacaggtggtcggtgtgg gctgcgtcct ggatggggtg cgctacaaca acggccagtc 480 cttccagcctaactgcaagt acaactgcac gtgcatcgac ggcgcggtgg gctgcacacc 540 actgtgcctccgagtgcgcc ccccgcgtct ctggtgcccc cacccgcggc gcgtgagcat 600 acctggccactgctgtgagc agtgggtatg tgaggacgac gccaagaggc cacgcaagac 660 cgcaccccgtgacacaggag ccttcgatgc tgtgggtgag gtggaggcat ggcacaggaa 720 ctgcatagcctacacaagcc cctggagccc ttgctccacc agctgcggcc tgggggtctc 780 cactcggatctccaatgtta acgcccagtg ctggcctgag caagagagcc gcctctgcaa 840 cttgcggccatgcgatgtgg acatccatac actcattaag gcagggaaga agtgtctggc 900 tgtgtaccagccagaggcat ccatgaactt cacacttgcg ggctgcatca gcacacgctc 960 ctatcaacccaagtactgtg gagtttgcat ggacaatagg tgctgcatcc cctacaagtc 1020 taagactatcgacgtgtcct tccagtgtcc tgatgggctt ggcttctccc gccaggtcct 1080 atggattaatgcctgcttct gtaacctgag ctgtaggaat cccaatgaca tctttgctga 1140 cttggaatcctaccctgact tctcagaaat tgccaactag gcaggcacaa atcttgggtc 1200 ttggggactaacccaatgcc tgtgaagcag tcagccctta tggccaataa cttttcacca 1260 atgagccttagttaccctga tctggaccct tggcctccat ttctgtctct aaccattcaa 1320 atgacgcctgatggtgctgc tcaggcccat gctatgagtt ttctccttga tatcattcag 1380 catctactctaaagaaaaat gcctgtctct agctgttctg gactacaccc aagcctgatc 1440 cagcctttccaagtcactag aagtcctgct ggatcttgcc taaatcccaa gaaatggaat 1500 caggtagacttttaatatca ctaatttctt ctttagatgc caaaccacaa gactctttgg 1560 gtccattcagatgaatagat ggaatttgga acaatagaat aatctattat ttggagcctg 1620 ccaagaggtactgtaatggg taattctgac gtcagcgcac caaaactatc ctgattccaa 1680 atatgtatgcacctcaaggt catcaaacat ttgccaagtg agttgaatag ttgcttaatt 1740 ttgatttttaatggaaagtt gtatccatta acctgggcat tgttgaggtt aagtttctct 1800 tcacccctacactgtgaagg gtacagatta ggtttgtccc agtcagaaat aaaatttgat 1860 aaacattcctgttgatggga aaagccccca gttaatactc cagagacagg gaaaggtcag 1920 cccgtttcagaaggaccaat tgactctcac actgaatcag ctgctgactg gcagggcttt 1980 gggcagttggccaggctctt ccttgaatct tctcccttgt cctgcttggg gttcatagga 2040 attggtaaggcctctggact ggcctgtctg gcccctgaga gtggtgccct ggaacactcc 2100 tctactcttacagagccttg agagacccag ctgcagacca tgccagaccc actgaaatga 2160 ccaagacaggttcaggtagg ggtgtgggtc aaaccaagaa gtgggtgccc ttggtagcag 2220 cctggggtgacctctagagc tggaggctgt gggactccag gggcccccgt gttcaggaca 2280 catctattgcagagactcat ttcacagcct ttcgttctgc tgaccaaatg gccagttttc 2340 tggtaggaagatggaggttt accggttgtt tagaaacaga aatagactta ataaaggttt 2400 aaagctgaagaggttgaagc taaaaggaaa aggttgttgt taatgaatat caggctatta 2460 tttattgtattaggaaaata taatatttac tgttagaatt cttttattta gggccttttc 2520 tgtgccagacattgctctca gtgctttgca tgtattagct cactgaatct tcacgacaat 2580 gttgagaagttcccattatt atttctgttc ttacaaatgt gaaacggaag ctcatagagg 2640 tgagaaaactcaaccagagt cacccagttg gtgactggga aagttaggat tcagatcgaa 2700 attggactgtctttataacc catattttcc ccctgttttt agagcttcca aatgtgtcag 2760 aataggaaaacattgcaata aatggcttga ttttttaaaa aaaaaaaaaa aaaaaaaaa 2819 <210> SEQ IDNO 81 <211> LENGTH: 2584 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 81 tggcggcggc ggcggcggtt gtcccggctg tgccggttgg tgtggcccgtcagcccgcgt 60 accacagcgc ccgggccgcg tcgagcccag tacagccaag ccgctgcggccgggtccggc 120 gcgggcggcg cgcgcagacg gagggcggcg gccgcggcca gggcggcccgtgggaccgcg 180 ggcccccggc gcagcgctgc ccggctcccg gccctgccgg cctcctcccttggcgccgcg 240 gccatggcgg ccagcgcgaa gcggaagcag gaggagaagc acctgaagatgctgcgggac 300 atgaccggcc tcccgcgcaa ccgaaagtgc ttcgactgcg accagcgcggccccacctac 360 gttaacatga cggtcggctc cttcgtgtgt acctcctgct ccggcagcctgcgaggatta 420 aatccaccac acagggtgaa atctatctcc atgacaacat tcacacaacaggaaattgaa 480 ttcttacaaa aacatggaaa tgaagtctgt aaacagattt ggctaggattatttgatgat 540 agatcttcag caattccaga cttcagggat ccacaaaaag tgaaagagtttctacaagaa 600 aagtatgaaa agaaaagatg gtatgtcccg ccagaacaag ccaaagtcgtggcatcagtt 660 catgcatcta tttcagggtc ctctgccagt agcacaagca gcacacctgaggtcaaacca 720 ctgaaatctc ttttagggga ttctgcacca acactgcact taaataagggcacacctagt 780 cagtccccag ttgtaggtcg ttctcaaggg cagcagcagg agaagaagcaatttgacctt 840 ttaagtgatc tcggctcaga catctttgct gctccagctc ctcagtcaacagctacagcc 900 aattttgcta actttgcaca tttcaacagt catgcagctc agaattctgcaaatgcagat 960 tttgcaaact ttgatgcatt tggacagtct agtggttcga gtaattttggaggtttcccc 1020 acagcaagtc actctccttt tcagccccaa actacaggtg gaagtgctgcatcagtaaat 1080 gctaattttg ctcattttga taacttcccc aaatcctcca gtgctgattttggaaccttc 1140 aatacttccc agagtcatca aacagcatca gctgttagta aagtttcaacgaacaaagct 1200 ggtttacaga ctgcagacaa atatgcagca cttgctaatt tagacaatatcttcagtgcc 1260 gggcaaggtg gtgatcaggg aagtggcttt gggaccacag gtaaagctcctgttggttct 1320 gtggtttcag ttcccagtca gtcaagtgca tcttcagaca agtatgcagctctggcagaa 1380 ctagacagcg ttttcagttc tgcagccacc tccagtaatg cgtatacttccacaagtaat 1440 gctagcagca atgtttttgg aacagtgcca gtggttgctt ctgcacagacacagcctgct 1500 tcatcaagtg tgcctgctcc atttggacgt acgccttcca caaatccatttgttgctgct 1560 gctggtcctt ctgtggcatc ttctacaaac ccatttcaga ccaatgccagaggagcaaca 1620 gcggcaacct ttggcactgc atccatgagc atgcccacgg gattcggcactcctgctccc 1680 tacagtcttc ccaccagctt tagtggcagc tttcagcagc ctgcctttccagcccaagca 1740 gctttccctc aacagacagc tttttctcaa cagcccaatg gtgcaggttttgcagcattt 1800 ggacaaacaa agccagtagt aacccctttt ggtcaagttg cagctgctggagtatctagt 1860 aatcctttta tgactggtgc accaacagga caatttccaa caggaagctcatcaaccaat 1920 cctttcttat agccttatat agacaattta ctggaacgaa cttttatgtggtcacattac 1980 atctctccac ctcttgcact gttgtcttgt ttcactgatc ttagctttaaacacaagaga 2040 agtctttaaa aagcctgcat tgtgtattaa acaccaggta atatgtgcaaaaccgagggc 2100 tccagtaaca ccttctaacc tgtgaattgg cagaaaaggg tagcggtatcatgtatatta 2160 aaattggcta atattaagtt attgcagata ccacattcat tatgctgcagtactgtacat 2220 atttttctta gaaattagct atttgtgcat atcagtattt gtaactttaacacattgtta 2280 tgtgagaaat gttactgggg aaatagatca gccactttta aggtgctgtcatatatcttg 2340 gaatgaatga cctaaaatca ttttaaccat tgctactgga aagtaacagagtcaaaattg 2400 gaaggtttta ttcattcttg aatttttcct ttctaaagag ctcttctatttatacatgcc 2460 taaattcttt taaaatgtag agggatacct gtctgcataa taaagctgatcatgttttgc 2520 tacagtttgc aggtgaaaaa aaataaatat tataaaataa aaaaaaaaaaaaagaaaaaa 2580 aaaa 2584 <210> SEQ ID NO 82 <211> LENGTH: 2115 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 82 gaaatgaacc tctcttattgatttttattg gcctagagcc aggagtactg cattcagttg 60 actttcaggg taaaaagaaaacagtcctgg ttgttgtcat cataaacata tggaccagtg 120 tgatggtgaa atgagatgaggctccgcaat ggaactgtag ccactgcttt agcatttatc 180 acttccttcc ttactttgtcttggtatact acatggcaaa atgggaaaga aaaactgatt 240 gcttatcaac gagaattccttgctttgaaa gaacgtcttc gaatagctga acacagaatc 300 tcacagcgct cttctgaattaaatacgatt gtgcaacagt tcaagcgtgt aggagcagaa 360 acaaatggaa gtaaggatgcgttgaataag ttttcagata ataccctaaa gctgttaaag 420 gagttaacaa gcaaaaaatctcttcaagtg ccaagtattt attatcattt gcctcattta 480 ttgaaaaatg aaggaagtcttcaacctgct gtacagattg gcaacggaag aacaggagtt 540 tcaatagtca tgggcattcccacagtgaag agagaagtta aatcttacct catagaaact 600 cttcattccc ttattgataacctgtatcct gaagagaagt tggactgtgt tatagtagtc 660 ttcataggag agacagatattgattatgta catggtgttg tagccaacct ggagaaagaa 720 ttttctaaag aaatcagttctggcttggtg gaagtcatat caccccctga aagctattat 780 cctgacttga caaacctaaaggagacattt ggagactcca aagaaagagt aagatggaga 840 acaaagcaaa acctagattactgttttcta atgatgtatg ctcaagaaaa gggcatatat 900 tacattcagc ttgaagatgatattattgtc aaacaaaatt attttaatac cataaaaaat 960 tttgcacttc aactttcttctgaggaatgg atgattctag agttttccca gctgggcttc 1020 attggtaaaa tgtttcaagcgccggatctt actctgattg tagaattcat attcatgttt 1080 tacaaggaga aacccattgattggctcctg gaccatattc tctgggtgaa agtctgcaac 1140 cctgaaaaag atgcaaaacattgtgataga cagaaagcaa atctgcgaat tcgcttcaga 1200 ccttcccttt tccaacatgttggtctgcac tcatcactat caggaaaaat ccaaaaactc 1260 acggataaag attatatgaaaccattactt cttaaaatcc atgtaaaccc acctgcggag 1320 gtatctactt ccttgaaggtctaccaaggg catacgctgg agaaaactta catgggagag 1380 gatttcttct gggctatcacaccgatagct ggagactaca tcttgtttaa atttgataaa 1440 ccagtcaatg tagaaagttatttgttccat agcggcaacc aagaacatcc tggagatatt 1500 ctgctaaaca caactgtggaagttttgcct tttaagagtg aaggtttgga aataagcaaa 1560 gaaaccaaag acaaacgattagaagatggc tatttcagaa taggaaaatt tgagaatggt 1620 gttgcagaag gaatggtggatccaagtctc aatcccattt cagcctttcg actttcagtt 1680 attcagaatt ctgctgtttgggccattctt aatgagattc atattaaaaa agccaccaac 1740 tgatcatctg agaaaccaacacattttttc ctgtgaattt gttaattaaa gatagttaag 1800 catgtatctt ttttttatttctacttgaac actacctctt gtgaagtcta ctgtagataa 1860 gacgattgtc atttccacttggaaagtgaa tctcccataa taattgtatt tgtttgaaac 1920 taagctgtcc tcagattttaacttgactca aacatttttc aattatgaca gcctgttaat 1980 atgacttgta ctattttggtattatactaa tacataagag ttgtacatat tgttacattc 2040 tttaaatttg agaaaaactaatgttacata cattttatga agggggtact tttgaggttc 2100 acttatttta ctatt 2115<210> SEQ ID NO 83 <211> LENGTH: 1635 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 83 gggggtggcg gggacgcgag tggcggccgc ggggccccggacaagggtcc gcagagctgc 60 agccttcgag ggccagccct ctccgagtcc ggggctgggtcccaccagtg acaaggcggc 120 agccccgcgc acaccaaaga gaaagcggct gtggcggcagcggcagcccc agccatgctg 180 tgttatgtga cgaggccgga cgcggtgctg atggaggtggaggtggaggc gaaagccaac 240 ggcgaggact gcctcaacca ggtgtgcagg cgactgggaatcatagaagt tgactatttt 300 ggactgcaat ttacgggtag caaaggtgaa agtttatggctaaacctgag aaaccggatc 360 tcccagcaga tggatgggct agccccttac aggcttaaacttagagtcaa gttcttcgtg 420 gagcctcatc tcatcttaca ggagcagact aggcatatctttttcttgca catcaaggag 480 gccctcttgg caggccacct cttgtgttcc ccagagcaggcagtggaact cagtgccctc 540 ctggcccaga ccaagtttgg agactacaac cagaacactgccaagtataa ctatgaggag 600 ctctgtgcca aggagctctc ctctgccacc ttgaacagcattgttgcaaa acataaggag 660 ttggagggga ccagccaggc ttcagctgaa taccaagttttgcagattgt gtcggcaatg 720 gaaaactatg gcatagaatg gcattctgtg cgggatagcgaagggcagag actgctcatt 780 ggggttggac ctgaaggaat ctcaatttgt aaagatgactttagcccaat taataggata 840 gcttatcctg tggtgcagat ggccacccag tcaggaaagaatgtatattt gacggtcacc 900 aaggaatctg ggaacagcat cgtgctcttg tttaaaatgatcagcaccag ggcggccagc 960 gggctctacc gagcgataac agagacgcac gcattctacaggtgtgacac agtgaccagc 1020 gccgtgatga tgcagtatag ccgtgacttg aagggccacttggcatctct gtttctgaat 1080 gaaaacatta accttggcaa gaaatatgtc tttgatattaaaagaacatc aaaggaggtg 1140 tatgaccatg ccaggagggc tctgtacaat gctggcgttgtggacctcgt ttcaagaagc 1200 aaccagagcc cttcacactc gcctctgaag tcctcagaaagcagcatgaa ctgcagcagc 1260 tgcgagggcc tcagctgcca gcagacccgg gtgctgcaggagaagctacg caagctgaag 1320 gaagccatgc tgtgcatggt gtgctgcgag gaggagatcaactccacctt ctgtccctgt 1380 ggccacactg tgtgctgtga gagctgcgcc gcccagctacagtcatgtcc cgtctgcagg 1440 tcgcgtgtgg agcatgtcca gcacgtctat ctgccaacgcacaccagtct tctcaatctg 1500 actgtaatct aatctgttgt gcttttgttg gacttggcatgtttccatga actgcactat 1560 tataaactat taaaatgata gatgttggag aaagtaattattccaacacc catctgccca 1620 tgcgatgtta aaaaa 1635 <210> SEQ ID NO 84<211> LENGTH: 2118 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE:84 ctgtgaagat ggcgctctcc agggtgtgct gggctcggtc ggctgtgtgg ggctcggcag 60tcacccctgg acattttgtc acccggaggc tgcaacttgg tcgctctggc ctggcttggg 120gggcccctcg gtcttcaaag cttcaccttt ctccaaaggc agatgtgaag aacttgatgt 180cttatgtggt aaccaagaca aaagcgatta atgggaaata ccatcgtttc ttgggtcgtc 240atttcccccg cttctatatc ctgtacacaa tcttcatgaa aggattgcag atgttatggg 300ctgatgccaa aaaggctaga agaataaaga caaatatgtg gaagcacaat ataaagtttc 360atcaacttcc ataccgggag atggagcatt tgagacagtt ccgccaagac gtcaccaagt 420gtcttttcct aggtattatt tccattccac cttttgccaa ctacctggtc ttcttgctaa 480tgtacctgtt tcccaggcaa ctactgatca ggcatttctg gaccccaaaa caacaaactg 540atttcttaga tatctatcat gctttccgga agcagtccca cccagaaatt attagttatt 600tagaaaaggt catccctctc atttctgatg caggactccg gtggcgtctg acagatctgt 660gcaccaagat acagcgtggt acccacccag caatacatga tatcttggct ctgagagagt 720gtttctctaa ccatcctctg ggcatgaacc aactccaggc tttgcacgtg aaagccttga 780gccgggccat gcttctcaca tcttacctgc ctcctccctt gttgagacat cgtttgaaga 840ctcatacaac tgtgattcac caactggaca aggctttggc aaagctgggg attggccagc 900tgactgctca ggaagtaaaa tcggcttgtt atctccgtgg cctgaattct acgcatattg 960gtgaagatag gtgtcgaact tggctgggag aatggctgca gatttcctgc agcctgaaag 1020aagctgagct gtctctcttg ctgcacaacg tggtcctgct ctccaccaac taccttggga 1080caaggcgctg aatgaaccat ggagcggatg gcattgtcct gcagtcgtat agtatagcag 1140tgcaggaaca aacagcactt gccagcaaag tctgtgtgta ctgttaagtg tgtgggaggc 1200agagagagga gcaggggcca tgggcttcac agcatggcac acctgtggga actgcagaca 1260ttcctctcac agctagaact gaaacaaacc ctcttgctag gggtggtccg tgtgaggtgt 1320catcctgtcc ccctcataat tactaatagc tggaactggc agcagcctct actgggcttt 1380tactgtgatg tgttcagttc atgtcctagg aagtcagctt ttgccccagg tgggaatcct 1440tatttggctt aggactgatc cacttccatg ttacttacat ctgtgggttt ttgttgttgc 1500tgttagaaaa tttttggctg gtgaaaacag cactcctttg gctggagcac ttgtgtccat 1560gcatgtactt gggtgtttcc ctccatcctt tctgatatga ccaaaaatca agttgttttg 1620ttttttgtca ccttcactgg catgggctaa ccacttcttt ttcaaaccct ctgaacacct 1680ttttctgatg ggtaacttgc aggaatattc tattggaaaa gataacagga agtacaagtg 1740cttcttgacc ccttcctcaa tgtttctagc cttcactctc cattgtcttt tctgggctgt 1800attacagccc tctgtggatc ttcaactctg ctgcctccac tgtgatgcag cagtccaact 1860gtaactgaca gtggctgcct tctctgggcc atggatcaca cctgtaaggt actaattact 1920gcccagcctg gggagatcag gagaggtctg catagttagt aagttgggtt tagcttttgt 1980gtgtgcatca gtgacttaga gttctgtaat aacttattgt aaatgcatga agcactgttt 2040ttaaacccaa gtaaagactg cttgaaacct gttgatggaa aaaaaaaaaa aaaaaaaaaa 2100aaaaaaaaaa aaaaaaaa 2118 <210> SEQ ID NO 85 <211> LENGTH: 4221 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 85 cgataacgat ttgtgttgtgagaggcgcaa gctgcgattt ctgctgaact tggaggcatt 60 tctacgactt ttctctcagctgaggctttt cctccgaccc tgatgctctt caattcggtg 120 ctccgccagc cccagcttggcgtcctgaga aatggatggt cttcacaata ccctcttcaa 180 tcccttctga ctggttatcagtgcagtggt aatgatgaac acacttctta tggagaaaca 240 ggagtcccag ttcctccttttggatgtacc ttctcttctg ctcccaatat ggaacatgta 300 ctagcagttg ccaatgaagaaggctttgtt cgattgtata acacagaatc acaaagtttc 360 agaaagaagt gcttcaaagaatggatggct cactggaatg ccgtctttga cctggcctgg 420 gttcctggtg aacttaaacttgttacagca gcaggtgatc aaacagccaa attttgggac 480 gtaaaagctg gtgagctgattggaacatgc aaaggtcatc aatgcagcct caagtcagtt 540 gccttttcta agtttgagaaagctgtattc tgtacgggtg gaagagatgg caacattatg 600 gtctgggata ccaggtgcaacaaaaaagat gggttttata ggcaagtgaa tcaaatcagt 660 ggagctcaca atacctcagacaagcaaacc ccttcaaaac ccaagaagaa acagaattca 720 aaaggacttg ctccttctgtggatttccag caaagtgtta ctgtggtcct ctttcaagac 780 gagaatacct tagtctcagcaggagctgtg gatgggataa tcaaagtatg ggatttacgt 840 aagaattata ctgcttatcgacaagaaccc atagcatcca agtctttcct gtacccaggt 900 agcagcactc gaaaacttggatattcaagt ctgattttgg attccactgg ctctacttta 960 tttgctaatt gcacagacgataacatctac atgtttaata tgactgggtt gaagacttct 1020 ccagtggcta ttttcaatggacaccagaac tctacctttt atgtaaaatc cagccttagt 1080 ccagatgacc agtttttagtcagtggctca agtgatgaag ctgcctacat atggaaggtc 1140 tccacaccct ggcaacctcctactgtgctc ctgggtcatt ctcaagaggt cacgtctgtg 1200 tgctggtgtc catctgacttcacaaagatt gctacctgtt ctgatgacaa tacactaaaa 1260 atctggcgct tgaatagaggcttagaggag aaaccaggag gtgataaact ttccacggtg 1320 ggttgggcct ctcagaagaaaaaagagtca agacctggcc tagtaacagt aacgagtagc 1380 cagagtactc ctgccaaagcccccagggta aagtgcaatc catccaattc ttccccgtca 1440 tccgcagctt gtgccccaagctgtgctgga gacctccctc ttccttcaaa tactcctacg 1500 ttctctatta aaacctctcctgccaaggcc cggtctccca tcaacagaag aggctctgtc 1560 tcctccgtct ctcccaagccaccttcatct ttcaagatgt cgattagaaa ctgggtgacc 1620 cgaacacctt cctcatcaccacccatcact ccacctgctt cggagaccaa gatcatgtct 1680 ccgagaaaag cccttattcctgtgagccag aagtcatccc aagcagaggc ttgctctgag 1740 tctagaaata gagtaaagaggaggctagac tcaagctgtc tggagagtgt gaaacaaaag 1800 tgtgtgaaga gttgtaactgtgtgactgag cttgatggcc aagttgaaaa tcttcatttg 1860 gatctgtgct gccttgctggtaaccaggaa gaccttagta aggactctct aggtcctacc 1920 aaatcaagca aaattgaaggagctggtacc agtatctcag agcctccgtc tcctatcagt 1980 ccgtatgctt cagaaagctgtggaacgcta cctcttcctt tgagaccttg tggagaaggg 2040 tctgaaatgg taggcaaagagaatagttcc ccagagaata aaaactggtt gttggccatg 2100 gcagccaaac ggaaggctgagaatccatct ccacgaagtc cgtcatccca gacacccaat 2160 tccaggagac agagcggaaagacattgcca agcccggtca ccatcacgcc cagctccatg 2220 aggaaaatct gcacatacttccatagaaag tcccaggagg acttctgtgg tcctgaacac 2280 tcaacagaat tatagattctaatctgagtg agttactgag ctttggtcca ctaaaacaag 2340 ctgagctttg gtccactaaaacaagatgaa aaatacaaga gtgactctat aactctggtc 2400 tttaagaaag ctgccttttcatttttagac aaaatctttt caacgctgaa atgtacctaa 2460 tctggttcta ctaccataatgtatatgcag cttcccgagg atgaatgctg tgtttaaatt 2520 tcataaagta aatttgtcactctagcattt tgaatgaata gtcttcactt tttaaattat 2580 tcatcttctc tataataatgacatcccagt tcatggaggc aaaaaacaag tttcttgtta 2640 tcctgaaact ttctatgctcagtggaaagt atctgccagc cacagcatga ggcctgtgaa 2700 ggctgactga gaaatcctctgctgaagacc cctggttctg ttctgcctcc aacatgtata 2760 attttatttg aaatacataatcttttcact atgcttttgt ggggtttttt ttaagtatgt 2820 gtaaaaatgt gatgctcagataagtacatt tatatcagtt cagtgttaaa atgcagtctc 2880 ttgagttaaa gtcatctttattttaaatgc agtgataaat gtcaactctt cggagaaact 2940 aggagaacaa caacagaaagctgtgtttgt cttttttctc tcaaatatat ctcccgtatg 3000 agatttcagg tccccatgttttcaccaagc aatctgctat gtcagccaac ccaacatcac 3060 tttctacagg aggttatgatttttgccatt tactagagga agatgtttta tgaaatcaat 3120 ttggggtttg aattcaggtgcagtcatcag ttctttaggg gctgcaatgt tttaaaaaaa 3180 ataagtcatc agattttaagaaaaaagtga tgatttctta ttgatatttt tgtaacagaa 3240 tatagctctt aactgaaaatccagaaccag aaacataaat cttgagtttc ttttcatgta 3300 cataaaaagc aatagccttttagtatagat agccctgagc caaaaagtaa tagaattttc 3360 tctagatatt taatacagagagtgtataga ctgactctaa gttaataatg tgcaaaatat 3420 cttaaacatc cctccccttattcaacaatt atgtatcagt gatcttgaac cattgtttta 3480 tatttttcac ctttgtaacctcatggaaag aggctttaca tactttctat gtactattta 3540 cttagaaggg agcccccttccagtcatgaa acttcatttg ttttatccat atccctgagg 3600 actgtgtaga ctttatgtcagttctgtgta gactttatgt cagtttttgt cattatttga 3660 aaatctattc tgacaactttttaattcctt tgatcttata agttaaagct gtaacaactg 3720 aaattgcatg gatcaagtaagcatagtttt atccagggag aaaaataaaa ggaagccata 3780 gaattgctct ggtcaaaaccaagcacacca tagccttaac tgaatattta ggaaatctgc 3840 ctaatctgct tatatttggtgtttgttttt tgactgttgg gctttgggaa gatgttattt 3900 atgaccaata tctgccagtaacgctgttta tctcacttgc tttgaaagcc aatgggggaa 3960 aaaaatccat gaaaaaaaaaagattgataa agtagatgat tttgtttgta tccctaccca 4020 tctcctggca gccctactgagtgaaattgg gatacatttg gctgtcagaa attataccga 4080 gtctactggg tataacatgtctcacttgga aagctagtac ttttaaatgg gtgccaaagg 4140 tcaactgtaa tgagataattatccctgcct gtgtccatgt cagactttga gctgatcctg 4200 aataataaag ccttttacct t4221 <210> SEQ ID NO 86 <211> LENGTH: 867 <212> TYPE: DNA <213>ORGANISM: human <400> SEQUENCE: 86 cgtttcagcg tggcggcgct ggtgctggcgttggccctgg aggacggccc cgagtgatgg 60 ctggcgcctg cctcccgggt gtctcccgggtacagatgga gtcgtcccgc ggccgccggc 120 ggcaaggtcg gcagctgcga ggccaagagagaccccagga cacacacagc tgcctcccgg 180 tgcgagaaga agaccccggc ttgagagtgagatggcgttt aatgattgct tcagtttgaa 240 ctaccctggc aacccctgcc caggggacttgatcgaagtg ttccgtcctg gctatcagca 300 ctgggccctg tacttgggtg atggttacgttatcaacata gcacctgtag atggcattcc 360 tgcgtccttt acaagcgcca agtctgtattcagcagtaag gccctggtga aaatgcagct 420 cttgaaggat gttgtgggaa atgacacatacagaataaac aataaatacg atgaaacgta 480 cccccctctc cctgtggaag aaatcataaagcggtcagag tttgtaattg gacaggaggt 540 ggcctataac ttacttgtca acaactgtgaacattttgtg acattgcttc gctatggaga 600 aggagtttca gagcaggcca accgagcgataagtaccgtt gagtttgtga cagctgctgt 660 tggtgtcttc tcattcctgg gcttgtttccaaaaggacaa agagcaaaat actattaaca 720 atttaccaaa gagatattga tattgaaggaatttgggagg aggaaaagaa acctggggtg 780 aatacttatt ttcagtgcat cattactgttccagattcct atgatggatg gcagactctt 840 taataaattg cttactgata ttatctt 867<210> SEQ ID NO 87 <211> LENGTH: 561 <212> TYPE: DNA <213> ORGANISM:human <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:(534)..(534) <223> OTHER INFORMATION: any kind of base <400> SEQUENCE:87 tttttttttc aaattttatt ttttgtactt ttattgaaaa ggtacattta aaaaaataca 60cagacatttt accatttaca ggttgcagat atagatgctc taaaagagtc cactctattt 120tgttgttcta tgataactct tgcccctgat atcacaaaca ttccagtctt gttgatatcg 180gcttaaaaag gggggcatgg gagcatgacc tgcaatatat tcagcgaaca gaaagacaaa 240ttgttcaatt ataaattttt ttatcttctg tacattattg cattagggag ccacaaaatt 300atgtagcatc attacaaatg aaaacaggtt aaaaatgaag aagatactta tatagaaata 360catggattca ttgtcttctt gcagaatgca caagaggtgc aaaaatgtgc aatttaggaa 420gctctttttc tgtttgtata cgtttgctta gcaacacaaa ccagtgagga agctacaaaa 480taagttaaac aaaaatagca aacaggtagt aattatagct atgttatatg gctntctatt 540tcatttaaat atctccaaat a 561 <210> SEQ ID NO 88 <211> LENGTH: 471 <212>TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 88 tttcatgaat aattttatttttattttggt catgactttt taaaattaat ggaaagtctc 60 agtctgctca aatgataaaccaaaaaatgg ggtcatgaag caaattcagt ctttgcattt 120 cttcaacaac caactcacatttctctgctc cttgactcag aggctggaca tgtgctaaca 180 gcttttttgc ttctgtatatccttaatagg atggcagaat cccggtgtta aaagaatctt 240 aaagtcagcc gtgtcaccatgggacctcga ttagcaaaca gatgtagaca ttccttccaa 300 attcagtcaa agaaaaaactctaataccag cagccatgtt cagggtgtgc acgacatgct 360 gagcgcttgg gatacatccccttgtttaat tctcacagaa actttgtgag acaagtacta 420 taatccctgt ttaacagatgggcaaactga ggtttggaaa aacactcatt t 471 <210> SEQ ID NO 89 <211> LENGTH:727 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 89 taaaatattaccttttattt tctcaggcac acaagtgatt tggataccaa ttatcaagac 60 attttactgatttcccttta gaatgatcta ttttaaatct tcagccacct tagaaaaagt 120 ttgcagcaatcactttgcaa ttcataagta tcaggttaga atttagttgt ggaataagtt 180 aacagtttatgttcaatatg tgaggttatt tgaactcctg agttttaaat atcctgtgga 240 acagtgattcctctcccttc taatggcttt tcagattaaa gcaatgactt taaaaagatt 300 acatcctaaatacttgatta caacagaaat cgaccaatct aaaaatcaga tagtgttata 360 ctgaacatcattctgatata atgagtagcc tctggctgaa acaaaattcc accaccaagg 420 ccatcaaccaggttagtact gtttttcctg gggtctatgt aaactctcct tttctctgca 480 aatgctgcttggctgtgaac agcatggatt tacctgcacc aatgtggcac acacctagca 540 actttctcaagcattctaaa gatatcccca gagctacaat attgacatat gcacagcact 600 ttctctagacagtccaatca gcgtgcacat cacacacaca gaatgctggg atatgctata 660 ctgcacacttagtacacagg tggaatagag tacaatgact aaagctcaca gaaaatgttt 720 tagtctt 727<210> SEQ ID NO 90 <211> LENGTH: 460 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 90 tttttgatat aaagggcttt tattttcttt acagttttctgtattttcca aatttctaca 60 taaacataca cataaaagtc ataaaaatgt ccctcaaaatgacactccct ccaatgcagg 120 gagtgaggag gtgtgtgctg ggacgccaca gggtggctgctgcagctaat ccctgtgcag 180 gtgcagccac tgctacactc cagcgtctga ggcccctctgcactggcagt gttagaatgg 240 ctgtctgaga gccaaggctg ttcacccgag cagagagtcatggagctggt acaggcagga 300 gccaaggtaa gcactaggct ggtgtgtgcc ctccagggggcaccctcctt gaagcaggcc 360 ctccaaggta ctcgccccct gaggcagccg ataacagccggaagccttcc cctgggggga 420 cctggccatt tgtggagcag ggaaaggctc cactgccagt460 <210> SEQ ID NO 91 <211> LENGTH: 392 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 91 tttttttttt tttttttgag ttgctgaaaa gtttacttttgagttttaaa ctgtactttg 60 aaaactatat tgtgaactgt gttgacatga ggaaaggctgggctccctga aaacatccag 120 ttccacagca gggcgggccc aagcccagcc aatccccaggcaatgcaggg cagggatccc 180 acctggtata agtacgggca gagggcagag ccaggctgtatcgaggggcg gcgctgggac 240 cctcctcgcc cagaattcct actcatcccc agcacagaagtgctctgtag ggccagctga 300 ggacaccccg gttcactgag ggtggcccac agtaagtcgccgtctggcag taagttagct 360 ctgcaggtgt ggaccccaag accacacacg gc 392 <210>SEQ ID NO 92 <211> LENGTH: 496 <212> TYPE: DNA <213> ORGANISM: human<400> SEQUENCE: 92 ttttttgtat ttttctcaat ataatgttgc aagatgtcattatattctca ttacccataa 60 cttcccatcc aaatcttaat ggcacatttg atattttttcaaatggcttt gagatataat 120 tcacatacca cacaattcat gtatctaaag tatacagttctgtagttctg tggttgttgg 180 ttacatccac cagactgagg gctccctgag ggttggtgcctcagctttcc cttcacttac 240 tcattcacca aacattcagc gcctactgag tactggggttatgatggcca acaggagaga 300 cagtctctgc ctactgtttg gtgggggtgg agtacttagtaaccgtcgtc attattgagt 360 gcttacctgt gctgggcaca gtgctgctac tgggtgactgtgtccccagg gctgtcccag 420 gctgggggtc tggaggagta gttatcagtt gaactgagttaatccacagt ggaaggtaac 480 ccactccctg ccctag 496 <210> SEQ ID NO 93 <211>LENGTH: 472 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 93ttaacacaaa agcttttact tggaaactgg caaatactgg actagaatac tgacatgctc 60acgctctggc gggagctcgg atgcagaagc tattgcacaa agcccctctg attgccttgc 120tcctctttgg catgtatcag cagagcccca agggccaatt gcccacaggt ggggactgtt 180ctccatcaag gtatggggac ccctacttcc ttgttttgtt aaaaagtgca ggtaggcgaa 240gaaagcccag gcagttgacc cagtctttga aacagctgac tccccagagc tggggccagg 300ggagcctggt cttgaggggt aagggctgca gggccaggct gatggcctgt gtcatggcat 360tggccatctc ctctccagct tctcctcagc catcgcccgt ccgtcatggt ggtgtcggct 420gcacctggac cttcctgcct ctccgctcag ggcagcagca gtgagtgcag ca 472 <210> SEQID NO 94 <211> LENGTH: 585 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 94 tttttatatt atagtaaatt tatttggtat aattacatat taacattatttacaatgcta 60 atttttttat ttataaagta tctttatatg gacaaaaaga tacaaactgttatcatttta 120 agtacaaagt atttctagaa atacattata agccattaaa aaaaaaaacgatatttcaag 180 attggttctt acatgctatg accaactcat atgaaagagc aagttgctcccccttcattc 240 cttcccccaa ctccaaaggg aaaggaattt gatatttagg ctttaaaaaatttcctacta 300 cctttatctt ttaaaaaacc ctactcaaaa caactatctc ttataagggaaaatatcata 360 gataagattt tcctttagaa aatgacatta aaagtggcat gagccctagaatgatatgtg 420 tattagaggc acttaaaaaa aatcagaagg gatccatagg aaggaatttaattcagcaaa 480 tactgagtgt ccactgcatg caaggtaccc tgccagaaat ctcaaatgagtaagttgtcc 540 ttagggatag aaggtgctaa gcatcatgca aaagatatga actga 585<210> SEQ ID NO 95 <211> LENGTH: 400 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 95 ttattgtttt ttaaaaatac aattttgaaa tttattgttgaaaatggaca catggaacaa 60 accaaacctt gttttatcat gtaattttca gaaaatatgtgatccataaa gattaaaaga 120 aagttgtatt aagtctggca gctttagtat taacttgaaataaaatatgg caagctttcc 180 acgtcctcct ttatttccac aatccatatg tacgagctagattccagtca gaacttccac 240 aaatacttca ctctttggta gcagcggtta taaattacgcctttgctaat ttgcgttgtt 300 cccaaccagg agaaacatta ccacaaaaaa agtcagtttcatcctgcagt gttcccgcag 360 caaccatatt aaagctgaag aataaagctc ctttgtagta400 <210> SEQ ID NO 96 <211> LENGTH: 461 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 96 ttatgccatg aattcctttt tactgaaata ccgtaggactcactaccaca ataagtactt 60 aagctgaaag agtttctaat gggagccaag taaattcagctctccactgt gcaaagcatc 120 ttgtcatttc tataataaaa gtctttccat gttcagtccactttggctct ggaacctgga 180 tgagtcatgc ttggggccca gggtgcctgt gaggatgctgcatgagaatt tcagctgtgg 240 tggcagtggc tgggagtccc actgactcag ggggaggccaggcgagatga gctggaactt 300 ttaggggaga gctggcactt agggacatca ttgattgtgcttttcttagc ctagttctgt 360 cctgcaattt atttttctta tcatgtgact gtcggctgaagtctggggtt atttggtttc 420 tttttcttct tccttgctgg acagtctcca tggggtcacg g461 <210> SEQ ID NO 97 <211> LENGTH: 542 <212> TYPE: DNA <213> ORGANISM:human <400> SEQUENCE: 97 taaatccagt aaagcatagt actagattca tcatacttgtacaatacaac gggcgacatg 60 aaaatggcaa aggctctcct ttttgtgaac aatttaatacaactggtggt ccaataactc 120 tacaatcagc cttgtagagg tcattaaaga cagaatcctgaaagtccgtg actacaaata 180 cattttcaaa ttccggagaa tccaaacctt caaattcttccactgactcc atctttacaa 240 agcccacttt aatgtccttt aaggctttta taagttcttcttgttttcca gcttcttgaa 300 ccaatatcac tcttgtttca atctgaggca tctcttcttctacatatgaa gtagatccaa 360 taagtaagtt ttccttggaa atctcagtaa ctttagaatcaaaaatggaa gagtctgcca 420 agctagtcct cccagtagtg gatgttaata cactattttcagccatgatt tgtattcttc 480 taaatcagca ctctcaaaaa agccctagga gttccacctcttcaaacgcc gactcctctc 540 ac 542 <210> SEQ ID NO 98 <211> LENGTH: 1017<212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 98 atgggcacctggcttctggc ctgcacctgc gtctgcacct gtgtctgctc gggagtctct 60 gtctcaggggatggacgagg gccaagggct ggaacctcca cctgcctcac caacaacatt 120 ctcaggattgattgccactg gtctgcccca gagctgggtc agggctccag ccccgggctc 180 cccttcatcagccccgtggt gctgacacat gcccttttca gcaaccaggc tgctggtggc 240 acacagaagtgcatctggca gggcagtgag tgcactgtag tgttgccgcc caaggcagca 300 ctcctgccatctgacaattt catcatcact ttctaccact gcatgtccgg gagggatcag 360 agcacgtcagctcgccactg catcctgacc tggagcctca gtcctgcctt ggagtcaatg 420 accacacttctcagctatga gctggacttc aagaggcagg aagaggcctg ggagcgggcc 480 cagcacagggatcacattgt cggggtgacc tggctcatac ttgaagcctt tgagctggac 540 cctggctttatccttgaggc caggctgcgt gtccagacgg ccatgctggg ggatgacggg 600 gcacaggaggagcgagggga gccagcccat gggaagagtg aggcccagga gtgtggttca 660 cacaaggtccttcagcaggt gacacaaacc tccaaggccc atcacaaggt ccttcagcag 720 atgacacaaacctccaaggc tcatcacaaa ccttccactt tggcccaggg cactaaaggg 780 cgcacttttgccagccctgg gcccttcctg cccacggacc ctctgatccc accctggggg 840 tggccaggcaacacctttgt tgctgtgtcc atctttctcc tgctgactgg cccgacctac 900 ctcctgttcaagctgtcgcc cagactcctc actttgggca aaggacaaga agcaactcgg 960 atgggggcccacagggctgg tgtgctgctg agccaggact gtgctggcac ccgatga 1017 <210> SEQ ID NO99 <211> LENGTH: 1099 <212> TYPE: DNA <213> ORGANISM: human <400>SEQUENCE: 99 agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtcccggttgtct 60 tcctcaccct gtccgtgacg tggattggtg agaggggcca tggttggggggatgcaggag 120 agggagccag ccctgactgt caagctgagg ctctttcccc cccaacccagcaccccagcc 180 cagacaggga gctgggctct tttctgtctc tcccagcccc actccaagcccataccccca 240 gcccctccat attgcaacag tcctcactcc cacaccaggt ccccgctccctcccacttac 300 cccagaactt tctccccatt gcccagccag ctccctgctc ccagctgctttactaaaggg 360 gaagttcctg ggcatctccg tgtttctctt tgtggggctc aaaacctccaaggacctctc 420 tcaatgccat tggttccttg gaccgtatca ctggtccacc tcctgagcccctcaatccta 480 tcacagtcta ctgacttttc ccattcagct gtgagtgccc aaccctatcccagagacctt 540 gatgcttggc ctcccaatct tgccctagga tacccagatg ccaaccagacacctccttct 600 tcctagccag gctatctggc ctgagacaac aaatgggtcc ctcagtctggcaatgggact 660 ctgagaactc ctcattccct gactcttagc cccagactct tcattcagtggcccacattt 720 tccttaggaa aaacatgagc atccccagcc acaactgcca gctctctgattccccaaatc 780 tgcatccttt tcaaaaccta aaaacaaaaa gaaaaacaaa taaaacaaaaccaactcaga 840 ccagaactgt tttctcaacc tgggacttcc taaactttcc aaaaccttcctcttccagca 900 actgaacctc gccataaggc acttatccct ggttcctagc accccttatcccctcagaat 960 ccacaacttg taccaagttt cccttctccc agtccaagac cccaaatcaccacaaaggac 1020 ccaatcccca gactcaagat atggtctggg cgctgtcttg tgtctcctaccctgatccct 1080 gggttcaact ctgctccca 1099 <210> SEQ ID NO 100 <211>LENGTH: 1095 <212> TYPE: DNA <213> ORGANISM: human <400> SEQUENCE: 100ccaagcttac cacctgcacc cggagagctg tgtcaccatg tgggtcccgg ttgtcttcct 60caccctgtcc gtgacgtgga ttggtgagag gggccatggt tggggggatg caggagaggg 120agccagccct gactgtcaag ctgaggctct ttccccccca acccagcacc ccagcccaga 180cagggagctg ggctcttttc tgtctctccc agccccactt caagcccata cccccagccc 240ctccatattg caacagtcct cactcccaca ccaggtcccc gctccctccc acttacccca 300gaactttctc cccattgccc agccagctcc ctgctcccag ctgctttact aaaggggaag 360ttcctgggca tctccgtgtt tctctttgtg gggctcaaaa cctccaagga cctctctcaa 420tgccattggt tccttggacc gtatcactgg tccatctcct gagcccctca atcctatcac 480agtctactga cttttcccat tcagctgtga gtgtccaacc ctatcccaga gaccttgatg 540cttggcctcc caatcttgcc ctaggatacc cagatgccaa ccagacacct ccttcttcct 600agccaggcta tctggcctga gacaacaaat gggtccctca gtctggcaat gggactctga 660gaactcctca ttccctgact cttagcccca gactcttcat tcagtggccc acattttcct 720taggaaaaac atgagcatcc ccagccacaa ctgccagctc tctgagtccc caaatctgca 780tccttttcaa aacctaaaaa caaaaagaaa aacaaataaa acaaaaccaa ctcagaccag 840aactgttttc tcaacctggg acttcctaaa ctttccaaaa ccttcctctt ccagcaactg 900aacctcgcca taaggcactt atccctggtt cctagcaccc cttatcccct cagaatccac 960aacttgtacc aagtttccct tctcccagtc caagacccca aatcaccaca aaggacccaa 1020tccccagact caagatatgg tctgggcgct gtcttgtgtc tcctaccctg atccctgggt 1080tcaactctgc tccca 1095

I claim:
 1. A method of selecting a portfolio of markers for use in adiagnostic application comprising: a) definining diagnostic parameters,b) establishing a relationship among the diagnostic parameters thatidentifies an optimized portfolio of markers, c) and selecting saidportfolio.
 2. The method of claim 1 wherein the markers comprise genes.3. The method of claim 2 wherein the relationship is based on theexpression of the gene.
 4. The method of claim 2 wherein therelationship is based on the variance of the expression of the gene. 5.The method of claim 4 wherein the diagnostic parameters include ameasure of the relative degree of expression of a gene and a measure ofthe variation in the measurement of the degree of expression of thegene; and the relationship is a mean variance relationship.
 6. Themethod of claim 1 further comprising the application of a heuristicrule.
 7. The method of claim 1 wherein the diagnostic parametersrepresent sensitivity and specificity.
 8. A machine comprising a generalpurpose computer programmed to identify a portfolio of markers whereinsaid machine comprises instructions to employ a relationship amongdiagnostic parameters so that markers are optimized.
 9. The machine ofclaim 8 wherein the markers comprise genes.
 10. The machine of claim 9wherein the relationship is based on the expression of the gene.
 11. Themachine of claim 9 wherein the relationship is based on the variance ofthe expression of the gene.
 12. The machine of claim 9 wherein theinstructions include a measure of the relative degree of expression of agene and a measure of the variation in the measurement of the degree ofexpression of the gene; and the relationship is a mean variancerelationship.
 13. The machine of claim 8 further comprising instructionsto execute a heuristic rule.
 14. The machine of claim 8 wherein thediagnostic parameters represent sensitivity and specificity.
 15. Anarticle comprising instructions for selecting a portfolio of markers foruse in a diagnostic application comprising: a) instructions forinputting diagnostic parameters into an algorithm, b) instructions foroperating said algorithm wherein said algorithm relates the diagnosticparameters such that an optimized portfolio of markers is identifiable,and c) instructions for selecting said portfolio.
 16. The article ofclaim 15 wherein said markers comprise genes.
 17. The article of claim16 wherein the relationship is based on the expression of the gene. 18.The article of claim 17 wherein the relationship is based on thevariance of the expression of the gene.
 19. The article of claim 17wherein the diagnostic parameters include a measure of the relativedegree of expression of a gene and a measure of the variation in themeasurement of the degree of expression of the gene; and therelationship is a mean variance relationship.
 20. The article of claim16 further comprising instructions for the application of a heuristicrule.
 21. The article of claim 16 wherein the diagnostic parametersrepresent sensitivity and specificity.
 22. The article of claim 16wherein the instructions are machine readable.
 23. The article of claim22 wherein the instructions are computer readable.
 24. A diagnosticportfolio selected according to the method of claim
 1. 25. The portfolioof claim 24 comprising genes.